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Newly developed bio-active implant by minute control of apatite coating layer.

Research Project

Project/Area Number 17390516
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionOkayama University

Principal Investigator

MAEKAWA Kenji  Okayama University, 医学部・歯学部附属病院, 講師 (20304313)

Co-Investigator(Kenkyū-buntansha) YOSHIDA Yasuhiro  岡山大学, 大学院医歯薬学総合研究科, 准教授 (90281162)
KUBOKI Takuo  岡山大学, 大学院医歯薬学総合研究科, 教授 (00225195)
鈴木 一臣  岡山大学, 大学院・医歯薬学総合研究科, 教授 (30050058)
早川 聡  岡山大学, 大学院・自然科学研究科, 准教授 (20263618)
尾坂 明義  岡山大学, 大学院・自然科学研究科, 教授 (20033409)
Project Period (FY) 2005 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥17,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2007: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2006: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2005: ¥6,300,000 (Direct Cost: ¥6,300,000)
Keywordsチタン / インプラント / 表面改質 / 骨伝導性 / 酸化膜 / アパタイト / ポリリン酸 / 骨形成能 / 微細表面形状 / 細胞増殖 / 骨伝導能 / 細胞増殖因子
Research Abstract

失われた歯を補う目的で顎の骨に埋入されるチタンインプラントが,早期に確実に骨と結合して治療期間が短縮できるよう,チタン表面に生物学的な表面の改質を施した.具体的には,生体内に埋入された時に骨と親和性の高いアパタイトがチタン表面に自己形成される酸化膜を施し,骨の形成能が亢進される表面を開発した。また,ポリリン酸をチタン表面に吸着させることにより,高い生体活性を有するチタンインプラントの開発に繋がる可能性を示した。

Report

(5 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (24 results)

All 2008 2007 2006 2005 Other

All Journal Article (12 results) (of which Peer Reviewed: 6 results) Presentation (10 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Effect of polyphosphoric-acid pre-treatment of titanium on attachment, proliferation and differentiation of osteoblast like cells (MC3T3-E1)2008

    • Author(s)
      Maekawa K, Yoshida Y, Mine A, Van Meerbeek B, Suzuki K, Kuboki T
    • Journal Title

      Clin Oral Imp Res 19

      Pages: 320-325

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of polyphosphoric acid pre-treatment of titanium on attachment, proliferation, and differentiation of osteoblast-like cells (MC3T3-E1).2008

    • Author(s)
      Mekawa, et. al.
    • Journal Title

      Clinical Oral Implant Research 19

      Pages: 320-320

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemical interaction of polyphosphoric acid with titanium and its effect on human bone marrow derived mesenchymal stem cell behavior2007

    • Author(s)
      Maekawa K, Yoshida Y, Mine A, Fujisawa T, Van Meerbeek B, Suzuki K, Kuboki T
    • Journal Title

      J Biomed Mater Res A 82

      Pages: 195-200

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemical interacton of polyphosphoric acid with titanium and its effect on human bone marrow derived mesenchymal stem cell behavior.2007

    • Author(s)
      Maekawa, et. al.
    • Journal Title

      Journal of Biomedical Materials Research 82

      Pages: 195-200

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ti-surface modification using polyphosphoric-acid enhanced osteoblast proliferation and bFGF adsorption.2007

    • Author(s)
      Maekawa K, et al.
    • Journal Title

      Journal of Dental research 85(Special Issue A)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] ポリリン酸処理によるチタンインプラントの細胞応答促進と成長因子吸着制御2007

    • Author(s)
      前川賢治, 他
    • Journal Title

      日本補綴歯科学会雑誌 50(115回特別号)

      Pages: 91-91

    • NAID

      10024183837

    • Related Report
      2006 Annual Research Report
  • [Journal Article] ポリリン酸処理によるチタン0.05無処理チタンセンサー無処理チタンセンサーインプラントへの細胞応答促進と成長因子吸着制御2006

    • Author(s)
      前川賢治
    • Journal Title

      The Journal of Dental Engineering 156

      Pages: 35-36

    • Related Report
      2008 Final Research Report
  • [Journal Article] Adsorption of polyphosphoric acid to titanium surface and its effect on hBMSC attachment2005

    • Author(s)
      K.Maekawa et al.
    • Journal Title

      International Congress Series 1284, Interface Oral Science

      Pages: 332-333

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Polyphosphoric acid treatment promotes bone formation around titanium implants

    • Author(s)
      Maekawa K, Shimono K, Oshima M, Yoshida Y, Van Meerbeek B, Suzuki K, Kuboki T
    • Journal Title

      Oral Rehabil (in press)

      Pages: 0-0

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polyphosphoric acid treatment promotes bone regeneration around titaniumimplants

    • Author(s)
      Maekawa, et al.
    • Journal Title

      Journal of Oral Rehabilitation (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemical interaction of polyphosphoric acid with titanium and its effect on human bone marrow derived mesenchymal stem cell behavior

    • Author(s)
      Maekawa K, et al.
    • Journal Title

      Journal of Biomedical Materials Research (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effect of polyphosphoric-acid pre-treatment of titanium on attachment, proliferation and differentiation of osteoblast like cells(MC3T3-E1).

    • Author(s)
      Maekawa K, et al.
    • Journal Title

      Clinical Oral Implant Research (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Presentation] Effect of CH-treatment of titanium on bone formation around implants2008

    • Author(s)
      Maekawa, et al.
    • Organizer
      86th General session and exibhition of International Association of Dental Research
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2008-07-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] ポリリン酸を用いたチタンインプラントの生物学的表面改質2008

    • Author(s)
      前川賢治,下野賢吾,大島正充,峯 篤史,吉田靖弘,鈴木一臣,窪木拓男
    • Organizer
      第38回(社)日本口腔インプラント学会・学術大会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Effect of CH-treatment of titanium on bone formation around implants2008

    • Author(s)
      K. Maekawa, K. Kawanishi, S. Hayakawa, M. Oshika, K. Shimono, Y. Yoshida, K. Suzuki, A. Osaka, T. Kuboki
    • Organizer
      86^<th> General Session and Exhibition of the International Association for Dental Research
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2008 Final Research Report
  • [Presentation] Chemical, mechanical, and biological properties of titanium implant surface treated with polyphosphoric acid.2007

    • Author(s)
      Maekawa, et. al.
    • Organizer
      International Dental Materials Congress 2007
    • Place of Presentation
      Bangkok
    • Year and Date
      2007-11-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] Chemical, mechanical, and biological properties of titanium implant surface treated with polyphosphoric acid2007

    • Author(s)
      K. Maekawa, Y. Yoshida, I. Hirata, M. Okazaki, K. Suzuki, T. Kuboki
    • Organizer
      International Dental Materials Congress 2007
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2008 Final Research Report
  • [Presentation] Surface treatment with polyphos- phoric acid promotes osteogenesis around titanium implants2007

    • Author(s)
      K. Maeakwa, K. Shimono, M. Oshima, Y. Yoshida, K. Suzuki, T. Kuboki
    • Organizer
      85^<th> General Session and Exhibition of the International Association for Dental Research
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Titanium surface modification by polyphos- phoric acid accelerated mouse osteoblast like cell behavior2006

    • Author(s)
      K. Maekawa, Y. Yoshida, A. Mine, K. Akiyama, M. Ohshima, T. Fujisawa, K. Suzuki, T. Kuboki
    • Organizer
      2006 Spring Scientific Meeting of the Korean Academy of Prosthodontics: The 3rd International Joint Meeting with Japanese Prosthodontic Society
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2006-04-28
    • Related Report
      2008 Final Research Report
  • [Presentation] ポリリン酸処理によるチタンインプラントの細胞応答促進と成長因子吸着制御2006

    • Author(s)
      前川賢治,吉田靖弘,峯 篤史,大島正充,下野賢吾,秋山謙太郎,藤澤拓生,鈴木一臣,窪木拓男
    • Organizer
      社団法人日本補綴歯科学会第115回学術大会
    • Place of Presentation
      札幌
    • Related Report
      2008 Final Research Report
  • [Presentation] Ti-surface modification using polyphosphoric acid enhanced osteoblast proliferation and bFGF adsorption2006

    • Author(s)
      K. Maekawa, A. Mine, I. Hirata, Y. Yoshida, M. Okazaki, K. Suzuki, T. Kuboki
    • Organizer
      35^<th> American Association for Dental Research
    • Place of Presentation
      Orlando, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Acceleration of cell behavior and growth factor adsorption onto titanium implant surface by polyphosphoric acid treatment2005

    • Author(s)
      K. Maekawa, Y. Yoshida, I. Hirata, A. Mine, T. Fujisawa, M. Okazaki, K. Suzuki, T. Kuboki
    • Organizer
      The 1^<st> Congress of Asian Academy of Osseointegration
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] Implant made with titanium or titanium alloy and surface treating method thereof2008

    • Inventor(s)
      Kuboki T, Maekawa K, Yoshida Y, Mine A, Fujisawa T, Van Meerbeek Bart, Kaneko T
    • Industrial Property Rights Holder
      Kuboki T, Maekawa K, Yoshida Y, Mine A, Fujisawa T, Van Meerbeek Bart, Kaneko T
    • Acquisition Date
      2008-08-13
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] Implant made with titaniumor titanium alloy and surface treating methodthereof.2008

    • Inventor(s)
      Kuboki T, Maekawa K, et al.
    • Industrial Property Rights Holder
      Kuboki T, Maekawa K, et al.
    • Filing Date
      2008-08-13
    • Related Report
      2008 Annual Research Report
    • Overseas

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Published: 2005-04-01   Modified: 2016-04-21  

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