Newly developed bio-active implant by minute control of apatite coating layer.

• Project/Area Number: 17390516
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 補綴理工系歯学
• Research Institution: Okayama University
• Principal Investigator: MAEKAWA Kenji Okayama University, 医学部・歯学部附属病院, 講師 (20304313)
• Co-Investigator(Kenkyū-buntansha): YOSHIDA Yasuhiro 岡山大学, 大学院医歯薬学総合研究科, 准教授 (90281162) ; KUBOKI Takuo 岡山大学, 大学院医歯薬学総合研究科, 教授 (00225195) ; 鈴木 一臣 岡山大学, 大学院・医歯薬学総合研究科, 教授 (30050058) ; 早川 聡 岡山大学, 大学院・自然科学研究科, 准教授 (20263618) ; 尾坂 明義 岡山大学, 大学院・自然科学研究科, 教授 (20033409)
• Project Period (FY): 2005 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥17,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥1,620,000); Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2007: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2006: ¥3,700,000 (Direct Cost: ¥3,700,000); Fiscal Year 2005: ¥6,300,000 (Direct Cost: ¥6,300,000)
• Keywords: チタン / インプラント / 表面改質 / 骨伝導性 / 酸化膜 / アパタイト / ポリリン酸 / 骨形成能 / 微細表面形状 / 細胞増殖 / 骨伝導能 / 細胞増殖因子

Research Abstract

失われた歯を補う目的で顎の骨に埋入されるチタンインプラントが,早期に確実に骨と結合して治療期間が短縮できるよう,チタン表面に生物学的な表面の改質を施した.具体的には,生体内に埋入された時に骨と親和性の高いアパタイトがチタン表面に自己形成される酸化膜を施し,骨の形成能が亢進される表面を開発した。また,ポリリン酸をチタン表面に吸着させることにより,高い生体活性を有するチタンインプラントの開発に繋がる可能性を示した。

Research Products

• [Journal Article] Effect of polyphosphoric-acid pre-treatment of titanium on attachment, proliferation and differentiation of osteoblast like cells (MC3T3-E1) (2008)
  • Author(s): Maekawa K, Yoshida Y, Mine A, Van Meerbeek B, Suzuki K, Kuboki T
  • Journal Title: Clin Oral Imp Res 19 Pages: 320-325
  • Peer Reviewed
• [Journal Article] Effect of polyphosphoric acid pre-treatment of titanium on attachment, proliferation, and differentiation of osteoblast-like cells (MC3T3-E1). (2008)
  • Author(s): Mekawa, et. al.
  • Journal Title: Clinical Oral Implant Research 19 Pages: 320-320
  • Peer Reviewed
• [Journal Article] Chemical interaction of polyphosphoric acid with titanium and its effect on human bone marrow derived mesenchymal stem cell behavior (2007)
  • Author(s): Maekawa K, Yoshida Y, Mine A, Fujisawa T, Van Meerbeek B, Suzuki K, Kuboki T
  • Journal Title: J Biomed Mater Res A 82 Pages: 195-200
  • Peer Reviewed
• [Journal Article] Chemical interacton of polyphosphoric acid with titanium and its effect on human bone marrow derived mesenchymal stem cell behavior. (2007)
  • Author(s): Maekawa, et. al.
  • Journal Title: Journal of Biomedical Materials Research 82 Pages: 195-200
  • Peer Reviewed
• [Journal Article] Ti-surface modification using polyphosphoric-acid enhanced osteoblast proliferation and bFGF adsorption. (2007)
  • Author(s): Maekawa K, et al.
  • Journal Title: Journal of Dental research 85(Special Issue A)
• [Journal Article] ポリリン酸処理によるチタンインプラントの細胞応答促進と成長因子吸着制御 (2007)
  • Author(s): 前川賢治, 他
  • Journal Title: 日本補綴歯科学会雑誌 50(115回特別号) Pages: 91-91
  • NAID: 10024183837
• [Journal Article] ポリリン酸処理によるチタン0.05無処理チタンセンサー無処理チタンセンサーインプラントへの細胞応答促進と成長因子吸着制御 (2006)
  • Author(s): 前川賢治
  • Journal Title: The Journal of Dental Engineering 156 Pages: 35-36
• [Journal Article] Adsorption of polyphosphoric acid to titanium surface and its effect on hBMSC attachment (2005)
  • Author(s): K.Maekawa et al.
  • Journal Title: International Congress Series 1284, Interface Oral Science Pages: 332-333
• [Journal Article] Polyphosphoric acid treatment promotes bone formation around titanium implants
  • Author(s): Maekawa K, Shimono K, Oshima M, Yoshida Y, Van Meerbeek B, Suzuki K, Kuboki T
  • Journal Title: Oral Rehabil (in press) Pages: 0-0
  • Peer Reviewed
• [Journal Article] Polyphosphoric acid treatment promotes bone regeneration around titaniumimplants
  • Author(s): Maekawa, et al.
  • Journal Title: Journal of Oral Rehabilitation (印刷中)
  • Peer Reviewed
• [Journal Article] Chemical interaction of polyphosphoric acid with titanium and its effect on human bone marrow derived mesenchymal stem cell behavior
  • Author(s): Maekawa K, et al.
  • Journal Title: Journal of Biomedical Materials Research (印刷中)
• [Journal Article] Effect of polyphosphoric-acid pre-treatment of titanium on attachment, proliferation and differentiation of osteoblast like cells(MC3T3-E1).
  • Author(s): Maekawa K, et al.
  • Journal Title: Clinical Oral Implant Research (印刷中)
• [Presentation] Effect of CH-treatment of titanium on bone formation around implants (2008)
  • Author(s): Maekawa, et al.
  • Organizer: 86th General session and exibhition of International Association of Dental Research
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2008-07-05
• [Presentation] ポリリン酸を用いたチタンインプラントの生物学的表面改質 (2008)
  • Author(s): 前川賢治,下野賢吾,大島正充,峯 篤史,吉田靖弘,鈴木一臣,窪木拓男
  • Organizer: 第38回(社)日本口腔インプラント学会・学術大会
  • Place of Presentation: 東京
• [Presentation] Effect of CH-treatment of titanium on bone formation around implants (2008)
  • Author(s): K. Maekawa, K. Kawanishi, S. Hayakawa, M. Oshika, K. Shimono, Y. Yoshida, K. Suzuki, A. Osaka, T. Kuboki
  • Organizer: 86^<th> General Session and Exhibition of the International Association for Dental Research
  • Place of Presentation: Toronto, Canada
• [Presentation] Chemical, mechanical, and biological properties of titanium implant surface treated with polyphosphoric acid. (2007)
  • Author(s): Maekawa, et. al.
  • Organizer: International Dental Materials Congress 2007
  • Place of Presentation: Bangkok
  • Year and Date: 2007-11-24
• [Presentation] Chemical, mechanical, and biological properties of titanium implant surface treated with polyphosphoric acid (2007)
  • Author(s): K. Maekawa, Y. Yoshida, I. Hirata, M. Okazaki, K. Suzuki, T. Kuboki
  • Organizer: International Dental Materials Congress 2007
  • Place of Presentation: Bangkok, Thailand
• [Presentation] Surface treatment with polyphos- phoric acid promotes osteogenesis around titanium implants (2007)
  • Author(s): K. Maeakwa, K. Shimono, M. Oshima, Y. Yoshida, K. Suzuki, T. Kuboki
  • Organizer: 85^<th> General Session and Exhibition of the International Association for Dental Research
  • Place of Presentation: New Orleans, USA
• [Presentation] Titanium surface modification by polyphos- phoric acid accelerated mouse osteoblast like cell behavior (2006)
  • Author(s): K. Maekawa, Y. Yoshida, A. Mine, K. Akiyama, M. Ohshima, T. Fujisawa, K. Suzuki, T. Kuboki
  • Organizer: 2006 Spring Scientific Meeting of the Korean Academy of Prosthodontics: The 3rd International Joint Meeting with Japanese Prosthodontic Society
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2006-04-28
• [Presentation] ポリリン酸処理によるチタンインプラントの細胞応答促進と成長因子吸着制御 (2006)
  • Author(s): 前川賢治,吉田靖弘,峯 篤史,大島正充,下野賢吾,秋山謙太郎,藤澤拓生,鈴木一臣,窪木拓男
  • Organizer: 社団法人日本補綴歯科学会第115回学術大会
  • Place of Presentation: 札幌
• [Presentation] Ti-surface modification using polyphosphoric acid enhanced osteoblast proliferation and bFGF adsorption (2006)
  • Author(s): K. Maekawa, A. Mine, I. Hirata, Y. Yoshida, M. Okazaki, K. Suzuki, T. Kuboki
  • Organizer: 35^<th> American Association for Dental Research
  • Place of Presentation: Orlando, USA
• [Presentation] Acceleration of cell behavior and growth factor adsorption onto titanium implant surface by polyphosphoric acid treatment (2005)
  • Author(s): K. Maekawa, Y. Yoshida, I. Hirata, A. Mine, T. Fujisawa, M. Okazaki, K. Suzuki, T. Kuboki
  • Organizer: The 1^<st> Congress of Asian Academy of Osseointegration
  • Place of Presentation: Seoul, Korea
• [Patent(Industrial Property Rights)] Implant made with titanium or titanium alloy and surface treating method thereof (2008)
  • Inventor(s): Kuboki T, Maekawa K, Yoshida Y, Mine A, Fujisawa T, Van Meerbeek Bart, Kaneko T
  • Industrial Property Rights Holder: Kuboki T, Maekawa K, Yoshida Y, Mine A, Fujisawa T, Van Meerbeek Bart, Kaneko T
  • Acquisition Date: 2008-08-13
• [Patent(Industrial Property Rights)] Implant made with titaniumor titanium alloy and surface treating methodthereof. (2008)
  • Inventor(s): Kuboki T, Maekawa K, et al.
  • Industrial Property Rights Holder: Kuboki T, Maekawa K, et al.
  • Filing Date: 2008-08-13
  • Overseas