Gene therapy targeting lipid mediators for prevention of bone destruction
| Project/Area Number |
17390529
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HIKIJI Hisako The University of Tokyo, Faculty of medicine, Assistant professor (50292876)
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| Co-Investigator(Kenkyū-buntansha) |
TAKATO Tuyoshi The University of Tokyo, Faculty of medicine, Professor (90171454)
MIZUKAMI Hiroaki Jichi Medical School, Faculty of medicine, Assistant professor (20311938)
ISHII Satoshi The University of Tokyo, Faculty of medicine, Associate professor (10300815)
KOYAMA Hiroyuki The University of Tokyo, Faculty of medicine, Specially appointed associate professor (10241994)
KATAYAMA Kazunori The University of Tokyo, Faculty of engineering, Professor (00130245)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥15,650,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2007: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2006: ¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥7,500,000 (Direct Cost: ¥7,500,000)
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| Keywords | lipid mediator / bone destruction / osteoclast / platelet-activating factor / 非病原性ベクター / 骨破壊病変遺伝子治療 |
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| Research Abstract |
Bone-resorptive diseases such as osteoporosis, rheumatoid arthritis, osteoarthritis, and periodontitis enhanced the production of a variety of lipid mediators. Platelet-activating factor (PAF) is one of the potent lipid mediators. -This study has shown that PAF receptor deficient mice develop only mild osteoporosis. Osteoclastic bone resorption is impaired in these deficient mice. This investigation also focuses on the other families of lipids and their function during bone metabolism and disease.
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Report
(4 results)
Research Products
(10 results)
