• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Gene therapy targeting lipid mediators for prevention of bone destruction

Research Project

Project/Area Number 17390529
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionThe University of Tokyo

Principal Investigator

HIKIJI Hisako  The University of Tokyo, Faculty of medicine, Assistant professor (50292876)

Co-Investigator(Kenkyū-buntansha) TAKATO Tuyoshi  The University of Tokyo, Faculty of medicine, Professor (90171454)
MIZUKAMI Hiroaki  Jichi Medical School, Faculty of medicine, Assistant professor (20311938)
ISHII Satoshi  The University of Tokyo, Faculty of medicine, Associate professor (10300815)
KOYAMA Hiroyuki  The University of Tokyo, Faculty of medicine, Specially appointed associate professor (10241994)
KATAYAMA Kazunori  The University of Tokyo, Faculty of engineering, Professor (00130245)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥15,650,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2007: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2006: ¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥7,500,000 (Direct Cost: ¥7,500,000)
Keywordslipid mediator / bone destruction / osteoclast / platelet-activating factor / 非病原性ベクター / 骨破壊病変遺伝子治療
Research Abstract

Bone-resorptive diseases such as osteoporosis, rheumatoid arthritis, osteoarthritis, and periodontitis enhanced the production of a variety of lipid mediators. Platelet-activating factor (PAF) is one of the potent lipid mediators. -This study has shown that PAF receptor deficient mice develop only mild osteoporosis. Osteoclastic bone resorption is impaired in these deficient mice. This investigation also focuses on the other families of lipids and their function during bone metabolism and disease.

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (10 results)

All 2008 2007 2005

All Journal Article (7 results) (of which Peer Reviewed: 2 results) Presentation (3 results)

  • [Journal Article] The roles of prostanoids, leukotrienes, and platelet-activating factor in bone metabolism and disease.2008

    • Author(s)
      Hikiji H, et. al
    • Journal Title

      Prog Lipid Res. 47

      Pages: 107-26

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The roles of prostanoids, leukotrienes, and platelet-activating factor in bone metabolism and disease2008

    • Author(s)
      Hikiji H, et. al.
    • Journal Title

      Prog Lipid Res. 47

      Pages: 107-126

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The roles of prostanoids,leukotrienes,and platelet-activating factor in bone metabolism and disease2008

    • Author(s)
      Hiikiji H, Takato T, Shimizu T, Ishii S.
    • Journal Title

      Prog Lipid Res 47

      Pages: 107-26

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in the awareness of oral health among new students newly enrolled at the University of Tokyo over the past 15 years.2005

    • Author(s)
      Hikiji H
    • Journal Title

      International Journal of Dental Hygiene 3(3)

      Pages: 137-144

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Molecular and pharmacological characteristics of transient voltage-dependent K+ currents in cultured human pulmonary arterial smooth muscle cells.2005

    • Author(s)
      Iida H
    • Journal Title

      Br J Pharmacol. 146(1)

      Pages: 49-59

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Dual phase regulation of experimental allergic encephalomyelitis by platelet-activating factor.2005

    • Author(s)
      Kihara Y
    • Journal Title

      J Exp Med. 202(6)

      Pages: 853-863

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Staphylococcal lipoteichoic acid inhibits delayed-type hypersensitivity reactions via the platelet-activating factor receptor.2005

    • Author(s)
      Zhang Q
    • Journal Title

      J Clin Invest. 115(10)

      Pages: 2855-2861

    • Related Report
      2005 Annual Research Report
  • [Presentation] An in vivo murine model for screening of craniofacial bone-regenerative materials2008

    • Author(s)
      Hikiji, H, et. al.
    • Organizer
      TERMIS, 3-5, Dec
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] An in vivo murine model for screening of craniofacial bone-regenerative materials.2007

    • Author(s)
      Hikiji, H., 他
    • Organizer
      TERMIS
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] An in Vivo murine model for screering of craniofacial bone-regenerative materials2007

    • Author(s)
      Hikiji, H., 他
    • Organizer
      TERMIS
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi