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Tissue engineered periodontal regeneration using human autologous derived cells

Research Project

Project/Area Number 17390558
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontal dentistry
Research InstitutionNiigata University

Principal Investigator

OKUDA Kazuhiro  Niigata University, Institute ofMedicine and Dentistry, Associate Professor (00169228)

Co-Investigator(Kenkyū-buntansha) KAWASE Tomoyuki  Niigata University, Institute of Medicine and Dentistry, Associate Professor (90191999)
SUZUKI Hironobu  Niigata University, Institute ofMedicine and Dentistry, Assistant Professor (60377190)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥15,670,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥570,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2006: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2005: ¥11,300,000 (Direct Cost: ¥11,300,000)
KeywordsTissue Engineering / Periosteum / Bone / Osteoblast / Periodontal Ligament Cell / Hydroxyapatite / Polylactic acid / Clinical Comparative Study / 組織培養 / 多血小板血漿 / 回転培養
Research Abstract

The aim of this project is In regenerate gingival recession and infrabony defect caused by periodontal disease using tissue engineered technique.
To achieve this requirement, three important factors such as cells, growth factors and scaffold are known to be needed. Especially, regarding cell supply, it was possible to practice in clinical situation by being cultured from a small specimen to an appropriate sire of sheet The human cultured gingival epithelial (HCGE) sheet or human cultured gingival fibroblast (HCGF) sheet was prepared by modified methods of those developed by Green and Hata, or Kuroyanagi. The HCGE sheet was applied clinically to treat an desquamative gingivitis, and the HCGF sheet was applied to treat gingival recession. Moreover, the human cultured periosteum (HCP) sheet preparation procedure was performed. Treatment with a combination of HCP sheets, platelet-rich plasma (PRP) and hydroxyapatite (HA) granules, when compared to PRP with HA granules, led to a significantly more favorable clinical improvement after 12-months post-surgery. A factor likely contributing to these favorable clinical results would be the presence of osteogenic cells in the HCP sheets which provided greater regeneration potential. To obtain scientific evidences of these tissue-engineered trials described above, we performed some in vitro experiments: the effect of hepatocyte growth factor on osteoblasts or periodontal ligament (PDL) cells, the mechanism of extracellular ATP and ATPrS on PDL cells. As a next stage, we began to challenge to develop cultured bone. Regarding cultured bone, established human osteoblasts were easily infiltrated into the bottom of pore of HA block after treatment of surface condition by acid-etching. In addition, we tried to 3-D culture of PDL cells on the surface of polylactic-acid (PLA) knit sheet. By adding atelo-collagen gel to PLA knit sheet, many cells were cultured easily compared with culture on only PLA knit alone.

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (97 results)

All 2008 2007 2006 2005 Other

All Journal Article (20 results) (of which Peer Reviewed: 10 results) Presentation (74 results) Book (3 results)

  • [Journal Article] Root coverage with cultured gingival dermal substitute composed of gingival fibroblasts and matrix: a case series.2008

    • Author(s)
      Masashi Murata
    • Journal Title

      The International Journal of Periodontics and Restorative Dentistry (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Treatment of human infrabony periodontal defects by grafting human cultured periosteum sheets combined with platelet-rich plasma and porous hydroxyapatite granules: case series.2008

    • Author(s)
      Kazuhiro Okuda
    • Journal Title

      Journal of the International Academy of Periodontology (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Tissue engineered cultured periosteum sheets combined with platelet-rich plasmaand porous hydroxyapatite graft in treating human periodontal infrabony osseous defects: a comparative controlled clinicalstudy.2008

    • Author(s)
      Kanoko Yamamiya
    • Journal Title

      Journal of Periodontology (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Extracellular ATP and ATPrS suppress the proliferation of human periodontal ligament cells by different mechanisms.2007

    • Author(s)
      Tomoyuki Kawase
    • Journal Title

      Journal of Periodontology 78

      Pages: 748-756

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Extracellular ATP and ATPrS suppress the proliferation of human periodontal ligament cells by different mechanisms2007

    • Author(s)
      Tomoyuki, Kawase
    • Journal Title

      Journal of Periodontology 78(4)

      Pages: 748-756

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Extracellular ATP and ATPrS suppress the proliferation of human perio dontal ligament cells by different mechanisms.2007

    • Author(s)
      tomoyuki Kawase
    • Journal Title

      Journal of Periodontology 78

      Pages: 748-756

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical localization of cytokeratin 19, involucrin and proliferationg cell nuclear antigen(PCNA)in cultured human gingival epithelial sheets.2006

    • Author(s)
      Masashi Murata
    • Journal Title

      Journal of the International Academy of Periodontology 8

      Pages: 33-38

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Fabrication of cultured oral gingiva by tissue engineering techniques without materials of animal origin.2006

    • Author(s)
      Kazuto Yamada
    • Journal Title

      Journal of Periodontology 77

      Pages: 672-677

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A hepatocyte growth factor(HGF)/receptor autocrine loop regulates constitutive self-renewal of human periodontal ligament cells but reduces sensitivity to exogenous HGF.2006

    • Author(s)
      Tomoyuki Kawase
    • Journal Title

      Journal of Periodontology 77

      Pages: 1723-1730

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Immunohistochemical localization of cytokeratin 19, involucrin and proliferationg cell nuclear antigen(PCNA) in cultured human gingival epithelial sheets2006

    • Author(s)
      Masashi, Murata
    • Journal Title

      Journal of the International Academy of Periodontology 8(1)

      Pages: 33-38

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Fabrication of cultured oral gingiva by tissue engineering techniques without materials of animal origin2006

    • Author(s)
      Kazuto, Yamada
    • Journal Title

      Journal of Periodontology 77(4)

      Pages: 672-677

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A hepatocyte growth factor(HGF)/receptor autocrine loop regulates constitutive self-renewal of human periodontal ligament cells but reduces sensitivity to exogenous HGF2006

    • Author(s)
      Tomoyuki, Kawase
    • Journal Title

      Journal of Periodontology 77(10)

      Pages: 1723-1730

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] platelet rich plasma: PRP2006

    • Author(s)
      Kazuhiro, Okuda
    • Journal Title

      Medical Review, Growth factors and Regenerative Therapy 401

      Pages: 386-392

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Root coverage with cultured gingival dermal substitute composed of gingival fibroblasts and matrix: a case series

    • Author(s)
      Masashi, Murata
    • Journal Title

      International Journal of Periodontics and Restorative Dentistry in press

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Treatment of human infrabony periodontal defects by grafting human cultured periosteum sheets combined with platelet-rich plasma and porous hydroxyapatite granules: case series. 84-85)

    • Author(s)
      Kazuhiro, Okuda
    • Journal Title

      Journal of the International Academy of Periodontology in press

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Tissue engineered cultured periosteum sheets combined with platelet-rich plasma and porous hydroxyapatite graft in treating human periodontal infrabony osseous defects: a comparative controlled clinical study

    • Author(s)
      Kanoko, Yamamiya
    • Journal Title

      Journal of Periodontology in press

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Periodontal tissue regeneration using by cultured Periosteum sheet

    • Author(s)
      Kazuhiro, Okuda
    • Journal Title

      Nippon Igakukann, Tissue Engineering 2007 326

      Pages: 212-219

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Periodontal Tissue Regeneration

    • Author(s)
      Hiroinasa, Yoshie
    • Journal Title

      Quintessence, the Quintessence YEAR BOOK 2008 257

      Pages: 84-85

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Root coverage with cultured gingival dermal substitute composed of gingival fibroblasts and matrix: a case series.

    • Author(s)
      Masashi Murata
    • Journal Title

      The International Journal of Periodontics and Restorative Dentistry (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Treatment of human infrabony periodontal defects by grafting human cultured periosteum sheets combined with platelet-rich plasma and porous hydroxyapatite granules: case series.

    • Author(s)
      Kazuhiro Okuda
    • Journal Title

      Journal of the International Academy of Periodontology (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] シンポジウム『歯周組織再生』 4.「培養骨膜シートを用いた歯周組織再生療法」.2007

    • Author(s)
      奥田一博
    • Organizer
      特定非営利活動法人日本歯周病学会第1回信越・北陸地区臨床研修会-歯周治療の未来への展望-
    • Place of Presentation
      新潟市
    • Year and Date
      2007-12-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Tissue engineered cultured periosteum sheets combined with platelet-rich plasma and porous hydroxyapatite in regenerating human periodontal infrabony osseous defects2007

    • Author(s)
      Kazuhiro, Okuda
    • Organizer
      The clinical seminar of Japanese Society of Periodontology in Sshinetsu-Hokuriku District
    • Place of Presentation
      Niigata
    • Year and Date
      2007-12-09
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] シンポジウム『歯周組織再生』4.「培養骨膜シートを用いた歯周組織再生療法」.2007

    • Author(s)
      奥田一博
    • Organizer
      特定非営利活動法人日本歯周病学会第1回信越・北陸地区臨床研修会-歯周治療の未来への展望-
    • Place of Presentation
      新潟県歯科医師会館
    • Year and Date
      2007-12-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] Tissue engineered cultured periosteum sheets combined with platelet-rich plasma and porous hydroxyapatite in regenerating human periodontal infrabony osseous defects.2007

    • Author(s)
      Kazuhiro Okuda
    • Organizer
      Tissue Engineering International & Regenerative Medicine Society Asia-Pacific Chapter Meeting 2007.
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-12-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Tissue engineered cultured periosteum sheets combined with platelet-rich plasma and porous hydroxyapatite in regenerating human periodontal infrabony osseous defects2007

    • Author(s)
      Kazuhiro, Okuda
    • Organizer
      Tissue Engineering International & Regenerative Medicine Society Asia-Pacific Chapter Meeting 2007
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-12-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Tissue engineered cultured periosteum sheets combined with platelet-rich plasma and porous hydroxyapatite in regenerating human periodontal infrabony osseous defect s.2007

    • Author(s)
      Kazuhiro Okuda
    • Organizer
      Tissue Engineering International & Regenerative Medicine Society Asia-Pacific Chapter Meeting 2007.
    • Place of Presentation
      Grand Prince Hotel Akasaka
    • Year and Date
      2007-12-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] 培養骨膜シートの臨床応.研究課題「歯周組織細胞を用いた歯周組織再生療法の確立と臨床応用.2007

    • Author(s)
      吉江弘正
    • Organizer
      平成19年度科学研究費補助金(基盤研究A)研究成果報告会=最終年度=
    • Place of Presentation
      東京都
    • Year and Date
      2007-11-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Clinical application of cultured periosteum sheet2007

    • Author(s)
      Hiromasa, Yoshie
    • Organizer
      The meeting for final presentation of Grant-in-Aid for Scientific Research(A)
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-11-22
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 培養骨膜シートの臨床応.研究課題「歯周組織細胞を用いた歯周組織再生療法の確立と臨床応用.2007

    • Author(s)
      吉江弘正
    • Organizer
      平成19年度科学研究費補助金(基盤研究A)研究成果報告会=最終年度=
    • Place of Presentation
      東京女子医科大学
    • Year and Date
      2007-11-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] 再生医療用基材としてのポリ乳酸ニットの可能性.2007

    • Author(s)
      川瀬知之
    • Organizer
      第10回日本組織工学会
    • Place of Presentation
      東京都
    • Year and Date
      2007-11-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The possibility of polylactic acid knitsheet as a scaffold for regenerative therapy2007

    • Author(s)
      Tomoyuki, Kawase
    • Organizer
      The 10th Annual Meeting of the Japanese Society for Tissue Engineering
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-11-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 再生医療用基材としてのポリ乳酸ニットの可能性.2007

    • Author(s)
      川瀬知之
    • Organizer
      第10回日本組織工学会
    • Place of Presentation
      大手町サンケイプラザ
    • Year and Date
      2007-11-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] 再生医療用基材としてのポリ乳酸ニットの試作.2007

    • Author(s)
      川瀬知之
    • Organizer
      第16回新潟移植再生研究会
    • Place of Presentation
      新潟市
    • Year and Date
      2007-11-05
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 再生医療用基材としてのポリ乳酸ニットの試作.2007

    • Author(s)
      川瀬知之
    • Organizer
      第16回新潟移植再生研究会
    • Place of Presentation
      新潟大学医学部有壬記念館
    • Year and Date
      2007-11-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] Tissue engineered cultured periosteum sheets combined with platelet-rich plasma and porous hydroxyapatite in regenerating human periodontalinfrabony osseous defects.2007

    • Author(s)
      Kanoko Yamamiya
    • Organizer
      93rd Annual Meeting of American Academy of Periodontology
    • Place of Presentation
      Washington D. C.
    • Year and Date
      2007-10-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Tissue engineered cultured periosteum sheets combined with platelet-rich plasma and porous hydroxyapatite in regenerating human periodontal infrabony osseous defects2007

    • Author(s)
      Kanoko, Yamamiya
    • Organizer
      93rd Annual Meeting of American Academy of Periodontology
    • Place of Presentation
      Washington, D.C., USA
    • Year and Date
      2007-10-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Tissue engineered cultured periosteum sheets combined with platelet-rich plasma and porous hydroxyapatite in regenerating human periodontalinfrabony osseous defects.2007

    • Author(s)
      Kanoko Yamamiya
    • Organizer
      93rd Annual Meeting of American Academy of Periodontology
    • Place of Presentation
      Washington convention center
    • Year and Date
      2007-10-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] 「歯科臨床における再生医療とその可能性」-日常臨床における培養骨膜の応用-.2007

    • Author(s)
      奥田一博
    • Organizer
      千葉県歯科医師会第1回ブロック別研修会
    • Place of Presentation
      船橋市
    • Year and Date
      2007-07-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The possibility of regenerative therapy in clinical dentistry -application of cultured periosteum sheet in daily clinical dental practice-2007

    • Author(s)
      Kazuhiro, Okuda
    • Organizer
      The dental association of Chiba prefecture
    • Place of Presentation
      Funabashi
    • Year and Date
      2007-07-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 「歯科臨床における再生医療とその可能性」-日常臨床における培養骨膜の応用-.2007

    • Author(s)
      奥田一博
    • Organizer
      平成19年度千葉県歯科医師会第1回ブロック別研修会
    • Place of Presentation
      フローラ西船
    • Year and Date
      2007-07-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] 培養歯肉線維芽細胞シートおよび培養骨膜シートを用いた組織工学的歯周組織再生療法.2007

    • Author(s)
      奥田一博
    • Organizer
      新潟大学歯学部クラウン・ブリッジ同門会
    • Place of Presentation
      新潟市
    • Year and Date
      2007-06-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Tissue engineered periodontal regeneration using cultured periosteum sheet and cultured dermal substitute composed of gingival fibroblasts and matrix2007

    • Author(s)
      Kazuhiro, Okuda
    • Organizer
      The Alumni Association of Department of Fixed Prosthodontics
    • Place of Presentation
      Niigata
    • Year and Date
      2007-06-16
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 培養歯肉線維芽細胞シートおよび培養骨膜シートを用いた組織工学的歯周組織再生療法.2007

    • Author(s)
      奥田一博
    • Organizer
      平成19年度クラウン・ブリッジ同門会学術講演会
    • Place of Presentation
      新潟大学歯学部
    • Year and Date
      2007-06-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] 培養歯肉線維芽細胞シートの根面被覆への応用.2007

    • Author(s)
      村田雅史
    • Organizer
      第25回日本顎咬合学会学術大会
    • Place of Presentation
      東京都
    • Year and Date
      2007-06-10
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Root coverage with cultured dermal substitute composed of gingival fibroblasts and matrix2007

    • Author(s)
      Masashi, Murata
    • Organizer
      The Academy of Clinical Dentistry
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-06-10
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 培養歯肉線維芽細胞シートの根面被覆への応用.2007

    • Author(s)
      村田雅史
    • Organizer
      第25回日本顎咬合学会学術大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2007-06-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] 培養骨膜シートを用いた歯周組織再生療法 第6回再生歯科シンポジウム-再生医療の現在と将来-.2007

    • Author(s)
      奥田一博
    • Organizer
      第6回再生歯科シンポジウム
    • Place of Presentation
      東京都
    • Year and Date
      2007-06-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Tissue engineered periodontal regeneration using cultured periosteum sheet2007

    • Author(s)
      Kazuhiro, Okuda
    • Organizer
      The Symposium of Regenerative Dentistry
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-06-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 培養骨膜シートを用いた歯周組織再生療法 第6回再生歯科シンポジウムー再生医療の現在と将来-.2007

    • Author(s)
      奥田一博
    • Organizer
      第6回再生歯科シンポジウム
    • Place of Presentation
      東京大学
    • Year and Date
      2007-06-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] 培養骨膜シート+多血小板血漿+ハイドロキシアパタイト顆粒の歯周骨内欠損に及ぼす効果-臨床比較研究:6か月予後.2007

    • Author(s)
      山宮かの子
    • Organizer
      第50回日本歯周病学会春季学術大会
    • Place of Presentation
      横須賀市
    • Year and Date
      2007-05-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Comparative 6-month clinical study of cultured periosteum sheet combined with platelet-rich plasma and a porous hydroxyapatite graft fot the treatment of infrabony periodontal defects in humans2007

    • Author(s)
      Kanoko, Yamamiya
    • Organizer
      The Japanese Society of Periodontology
    • Place of Presentation
      Yokosuka
    • Year and Date
      2007-05-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 培養骨膜シート+多血小板血漿+ハイドロキシアパタイト顆粒の歯周骨内欠損に及ぼす効果-臨床比較研究:6か月予後.2007

    • Author(s)
      山宮かの子
    • Organizer
      第50回日本歯周病学会春季学術大会
    • Place of Presentation
      横須賀芸術劇揚
    • Year and Date
      2007-05-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] 新潟大学医歯学総合病院生命科学医療センター再生・移植医療部門における歯周再生医療.2007

    • Author(s)
      川瀬知之
    • Organizer
      第50回日本歯周病学会春季学術大会
    • Place of Presentation
      横須賀市
    • Year and Date
      2007-05-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The periodontal tissue engineering in cell processing center of bioscience medical research center, Niigata University Hospital2007

    • Author(s)
      Tomoyuki, Kawase
    • Organizer
      The Japanese Society of Periodontology
    • Place of Presentation
      Yokosuka
    • Year and Date
      2007-05-18
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 新潟大学医歯学総合病院生命科学医療センター再生・移植医療部門における歯周再生医療.2007

    • Author(s)
      川瀬知之
    • Organizer
      第50回日本歯周病学会春季学術大会
    • Place of Presentation
      横須賀芸術劇揚
    • Year and Date
      2007-05-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] 歯肉線維芽細胞シート・骨膜シートの臨床応用.2007

    • Author(s)
      吉江弘正
    • Organizer
      第6回日本再生医療学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-03-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Clinical application of cultured fibroblasts and periosteum sheet2007

    • Author(s)
      Hiromasa, Yoshie
    • Organizer
      The 6th Congress of the Japanese Society for Regenerative Medicine
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-03-13
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 歯周組織再生療法の最前線.2006

    • Author(s)
      奥田一博
    • Organizer
      新潟大学歯学部群馬県人会
    • Place of Presentation
      高崎市
    • Year and Date
      2006-12-10
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The forefront of periodontal regenerative therapy2006

    • Author(s)
      Kazuhiro, Okuda
    • Organizer
      The Alumni Association of Niigata Univ. Sch. if Dentistry, Gunma branch
    • Place of Presentation
      Takasaki
    • Year and Date
      2006-12-10
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 培養骨膜シート+多血小板血漿+ハイドロキシアパタイト顆粒による歯周組織再生-症例報告-.2006

    • Author(s)
      奥田一博
    • Organizer
      第626回新潟医学会
    • Place of Presentation
      新潟市
    • Year and Date
      2006-11-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regenerating periodontal tissue by grafting cultured periosteum with PRP-hydroxyapatite complex2006

    • Author(s)
      Kazuhiro, Okuda
    • Organizer
      626th Niigata Medical Society
    • Place of Presentation
      Niigata
    • Year and Date
      2006-10-18
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 培養骨膜シート+多血小板血漿+ハイドロキシアパタイト顆粒による歯周組織再生.2006

    • Author(s)
      奥田一博
    • Organizer
      新潟ジョイント 研究シーズプレゼンテーション
    • Place of Presentation
      新潟市
    • Year and Date
      2006-09-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regenerating periodontal tissue by grafting cultured periosteum with PRP-hydroxyapatite complex2006

    • Author(s)
      Kazuhiro, Okuda
    • Organizer
      2006 meeting for seed of research
    • Place of Presentation
      Niigata
    • Year and Date
      2006-09-22
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regenerating Periodontal tissue by grafting cultured periosteum with PRP-hydroxyapatite complex.2006

    • Author(s)
      Kazuhiro Okuda
    • Organizer
      92nd Annual Meeting of American Academy of Periodontology
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2006-09-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regenerating periodontal tissue by grafting cultured Periosteum with PRP-hydroxyapatite complex2006

    • Author(s)
      Kazuhiro, Okuda
    • Organizer
      92nd Annual Meeting of American Academy of Periodontology
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2006-09-18
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Tissue engineered cultured periosteum sheets combined with platelet-rich plasma and porous hydroxyapatite in regenerating human periodontal infrabony osseous defects-case report-2006

    • Author(s)
      Kazuhiro, Okuda
    • Organizer
      The 9th Annual Meeting of the Japanese Society for Tissue Engineering
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-09-09
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 培養骨膜シート+多血小板血漿+ハイドロキシアパタイト顆粒による歯周組織再生-症例報告-.2006

    • Author(s)
      奥田一博
    • Organizer
      第9回日本組織工学会
    • Place of Presentation
      京都市
    • Year and Date
      2006-09-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 培養骨膜シート+多血小板血漿+ハイドロキシアパタイト顆粒による歯周組織再生-症例報告-.2006

    • Author(s)
      奥田一博
    • Organizer
      ニプロ社 総合研究所におけるセミナー
    • Place of Presentation
      草津市
    • Year and Date
      2006-09-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Tissue engineered cultured periosteum sheets combined with platelet-rich plasma and porous hydroxyapatite in regenerating human periodontal infrabony osseous defects-case report-2006

    • Author(s)
      Kazuhiro, Okuda
    • Organizer
      Seminer in NIPRO company
    • Place of Presentation
      Kusatsu
    • Year and Date
      2006-09-06
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 培養骨膜シート+多血小板血漿+ハイドロキシアパタイト顆粒による歯周組織再生-症例報告-.2006

    • Author(s)
      奥田一博
    • Organizer
      第13回新潟移植再生研究会
    • Place of Presentation
      新潟市
    • Year and Date
      2006-06-05
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Tissue engineered cultured periosteum sheets combined with platelet-rich plasma and porous hydroxyapatite in regenerating human periodontal infrabony osseous defects-case report-2006

    • Author(s)
      Kazuhiro, Okuda
    • Organizer
      3th Transplantation/Tissue Regeneration meeting in Niigata
    • Place of Presentation
      Niigata
    • Year and Date
      2006-06-05
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The trial piece of polylactic acid knitsheet as a scaffold for regenerative therapy2006

    • Author(s)
      Tomoyuki, Kawase
    • Organizer
      16th Transplantation/Tissue Regeneration meeting in Niigata
    • Place of Presentation
      Niigata
    • Year and Date
      2006-06-05
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 培養骨膜シート+多血小板血漿+ハイドロキシアパタイト顆粒による歯周組織再生-症例報告-.2006

    • Author(s)
      奥田一博
    • Organizer
      第一回新潟医療関連産学連携交流会
    • Place of Presentation
      新潟市
    • Year and Date
      2006-05-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Tissue engineered cultured periosteum sheets combined with platelet-rich plasma and porous hydroxyapatite in regenerating human periodontal infrabony osseous defects-case report-2006

    • Author(s)
      Kazuhiro, Okuda
    • Organizer
      1st.interchangeable meeting between industrial field and medicak field in Niigata
    • Place of Presentation
      Niigata
    • Year and Date
      2006-05-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 培養骨膜シート+多血小板血漿+ハイドロキシアパタイト顆粒による歯周組織再生-症例報告-.2006

    • Author(s)
      山宮かの子
    • Organizer
      第49回日本歯周病学会春季学術大会
    • Place of Presentation
      市川市
    • Year and Date
      2006-04-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 歯根膜細胞における肝細胞成長因子(HGF)のautocrine loopを介した増殖制御機構.2006

    • Author(s)
      川瀬知之
    • Organizer
      第49回日本歯周病学会春季学術大会
    • Place of Presentation
      市川市
    • Year and Date
      2006-04-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cultured periosteum combined with platelet-rich plasma and a porous hydroxyapatite graft for the treatment of intrabony periodontal defects in humans-case reports-2006

    • Author(s)
      Kanoko, Yamamiya
    • Organizer
      The Japanese Society of Periodontology
    • Place of Presentation
      Ichikawa
    • Year and Date
      2006-04-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The autocrine loop of hepatocyte growth factor(HGF) is Involved in the proliferation of human periodontal ligament cells in vitro2006

    • Author(s)
      Tomoyuki, Kawase
    • Organizer
      The Japanese Society of Periodontology
    • Place of Presentation
      Ichikawa
    • Year and Date
      2006-04-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 培養骨膜シート+多血小板血漿+ハイドロキシアパタイト顆粒による歯周組織再生-症例報告-.2006

    • Author(s)
      奥田一博
    • Organizer
      ジャパン・テイッシュエンジニアリング社におけるセミナー
    • Place of Presentation
      蒲郡市
    • Year and Date
      2006-02-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 口腔粘膜培養シートによる歯肉増大への試み.2006

    • Author(s)
      奥田一博
    • Organizer
      新潟細胞・再生療法シンポジウム
    • Place of Presentation
      新潟市
    • Year and Date
      2006-01-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A trial of periodontal regeneration using cultured oral mucosal cell sheet2006

    • Author(s)
      Kazuhiro, Okuda
    • Organizer
      Cell and Tissue Regeneration Symposium in Niigata
    • Place of Presentation
      Niigata
    • Year and Date
      2006-01-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Tissue engineered cultured periosteum sheets combined with platelet-rich plasma and porous hydroxyapatite in regenerating human periodontal infrabony osseous defects-case report-2006

    • Author(s)
      Kazuhiro, Okuda
    • Organizer
      Seminer in JTEC company
    • Place of Presentation
      Gamagori
    • Year and Date
      2006-01-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ペンタックス社製ハイドロキシアパタイト多孔体を用いた培養人工骨作製の試み.2005

    • Author(s)
      川瀬知之
    • Organizer
      ペンタックス株式会社におけるセミナー
    • Place of Presentation
      東京都
    • Year and Date
      2005-12-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Periodontal bone tissue engineering using porous Hydroxyapatite made in PENTAX Co. Ltd2005

    • Author(s)
      Tomoyuki, Kawase
    • Organizer
      Seminer in PENTAX company
    • Place of Presentation
      Tokyo
    • Year and Date
      2005-12-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 口腔粘膜培養上皮シートによる歯周組織再生への試み.2005

    • Author(s)
      奥田一博
    • Organizer
      平成17年度 研究シーズプレゼンテーション
    • Place of Presentation
      新潟市
    • Year and Date
      2005-10-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A trial of periodontal regeneration using cultured oral mucosal cell sheet2005

    • Author(s)
      Kazuhiro, Okuda
    • Organizer
      2005 meeting for seed of research
    • Year and Date
      2005-10-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Platelet-rich plasma induces nucleation of mineralization in PDL cell cultures.2005

    • Author(s)
      Kazuhiro Okuda
    • Organizer
      91th Annual Meeting of American Academy of Periodontology
    • Place of Presentation
      Denver, USA
    • Year and Date
      2005-09-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Platelet-rich plasma induces nucleation of mineralization in PDLcell cultures.2005

    • Author(s)
      Kazuhiro, Okuda
    • Organizer
      91th Annual Meeting of American Academy of 1Periodontology
    • Place of Presentation
      Demver
    • Year and Date
      2005-09-25
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ハイドロキシアパタイト多孔体による歯周組織に特化した培養人工骨作製の試み-第一報深部気孔での安定した細胞増殖の誘導-.2005

    • Author(s)
      川瀬知之
    • Organizer
      第48回日本歯周病学会秋季学術大会
    • Place of Presentation
      札幌市
    • Year and Date
      2005-09-23
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Periodontal bone tissue engineering using porous hydroxyapatite-1. supporting osteoblastic cell growth in pores of deep layers2005

    • Author(s)
      Tomoyuki, Kawase
    • Organizer
      The Japanese Society of Periodontology
    • Place of Presentation
      Sapporo
    • Year and Date
      2005-09-23
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] シンポジウムI「歯周疾患における上皮細胞と線維芽細胞の役割」4.エムドゲインの生理活性受容体の解析.2005

    • Author(s)
      奥田一博
    • Organizer
      第48回日本歯周病学会秋季学術大会
    • Place of Presentation
      札幌市
    • Year and Date
      2005-09-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] "Role of epithelial and fibroblastic cells. In periodontal disiease": Analysis of physiological receptor related EMDOGAIN2005

    • Author(s)
      Kazuhiro, Okuda, Symposium, I
    • Organizer
      The Japanese Society of Periodontology
    • Place of Presentation
      Sapporo
    • Year and Date
      2005-09-22
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Application of tissue-engineered human mucosal cell sheets for gingival augmentation.2005

    • Author(s)
      Kazuhiro Okuda
    • Organizer
      全国副省級城市第十回および東北三省第八回口腔医学学術会議
    • Place of Presentation
      Harbin, China
    • Year and Date
      2005-09-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Application of tissue-engineered human mucosal cell sheets for gingival augmentation2005

    • Author(s)
      Kazuhiro, Okuda
    • Organizer
      The Chinese Society of Oral Medicine, September 7
    • Place of Presentation
      Harbin, China
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 別冊the Quintessence YEAR BOOK 2008 現代の治療指針2008

    • Author(s)
      吉江弘正
    • Publisher
      クインテッセンス出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Book] ティッシュエンジニアリング20072007

    • Author(s)
      奥田一博
    • Publisher
      日本医学館
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Book] 細胞増殖因子と再生医療2006

    • Author(s)
      奥田一博
    • Publisher
      メデイカルレビュー社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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