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Influence of dental plaque on general health condition-Animal model experiments-

Research Project

Project/Area Number 17390565
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Social dentistry
Research InstitutionKagoshima University

Principal Investigator

OHO Takahiko  Kagoshima University, Graduate School of Medical and Dental Sciences, Professor, 大学院医歯学総合研究科, 教授 (50160940)

Co-Investigator(Kenkyū-buntansha) KITADA Katsuhiro  Kagoshima University, Graduate School of Medical and Dental Sciences, Research Associate, 大学院医歯学総合研究科, 助手 (90195264)
NAGATA Emi  Kagoshima University, Medical and Dental Hospital, Research Associate, 医学部・歯学部附属病院, 助手 (00304816)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥14,200,000 (Direct Cost: ¥14,200,000)
Fiscal Year 2006: ¥5,600,000 (Direct Cost: ¥5,600,000)
Fiscal Year 2005: ¥8,600,000 (Direct Cost: ¥8,600,000)
KeywordsDental plaque / Oral bacteria / Animal model / Endocardit is / Pneumonia / Adherence / Streptococci
Research Abstract

We examined the ability of human supragingival dental plaque to induce infective endocarditis in rats. In total, 15 out of 27 catheterized rats survived after intravenous injections with human supragingival dental plaque suspensions containing 3 x 10^6 colony forming unit of bacterial cells. In surviving rats, infected vegetations were formed in all except one rat. The microbial composition of the infected vegetations was different from that of the respective dental plaque inocula, and Streptococcus oralis comprised the majority of the isolates. In rats affected with endocarditis, the aortic sinus was filled with fibrinous vegetation containing bacteria. Inflammatory cells infiltrated the aortic valve, the aorta adjacent to the valve, and the cardiac muscles. We also examined the contribution of cell surface polysaccharides to the infectivity of Streptococcus mutans in infective endocarditis using a rat model. The polysaccharides-defective mutant of S. mutans reduced its ability to induce infective endocarditis compared to tie parental strain. The results suggest that the cell surface polysaccharides have an important role for the induction of infective endocarditis by S. mutans.
Next, we examined the ability of human dental plaque to induce pneumonia in mice. All the human dental plaque samples tested induced pneumonia in mice. In total, 12 out of 18 mice died within 3 days after inoculation with dental plaque suspension, and bacterial cells were recovered from all dead mice. Significantly larger number of bacterial cells including oral microorganisms was recovered from lungs of dead mice than that of survived ones. No characteristics were observed in the microbial composition of infected lung specimens.
These results suggest that dental plaque serves as a potent source of bacteria causing infective endocarditis and pneumonia in humans.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (14 results)

All 2006 2005

All Journal Article (14 results)

  • [Journal Article] 緑茶抽出物のStreptococcus anginosus groupに対する抗菌作用2006

    • Author(s)
      北田勝浩 他
    • Journal Title

      口腔衛生会誌 56・2

      Pages: 132-136

    • NAID

      110004729662

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] 歯垢による全身疾患の誘発-動物モデルを用いての検討-2006

    • Author(s)
      長田恵美 他
    • Journal Title

      鹿児島県歯科医師会会報 55・11

      Pages: 4-5

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Serotype-specific polysaccharide of Streptococcus mutans contributes to infectivity in endocarditis2006

    • Author(s)
      Nagata, E. et al.
    • Journal Title

      Oral Microbiol. Immunol. 21・6

      Pages: 420-423

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Antibacterial activity of green tea extracts against Streptococcus anginosus group2006

    • Author(s)
      Kitada, K. et al.
    • Journal Title

      J. Dent. Hlth 56(2)

      Pages: 132-136

    • NAID

      110004729662

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Induction of systemic diseases by dental plaque-animal experiments-2006

    • Author(s)
      Nagata, E. et al.
    • Journal Title

      The Bulletin of the Kagoshima Dent,. Assoc. 55(11)

      Pages: 4-5

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Serotype-specific polysaccharide of Streptococcus mutans contributes to infectivity in endocarditis2006

    • Author(s)
      Nagata, E. et al.
    • Journal Title

      Oral Microbiol. Immunol. 21(6)

      Pages: 420-423

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Serotype-specific polysaccharide of Streptococcus mutans contributes to infectivity in endocarditis2006

    • Author(s)
      Nagara, E. et al.
    • Journal Title

      Oral Microbiol.Immunol. 21・6

      Pages: 420-423

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Induction of immune response to Streptococcus pneumoniae by administration of oral viridans streptococci via phosphorylcholine determinant2005

    • Author(s)
      Miwa, Y. et al.
    • Journal Title

      FEMS Immunol. Med. Microbiol. 43・3

      Pages: 441-448

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Experimental abscess formation caused by human dental plaque2005

    • Author(s)
      Okayama, H. et al.
    • Journal Title

      Microbiol. Immunol. 49・5

      Pages: 399-405

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Experimental infective endocarditis induced by human supragingival dental plaque in rats2005

    • Author(s)
      Nagata, E. et al.
    • Journal Title

      Eur. J. Oral Sci. 113・6

      Pages: 499-504

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Induction of immune response to Streptococcus pneumoniae by administration of oral viridans streptococci via phosphorylcholine determinant2005

    • Author(s)
      Miwa, Y. et al.
    • Journal Title

      FEMS Immunol. Med. Microbiol. 43(3)

      Pages: 441-448

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Experimental abscess formation caused by human dental plaque2005

    • Author(s)
      Okayama, H. et al.
    • Journal Title

      Microbiol. Immunol. 49(5)

      Pages: 399-405

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Experimental infective endocarditis induced by human supragingival dental plaque in rats2005

    • Author(s)
      Nagata, E. et al.
    • Journal Title

      Eur. J. Oral Sci. 113(6)

      Pages: 499-504

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Induction of immune response to Streptococcus pneumoniae by administration of oral viridans streptococci via phosphoryicholine determinant2005

    • Author(s)
      Miwa, Y. et al.
    • Journal Title

      FEMS Immunol. Med. Microbiol. 43・3

      Pages: 441-448

    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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