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Research for Antitumor Crude Drug from Malaysian Unutilized Plant Resorces

Research Project

Project/Area Number 17404005
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Living organism molecular science
Research InstitutionHoshi University

Principal Investigator

MORITA Hiroshi  Hoshi University, Faculty of Pharmaceutical Sciences, Professor (70220069)

Co-Investigator(Kenkyū-buntansha) ISHIYAMA Haruaki  Hokkaido University, Graduate School of Pharmaceutical Sciences, Assistant Professor (70333622)
TAKEYA Koichi  Tokyo University of Pharmacy & Life Sciences, School of Pharmacy, Assistant Professor (20120149)
KOBAYASHI Jun'ichi  Hokkaido University, Graduate School of Pharmaceutical Sciences, Professor (90221241)
HIRASAWA Yusuke  Hoshi University, Faculty of Pharmaceutical Sciences, Assistant Professor (90434183)
南雲 清二  星薬科大学, 薬学部, 准教授 (80097162)
飯塚 徹  星薬科大学, 薬学部, 助手 (70328920)
四元 英臣  星薬科大学, 薬学部, 助手 (80339522)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥10,890,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥690,000)
Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2006: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2005: ¥5,200,000 (Direct Cost: ¥5,200,000)
Keywordsantitumor / plant / crude drug / Malaysia / 抗マラリア
Research Abstract

Malaysia is situated in South East Asia, has one of the oldest and the richest flora in the world. Malaysia has a climate, which is constantly warm, and nearly uniform suitable for the growth of tropical rainforests. Malaysian forest is rather unique in the sense that it serves as a major migratory track for two great floras between the continental Asiatic(extending form Eastern India to Indochina) in the north and the Malaysian flora(extending to all the Malay Archipelago) in the south.
Plants were collected from the Malayan flora and their extracts from plants belonging to Meliaceae, Leguminosae, and Apocynaceae were tested for bioactivity. From these studies, a number of cytotoxic and antiplasmodial compounds were isolated and characterized chemically.
Five new limonoids, erythrocarpines A-E belonging to mexicanolide-type and A, B, D-seco heptacyclic skeletons were isolated from Chisocheton erythrocarpus, which showed cytotoxicity against P-388 murine leukemia cells. Cassiarins A and B, novel aromatic alkaloids with an unprecedented tricyclic skeleton and potent antiplasmodial activity have been isolated from the leaves of Cassia siamea(Leguminosae), which have been widely used for the treatment of periodic fever and malaria. Huncaniterine A, a new bisindole alkaloid with an N-oxide moiety consisting of corynantheine-type and aspidosperma-type skeletons, which exhibited a moderate vasorelaxant activity on isolated rat aorta ring, has been isolated from the bark of Hunteria zeylanica collected in Kampung Padang, Malaysia.

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (39 results)

All 2007 2006 2005

All Journal Article (33 results) (of which Peer Reviewed: 16 results) Presentation (6 results)

  • [Journal Article] Cassiarins A and B,Novel Antiplasmodial Alkaloids from Cassia siamea2007

    • Author(s)
      Hiroshi Morita
    • Journal Title

      Org. Lett. 9

      Pages: 3691-3693

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Carinatumins A - C,New Alkaloids from Lycopodium carinatum inhibiting Acetylcholinesterase2007

    • Author(s)
      Chee Yan Choo
    • Journal Title

      Bioorg.Med.Chem. 15

      Pages: 1703-1707

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Huncaniterine A,A New Bisindole Alkaloid from Hunteria zeylanica2007

    • Author(s)
      Khalit Mohamad
    • Journal Title

      Heterocycles 74

      Pages: 969-976

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Erythrocarpines A-E,new cytotoxic limonoids from Chisochetonerythrocarpus2007

    • Author(s)
      Khalijah Awang
    • Journal Title

      Bioorg.Med.Chem. 15

      Pages: 5997-6002

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cyclonatsudamine A,a new vasodilator cyclic peptide from Citrus natsudaidai2007

    • Author(s)
      Hiroshi Morita
    • Journal Title

      Bioorg.Med.Chem.Lett. 17

      Pages: 5410-5413

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Pordamacrines A and B,Alkaloids from Daphniphyllum macropodum2007

    • Author(s)
      Yosuke Matsuno
    • Journal Title

      J.Nat.Prod. 70

      Pages: 1516-1518

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cryptadines A and B,Novel C27N3-Type Pentacyclic Alkaloids from Lycopodium cryptomerinum2007

    • Author(s)
      Koichiro Koyama
    • Journal Title

      Bioorg.Med.Chem. 15

      Pages: 7803-7808

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Taxodistines A and B,Abietane-type Diterpenes from Taxodium distichum2007

    • Author(s)
      Yusuke Hirasawa
    • Journal Title

      Bioorg.Med.Chem.Lett. 17

      Pages: 5868-5871

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Pecrassipines A and B,two new secobisbenzylisoquinolines alkaloids from Phaeanthus crassipetalus2007

    • Author(s)
      Khalijah Awang
    • Journal Title

      Heterocycles 71

      Pages: 2055-2061

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cassiarins A and B, Novel Antiplasmodial Alkaloids from Cassia siamea2007

    • Author(s)
      Hiroshi Morita
    • Journal Title

      Org. Lett. 9

      Pages: 3691-3693

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Carinatumins A-C, New Alkaloids from Lycopodium carinatum inhibiting Acetylcholinesterase2007

    • Author(s)
      Chee Yan Choo
    • Journal Title

      Bioorg. Med. Chem. 15

      Pages: 1703-1707

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Huncaniterine A, A New Bisindole Alkaloid from Hunteria zeylanica2007

    • Author(s)
      Khalit Mohamad
    • Journal Title

      Heterocycles 74

      Pages: 969-976

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Erythrocarpines A-E, new cytotoxic limonoids from Chisocheton erythrocarpus2007

    • Author(s)
      Khalijah Awang
    • Journal Title

      Bioorg. Med. Chem. 15

      Pages: 5997-6002

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cyclonatsudamine A, a new vasodilator cyclic peptide from Citrus natsudaidai2007

    • Author(s)
      Hiroshi Morita
    • Journal Title

      Bioorg. Med. Chem. Lett. 17

      Pages: 5410-5413

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Pordamactines A and B, Alkaloids from Daphniphyllum mactopodum2007

    • Author(s)
      Yosuke Matsuno
    • Journal Title

      J. Nat. Prod. 70

      Pages: 1516-1518

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cryptadines A and B, novel C_<27>N_3-type Pentacyclic Alkaloids from Lycopodium cryptomerinum2007

    • Author(s)
      Koichiro Koyama
    • Journal Title

      Bioorg. Med. Chem. 15

      Pages: 7803-7808

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Taxodistines A and B, Abietane-type Diterpenes form Taxodium distichum2007

    • Author(s)
      Yusuke Hirasawa
    • Journal Title

      Bioorg. Med. Chem. Lett. 17

      Pages: 5868-5871

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Pecrassipines A and B, two new secobisbenzylisoquinolines alkaloids from Phaeanthus crassipetalus2007

    • Author(s)
      Khalijah Awang
    • Journal Title

      Heterocycles 71

      Pages: 2055-2061

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] Cassiarins A and B, Novel Antiplasmodial Alkaloids from Cassia siamea2007

    • Author(s)
      Hiroshi Morita
    • Journal Title

      Org.Lett 9

      Pages: 3691-3693

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carinatunmins A-C, New Alkaloids from Lycopodium carinatum inhibiting Acetylcholinesterase2007

    • Author(s)
      Chenn Yan Choo
    • Journal Title

      Bioorg.Med.Chem 15

      Pages: 1703-1707

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Erythrocarpines A-E, new cytotoxic limonoids from Chisocheton erythrocarpus2007

    • Author(s)
      Khalijih Awang
    • Journal Title

      Bioorg.Med.Chem 15

      Pages: 5997-6002

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclonatsudamine A,a new vasodilator cyclic peptide from Citrus natsudaidai2007

    • Author(s)
      Hiroshi Morita
    • Journal Title

      Bioorg.Med.Chem.Lett 17

      Pages: 5410-5413

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pordamacrines A and B, Alkaloids from Daphniphyllum macropodum2007

    • Author(s)
      Yosuke Matsuno
    • Journal Title

      J.Nat.Prod 70

      Pages: 1516-1518

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cryptadines A and B, Novel C27N3-Type Pentacyclic Alkaloids from Lycopodium cryptomerinum2007

    • Author(s)
      Koichiro Koyama
    • Journal Title

      Bioorg.Med.Chem 15

      Pages: 7803-7808

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Taxodistines A and B, Abietane-type Diterpenes from Taxodium distichum2007

    • Author(s)
      Yusuke Hirasawa
    • Journal Title

      Bioorg.Med.Chem 17

      Pages: 5868-5871

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lycoperine A, A Novel C27N3-Type Pentacyclic Alkaloid from Lycopodium hamiltonii, Inhibiting Acetylcholinesterase2006

    • Author(s)
      Yusuke Hirasawa
    • Journal Title

      Org. Lett. 8

      Pages: 123-126

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Daphmanidins E and F, Alkaloids from Daphniphyllum teijsmannii2006

    • Author(s)
      Hiroshi Morita
    • Journal Title

      J. Nat. Prod. 69

      Pages: 418-420

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Lycovatine A, a C16N-type quaternary alkaloid from Lycopodium clavatum var.Robustum2006

    • Author(s)
      Takaaki Kubota
    • Journal Title

      Heterocycles 68

      Pages: 469-474

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Nankakurine B, a New Alkaloid from Lycopodium hamiltonii and Revised Stereostructure of Nankakurine A2006

    • Author(s)
      Yusuke Hirasawa
    • Journal Title

      Heterocycles 68

      Pages: 2357-2364

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Vasorelaxant Activity of Cyclic Peptide, Cyclosquamosin B, from Annona squamosa2006

    • Author(s)
      Hiroshi Morita
    • Journal Title

      Bioorg. Med. Chem. Lett. 16

      Pages: 4609-4611

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Daphtenidines A-D, new Daphniphyllum alkaloids from Daphniphyllum teijsmannii2006

    • Author(s)
      Takaaki Kubota
    • Journal Title

      Tetrahedron 62

      Pages: 4743-4748

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Conformational Analysis of Rhazinilam and Three-Dimensional Quantitative Structure-Activity Relationships of Rhazinilam Analogues2005

    • Author(s)
      Hiroshi Morita
    • Journal Title

      Bioorg.Med.Chem.Lett. 15

      Pages: 1045-1050

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Dichotomins J and K, New Vasodilator Cyclic Peptides from Stellaria dichotoma L.var.lanceolata Bge.2005

    • Author(s)
      Hiroshi Morita
    • Journal Title

      J.Nat.Prod. 68

      Pages: 1686-1688

    • Related Report
      2005 Annual Research Report
  • [Presentation] Isolation of Active Ingredients from Medicinal Plants2007

    • Author(s)
      Hiroshi Morita
    • Organizer
      ITB-UKM Joint Seminar
    • Place of Presentation
      Bundung,Indonesia
    • Year and Date
      2007-12-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Isolation of Active Ingredients from Medicinal Plants2007

    • Author(s)
      Hiroshi Morita
    • Organizer
      ITB-UKM Joint Seminar
    • Place of Presentation
      Bundung, Indonesia
    • Year and Date
      2007-12-12
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] New Antimitotic Natural Products from Medicinal Plants2007

    • Author(s)
      Hiroshi Morita
    • Organizer
      12th Asian Chemical Congress
    • Place of Presentation
      KL,Malaysia
    • Year and Date
      2007-08-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] New Antimitotic Natural Products from Medicinal Plants2007

    • Author(s)
      Hiroshi Morita
    • Organizer
      12th Asian Chemical Congress
    • Place of Presentation
      KL, Malaysia
    • Year and Date
      2007-08-24
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Bioactive Peptides from Higher Plants2007

    • Author(s)
      Hiroshi Morita
    • Organizer
      International Organization for Chemical Sciences in Development
    • Place of Presentation
      Surabaya,Indonesia
    • Year and Date
      2007-04-10
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Bioactive Peptides from Higher Plants2007

    • Author(s)
      Hiroshi Morita
    • Organizer
      International Organization for Chemical Sciences in Development
    • Place of Presentation
      Surabaya, Indonesia
    • Year and Date
      2007-04-10
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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