• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Environmental Research of naturally produced lipophilic halogenated compounds in Oceania

Research Project

Project/Area Number 17404006
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Environmental chemistry
Research InstitutionDaiichi University, College of Pharmaceutical Sciences

Principal Investigator

HARAGUCHI Koichi  Daiichi University, College of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Professor (00258500)

Co-Investigator(Kenkyū-buntansha) ENDO Tetsuya  Health Sciences University of Hokkaido, Faculty of Phamaceutical Sciences, Associate Professor (10133216)
NISHIMURA Eri  Daiichi College of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Research Associate (80412550)
森木 幸恵  第一薬科大学, 薬学部, 助手 (50412549)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥14,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2007: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2006: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2005: ¥6,000,000 (Direct Cost: ¥6,000,000)
Keywordsnatural organohalogen / brominated diphenyl ether / halogenated bipyrrole / marine sponge / human milk / fish / メトキシ臭素化ジフェニルエーテル / ジメチルビピロール / 三臭素化メトキシダイオキシン / 有害化学物質 / 天然物 / 環境 / 分析化学 / 臭素化合物 / 海綿動物 / ジメトキシ臭素化ビフェニル / 天然由来産物 / パラオ
Research Abstract

In order to investigate the origin of halogenated bipyrroles and brominated methoxylated diphenyl ethers in marine environment, we surveyed marine sponge, marine fish, sharks and mass-stranded mammals collected in Japanese coastal water, East Asia (Philippines, Taiwan and Hong Kong), Micronesia (Guam and Palau) and Oceania (Australia, New Zealand and Tahiti). Major persistent natural organohalogen products distributed in the Pacific were identified as halogenated 1-methyl-1',2-bipyrroles, 1,1'-dimethy1-2,2'-bipyrroles, methoxylated tetrabromodiphenyl ethers, dimethoxylated tetrabromobiphenyl. In Japanese mother's milk (n=65), these natural organohalogens were present at similar concentrations to polybrominated diphenyl ethers (PBDEs). These components were found to be widely distributed in marine fish from the Japanese coastal water. The dietary exposure to these compounds was suggested to be via consumption of marine fish. These products may be originated from marine sponge in Micronesia, where some of sponges contained high amounts of PBDE-like compounds. The distribution of these natural organohalogens was geographically different. Chlorinated 1-methyl-1',2-bipyrroles were abundant in marine fish from Oceania (East of Australia), whereas brominated1,1'-dimethyl-2,2'-bipyrroles were localized in the northern Pacific, especially in the Japanese coastal water. Natural PBDE-like compounds were distributed widely in the Pacific coast, but the biomagnification potential of these compounds seemed to be species-specific. The food chain study and toxicological evaluation are needed for natural persistent organohalogens described in this study.

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (35 results)

All 2008 2007 2006 2005 Other

All Journal Article (25 results) (of which Peer Reviewed: 10 results) Presentation (10 results)

  • [Journal Article] Hg, Zn and Cu levels in muscle and liver of tiger sharks (Galeocerdocuriei) on the coast of Ishigaki Island, Japan : Relationship between metal concentrations and body-length.2008

    • Author(s)
      Endo T.
    • Journal Title

      Marine Pollution Bulletin 56

      Pages: 1774-1780

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Hg, Zn, and Cu levels in muscle and liver of tiger sharks (Galeocerdo curvier) on the coast of Ishigaki Island, Japan.2008

    • Author(s)
      T. Endo, Y. Hisamichi, K. Haraguchi, Y. Kato, C. Ohta, N. Koga
    • Journal Title

      Mar. Pollut. Bull. 56

      Pages: 1774-1780

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Contamillation levels of mercury and cadmium in melon-headed whales(Peponocephala electra)from a mass stranding on the Japanese coast2008

    • Author(s)
      Endo T
    • Journal Title

      Science of the total Environment (in perss)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age-dependent accumulation of heavy metals in a pod of killer whales(Orcinus orca)stranded in the northern area of Japan2007

    • Author(s)
      Endo T
    • Journal Title

      Chemosphere 67

      Pages: 51-59

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contamination level of mercury in red meatproducts from cetaceansavailable from South Korea markets2007

    • Author(s)
      Endo T
    • Journal Title

      Marine Pollution Bulletin 54

      Pages: 669-677

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Natural persistent organohalogens in breast milk from Japan2007

    • Author(s)
      Haraguchi K
    • Journal Title

      Organohalogen Compounds 69

      Pages: 1705-1707

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age-dependent accumulation of heavy metals in a pod of killer whales (Orcinus orca) stranded in the northern area of Japan2007

    • Author(s)
      T.Endo
    • Journal Title

      Chemosphere 67

      Pages: 51-59

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Bioaccumulation of naturally occurring mixed halogenated dimethyl bipyrroles in whale and dolphin products on the Japanese market2006

    • Author(s)
      Haraguchi K.
    • Journal Title

      Archives of Environmental Contamination and Toxicology 51

      Pages: 135-141

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Distribution of total mercury, methyl mercury and selenium in pod of killer whales (Orcinus orca)stranded in the northern area of Japan2006

    • Author(s)
      Endo T.
    • Journal Title

      Environmental Pollution 144

      Pages: 145-150

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Bioaccumulation of naturally occurring mixed halogenated dimethyl bipyrroles in whale and dolphin products on the Japanese market.2006

    • Author(s)
      K. Haraguchi, Y. Hisamichi, T. Endo
    • Journal Title

      Arch. Environ. Contain. Toxicol. 51

      Pages: 135-141

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Distribution of total mercury, methyl mercury and selenium in pod of killer whales (Orcinus orca) stranded in the northern area of Japan.2006

    • Author(s)
      T. Endo, O. Kimura, Y. Hisamichi, Y. Minoshima, K. Haraguchi
    • Journal Title

      Environ. Pollut 144

      Pages: 145-150

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Bioaccumulation of naturally occurring mixed halogenated dimethylbipyrroles in whale and dolphin products on the Japanese market2006

    • Author(s)
      K.Haraguchi
    • Journal Title

      Archives of Environmental Contamination and Toxicology 51

      Pages: 135-141

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Organohalogen contaminants and metabolites in Killer whale (Orcinus orca) and melon-headed whale (Peponocephala electra)2006

    • Author(s)
      K.Haraguchi
    • Journal Title

      Organohalogen Compounds 68

      Pages: 1851-1854

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Distribution of total mercury, methyl mercury and selenium in pod of killer whales (Orcinus Orca) stranded in the northern area of Japan : comparison of mature females with calves2006

    • Author(s)
      T.Endo
    • Journal Title

      Environmental Pollution 144

      Pages: 145-150

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Distribution of total mercury, methyl mercury and selenium in pod of killer whales (Orcinus Orca) stranded in the northern area of Japan: Comparison of mature females with calves.2006

    • Author(s)
      T.Endo
    • Journal Title

      Environmental Pollution In press

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Bioaccumulation of Naturally Occurring Mixed Halogenated Dimethylbipyrroles in Whale and Dolphin Products on the Japanese Market.2006

    • Author(s)
      K.Haraguchi
    • Journal Title

      Archives of Environmental Contamination and Toxicology In press

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Identification, quantification and synthesis of a novel dimethoxylated polybrominated biphenyl in marine mammals caught off the coast of Japan2005

    • Author(s)
      Marsh G.
    • Journal Title

      Environmental Science & Technology 39

      Pages: 8654-8690

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Identification, quantification and synthesis of a novel dimethoxylated polybrominated biphenyl in marine mammals caught off the coast of Japan.2005

    • Author(s)
      G. Marsh, M. Athanasiadou, I. Athanassiadis, A. Bergman, T. Bndo, K. Haraguchi
    • Journal Title

      Environ. Sci. Technol. 39

      Pages: 8654-8690

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Identification, quantification, and synthesis of a novel dimethoxylated polybrominated biphenyl in marine mammals caught off the coast of Japan.2005

    • Author(s)
      G.Marsh
    • Journal Title

      Environmental Science and Technology 39

      Pages: 8684-8690

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Distribution and toxicity of mercury in rats after oral administration of mercury-contaminated whale red meat marketed for human consumption.2005

    • Author(s)
      T.Endo
    • Journal Title

      Chemosphere 61

      Pages: 1069-1073

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Total mercury, methyl mercury, and selenium levels in the red meat of small cetaceans sold for human consumption in Japan.2005

    • Author(s)
      T.Endo
    • Journal Title

      Environmental Science and Technology 39

      Pages: 5703-5708

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Negative APCI-LC/MS/MS method for determination of natural persistent halogenated products in marine biota.

    • Author(s)
      Haraguchi K.
    • Journal Title

      Analytical Chemistry (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Accumulation and mother-to-calf transfer of anthropogenic and natural organohalogens in killer whales (Orcinus orca) stranded on the Pacific coast of Japan.

    • Author(s)
      Haraguchi K.
    • Journal Title

      Science of the Total Environment (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Negative APCI-LC/MS/MS method for determination of natural persistent halogenated products in marine biota.

    • Author(s)
      K. Haraguchi, Y. Kato, K. Atobe, S. Okada, T. Endo, F. Matsubara, T. Oguma
    • Journal Title

      Anal. Chem. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Accumulation and mother-to-calf transfer of anthropogenic and natural organohalogens in killer whales {Orcinus orca) stranded on the Pacific coast of Japan.

    • Author(s)
      K. Haraguchi, Y. Hisamichi, T. Endo
    • Journal Title

      Sci. Total Environ. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ヒト母乳中に残留する天然由来ハロゲン化合物の環境起源調査2008

    • Author(s)
      原口 浩一
    • Organizer
      日本薬学会第128回年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] 母乳中に残留する天然有機ハロゲン化合物の環境起源調査2008

    • Author(s)
      原口 浩一
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Environmental research of naturally produced organohalogens accumulated in human milk.2008

    • Author(s)
      K. Haraguchi, E. Nishimura, Y. Hisamichi, T. Endo, C. Ohta, N. Koga, Y. Kato
    • Organizer
      128^<th> Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Yokohama, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Natural and anthropogenic POPs in bluefin tuna from Japanese market2007

    • Author(s)
      Hisamichi Y
    • Organizer
      27th International Sylnposium on Halogenated Persistent Organic Pollutants
    • Place of Presentation
      東京
    • Year and Date
      2007-09-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Natural persistent organohalogens in breast milk from Japan2007

    • Author(s)
      Haraguchi K.
    • Organizer
      27^<th> International Symposium on Halogenated Persistent Organic Pollutants, DIOXIN 2007
    • Place of Presentation
      Tokyo, Japan
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Natural and anthropogenic POPs in bluefin tuna from Japanese market.2007

    • Author(s)
      Hisamichi Y.
    • Organizer
      27^<th> International Symposium on Halogenated Persistent Organic Pollutants, DIOXIN 2007
    • Place of Presentation
      Tokyo, Japan
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Natural persistent organohalogens in breast milk from Japan.2007

    • Author(s)
      K. Haraguchi, Y. Hisamichi, E. Nishimura, T. Endo
    • Organizer
      27^<th> International Symposium on Halogenated Persistent Organic Pollutants
    • Place of Presentation
      Tokyo, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Natural and anthropogenic POPs in bluefin tuna from Japanese market.2007

    • Author(s)
      Y. Hisamichi, T. Endo, E. Nishimura, K. Haraguchi
    • Organizer
      27^<th> International Symposium on Halogenated Persistent Organic Pollutants
    • Place of Presentation
      Tokyo, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Persistent natural organohalogens in marine samples from Japanese coastal water.2005

    • Author(s)
      Haraguchi K.
    • Organizer
      25^<th> International Symposium on Halogenated Environmental Organic Pollutants, DIOXIN 2005
    • Place of Presentation
      Tronto, Canada
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Persistent natural organohalogens in marine samples from Japanese coastal water.2005

    • Author(s)
      K. Haraguchi, S. Moriki, Y. Hisamichi, T. Endo
    • Organizer
      25^<th> International Symposium on Halogenated Environmental Organic Pollutants
    • Place of Presentation
      Tronto, Canada
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi