Epidemiological study of lung cancer in elevated indoor radon and thoron areas, in China

• Project/Area Number: 17406002
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: Kagoshima University
• Principal Investigator: AKIBA Suminori Kagoshima University, 大学院・医歯学総合研究科, 教授 (50145554)
• Co-Investigator(Kenkyū-buntansha): YONEHARA Hidenori 放射線医学総合研究所, 放射線防護研究センター, グループリーダー (70175016) ; FURUKAWA Masahide 琉球大学, 理学部, 教授 (40238671) ; TOKONAMI Sinji 放射線医学総合研究所, 放射線防護研究センター, 室長 (80247254) ; KORIYAMA Chihaya 鹿児島大学, 大学院・医歯学総合研究科, 准教授 (30274814) ; 山田 裕司 放射線医学総合研究所, 緊急被ばく医療研究センター, 部長 (20166739)
• Project Period (FY): 2005 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥14,970,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥1,770,000); Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2007: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2006: ¥3,400,000 (Direct Cost: ¥3,400,000); Fiscal Year 2005: ¥3,900,000 (Direct Cost: ¥3,900,000)
• Keywords: 放射線 / 疫学 / 癌 / 特殊環境

Research Abstract

中国の高ラドン地域で肺がんの症例・対照研究を行った。喫煙などの影響を考慮したオッズ比は、屋内ラドンレベルが<20(Bq/m3)を参照カテゴリーとすると、20-49(Bq/m3)で3.7、50-149(Bq/m3)で3.3、150+(Bq/m3)で>999で、屋内ラドンで肺がんリスクが増加する可能性が示された。トロンでは関連は観察されなかった。さらに対象者を追加し、リスクの定量的な評価の精度を上げる必要がある

Research Products

• [Journal Article] BACKGROUND RADIATION AND CANCER INCIDENCE IN KERANA, INDIA-KARANAGAPPALLY COHORT STUDY (2009)
  • Author(s): Nair RR, Rajan B, Akiba S, et al.
  • Journal Title: Health Phys 96 Pages: 55-66
  • Peer Reviewed
• [Journal Article] Po-210 and Pb-210 inhalation dose by cigarette smoking inGansu and Yunnan provinces, China (2008)
  • Author(s): Tokonami S, Tibor K, Yoshinaga S, Kobayashi Y, Ishikawa T.
  • Journal Title: 保健物理 43(2) Pages: 131-134
  • Peer Reviewed
• [Journal Article] Thoron (220Rn) impact in the radon-and-lung-cancerepidemiological study (2008)
  • Author(s): Tokonami S, Yonehara H.
  • Journal Title: Proceedings of NIRS International Symposium on theEffects of Low Dose Radiation Pages: 61-66
• [Journal Article] 高自然放射線地域の健康影響研究の現状 (2008)
  • Author(s): 神田玲子, 小林羊佐, 吉永信治, 米原英典
  • Journal Title: 放射線生物研究 43(1) Pages: 10-24
• [Journal Article] Po-210 and Pb-210 inhalation dose by cigarette smoking in Gansu and Yunnan provinces, China (2008)
  • Author(s): Tokonami S, et al.
  • Journal Title: 保健物理 43 Pages: 131-134
  • Peer Reviewed
• [Journal Article] 高自然放射線地域の健康影響研究の現状 (2008)
  • Author(s): 神田玲子, 小林羊佐, 吉永信治, 米原英典
  • Journal Title: 放射線生物研究 43 Pages: 10-24
• [Journal Article] Calculation of dose conversion factors for thoron decay products (2007)
  • Author(s): Ishikawa T, Tokonami S et.al.
  • Journal Title: Journal of Radiological Protection 27(4) Pages: 447-456
  • Peer Reviewed
• [Journal Article] Influence of environmental thoron on radon estimates (2007)
  • Author(s): Tokonami S, Yoshinaga S, Sugino M, Kobayashi Y, Takahashi H, Sorimachi A, Ishikawa T et. al.
  • Journal Title: The Natural Radiation Environment : 8th International Symposium (NRE VIII), Buzios, Rio de Janeiro, Brazil(AIP Conference Proceedings) vol.1034 Pages: 145-148
• [Journal Article] 屋内ラドンリスクに関する疫学研究とその評価 (2007)
  • Author(s): 米原英典, 石森有, 秋葉澄伯, 飯田孝夫, 飯本武志, 甲斐倫明, 下道國, 床次眞司, 山田裕司, 吉永信治, 米澤理加
  • Journal Title: 保健物理 42(3) Pages: 201-213
  • NAID: 110006474066
• [Journal Article] Radiation dose originating from radon of workers in the Tourist Cave of Tapolca (Hungary) (2007)
  • Author(s): Somlai J, et. al.
  • Journal Title: J. Radioanal. Nucl. Chem. 279・1
  • Peer Reviewed
• [Journal Article] 220Rn and its progeny in dwellings of Korea (2007)
  • Author(s): Kim CK, et. al.
  • Journal Title: Radiat. Meas. 42・8 Pages: 1409-1414
  • Peer Reviewed
• [Journal Article] Calculation of dose conversion factors for thoron decay products (2007)
  • Author(s): Ishikawa T, et. al.
  • Journal Title: J. Radiol. Prot. 27 Pages: 447-456
  • Peer Reviewed
• [Journal Article] Anomalous radon emanation linked to preseismic electromagnetic phenomena (2007)
  • Author(s): Omori Y, et. al.
  • Journal Title: Natural Hazards and Earth System Sciences 7 Pages: 629-635
  • Peer Reviewed
• [Journal Article] A case study on the effect of water from groundwater sources on indoor radon levels (2007)
  • Author(s): Yasuoka Y, et. al.
  • Journal Title: J. Radioanal. Nucl. Chemist. 275・1 Pages: 165-172
  • Peer Reviewed
• [Journal Article] Continuous measurements of bronchial exposure induced by radon decay products during inharation (2007)
  • Author(s): Iwaoka K, et. al.
  • Journal Title: Rev. Sci. Instrum 78・9
  • Peer Reviewed
• [Journal Article] 222Rn concentrations of water in the Balaton Highland and in the southern part of Hungary, and the assessment of the resulting dose (2007)
  • Author(s): Somlai K, et. al.
  • Journal Title: Radiation Measurements 42・3 Pages: 491-495
  • Peer Reviewed
• [Journal Article] Radon and thoron parallel measurements in Hungary. (2007)
  • Author(s): Kavasi N, et. al.
  • Journal Title: Radiat. Prot. Dosim 123・2 Pages: 250-253
  • Peer Reviewed
• [Journal Article] A naturally ventilated accumulator for integrating measurements of radon flux from soil (2007)
  • Author(s): Zhuo W., et. al.
  • Journal Title: J. Nucl. Sci. Technol 44・8 Pages: 1100-1105
  • Peer Reviewed
• [Journal Article] Time-scale invariant changes in atmospheric radon concentration and crustal strain prior to a large earthquake (2007)
  • Author(s): Kawada Y., et. al.
  • Journal Title: Nonlinear Processes in Geophysics 14 Pages: 123-130
  • Peer Reviewed
• [Journal Article] Rn concentrations of water in the Balaton Highland and in the southern part of Hungary, and the assessment of the resulting dose (2007)
  • Author(s): K.Somlai., et al.
  • Journal Title: Radiation Measurements (in press)
• [Journal Article] Radon and thoron parallel measurements in Hungary. (2007)
  • Author(s): Kavasi, N., et al.
  • Journal Title: Radiat. Prot. Dosim (in press)
• [Journal Article] Radon-thoron discriminative measurements in Gansuprovince, China, and their implication for dose estimates. (2006)
  • Author(s): Yamada Y, Sun Q, Tokonami S, Akiba S, Zhuo W, Zhang S, Ishikawa T, Furukawa M, Fukutsu K, Yonehara H.
  • Journal Title: Journal of Toxicology andEnvironmental Health. Part A. 69(7/8) Pages: 723-734
  • Peer Reviewed
• [Journal Article] Radon-Thoron Discriminative Measurements in Gansu Province, China, and their Implication for Dose Estimates. (2006)
  • Author(s): Yamada Y., et al.
  • Journal Title: Journal of Toxicology and Environmental Health. 69・7 Pages: 723-734
• [Journal Article] Estimates of the cancer burden in Europe from radioactive fallout from the Chernobyl accident. (2006)
  • Author(s): Cardis E., et al.
  • Journal Title: Int J Cancer. 119・6 Pages: 1224-1235
• [Journal Article] Airborne and waterborne radon concentrations in areas with use of groundwater supplies. (2006)
  • Author(s): Ishikawa T., et al.
  • Journal Title: J. Radioanalytical and Nuclear Chemistry 267・1 Pages: 85-88
• [Journal Article] Evidence of precursor phenomena in the Kobe earthquake obtained from atmospheric radon concentration. (2006)
  • Author(s): Yumi Yasuoka., et al.
  • Journal Title: Applied Geochemistry 21・6 Pages: 1064-1072
• [Journal Article] 福岡・鹿家地区における水中ラドンによる屋内ラドン濃度への寄与ならびに線量評価. (2006)
  • Author(s): 楢崎 幸範., et al.
  • Journal Title: Radioisotopes 55・8 Pages: 457-467
• [Journal Article] 飲用水中におけるラドンの除去手法ならびに定量的解析. (2006)
  • Author(s): 楢崎 幸範, et al.
  • Journal Title: Radioisotopes 55・11 Pages: 679-686
• [Journal Article] Bidi smoking and lung cancer incidence among males in Karuna gappally cohort in Kerala, India
  • Author(s): Jayalekshmi P., et. al.
  • Journal Title: Int. J. Cancer (in press)
  • Peer Reviewed
• [Journal Article] Radon-Thoron discriminative measurements in Gansu Province, China, and their implication for dose estimates
  • Author(s): Yamada Y, Sun QF et al.
  • Journal Title: Journal of Toxicology and Environmental Health (in press)
• [Presentation] ラドン・トロン弁別問題に対するシミュレーション研究 (2008)
  • Author(s): 土居主尚, 床次眞司, 米原英典, 吉永信治
  • Organizer: 日本放射線影響学会第51回大会
  • Place of Presentation: 北九州
• [Presentation] A simulation study of lognormal measurement error effect -Discrimination problem of radon and thoron (2008)
  • Author(s): Doi K, Tokonami S, Kobayashi Y, Yonehara H, Yoshinaga S.
  • Organizer: 12th International Congress of the International Radiation ProtectioAssociation
  • Place of Presentation: Buenos Aires
• [Presentation] Reliability of up-to-date risk factor between residential radon and lung cancer (2008)
  • Author(s): Tokonami S, Ishikawa T, Sorimachi A, Kobayashi Y, Yoshinaga S, Akiba S et. al.
  • Organizer: 12th International Congress of the International Radiation Protection Association
  • Place of Presentation: Buenos Aires
• [Presentation] Field experience of thoron interference on radon measurements (2008)
  • Author(s): Tokonami S, Sun Q, Ishikawa T, Sorimachi A, Kobayashi Y, Tibor K, Yoshinaga S, Akiba S.
  • Organizer: 7th International Conference on Nuclear and Radiochemistry
  • Place of Presentation: Budapest
• [Presentation] 中国甘粛省における洞窟住居内ラドン濃度の詳細調査 (2008)
  • Author(s): 小林羊佐, 石川徹夫, 孫全冨, 床次眞司,吉永信治, 米原英典, 秋葉澄伯
  • Organizer: 日本保健物理学会第42回研究発表会
  • Place of Presentation: 宜野湾市
• [Presentation] 中国製タバコに含まれるPo-210及びPb-210の放射能濃度及び喫煙による被ばく線量評価 (2008)
  • Author(s): Tibor K, 床次眞司, 吉永信治, 小林羊佐, 石川徹夫
  • Organizer: 日本保健物理学会第42回研究発表会
  • Place of Presentation: 沖縄県宜野湾市
• [Presentation] ラドン濃度の測定誤差による肺がんリスクの過小評価の検討-SIMEX法によるバイアス補正- (2008)
  • Author(s): 土居主尚, 床次眞司, 小林羊佐, 米原英典, 吉永信治, その他
  • Organizer: 日本保健物理学会第42回研究発表会
  • Place of Presentation: 宜野湾市
• [Presentation] 中国甘粛省における洞窟住居内ラドン濃度の詳細調査 (2008)
  • Author(s): 小林羊佐, 石川徹夫, 孫全冨, 床次眞司, 吉永信治, 米原英典, 秋葉澄伯
  • Organizer: 日本保健物理学会第42回研究発表会
  • Place of Presentation: 沖縄コンベンションセンター(宜野湾市)
• [Presentation] 中国製タバコに含まれるPo-210及びPb-210の放射能濃度及び喫煙による被ばく線量評価 (2008)
  • Author(s): Tibor K, 床次眞司, 吉永信治, 小林羊佐, 石川徹夫
  • Organizer: 日本保健物理学会第42回研究発表会
  • Place of Presentation: 沖縄コンベンションセンター(宜野湾市)
• [Presentation] ラドン濃度の測定誤差による肺がんリスクの過小評価の検討-SIMEX法によるバイアス補正- (2008)
  • Author(s): 土居主尚, 床次眞司, 小林羊佐, 米原英典, 吉永信治, その他
  • Organizer: 日本保健物理学会第42回研究発表会
  • Place of Presentation: 沖縄コンベンションセンター(宜野湾市)
• [Presentation] ラドン・トロン弁別問題に対するシミュレーション研究 (2008)
  • Author(s): 土居主尚, 床次眞司, 米原英典, 吉永信治
  • Organizer: 日本放射線影響学会第51回大会
  • Place of Presentation: 北九州国際会議場北九州市
• [Presentation] A simulation study of lognormal measurement error effect - Discrimination problem of radon and thoron (2008)
  • Author(s): Doi K, et al.
  • Organizer: 12th International Congress of the International Radiation Protection Association
  • Place of Presentation: Buenos Aires, Argentina
• [Presentation] Reliability of up-to-date risk factor between residential radon and lung cancer (2008)
  • Author(s): Tokonami S, et al.
  • Organizer: 12th International Congress of the International Radiation Protection Association
  • Place of Presentation: Buenos Aires, Argentina
• [Presentation] Field experience of thoron interference on radon measurements (2008)
  • Author(s): Tokonami S, et al.
  • Organizer: 7th International Conference on Nuclear and Radiochemistry
  • Place of Presentation: Budapest, Hungary
• [Presentation] Influence of environmental thoron and radonmeasurements and related issues (2007)
  • Author(s): Tokonami S, Tibor K, Sugino M, Kavasi N, Takahashi H, Kobayashi Y, Sorimachi A, Ishikawa T, Yoshinaga S.
  • Organizer: 8th international symposium on the naturalradiation environment
  • Place of Presentation: Buzios
• [Presentation] Preliminary Results of a New Epidemiological Study ofLung Cancer and Residential Radon in GansuProvince, China (2007)
  • Author(s): Kobayashi Y, Sun Q, Yoshinaga S, Tokonami S, Ishikawa T, Takahashi H, Yonehara H, Akiba S et. al.
  • Organizer: Hungary-Japan Workshop on Radioecology
  • Place of Presentation: Veszprem
• [Presentation] Case-control study of lung cancer in relation toresidential radon and thoron in GansuProvince, China : Study design andpreliminary results (2007)
  • Author(s): Kobayashi Y, Sun Q, Yoshinaga S, Tokonami S, Ishikawa T, Takahashi H, Yonehara H, Akiba S et. al.
  • Organizer: 5th Conference on Protection against Radon at Home and at Work
  • Place of Presentation: Prague
• [Presentation] 屋内ラドン濃度測定値における不確実性が肺がんリスク推定値へ与える影響 (2006)
  • Author(s): 吉永信治, 小林羊佐, 床次眞司
  • Organizer: 日本放射線影響学会第49回大会
  • Place of Presentation: 札幌