Investigation on Kampo Drug Resources in Asia and Analysis on Diversity ofMedicinal Plants

• Project/Area Number: 17406004
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Environmental pharmacy
• Research Institution: University of Toyama
• Principal Investigator: KOMATSU Katsuko University of Toyama, Institute of Natural Medicine, Professor (50225570)
• Co-Investigator(Kenkyū-buntansha): HATTORI Masao University of Toyama, Institute of Natural Medicine, Professor (40126545) ; 田中 謙 富山大学, 和漢医薬学総合研究所, 准教授 (60418689) ; TOHDA Chihiro University of Toyama, Institute of Natural Medicine, Assistant Professor (10272931) ; 中村 憲夫 富山大学, 和漢医薬学総合研究所, 助手 (90377268)
• Project Period (FY): 2005 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥7,400,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥600,000); Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2006: ¥2,100,000 (Direct Cost: ¥2,100,000); Fiscal Year 2005: ¥2,700,000 (Direct Cost: ¥2,700,000)
• Keywords: medicinal plants / Chinese crude drug / molecular systematics / quality evaluation / dementia / hepatitis C virus / international exchange of researcher / China : Mongolia : Thailand / 薬用植物 / 抗炎症作用 / 痴呆 / 中国:モンゴル:タ

Research Abstract

1. Genetic and chemical diversity
(1) Rheum palmatum, R. tanguticum and R. officinale presented 22, 4 and 3 genotypes in matK gene, respectively and each showed regional specificity. Quality evaluation on 28 compounds revealed R. palmatum belonged to subclade I was of high quality.
(2) DNA microarray for authentication of ginseng drugs has been developed using genetic data of Panax plants. Analysis of ginsenosides by LC-FTICR-MS provided different mass chromatographic profiles for each species.
(3) Based on common sequences of 15 genotypes of Eleutherococcus senticosus in trnK gene, an identification method applying PCR-RFLP was developed. Production areas of rhizomes containing over 0.05% of each eleutherosides B and E were determined
(4) Regards to astragalosides and isoflavonoids contents, Astragali Radix cultivated in Inner Mongolia were with high quality as wild ones in Shanxi Prov. Comprehensive analysis of chemical constituents and multivariate data analysis showed the difference be tween Mongolian and Chinese Astragali Radix.
(5) 8 Ephedra species from Mongolia presented 14 genotypes in 18S rRNA-trnK gene sequences. In southwestern Mongolia, possible hybrids-derived populations were observed. 6 species contained more than 1.5% of ephedrine alkaloids.
(6) 7 types of volatile constituents' compositions were observed in "Gajutsu." Gajutsu derived from Curcuma phaeocaulis and from Japanese C. zedoaria belonged to the same type. Curcuma rhizomes from Thailand presented 9 types of volatile constituents' compositions, which related to genotypes.
2. Pharmacological active compounds
(1) Eleutherococcus Senticosus Rhizome showed significant effects on axonal and dendritic regenerations and synaptic reconstruction in A8(25-35)-treated rat cortical neurons. Eleutheroside B was identified as one of active components.
(2) Through chemomatric analysis on Curcuma phaemcanlis rhizome, furanodienone and curcumenol were determined as active compounds responsible for COX-2 inhibitory activity.
(3) In root bark of Tripterygium hypoglaucum which showed inhibitory effect on hepatitis C viral polymerase, demethylzeylasteral was identified as an active compound.

Research Products

• [Journal Article] Quality evaluation of Astragali Radix using a multivariate statistical approach (2008)
  • Author(s): Tanaka K., Tamura T., Fukuda S., Batkhuu J., Sanchir C., Komatsu K.
  • Journal Title: Phytochem. (in press)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Development of a DNA microarray for authentication of ginseng drugs based on 18S rRNA gene sequence (2008)
  • Author(s): Zhu S., Fushimi H., Komatsu K.
  • Journal Title: J. Agric. Food Chem. 56(in press)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Morphological, Genetic and Chemical Polymorphism of Curcuma kwangsiensis (2008)
  • Author(s): Komatsu K., Sasaki Y., Tanaka K., Kuba Y., Fushimi H., Cai S. Q.
  • Journal Title: J. Nat. Med. (in press)
  • NAID: 10024322937
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Prediction of cyclooxygenase inhibitory activity of Curcuma Rhizome from chromatograms by multivariate analysis (2008)
  • Author(s): Tanaka K., Kuba Y., Ina A., Watanabe H., Komatsu K.
  • Journal Title: Chem. Pharm. Bull. 56(in press)
  • NAID: 110006791971
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Curcuma drugs and curcumin regulate the expression and function of P-gp in Caco-2 cells in completely opposite ways (2008)
  • Author(s): Hou X. L., Takahashi K., Tanaka K., Tougou K., Qiu F., Komatsu K., Takahashi K., Azuma J.
  • Journal Title: Int. J. Pharm. (in press)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Inhibitory effects of Eleutherococcus senticosus extracts on amyloidβ(25-35)-induced neuritic atrophy and synaotic loss (2008)
  • Author(s): Tohda C., Ichimura M., Bai Y. J., Zhu S., Tanaka K., Komatsu K.
  • Journal Title: JPS (in press)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Quality evaluation of Astragali Radix using a multivariate statistical approach (2008)
  • Author(s): Tanaka, K., Tamura, T., Fukuda, S., Batkhuu, J., Sanchir, C., Komatsu, K
  • Journal Title: Phytochem (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Development of a DNA microarray for authentication of ginseng drugs based on 18S rRNA gene sequence (2008)
  • Author(s): Zhu, S., Fushimi, H., Komatsu, K
  • Journal Title: J. Agric. Food Chem 56(in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Morphological, Genetic and Chemical Polymorphism of Curcuma kwangsiensis (2008)
  • Author(s): K, Sasaki, Y., Tanaka, K, Kuba, Y., Fushimi, H., Cai, S.Q
  • Journal Title: J. Nat Med (in press)
  • NAID: 10024322937
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Prediction of cyclooxygenase inhibitory activity of Curcuma Rhizome from chromatograms by multivariate analysis (2008)
  • Author(s): Tanaka, K., Kuba, Y., Ina, A. Watanabe, H., Komatsu, K
  • Journal Title: Chem. Pharm. Bull 56(in press)
  • NAID: 110006791971
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Curcuma drugs and curcumin regulate the expression and function of P-gp in Caco-2 cells in completely opposite ways (2008)
  • Author(s): Hou, X.L., Takahashi, K, Tanaka, K, Tougou, K., Qiu, F., Komatsu, K., Takahashi, K., Azuma, J
  • Journal Title: Int. J Pharm (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Inhibitory effects of Eleutherococcus senticosus extracts on amyloid 13(25-35)-induced neuritic atrophy and synaptic loss (2008)
  • Author(s): Tohda, C., Ichimura, M., Bai, Y.J., Zhu, S., Tanaka, K., Komatsu, K
  • Journal Title: JPS (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Quality evaluation of Astragali Radix by multivariate statistical approach (2008)
  • Author(s): Tanaka K, Tamura T, Komatsu K
  • Journal Title: Phytochem (accepted)
  • Peer Reviewed
• [Journal Article] Development of a DNA microarray for authentication of ginseng drugs based on 18S rRNA gene sequence (2008)
  • Author(s): Zhu S, Fushimi H, Komatsu K
  • Journal Title: J. Agric. Food Chem 56(In press)
  • Peer Reviewed
• [Journal Article] A Novel Compound from Hedysarum polybotrys (2007)
  • Author(s): Zou K., Komatsu K., Zhu S.
  • Journal Title: J. Asian Nat. Prod. Res. 9 Pages: 481-485
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Analysis of Ginsenosides in Ginseng Drugs Using Liquid Chromatography-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (2007)
  • Author(s): Tanaka K., Kubota M., Zhu S., Sankawa U., Komatsu K.
  • Journal Title: Nat. Prod. Comm. 2 Pages: 625-632
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Anti-estrogenic Activity of Mansorins and Mansonones from the Heartwood of Mansonia gagei Drumm (2007)
  • Author(s): El-Halawany A. M., Chung M. H., Ma C. M., Komatsu K., Nishihara T., Hattori M.
  • Journal Title: Chem. Pharm. Bull. 55 Pages: 1332-1337
  • NAID: 110006379653
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Possible inhibitory mechanism of Curcuma drugs on CYP3A4 in 1α, 25 dihydroxyvitamin D3 treated Caco-2 cells (2007)
  • Author(s): Hou X. L., Takahashi K., Kinoshita N., Qiu F., Tanaka K., Komatsu K., Takahashi K., Azuma J.
  • Journal Title: Int. J. Pharm. 337 Pages: 169-177
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Molecular Identification of "Chuanxiong" by Nucleotide Sequence and Multiplex Single Base Extension Analysis on Chloroplast trnK Gene (2007)
  • Author(s): Zhu S., Fushimi H., Han G., Tsuchida T., Uno T., Takano A., Komatsu K.
  • Journal Title: Biol. Pharm. Bull. 30 Pages: 527-531
  • NAID: 110006239197
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Molecular Analysis of the Genus Mitragyna Existing in Thailand Based on rDNA ITS Sequences and Its Application to Identify A Narcotic Species: Mitragyna speciosa (2007)
  • Author(s): Sukrong S., Zhu S., Ruangrungsi N., Phadungcharoen T., Palanuvej C., Komatsu K.
  • Journal Title: Biol. Pharm, Bull. 30 Pages: 1284-1288
  • NAID: 110006342747
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Comparative study on volatile components of Nardostachys Rhizome (2007)
  • Author(s): Tanaka K., Komatsu K.
  • Journal Title: J. Nat. Med. 62 Pages: 112-116
  • NAID: 10024189505
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A Novel Compound from Hedysarum polybotrys (2007)
  • Author(s): Zou, K., Komatsu, K, Zhu, S
  • Journal Title: J Asian Nat. Prod. Res 9 Pages: 481-485
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Analysis of Ginsenosides in Ginseng Drugs Using Liquid Chromatography-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (2007)
  • Author(s): Tanaka, K., Kubota, M., Zhu, S., Sankawa, U., Komatsu, K
  • Journal Title: Nat. Prod. Comm 2 Pages: 625-632
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Anti-estrogenic Activity of Mansorins and Mansonones from the Heartwood of Mansonia gagei Drumm (2007)
  • Author(s): El-Halawany, A.M., Chung, M.H., Ma, C.M., Komatsu, K., Nishihara, T., Hattori, M
  • Journal Title: Chem. Pharm. Bull 55 Pages: 1332-1337
  • NAID: 110006379653
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Possible inhibitory mechanism of Curcuma drugs on CYP3A4 in la, 25 dihydroxyvitamin D3 treated Caco-2 cells (2007)
  • Author(s): Hou, X.L., Takahashi, K., Kinoshita, N., Qiu, F., Tanaka, K, Komatsu, K., Takahashi, K., Azuma, J
  • Journal Title: Int. J. Pharm 337 Pages: 169-177
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Molecular Identification of "Chuanxiong" by Nucleotide Sequence and Multiplex Single Base Extension Analysis on Chloroplast trnK Gene (2007)
  • Author(s): Zhu, S., Fushimi, H., Han, G., Tsuchida, T., Uno, T., Takano, A. Komatsu, K
  • Journal Title: Biol. Pharm. Bull 30 Pages: 527-531
  • NAID: 110006239197
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Molecular Analysis of the Genus Mitragyna Existing in Thailand Based on rDNA ITS Sequences and Its Application to Identify A Narcotic Species: Mitragyna speciosa (2007)
  • Author(s): Sukrong, S., Zhu, S., Ruangrungsi, N., Phadungcharoen, T., Palanuvej, C. Komatsu, K
  • Journal Title: Biol. Pharm. Bull 30 Pages: 1284-1288
  • NAID: 110006342747
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Comparative study on volatile components of Nardostachys Rhizome (2007)
  • Author(s): Tanaka, K., Komatsu, K
  • Journal Title: J. Nat 62 Pages: 112-116
  • NAID: 10024189505
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Molecular Identification of "Chuanxiong" by Nucleotide Sequence and Multiplex Single Base Extension Analysis on Chloroplast trnK Gene (2007)
  • Author(s): Zhu S, Fushimi H, Han G, Tsuchida T, Uno T, Takano A, Komatsu K
  • Journal Title: Biol. Pharm. Bull 30 Pages: 527-531
  • NAID: 110006239197
  • Peer Reviewed
• [Journal Article] A Novel Compound from Hedysarum polybotrys (2007)
  • Author(s): Zou K, Komatsu K, Zhu S
  • Journal Title: J. Asian Nat. Prod. Res 9 Pages: 481-485
  • Peer Reviewed
• [Journal Article] Analysis of Ginsenosides in Ginseng Drugs Using Liquid Chromatography-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (2007)
  • Author(s): Tanaka K, Kubota M, Zhu S, Sankawa U, Komatsu K
  • Journal Title: Nat. Prod. Comm 2 Pages: 625-632
  • Peer Reviewed
• [Journal Article] Molecular Analysis of thc Genus Mitragyna Existing in Thailand Bascd on DNA ITS Sequences and Its Application to Identify A Narcotic Species: Mitragyna speclosa (2007)
  • Author(s): Sukrong S, Zhu S, Ruangrungsi N, Phadungcharoen T, Palanuvej C, Komatsu K
  • Journal Title: Biol. Pharm. Bull 30 Pages: 1284-1288
  • Peer Reviewed
• [Journal Article] Anti-estrogenic Activity of Mansorhls and Mansonones from the Heartwood of Mansonia gagei Drumm (2007)
  • Author(s): El-Halawany AM, Chung MH, MaCM, Komatsu K, Nishihara T, Hattori M
  • Journal Title: Chem. Pharm. Bull 55 Pages: 1332-1337
  • Peer Reviewed
• [Journal Article] Comparative study on volatile components of Nardostachys Rhizome (2007)
  • Author(s): Tanaka K, Komatsu K
  • Journal Title: J. Nat. Med 62 Pages: 112-116
  • NAID: 10024189505
  • Peer Reviewed
• [Journal Article] Metabolite 1 of protopanaxadiol-type saponins, an axonal regenerative factor, stimulates teneurin-2 linked by PI3-kinase cascade (2006)
  • Author(s): Tohda C., Hashimoto L., Kuboyama T., Komatsu K.
  • Journal Title: Neuropsychopharmacology 30 Pages: 1158-1164
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Comparison of anti-inflammatory activities of six Curcuma rhizomes: a possiblecurcuminoid-independent pathway mediated by Curcuma phaeocaulis extract (2006)
  • Author(s): Tohda C., Nakayama N., Hatanaka F., Komatsu K.
  • Journal Title: Evid. Based Complement. Alternat. Med. 3 Pages: 255-260
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Withanoside IV and its active metabolite, sominone, attenuate Aβ(25-35)-induced neurodegeneration (2006)
  • Author(s): Kuboyama T., Tokda C., Komatsu K.
  • Journal Title: Eur. J. Neurosci. 23 Pages: 1417-1426
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Promotion of axonal maturation and prevention of memory loss in mice by extracts of Astragalus mongholicus (2006)
  • Author(s): Tohda C., Tamura T., Matsuyama S., Komatsu K.
  • Journal Title: Br. J. Pharmacol. 149 Pages: 532-541
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Development of a High Performance Liquid Chromatographic Method for Systematic Quantitative Analysis of Chemical Constituentsin Rhubarb (2006)
  • Author(s): Komatsu K., Nagayama Y., Tanaka K., Ling Y., Basnet P., Meselhy M. R.
  • Journal Title: Chem. Pharm. Bull. 54 Pages: 941-947
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Comparative study on chemical constituents of Rhubarb from different origin (2006)
  • Author(s): Komatsu K., Nagayama Y., Tanaka K., Ling Y., Cai S. Q., Meselhy M. R.
  • Journal Title: Chem. Pharm. Bull. 54 Pages: 1491-1499
  • NAID: 110004836468
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase (2006)
  • Author(s): Jo M., Nakamura N., Kakiuchi N., Komatsu K., Shimotohno K., Shimotohno K., Qui M. H., Hattori M.
  • Journal Title: J. Nat. Med. 60 Pages: 217-224
  • NAID: 10017614610
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Metabolite 1 of protopanaxadiol-type saponins, an axonal regenerative factor, stimulates teneurin-2 linked by PI3-kinase cascade (2006)
  • Author(s): Tohda, C., Hashimoto, I., Kuboyama, T., Komatsu, K
  • Journal Title: Neuropsychopharmacology 30 Pages: 1158-1164
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Comparison of anti-inflammatory activities of six Curcuma rhizomes: a possible curcuminoid-independent pathway mediated by Curcuma phaeocaulis extract (2006)
  • Author(s): Tohda, C., Nakayama, N., Hatanaka, F., Komatsu, K
  • Journal Title: Evid. Based Complement. Alternat. Med 3 Pages: 255-260
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Withanoside IV and its active metabolite, sominone, attenuate A13(25-35)-induced neurodegeneration (2006)
  • Author(s): Kuboyama, T., Tohda, C., Komatsu, K
  • Journal Title: Eur. J. Neurosci 23 Pages: 1417-1426
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Promotion of axonal maturation and prevention of memory loss in mice by extracts of Astragalus mongholicus (2006)
  • Author(s): Tohda, C., Tamura, T., Matsuyama, S., Komatsu, K
  • Journal Title: Br. J. Pharmacol 149 Pages: 532-541
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Development of a High Performance Liquid Chromatographic Method for Systematic Quantitative Analysis of Chemical Constituents in Rhubarb (2006)
  • Author(s): Komatsu, K., Nagayama, Y., Tanaka, K., Ling, Y., Basnet, P., Meselhy, M.R
  • Journal Title: Chem. Pharm. Bull 54 Pages: 941-947
  • NAID: 110004836412
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Comparative study on chemical constituents of Rhubarb from different origin (2006)
  • Author(s): Komatsu, K., Nagayama, Y., Tanaka, K., Ling, Y., Cai, S.Q., Meselhy, M.R
  • Journal Title: Chem. Pharm. Bull 54 Pages: 1491-1499
  • NAID: 110004836468
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase (2006)
  • Author(s): Jo, M., Nakamura, N., Kakiuchi, N., Komatsu, K., Shimotohno, K., Shimotohno, K., Qui, M.H., Hattori, M
  • Journal Title: J. Nat Med 60 Pages: 217-224
  • NAID: 10017614610
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Survey on enigma of ethno-medicines (2006)
  • Author(s): Komatsu, K, Tohda, C
  • Journal Title: Development of Medicinal Plant(CMC Publishing Co., Ltd.) Pages: 278-298
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effect of coffee on dementia (2006)
  • Author(s): Tohda, C., Komatsu, K, Namura, N., Hatori, M
  • Journal Title: Sciences and functions of coffee(I K Publishing Co., Ltd.) Pages: 50-58
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Comparison of anti-inflammatory activities of six Curcuma rhizomes : a possible curcuminoid-independent pathway mediated by Curcuma phaeocaulis extract (2006)
  • Author(s): Tohda C., Nakayama N., Hatanaka F., Komatsu K.
  • Journal Title: Evidence-based Complementary and Alternative Medicine 3(2) Pages: 255-260
• [Journal Article] Withanoside IV and its active metabolite, sominone, attenuate AB(25-35)-induced neurodegeneration. (2006)
  • Author(s): Kuboyama T., Tohda C., Komatsu K.
  • Journal Title: Eur. J. Neurosci 23 Pages: 1417-1426
• [Journal Article] Axonal maturation and anti-dementia effect by Astragalus mongholicus (2006)
  • Author(s): Tohda C., Tamura T., Matsuyama S., Komatsu K.
  • Journal Title: Br. J. Pharmacol. 149 Pages: 532-541
• [Journal Article] Development of a High Performance Liquid Chromatographic Method for Systematic Quantitative Analysis of Chemical Constituents in Rhubarb (2006)
  • Author(s): Komatsu K., Nagayama Y., Tanaka K., Ling Y., Basnet P., Meselhy M.R.
  • Journal Title: Chem. Pharm. Bull. 54 Pages: 941-947
  • NAID: 110004836412
• [Journal Article] Comparative study on chemical constituents of Rhubarb from different origin (2006)
  • Author(s): Komatsu K., Nagayama Y., Tanaka K., Ling Y., Cai S.Q., Meselhy M.R
  • Journal Title: Chem. Pharm. Bull. 54 Pages: 1491-1499
  • NAID: 110004836468
• [Journal Article] Inhibitory effect of Yunnan medical plants on hepatitis C viral polymerase (2006)
  • Author(s): Jo M., Nakamura N., Kakiuchi N., Komatsu K., Shimotohno K., Shimotohno K., Qui M.H., Hattori M.
  • Journal Title: J. Nat. Med. 60 Pages: 217-224
• [Journal Article] Comparison of anti-inflammatory activities of six Curcuma rhizomes : a possible curcuminoid-independent pathway mediated by Curcuma phaeocaulis extract (2006)
  • Author(s): Tohda C., Nakayama N., Hatanaka F., Komatsu K.
  • Journal Title: Evidence-based Complementary and Alternative Medicine (in press)
• [Journal Article] A Novel Compound from Hedysarum polybotrys (2006)
  • Author(s): Zou K., Komatsu K., Zhu S.
  • Journal Title: Journal of Asian Natural Products Research (in press)
• [Journal Article] Metabolite 1 of protopanaxadiol-type saponins, an axonal regenerative factor, stimulates teneurin-2 linked by P13-kinase cascade (2006)
  • Author(s): Tohda C., Hashimoto I., Kuboyama T., Komatsu K.
  • Journal Title: Neuropsychopharmacology (in press)
• [Journal Article] Withanoside IV and its active metabolite, sominone, attenuate Aβ(25-35)-induced neurodegeneration. (2006)
  • Author(s): Kuboyama T., Tohda C., Komatsu K.
  • Journal Title: Eur.J.Neurosci (in press)
• [Journal Article] Development of a High Performance Liquid Chromatographic Method for Systematic Quantitative Analysis of Chemical Constituents in Rhubarb (2006)
  • Author(s): Komatsu K., Nagayama Y., Tanaka K., Ling Y., Basnet P., Meselhy M.R.
  • Journal Title: Chem.Pharm.Bull. (in press)
  • NAID: 110004836412
• [Journal Article] Effect of Curcuma Herbs on Vasomotion and Hemorheology in Spontaneously Hypertensive Rat (2005)
  • Author(s): Goto S., Sasaki Y., Fushimi H., Shibahara N., Shimada Y., Komatsu K.
  • Journal Title: Am. J. Chin. Med. 33 Pages: 449-457
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Neuritic regeneration and synaptic reconstruction induced by withanolide A (2005)
  • Author(s): Kuboyama T., Tohda C., Komatsu K.
  • Journal Title: Br. J. Pharmacol. 144 Pages: 961-971
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Anti-herpes simplex virus activities of traditional Chinese medicines, used in Yunnan and Tibetan provinces of China (2005)
  • Author(s): Jo M., Nakamura N., Kurokawa M., Komatsu K., Shiraki K., Hattori M.
  • Journal Title: J. Trad. Med. 22 Pages: 321-328
  • NAID: 110002976886
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 原子吸光光度法を用いた漢薬「石膏」の溶出量に関する研究 (2005)
  • Author(s): 伏見裕利, 織田しのぶ, 伊藤隆, 柴原直利, 喜多敏明, 小松かつ子, 寺沢捷年
  • Journal Title: J. Trad. Med. 22 Pages: 24-28
  • NAID: 110001867617
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Effect of Curcuma Herbs on Vasomotion and Hemorheology in Spontaneously Hypertensive Rat (2005)
  • Author(s): Goto, S., Sasaki, Y., Fushimi, H., Shibahara, N., Shimada, Y., Komatsu, K
  • Journal Title: Am. J. Chin. Med 33 Pages: 449-457
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Neuritic regeneration and synaptic reconstruction induced by withanolide A (2005)
  • Author(s): Kuboyama, T., Tohda, C., Komatsu, K
  • Journal Title: Br. J Pharmacol 144 Pages: 961-971
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Anti-herpes simplex virus activities of traditional Chinese medicines, used in Yunnan and Tibetan provinces of China (2005)
  • Author(s): Jo, M., Nakamura, N., Kurokawa, M., Komatsu, K., Shiraki, K., Hattori, M
  • Journal Title: J. Thad. Med 22 Pages: 321-328
  • NAID: 110002976886
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Quantitative analysis of Chinese crude drug, "Shigao(Gypsum)" extract by atomic absorption spectrometry (2005)
  • Author(s): Fushimi, H., Oda, S., Itoh, T., Shibahara, N., Kita, T., Komatsu, K., Terasawa, K
  • Journal Title: J. Trad. Med 22 Pages: 24-28
  • NAID: 110001867617
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Enigma of ethno-medicines: survey on ginseng drugs in the world-diversity analysis and possibility as antidementia drug (2005)
  • Author(s): Komatsu, K., Tohda, C
  • Journal Title: New Development of Medicinal Plant(CMC Publishing Co., Ltd.) Pages: 302-324
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effect of Curcuma Herbs on Vasomotion and Hemorheology in Spontaneously Hypertensive Rat (2005)
  • Author(s): Goto S., Sasaki Y., Fushimi H..Shibahara N., Shimada.Y., Komatsu K.
  • Journal Title: Am.J.Chin.Med. 33(3) Pages: 449-457
• [Journal Article] Neuritic regeneration and synaptic reconstruction induced by withanolide A (2005)
  • Author(s): Kuboyama T., Tohda C., Komatsu K.
  • Journal Title: Br.J.Pharmacol. 144 Pages: 961-971
• [Journal Article] 原子吸光光度法を用いた漢薬「石膏」の溶出量に関する研究 (2005)
  • Author(s): 伏見裕利, 織田しのぶ, 伊藤隆, 柴原直利, 喜多敏明, 小松かつ子, 寺沢捷年
  • Journal Title: J.Trad.Med. 22(1) Pages: 24-28
  • NAID: 110001867617
• [Journal Article] Anti-herpes simplex virus activities of traditional Chinese medicines, used in Yunnan and Tibetan provinces of China (2005)
  • Author(s): Jo M., Nakamura N., Kurokawa M., Komatsu K., Shiraki K., Hattori M.
  • Journal Title: J.Trad.Med. 22(6) Pages: 321-328
  • NAID: 110002976886
• [Presentation] 大黄の基源と品質に関する研究(2) (2008)
  • Author(s): 三石真生, 魏勝利, 田中謙, Bai Y. J., Zhu S., 小松かつ子
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-26
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 近赤外分光分析による簡便なウコン中クルクミノイドの定量 (2008)
  • Author(s): 田中謙, 久場良亮, 佐々木哲朗, 樋渡史子, 小松かつ子
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-26
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Development of a DNA microarray for authentication of ginseng drugs based on 18S rRNA gene sequence (2008)
  • Author(s): Zhu S., Fushimi H., Komatsu K.
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-26
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Study on the botanical sources and quality of Rhubarb(2) (2008)
  • Author(s): Mitsuishi, M., Wei, S.L., Tanaka, K, Bai, Y.J., Zhu, S., Komatsu, K
  • Organizer: The 128th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Tokyo
  • Year and Date: 2008-03-26
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Quantitation of curcuminoids in Curcuma Rhizome by near-infrared spectroscopic analysis (2008)
  • Author(s): Tanaka, K, Kuba, Y., Sasaki, T., Hiwatashi, F., Komatsu, K
  • Organizer: The 128th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Tokyo
  • Year and Date: 2008-03-26
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development of a DNA microarray for authentication of ginseng drugs based on 18S rRNA gene sequence (2008)
  • Author(s): Zhu, S., Fushimi, H., Komatsu, K
  • Organizer: The 128th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Tokyo
  • Year and Date: 2008-03-26
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] ウコンの成分含量測定法について (2007)
  • Author(s): 小松かつ子, 田中謙, 久場良亮, 嶋田康男, 山本豊
  • Organizer: 第36回生薬分析シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2007-11-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Quantitation method of curcuminoids in Curcuma Rhizome (2007)
  • Author(s): Komatsu, K., Tanaka, K, Kuba, Y., Shimada, Y., Yamamoto, Y
  • Organizer: The 36th Symposium on Natural Drug Analysis
  • Place of Presentation: Osaka
  • Year and Date: 2007-11-22
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 人参類生薬の遺伝的・成分化学的多様性と基原解析用DNAマイクロアレイの開発 (2007)
  • Author(s): 小松かつ子
  • Organizer: 富山大学21世紀COEプログラムシンポジウム
  • Place of Presentation: 富山
  • Year and Date: 2007-11-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Rheum属植物及び大黄の遺伝的・成分化学的多様性の解析 (2007)
  • Author(s): 魏勝利, 朱〓, 長山頼信, 田中謙, 屠鵬飛, 蔡少青, 小松かつ子
  • Organizer: 富山大学21世紀COEプログラムシンポジウム
  • Place of Presentation: 富山
  • Year and Date: 2007-11-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Genetic and chemical diversity of Ginseng drugs and the development of DNA microarray for authentication (2007)
  • Author(s): Komatsu, K
  • Organizer: Symposium of the 21st century COE Program in University of Toyama
  • Place of Presentation: Toyama
  • Year and Date: 2007-11-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Genetic and chemical diversity of Rheum plants and rhubarb (2007)
  • Author(s): Wei, S.L., Zhu, S., Nagayama, Y., Tanaka, K, Tu, P.F., Cai, S.Q., Komatsu, K
  • Organizer: Symposium of the 21st century COE Program in University of Toyama
  • Place of Presentation: Toyama
  • Year and Date: 2007-11-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 鬱金類生薬の成分多様性と抗炎症作用との関連 (2007)
  • Author(s): 小松かつ子, 田中謙, 久場良亮, 伊奈隆年
  • Organizer: 第2回食品薬学シンポジウム
  • Place of Presentation: 静岡
  • Year and Date: 2007-10-18
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Diversity of chemical constituents of Curcuma Rhizome and their Anti-inflammatory activities (2007)
  • Author(s): Komatsu, K, Tanaka, K, Kuba, Y., Ina, A
  • Organizer: The 2nd Symposium on Pharmaceutical Food Science
  • Place of Presentation: Shizuoka
  • Year and Date: 2007-10-18
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Rheum属植物の分子系統学的研究(4)-遺伝子型の地域特異性について- (2007)
  • Author(s): 魏勝利, 朱妹, 屠鵬飛, 蔡少青, 小松かつ子
  • Organizer: 日本生薬学会第54回年会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-09-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Molecular analysis of Rheum plants(4) - Regional specificity of genotypes (2007)
  • Author(s): Wei, S.L., Zhu, S., Tu, P.F., Cai, S.Q., Komatsu, K
  • Organizer: The 54th Annual Meeting of the Japanese Society of Pharmacognosy
  • Place of Presentation: Nagoya
  • Year and Date: 2007-09-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Ephedra属植物の遺伝子解析とモンゴル産同属植物の有用性に関する研究(3) (2007)
  • Author(s): 木谷友紀, Zhu S., 田中謙, Batkhuu J., Sanchir C., 小松かつ子
  • Organizer: 日本生薬学会第54回年会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-09-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 多変量解析による生薬評価指標の開発(1)-Curcuma phaeocaulisの抗炎症活性をモデルとして- (2007)
  • Author(s): 田中謙, 伊奈隆年, 久場良亮, 小松かつ子
  • Organizer: 日本生薬学会第54回年会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-09-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Molecular analysis of Ephedra plants and usefulness of Mongolian congener(3) (2007)
  • Author(s): Kitani, Y., Zhu, S., Tanaka, K, Batkhuu, J., Sanchir, C., Komatsu, K
  • Organizer: The 54th Annual Meeting of the Japanese Society of Pharmacognosy
  • Place of Presentation: Nagoya
  • Year and Date: 2007-09-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development of indices for quality evaluation of crude drugs using multivariate analysis - Anti-inflammatory activity of Curcuma phaeocanlis (2007)
  • Author(s): Tanaka, K, Ina, A. Kuba, Y., Komatsu, K
  • Organizer: The 54th Annual Meeting of the Japanese Society of Pharmacognosy
  • Place of Presentation: Nagoya
  • Year and Date: 2007-09-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] ウコン類生薬の基原と品質 (2007)
  • Author(s): 小松かつ子, 佐々木陽平, 田中謙, 東田千尋
  • Organizer: 第9回応用薬理シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2007-09-11
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Botanical source and quality of Crucuma drugs (2007)
  • Author(s): Komatsu, K., Sasaki, Y., Tanaka, K., Tohda, C
  • Organizer: The 9th Applied Pharmacology Symposium
  • Place of Presentation: Tokyo
  • Year and Date: 2007-09-11
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 生薬の品質の多様性-莪朮と大黄 (2007)
  • Author(s): 小松かつ子
  • Organizer: 第24回和漢医薬学会大会 シンポジウム
  • Place of Presentation: 富山
  • Year and Date: 2007-09-08
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 黄耆成分Astragaloside類の体内吸収成分に関する研究 (2007)
  • Author(s): 福田祥子, 田中謙, 小松かつ子
  • Organizer: 第24回和漢医薬学会大会
  • Place of Presentation: 富山
  • Year and Date: 2007-09-08
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] trnK遺伝子の塩基配列に基づく刺五加の同定(2) (2007)
  • Author(s): 大家真由子, Zhu S., 田中謙, 丸山卓郎, 合田幸広, 川崎武志, 藤田正雄, 小松かつ子
  • Organizer: 第24回和漢医薬学会大会
  • Place of Presentation: 富山
  • Year and Date: 2007-09-08
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] LC-MSによる黄耆成分の比較分析 (2007)
  • Author(s): 田中謙, 福田祥子, 田村隆幸, 小松かつ子
  • Organizer: 第24回和漢医薬学会大会
  • Place of Presentation: 富山
  • Year and Date: 2007-09-08
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ウコン属生薬と由来成分クルクミンのP-gpに対する作用の相違 (2007)
  • Author(s): 候暁瓏, 高橋京子, 田中謙, 小松かつ子, 高橋幸一, 東純一
  • Organizer: 第24回和漢医薬学会大会
  • Place of Presentation: 富山
  • Year and Date: 2007-09-08
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Quality diversity of crude drugs - Curcuma and Rheum (2007)
  • Author(s): Komatsu, K
  • Organizer: The 24th Annual Meeting of Medical and Pharmaceutical Society for WAKAN-YAKU
  • Place of Presentation: Toyama
  • Year and Date: 2007-09-08
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Study on absorption and metabolism of astragalosides, the major constituents of Astragali Radix (2007)
  • Author(s): Fukuda, S., Tanaka, K., Komatsu, K
  • Organizer: The 24th Annual Meeting of Medical and Pharmaceutical Society for WAKAN-YAKU
  • Place of Presentation: Toyama
  • Year and Date: 2007-09-08
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Authentication of Eleutherococcus Senticosus Rhizome based on trnK gene sequence(2) (2007)
  • Author(s): Oya, M., Zhu, S., Tanaka, K., Komatsu, K., Maruyama, T., Goda, Y., Kawasaki, T., Fujita, M., Yamamoto, Y
  • Organizer: The 24th Annual Meeting of Medical and Pharmaceutical Society for WAKAN-YAKU
  • Place of Presentation: Toyama
  • Year and Date: 2007-09-08
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Comparative analysis on constituents of Astragali Radix by LC-MS (2007)
  • Author(s): Tanaka, K., Fukuda, S., Komatsu, K
  • Organizer: The 24th Annual Meeting of Medical and Pharmaceutical Society for WAKAN-YAKU
  • Place of Presentation: Toyama
  • Year and Date: 2007-09-08
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Curcuma drugs and Curcumin regulate the expression and function of P-gp in Caco-2 cell in completely opposite way (2007)
  • Author(s): Hou, X.L., Takahashi, K, Tanaka, K., Komatsu, K, Takahashi, K, Azuma, J
  • Organizer: The 24th Annual Meeting of Medical and Pharmaceutical Society for WAKAN-YAKU
  • Place of Presentation: Toyama
  • Year and Date: 2007-09-08
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 生薬の品質の多様性-莪朮と大黄 (2007)
  • Author(s): 小松 かつ子
  • Organizer: 第24回和漢医薬学会大会
  • Place of Presentation: 富山
  • Year and Date: 2007-09-08
• [Presentation] trnK遺伝子の塩基配列に基づく刺五加の同定(2) (2007)
  • Author(s): 大家 真由子, Zhu S, 田中 謙, 丸山 卓郎, 合田 幸広, 川崎 武志, 藤田 正雄, 小松 かつ子
  • Organizer: 第24回和漢医楽学会大会
  • Place of Presentation: 富山
  • Year and Date: 2007-09-08
• [Presentation] 薬用植物の多様性の解析-標準化と有効利用に向けて (2007)
  • Author(s): 小松かつ子
  • Organizer: 薬用植物フォーラム2007
  • Place of Presentation: つくば
  • Year and Date: 2007-07-12
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Analysis on diversity of medicinal plants - for standardization and effective utilization (2007)
  • Author(s): Komatsu, K
  • Organizer: Forum 2007 on Medicinal Plants, Research Center for Medicinal Plant Resources, National Institute of Biomedical Innovation
  • Place of Presentation: Tsukuba
  • Year and Date: 2007-07-12
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Genetic and chemical diversity of Rhubarb (2007)
  • Author(s): Komatsu K., Nagayama Y., Wei S. L., Tanaka K., Zhu S., Tu P. F., Cai S. Q.
  • Organizer: Innovative Team Program in Peking University & 21st Century COE Program in University of Toyama-Joint Symposium
  • Place of Presentation: Beijing, China
  • Year and Date: 2007-06-25
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Genetic and chemical diversity of Rhubarb (2007)
  • Author(s): Komatsu, K., Nagayama, Y., Wei, S.L., Tanaka, K, Zhu, S., Tu, P.F., Cai, S.Q
  • Organizer: Joint Symposium of the Innovative Team Program in Peking University and the 21st Century COE Program in University of Toyama
  • Place of Presentation: Beijing, China
  • Year and Date: 2007-06-25
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] ガジュツの精油成分による品質評価 (2007)
  • Author(s): 久場良亮, 田中謙, Zhu S., 魏勝利, 合田幸広, 渡邉裕司, 小松かつ子
  • Organizer: 日本薬学会第127年会
  • Place of Presentation: 富山
  • Year and Date: 2007-03-30
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] LC/MSによるモンゴル産Astragalus属植物の品質評価 (2007)
  • Author(s): 福田祥子, 田村隆幸, 田中謙, 荒川清美, 小松かつ子
  • Organizer: 日本薬学会第127年会
  • Place of Presentation: 富山
  • Year and Date: 2007-03-30
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Quality evaluation of "Gajutsu" on volatile constituents (2007)
  • Author(s): Kuba, Y., Tanaka, K, Zhu, S., Wei, S.L., Goda, Y., Watanabe, H., Komatsu, K
  • Organizer: The 127th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Toyama
  • Year and Date: 2007-03-30
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Quality evaluation of Mongolian Astragali Radix by LC-MS (2007)
  • Author(s): Fukuda, S., Tamura, T., Tanaka, K, Arakawa, K, Komatsu, K
  • Organizer: The 127th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Toyama
  • Year and Date: 2007-03-30
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] CYP3A誘導Caco-2細胞を用いた薬物相互作用の解析 (2007)
  • Author(s): 候暁瓏, 高橋京子, 邱峰, 田中謙, 小松かつ子, 高橋幸一, 東純一
  • Organizer: 日本薬学会第127年会
  • Place of Presentation: 富山
  • Year and Date: 2007-03-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Study on drug interaction using CYP3A induced Caco-2 cell (2007)
  • Author(s): Hou, X.L., Takahashi, K, Qiu, F., Tanaka, K, Komatsu, K, Takahashi, K., Azuma, J
  • Organizer: The 127th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Toyama
  • Year and Date: 2007-03-28
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 食か薬か-ウコン類生薬 (2006)
  • Author(s): 小松かつ子
  • Organizer: 静岡県立大学21世紀COEプログラム・富山大学21世紀COEプログラムジョイントシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2006-12-13
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Food or drug?-Herbal drugs of genus Curcuma (2006)
  • Author(s): Komatsu, K
  • Organizer: Joint Symposium of the 21st century COE Program in University of Shizuoka and the 21st century COE Program in University of Toyama
  • Place of Presentation: Tokyo
  • Year and Date: 2006-12-13
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Genetic and chemical diversity of Ginseng drugs and the development of DNA microarray for authentication (2006)
  • Author(s): Komatsu K., Zhu S.
  • Organizer: JSPS-NRCT Core University Program-The Seventh Joint Seminar
  • Place of Presentation: Toyama
  • Year and Date: 2006-12-03
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Genetic and chemical diversity of Ginseng drugs and the development of DNA microarray for authentication (2006)
  • Author(s): Komatsu, K., Zhu, S
  • Organizer: JSPS-NRCT Core University Program - The Seventh Joint Seminar
  • Place of Presentation: Toyama
  • Year and Date: 2006-12-03
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] olecular analysis and quality evaluation of Ephedra plants in Mongolia (2006)
  • Author(s): Kitani, Y., Tanaka, K., Zhu, S., Komatsu, K
  • Organizer: JSPS-NRCT Core University Program - The Seventh Joint Seminar
  • Place of Presentation: Toyama
  • Year and Date: 2006-12-03
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Molecular analysis and quality evaluation of Ephedra plants in Mongolia (2006)
  • Author(s): Kitani Y., Tanaka K, Zhu S., Komatsu K.
  • Organizer: JSPS-NRCT Core University Program-The Seventh Joint Seminar
  • Place of Presentation: Toyama
  • Year and Date: 2006-12-02
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 人参類生薬の遺伝的・成分化学的多様性と基原解析用DNAマイクロアレイの開発 (2006)
  • Author(s): 小松かつ子
  • Organizer: 北里大学21世紀COEプログラム・富山大学21世紀COEプログラムジョイントシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2006-11-09
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Genetic and chemical diversity of Ginseng drugs and the development of DNA microarray for authentication (2006)
  • Author(s): Komatsu, K
  • Organizer: Joint Symposium of the 21st century COE Program in Kitasato University and the 21st century COE Program in University of Toyama
  • Place of Presentation: Tokyo
  • Year and Date: 2006-11-09
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Genetic and chemical diversity of Rhubarb (2006)
  • Author(s): Komatsu K.
  • Organizer: The 2nd International Symposium on Natural Drugs in Seoul
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2006-10-31
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] trnK遺伝子の塩基配列に基づく刺五加の同定 (2006)
  • Author(s): 大家真由子, Zhu Shu, 田中謙, 小松かつ子, 丸山卓郎, 合田幸広, 川崎武志, 藤田正雄, 山本豊
  • Organizer: 日本生薬学会第53回年会
  • Place of Presentation: 埼玉
  • Year and Date: 2006-09-30
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Authentication of Eleutherococcus Senticosus Rhizome based on trnK gene sequence(1) (2006)
  • Author(s): Oya, M., Zhu, S., Tanaka, K., Komatsu, K., Maruyama, T., Gohda Y., Kawasaki, T., Fujita M., Yamamoto, Y
  • Organizer: The 55th Annual Meeting of the Japanese Society of Pharmacognosy
  • Place of Presentation: Saitama
  • Year and Date: 2006-09-30
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Genetic and chemical diversity of Ginseng drugs (2006)
  • Author(s): Zhu S., Komatsu K.
  • Organizer: The 9th International Symposium on Ginseng
  • Place of Presentation: Geumsan, Korea
  • Year and Date: 2006-09-27
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Genetic and chemical diversity of Ginseng drugs (2006)
  • Author(s): Zhu, S., Komatsu, K
  • Organizer: IThe 9th International Symposium on Ginseng
  • Place of Presentation: Geumsan, Korea
  • Year and Date: 2006-09-27
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 民族薬物データベースの構築とその応用-ウコン類生薬について (2006)
  • Author(s): 小松かつ子
  • Organizer: 第28回日本アーユルヴェーダ学会富山研究総会
  • Place of Presentation: 富山
  • Year and Date: 2006-09-23
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Nardostachys属植物由来生薬の精油成分の分析 (2006)
  • Author(s): 田中謙, 小松かつ子
  • Organizer: 第28回日本アーユルヴェーダ学会富山研究総会
  • Place of Presentation: 富山
  • Year and Date: 2006-09-23
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Construction and utility of the database on traditional herbal drugs - Curcuma drugs as an example (2006)
  • Author(s): Komatsu, K
  • Organizer: The 28th Annual Meeting of Ayurveda Society in Japan
  • Place of Presentation: Toyama
  • Year and Date: 2006-09-23
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Comparative study of volatile components of Nardostachys rhizomes (2006)
  • Author(s): Tanaka, K., Komatsu, K
  • Organizer: The 28th Annual Meeting of Ayurveda Society in Japan
  • Place of Presentation: Toyama
  • Year and Date: 2006-09-23
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 認知症に有効な漢方処方の開発 (2006)
  • Author(s): 松山修二, 東田千尋, 小松かつ子
  • Organizer: 第23回和漢医薬学会大会
  • Place of Presentation: 岐阜
  • Year and Date: 2006-08-26
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Development of effective formulation for dementia treatment (2006)
  • Author(s): Matsuyama, S., Tohda, C., Komatsu, K
  • Organizer: The 23rd Annual Meeting of Medical and Pharmaceutical Society for WAKAN-YAKU
  • Place of Presentation: Gifu
  • Year and Date: 2006-08-26
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] ウコン類生薬の品質の多様性:遺伝子型,成分組成,駆〓血作用の比較 (2006)
  • Author(s): 小松かつ子
  • Organizer: 医療薬学フォーラム2006/第14回クリニカルファーマシーシンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2006-07-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Quality diversity of Curcuma drugs: comparison of genotypes, chemical constituents and pharmacological effects (2006)
  • Author(s): Komatsu, K
  • Organizer: The 14th Clinical Pharmacy Symposium
  • Place of Presentation: Osaka
  • Year and Date: 2006-07-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Genetic and chemical diversity of Rhubarb (2006)
  • Author(s): Komatsu K.
  • Organizer: China-Japan Joint Symposium on Natural Medicine
  • Place of Presentation: Nanjing, China
  • Year and Date: 2006-04-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Systematic study on Ginseng drugs-from phylogenetic analysis to quality Evaluation (2006)
  • Author(s): Zhu S., Komatsu K.
  • Organizer: China-Japan Joint Symposium on Natural Medicine
  • Place of Presentation: Nanjing, China
  • Year and Date: 2006-04-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Genetic and chemical diversity of Rhubarb (2006)
  • Author(s): Komatsu, K
  • Organizer: China-Japan Joint Symposium on Natural Medicine - Recent Trends of Natural Medicine Researches
  • Place of Presentation: Nanjing, China
  • Year and Date: 2006-04-28
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Systematic study on Ginseng drugs- from phylogenetic analysis to quality evaluation (2006)
  • Author(s): Zhu, S., Komatsu, K
  • Organizer: China-Japan Joint Symposium on Natural Medicine - Recent Trends of Natural Medicine Researches
  • Place of Presentation: Nanjing, China
  • Year and Date: 2006-04-28
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 日本導入Rheum属植物の基源と品質に関する研究 (2006)
  • Author(s): 表貴之, 堂井美里, 楊冬野, 伏見裕利, 田中謙, 小松かつ子
  • Organizer: 日本薬学会第126年会
  • Place of Presentation: 仙台
  • Year and Date: 2006-03-30
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Ephedra属植物の遺伝子解析とモンゴル産同属植物の有用性に関する研究(2) (2006)
  • Author(s): 木谷友紀, 表貴之, Zhu Shu, 田中謙, 小松かつ子, 御影雅幸
  • Organizer: 日本薬学会第126年会
  • Place of Presentation: 仙台
  • Year and Date: 2006-03-30
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] LC-FT-MSによる人参類トリテルペンサポニンの網羅的分析 (2006)
  • Author(s): 田中謙, Zhu Shu, 小松かつ子, 大木靖, 窪田雅之, 三川潮
  • Organizer: 日本薬学会第126年会
  • Place of Presentation: 仙台
  • Year and Date: 2006-03-30
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 刺五加メタノールエキスによるシナプス再形成作用と記憶障害改善作用 (2006)
  • Author(s): 東田千尋, 市村真帆子, 末次一博, 小松かつ子
  • Organizer: 日本薬学会第126年会
  • Place of Presentation: 仙台
  • Year and Date: 2006-03-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Restoration from neurodegenerative changes by withanoside IV and by its active metabolite, sominone (2005)
  • Author(s): 久保山友晴, 東田千尋, 小松かつ子
  • Organizer: 第48回日本神経化学会
  • Place of Presentation: 福岡
  • Year and Date: 2005-09-29
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Restoration from neurodegenerative changes by withanoside IV and by its active metabolite, sominone (2005)
  • Author(s): Kuboyama, T., Tohda, C., Komatsu, K
  • Organizer: The 48th Annual Meeting of the Japanese society for Neurochemistry
  • Place of Presentation: Fukuoka
  • Year and Date: 2005-09-29
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Genetic and chemical diversity of Chinese medicinal plants: Panax and Rheum (2005)
  • Author(s): Komatsu K.
  • Organizer: 日本植物学会第69回大会 シンポジウム
  • Place of Presentation: 富山
  • Year and Date: 2005-09-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Genetic and chemical diversity of Chinese medicinal plants: Panax and Rheum (2005)
  • Author(s): Komatsu, K
  • Organizer: Symposium"Metabolic diversity of indigenous plants in Africa", The 69th annual meeting of the botanical Society of Japan
  • Place of Presentation: Toyama
  • Year and Date: 2005-09-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Ephedra属植物の遺伝子解析とモンゴル産同属植物の有用性に関する研究(1) (2005)
  • Author(s): 表貴之, 木谷友紀, Shu Zhu, 小松かつ子, 御影雅幸
  • Organizer: 日本生薬学会第52回年会
  • Place of Presentation: 金沢
  • Year and Date: 2005-09-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 紫金皮(Tripterygium hypograucum)のC型肝炎ウイルスポリメラーゼ阻害活性成分の検討 (2005)
  • Author(s): 条美智子, 中村憲夫, 小松かつ子, 服部征雄, 垣内信子, 下遠野久美子, 下遠野邦忠, 邱明華
  • Organizer: 日本生薬学会第52回年会
  • Place of Presentation: 金沢
  • Year and Date: 2005-09-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Molecular analysis of Ephedra plants and usefulness of Mongolian congener(1) (2005)
  • Author(s): Omote, T., Kitani, Y., Zhu, S., Komatsu, K, Mikage, M
  • Organizer: The 52nd Annual Meeting of the Japanese Society of Pharmacognosy
  • Place of Presentation: Kanazawa
  • Year and Date: 2005-09-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Active compounds from Tripterygium hypograucum with inhibitory effect on hepatitis C viral polymerase (2005)
  • Author(s): Jo, M., Nakamura, N., Komatsu, K, Hattori, M., Kakiuchi, N., Shimotohno, K., Shimotohno, K., Qiu, M.H
  • Organizer: The 52ndAnnual Meeting of the Japanese Society of Pharmacognosy
  • Place of Presentation: Kanazawa
  • Year and Date: 2005-09-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 東西薬物併用による薬物間相互作用予見へのアプローチ:ヒト結腸癌由来Caco-2細胞におけるウコン属生薬の影響 (2005)
  • Author(s): 侯暁瓏, 高橋京子, 小松かつ子, 木下奈津美, 高橋幸一, 東純一
  • Organizer: 第22回和漢医薬学会大会
  • Place of Presentation: 東京
  • Year and Date: 2005-08-20
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Approach for predicting drug-interactions in combination therapy of Oriental and Western medicines - Effects of Curcuma drugs on Caco-2 cell (2005)
  • Author(s): Hou, X.L., Takahashi, K, Komatsu, K, Kinoshita, N., Takahashi, K., Azuma, J
  • Organizer: The 22nd Annual Meeting of the Medical and Pharmaceutical Society for WAKAN-YAKU
  • Place of Presentation: Tokyo
  • Year and Date: 2005-08-20
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 和漢薬の品質の多様性-大黄と人参類を例にして- (2005)
  • Author(s): 小松かつ子
  • Organizer: 第12回日本東洋医学会北陸支部特別講演会
  • Place of Presentation: 富山
  • Year and Date: 2005-07-10
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Quality diversity of traditional herbal drugs - focused on Ginseng and Rhubarb - (2005)
  • Author(s): Komatsu, K
  • Organizer: The 12th Special lecture in Hokuriku branch of The Japan Society for Oriental Medicine
  • Place of Presentation: Toyama
  • Year and Date: 2005-07-10
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Molecular analysis, identification and quality evaluation of Curcuma drugs from China and Japan (2005)
  • Author(s): Komatsu K., Sasaki Y., Fushimi H., Tohda C., Goto H., Shibahara N., Terasawa K.
  • Organizer: 2005' International Symposium in Beijing on Pharmacognosy
  • Place of Presentation: Beijing, China
  • Year and Date: 2005-05-13
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Study on origin and quality of Rheum plants cultivated in Japan (2005)
  • Author(s): Omote ,T., Dohi, M., Yang, D.Y., Fushimi, H., Tanaka, K, Komatsu, K
  • Organizer: The 126th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Sendai
  • Year and Date: 2005-03-30
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Molecular analysis of Ephedra plants and usefulness of Mongolian congener(2) (2005)
  • Author(s): Kitani, Y., Omote, T., Zhu, S., Tanaka, K., Komatsu, K., Mikage, M
  • Organizer: The 126th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Sendai
  • Year and Date: 2005-03-30
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Analysis of triterpenoidal saponin in Ginseng drugs using liquid chromatography-Fourier transform ion cyclotron resonance mass spectrometry (2005)
  • Author(s): Tanaka, K., Zhu, S., Komatsu, K, Ohki, Y., Kubota, M., Sankawa, U
  • Organizer: The 126th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Sendai
  • Year and Date: 2005-03-30
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synaptic reconstruction and amelioration of memory loss by methanol extract of Eleutherococcus Senticosus Rhizome (2005)
  • Author(s): Tohda, C., Ichimura, M., Suestugu, K., Komatsu, K
  • Organizer: The 126th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Sendai
  • Year and Date: 2005-03-28
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] 民族薬物の謎を追って, 佐竹元吉監修『薬用植物・生薬の開発』 (2006)
  • Author(s): 小松かつ子, 東田千尋
  • Publisher: シーエムシー
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 認知症に対するコーヒーの作用, 『コーヒーの科学と機能』 (2006)
  • Author(s): 東田千尋, 小松かつ子, 中村憲夫, 服部征雄
  • Publisher: アイ・ケイコーポレーション
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 民族薬物の謎を追って『薬用植物・生薬の開発』(佐竹元吉監修) (2006)
  • Author(s): 小松かつ子, 東田千尋
  • Publisher: シーエムシー出版
• [Book] 民族薬物の謎:世界の人参を追って-多様性の解析と認知症治療薬としての可能性-, 佐竹元吉監修『薬用植物・生薬開発の新展開』 (2005)
  • Author(s): 小松かつ子, 東田千尋
  • Publisher: シーエムシー
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 第21章 民族薬物の謎:世界の人参を追って-多様性の解析と認知症治療薬としての可能性-,佐竹元吉監修『薬用植物・生薬開発の新展開』 (2005)
  • Author(s): 小松かつ子, 東田千尋
  • Publisher: シーエムシー
• [Remarks] 「研究成果報告書概要(和文)」より
  • URL: http://www.inm.u-toyama.ac.jp/section/01_pharmacognosy.html
• [Remarks] 「研究成果報告書概要(和文)」より
  • URL: http://www.inm.u-toyama.ac.jp/pharmacognosy/index-j.html
• [Patent(Industrial Property Rights)] 類似植物体および生薬同定用DNAマイクロアレイ (2007)
  • Inventor(s): 小松かつ子, 朱シュウ
  • Industrial Property Rights Holder: 富山大学
  • Industrial Property Number: 2007-296158
  • Filing Date: 2007-11-14
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 類似植物体および生薬同定用DNAマイクロアレイ (2007)
  • Inventor(s): 小松 かつ子、朱 シュウ
  • Industrial Property Rights Holder: 富山大学
  • Industrial Property Number: 2007-296158
  • Filing Date: 2007-11-14
  • Overseas
• [Patent(Industrial Property Rights)] 漢方処方による神経回路網再構築剤および神経回路網再構築方法 (2005)
  • Inventor(s): 東田千尋, 小松かつ子
  • Industrial Property Rights Holder: 富山医科薬科大学
  • Filing Date: 2005-12-20
  • Description: 「研究成果報告書概要(和文)」より
  • Overseas