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Study on dose-dependency of the central nervous system toxicity of 1-bromopropane in humans

Research Project

Project/Area Number 17406017
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Hygiene
Research InstitutionNagoya University

Principal Investigator

ICHIHARA Gaku  Nagoya University, 大学院・医学系研究科, 准教授 (90252238)

Co-Investigator(Kenkyū-buntansha) SAHOKO Ichihara  三重大学, 生命科学研究支援センター, 助教 (20378326)
玉腰 暁子  愛知医科大学, 医学部, 准教授 (90236737)
八谷 寛  名古屋大学, 大学院・医学系研究科, 准教授 (30324437)
山本 直彦  名古屋大学, 大学院・医学系研究科, 准教授 (40220488)
山本 敏充  名古屋大学, 大学院・医学系研究科, 准教授 (50260592)
Co-Investigator(Renkei-kenkyūsha) AKIKO Tamakoshi  愛知医科大学, 大学院・医学系研究科, 准教授 (90236737)
HIROSHI Yatsuya  名古屋大学, 大学院・医学系研究科, 准教授 (30324437)
NAOHIKO Yamamoto  名古屋大学, 大学院・医学系研究科, 准教授 (40220488)
TOSHIMITSU Yamamoto  名古屋大学, 大学院・医学系研究科, 准教授 (50260592)
Project Period (FY) 2005 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥15,260,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2008: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2007: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2006: ¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 2005: ¥4,600,000 (Direct Cost: ¥4,600,000)
Keywordsオゾン層 / 代替物質 / ブロモプロパン / 神経毒性 / 疫学 / 健康影響 / 量反応性 / フロン代替物質 / 量反応関係 / 疫学調査 / 中枢神経毒性 / 症例 / 血液毒性 / 神経 / フロン代替 / 有機溶剤 / 神経行動 / クレアチンキナーゼ / 1-ブロモプロパン / オゾン破壊物質代替物 / 遺伝子多型 / グルタチオンS-トランスフェラーゼ / 神経伝導速度 / クレアチニンキナーゼ / 共分散分析 / 感受性 / マイクロアレイ / GST
Research Abstract

1-ブロモプロパンに曝露された中国労働者の個人曝露量、曝露期間を調べるとともに、健康調査を行った。健康調査は、下肢の運動神経伝導速度、感覚神経伝導速度、遠位潜時、F波伝導速度、WHO神経行動学的検査、血球検査、生化学検査、振動覚検査であった。その結果、1-ブロモプロパン曝露が遠位潜時を延長することがわかった。一方、同時に調査した米国の重症1-ブロモプロパン症例は中枢神経系障害を示した。

Report

(5 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (124 results)

All 2009 2008 2007 2006 2005 Other

All Journal Article (45 results) (of which Peer Reviewed: 35 results) Presentation (76 results) Book (3 results)

  • [Journal Article] Inhibition of ischemia-induced angiogenesis by benzo[a]pyrene in a manner dependent on the aryl hydrocarbon receptor.2009

    • Author(s)
      Ichihara S., et al.
    • Journal Title

      Biochemical and Biophysical Research Communication (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro cytotoxicity and oxidative damage effects of multi-wall carbon nanotube on RAW246.7 macrophages2008

    • Author(s)
      Liu Y, Song W, Li W, Ichihara G
    • Journal Title

      Wei Sheng Yan Jiu 37

      Pages: 281-4

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nanotubes in historical and future perspective : summary of an extended session at Carbon 2008 in Nagano (JP)2008

    • Author(s)
      Endo M, et al.
    • Journal Title

      Part Fibre Toxicol 5

      Pages: 21-21

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Melatonin pretreatment attenuates 2-broraopropane-induced testicular to xicity in rats.2008

    • Author(s)
      Huang F, et al.
    • Journal Title

      Toxicology 256

      Pages: 75-82

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro cytotoxicity and oxidative damage effects of multi-wall carbon nanotube on RAW246.7 macrophages2008

    • Author(s)
      Liu Y, et al.
    • Journal Title

      Wei Shens Yan Jiu 37

      Pages: 281-4

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Re : Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube.2008

    • Author(s)
      Ichihara G, et al.
    • Journal Title

      J Toxicol Sci 33

      Pages: 381-2

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methylation of dimethyltin in mice and rats.2008

    • Author(s)
      Furuhashi K, et al.
    • Journal Title

      Chemical Research in Toxicology 21

      Pages: 467-714

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mechanism of trichloroethylene-induced hepatotoxicity mediated by CYP2E12008

    • Author(s)
      Ramdhan DH, et al.
    • Journal Title

      Toxicology and Applied Pharmacology 231

      Pages: 300-7

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methylation of dimethyltin in mice and rats.2008

    • Author(s)
      Furuhashi K., et. al.
    • Journal Title

      Chemical Research in Toxicology 21

      Pages: 467-471

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemopreventive Effect of Selenium-Enriched Japanese Radish Sprout against Breast Cancer Induced by 12 Dimethylbenz[a]anthracene in Rats2007

    • Author(s)
      Yamanoshita O, Ichihara S, Hama H, Ichihara G, Chiba M, Kamijima M, Takeda I, Nakajima T
    • Journal Title

      Tohoku J Exp Med 212

      Pages: 191-8

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Di(2-ethylhexyl)phthalate induces hepatic tumorigenesis through a peroxisome proliferator-activated receptor alpha-independent pathway2007

    • Author(s)
      6. Ito Y, Yamanoshita O, Asaeda N, Tagawa Y, Lee C, Aoyama T, Ichihara G, Furuhashi K, Kamijima M, Gonzalez FJ, Nakajima T
    • Journal Title

      J Occup Health 49

      Pages: 172-82

    • NAID

      110006278711

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A role for the aryl hydrocarbon receptor in regulation of ischemia induced angiogenesis2007

    • Author(s)
      Ichihara S, Yamada Y, Ichihara G, Nakajima T, Kondo T, Gonzalez FJ, Murohara T
    • Journal Title

      Arterioscler Thromb Vasc Biol 27

      Pages: 1297-1304

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of oxidative stress and Akt signaling in doxorubicin cardiotoxicity2007

    • Author(s)
      Ichihara S, Yamada Y, Kawai Y, Osawa T, Furuhashi K, Duan Z, Ichihara G
    • Journal Title

      Biochem Biophys Res Commun 359

      Pages: 27-33

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential cardiovascular effects of endotoxin derived from Escherichia coli or Pseudomonas aeruginosa2007

    • Author(s)
      Matsushita A, Iwase M, Kato Y, Ichihara S, Ichihara G, Kimata H, Hayashi K, Hashimoto K, Yokoi T, Noda A, Koike Y, Yokota M, Nagata K
    • Journal Title

      Exp Anim 56

      Pages: 339-48

    • NAID

      130000068018

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Globin S-propyl cysteine and urinary N-acetyl-S-propylcysteine as internal biomarkers of 1-bromopropane exposure2007

    • Author(s)
      Valentine H, Amarnath K, Amarnath V, Li W, Ding X, Valentine WM, Ichihara G
    • Journal Title

      Toxicological Sciences 98

      Pages: 427-35

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reversibility of the adverse effects of 1-bromopropane exposure in rats2007

    • Author(s)
      Banu S, Ichihara S, Huang F, Ito H, Inaguma Y, Furuhashi K, Fukunaga Y, Wang Q, Kitoh J, Ando H, Kikkawa F, Ichihara G
    • Journal Title

      Toxicol Sci 100

      Pages: 504-12

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reversibility of the adverse effects of 1-bromopropane exposure in rats.2007

    • Author(s)
      Banu S., et. al.
    • Journal Title

      Toxicological Sciences 100

      Pages: 504-512

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Globin S-propyl cysteine and urinary N-acetyl-S-propylcysteine as internal biomarkers of 1-bromopropane exposure.2007

    • Author(s)
      Valentine H., et. al.
    • Journal Title

      Toxicological Sciences 98

      Pages: 427-435

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of oxidative stress and Akt signaling in doxorubicin cardiotoxicity.2007

    • Author(s)
      Ichihara S, et. al.
    • Journal Title

      Biochemical and Biophysical Research Communication 359

      Pages: 27-33

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A role for the aryl hydrocarbon receptor in regulation of ischemia-induced angiogenesis.2007

    • Author(s)
      Ichihara S, et. al.
    • Journal Title

      Arteriosclerosis, Thrombosis and Vascular Biology 27

      Pages: 1297-1304

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential cardiovascular effects of endotoxin derived from Escherichia coli or Pseudomonas aeruginosa.2007

    • Author(s)
      Matsushita A, et. al.
    • Journal Title

      Exp Anim 56

      Pages: 339-348

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Di (2-ethylhexyl) phthalate induces hepatic tumorigenesis through a peroxisome proliferator-activated receptor alpha-independent pathway.2007

    • Author(s)
      Ito Y., et. al.
    • Journal Title

      J Occup Health. 49

      Pages: 172-182

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemopreventive Effect of Selenium-Enriched Japanese Radish Sprout against Breast Cancer Induced by 7, 12-Dimethylbenz [a] anthracene in Rats.2007

    • Author(s)
      Yamanoshita O, et. al.
    • Journal Title

      Tohoku J Exp Med 212

      Pages: 191-198

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A role for the aryl hydrocarbon receptor in regulation of ischemia-induced angiogenesis2007

    • Author(s)
      Ichihara S. et al.
    • Journal Title

      Arteriosclerosis Thrombosis and Vascular Biology (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effects of exposure of rat dams to 1-bromopropane during pregnancy and lactation on growth and sexual maturation of their offspring2006

    • Author(s)
      Furuhashi K, Kitoh J, Tsukamura H, Maeda K, Wang H, Li W, Ichihara S, Nakajima T, Ichihara G
    • Journal Title

      Toxicology 224

      Pages: 219-228

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of exposure of rat dams to 1-bromopropane during pregnancy and lactation on growth and sexual maturation of their offspring.2006

    • Author(s)
      Furuhashi K. et al.
    • Journal Title

      Toxicology 224

      Pages: 219-228

    • Related Report
      2006 Annual Research Report
  • [Journal Article] PPAR-alpha attenuates left ventricular remodeling and dysfunction by the suppression of the redox-regulated transcription factors activity.2006

    • Author(s)
      Ichihara S. et al.
    • Journal Title

      Journal of Molecular Cellular Cardiology 41

      Pages: 318-329

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Pravastatin increases survival and suppresses an increase in myocardial MMP activity in a rat model of heart failure.2006

    • Author(s)
      Ichihara S. et al.
    • Journal Title

      Cardiovascular Research 69

      Pages: 726-735

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Attenuation of oxidative stress and cardiac dysfunction by bisoprolol in an animal model of dilated cardiomyopathy.2006

    • Author(s)
      Ichihara S. et al.
    • Journal Title

      Biochem Biophys Res Commun 350

      Pages: 105-113

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Pravastatin increases survival and suppresses an increase in myocardial matrix metalloproteinase activity in a rat model of heart failure.2006

    • Author(s)
      Ichihara S. et al.
    • Journal Title

      Cariovasc Res 213

      Pages: 726-735

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A comprehensive evaluation of the testicular toxicity of dichlorvos in Wistar rats2005

    • Author(s)
      Okamura A, Kamijima M, Shibata E, Ohtani K, Takagi K, Ueyama J, Watanabe Y, Omura M, Wang H, Ichihara G, Kondo T, Nakajima T
    • Journal Title

      Toxicology 213(1-2)

      Pages: 129-37

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuro-reproductive toxicities of 1-bromopropane and 2-bromopropane.2005

    • Author(s)
      Ichihara G
    • Journal Title

      International Archives of Occupational and Environmental Health 78

      Pages: 79-96

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 事例と動物実験からの毒性解明-ブロモプロパン研究を例として-2005

    • Author(s)
      市原 学
    • Journal Title

      日本衛生学雑誌 60

      Pages: 405-410

    • NAID

      10016884376

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A comprehensive evaluation of the testicular toxicity of dichlorvos in Wistar rats.2005

    • Author(s)
      Okamura A. et al.
    • Journal Title

      Toxicology 213

      Pages: 129-137

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Species differences in the metabolism of di(2-ethylhexyl) phthalate (DEHP) in several organs of mice, rats, and marmosets.2005

    • Author(s)
      Ito Y.et al.
    • Journal Title

      Archives of Toxicology 79

      Pages: 147-154

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Inhibition of ischemia-induced angiogenesis by benzo[a]pyrene in a manner dependent on the aryl hydrocarbon receptor

    • Author(s)
      Ichihara S, Yamada Y, Gonzalez FJ, Nakajima T,Murohara T, Ichihara G
    • Journal Title

      Biochem Biophys Res Commun 2009 (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Melatonin pretreatment attenuates 2-bromopropane-induced testicular toxicity in rats

    • Author(s)
      Huang F, Ning H, Xin QQ, Huang Y, Wang H, Zhang ZH, Xu DX, Ichihara G, Ye DQ.
    • Journal Title

      Toxicology 2009 256

      Pages: 75-82

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Carbon Nanotubes in historical and future perspective: summary of an extended session at Carbon 2008 in Nagano (JP)

    • Author(s)
      Endo M, Tsuruoka S, Ichihara G
    • Journal Title

      Part Fibre Toxicol 2008 5

      Pages: 21-21

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Re : Induction of mesothelioma in p53+/-mouse by intraperitoneal application of multi-wall carbon nanotube

    • Author(s)
      Ichihara G, Castranova V, Tanioka A, Miyazawa K
    • Journal Title

      J Toxicol Sci 2008 33

      Pages: 381-2

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Methylation of dimethyltin in mice and rats

    • Author(s)
      Furuhashi K, Ogawa M, Suzuki Y, Endo Y, Kim Y, Ichihara G
    • Journal Title

      Chemical Research in Toxicology 2008 21

      Pages: 467-71

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mechanism of trichloroethylene-induced hepatoxicity mediated by CYP2E1

    • Author(s)
      Ramdhan DH, Kamijima M, Yamda N, Ito Y, Yanagiba Y, Nakamura D, Okamura A, Ichihara G, Aoyama T, Gonzalez FJ, Nakajima T
    • Journal Title

      Toxicol Appli Pharmacol 2008 231

      Pages: 300-7

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Attenuation of oxidative stress and cardiac dysfunction by bisoprolol in an animal model of dilated cardiomyopathy

    • Author(s)
      Ichihara S, Yamada Y, Ichihara G, Kanazawa H, Hashimoto K, Kato Y, Matsushita A, Oikawa S, Yokota M, Iwase M
    • Journal Title

      Biochem Biophys Res Commun 2006

      Pages: 350105-13

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] PPAR-alpha attenuates left ventricular remodeling and dysfunction by the suppression of the redox-regulated transcription factors activity

    • Author(s)
      Ichihara S, Obata K, Yamada Y, Nagata K, Noda A, Ichihara G, Yomada A, Kato T, Murohara T, Yokota M
    • Journal Title

      Journal of Molecular Cellular Cardiology 2006 41

      Pages: 318-329

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pravastatin increases survival and suppresses an increase in myocardial MMP activity in a rat model of heart failure

    • Author(s)
      Ichihara S, Noda A, Nagata K, Obata K, Xu J, Ichihara G, Oikawa S, Kawanishi S, Yamada Y, Yokota M
    • Journal Title

      Cardiovascular Research 2006 69

      Pages: 726-735

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Species difference in the metabolism of di(2-ethylhexyl) phthalate (DEHP) in several organs of mice, rats, and marmosets

    • Author(s)
      Ito Y, Yokota H, Wang R, Yamanoshita O, Ichihara G, Wang H, Kurata Y, Takagi K, Nakajima T.
    • Journal Title

      Archives of Toxicology 2005 79

      Pages: 147-54

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] Dose-dependent neurological and hematological effects of 1-bromopropane exposure on workers2009

    • Author(s)
      Ichihara G, Li W, Shibata E, Zhou Z, Ichihara S, Wang Q, Li J, Ding X, Takeuchi Y
    • Organizer
      The 29^<th> International Congress on Occupational Health
    • Place of Presentation
      Cape Town, South Africa
    • Related Report
      2008 Final Research Report
  • [Presentation] Occupational Health Survey on workers handling titanium dioxide2009

    • Author(s)
      Ichihara S, Li W, Kobayashi T, Ding X, Fujitani Y, Liu Y, Wang Q, Cui U, Hata N, Ichihara G
    • Organizer
      The 29^<th> International Congress on Occupational Health
    • Place of Presentation
      Cape Town, South Africa
    • Related Report
      2008 Final Research Report
  • [Presentation] Exposure assessment and health examination of workers handling titanium dioxide2009

    • Author(s)
      Ichihara G, Li W, Kobayashi T, Ding X, Fujitani Y, Liu Y, Sai U, Hata N, Wang Q, Ichihara S
    • Organizer
      The 48th Annual Meeting of the Society of Toxicology
    • Place of Presentation
      Baltimore, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Inhibition of ischemia-induced angiogenesis by benzo[a]pyrene in a manner dependent on aryl hydrocarbon receptor2009

    • Author(s)
      Ichihara S, Yamada Y, Ichihara G, Nakajima T, Gonzalez E.J, Murohara T
    • Organizer
      The 48^<th> Annual Meeting of the Society of Toxicology
    • Place of Presentation
      Baltimore, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Exposure assessment and health examination on workers handling titanium dioxide.2009

    • Author(s)
      Ichihara G, et al.
    • Organizer
      The 48^<th> Annual Meeting of the Society of Toxicology
    • Place of Presentation
      Baltimore, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Inhibition of ischemia-induced angiogenesis by benzo[a]pyrene in a manner dependent on the aryl hydrocarbon, receptor.2009

    • Author(s)
      Ichihara S, et al.
    • Organizer
      The 48^<th> Annual Meeting of the Soci etyof Toxicology
    • Place of Presentation
      Baltimore, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Dose-dependent Neurological and Hematological Effects of 1-bromopropane Exposure on Workers2009

    • Author(s)
      Ichihara G, et al.
    • Organizer
      The 29^<th> International Congress on Ocoupational Health
    • Place of Presentation
      Cape town, South Africa
    • Related Report
      2008 Annual Research Report
  • [Presentation] Exposure Assessment and Health Examination on Workers Handling Titanium Dioxide2009

    • Author(s)
      Ichihara S, et al.
    • Organizer
      The 29^<th> International Congress on Occupational Health
    • Place of Presentation
      Cape town, South Africa
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウスを用いた1-ブロモプロパン曝露感受性の分子的基盤に関する研究2009

    • Author(s)
      劉芳, 他
    • Organizer
      第8回分子予防環境医学研究会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 1-ブロモプロパン曝露によるラツト脳遺伝子発現変化と毒性メカニズムに対する洞察2009

    • Author(s)
      Sheik Mohideen S, et al.
    • Organizer
      第8回分子予防環境医学研究会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 1-ブロモプロパン曝露によるラツト脳遺伝子発現変化に関するマイクロアレイ研究2009

    • Author(s)
      Sheik Mohideen S, et al.
    • Organizer
      第79回日本衛生学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] Balb/cAはG57BL/6JやDBA/2Jよりも1ブロモプロパン曝露に対して感受性が高い2009

    • Author(s)
      劉芳, 他
    • Organizer
      第79回日本衛生学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウスRAW264.7マクロファージとヒトA549肺細胞に対する多層カーボンナノチューブにより誘導される酸化ストレスのIn Vitro評価2009

    • Author(s)
      陳波, 他
    • Organizer
      第79回日本衛生学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 連続したアンクルクローヌスを呈した新しい重症1-ブロモプロパン中毒症例2009

    • Author(s)
      市原学, 他
    • Organizer
      第79回日本衛生学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 多層カーボンナノチューブ気管内投与の肺に対する影響2009

    • Author(s)
      李衛華, 他
    • Organizer
      第79回日本衛生学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒト肺癌細胞におけるメソポラスシリカナノ粒子のインビトロ細胞毒性評価2009

    • Author(s)
      韓路, 他
    • Organizer
      第79回日本衛生学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] Animal experiments and human studies in risk assessment of manufactured nanomaterials2008

    • Author(s)
      Ichihara G
    • Organizer
      Animal experiments and human studies in risk assessment of manufactured nanomaterials. International Workshop at Nagoya University "Recent Progress in EHS Research on Manufactured Nanomaterials."
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2008-12-12
    • Related Report
      2008 Final Research Report
  • [Presentation] Animal experiments and human studies in risk assessment of manufactured nanomaterials.2008

    • Author(s)
      Ichihara G
    • Organizer
      International Workshop at Nagoya University "Recent Progress in EHS Research on Manufactured Nanomaterials. "
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2008-12-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Occupational Health Survey on workers handling nano-titanium dioxide2008

    • Author(s)
      Ichihara G.
    • Organizer
      Roundtable on Nanotechnology and engineered nanoparticles: Research perspectives in Occupational Health and Safety
    • Place of Presentation
      Canadian Embassy, Tokyo
    • Year and Date
      2008-02-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] Assessment of exposure and health status in workers handling titanium dioxide2008

    • Author(s)
      Ichihara G, Li W, Kobayashi T, Ding X, Fujitani Y, Liu Y, Wang Q, Cui U, Hata N, Ichihara S.
    • Organizer
      Internatoinal Conference on safe production and use of nanomaterials, NANOSAFE 2008
    • Place of Presentation
      Minatec, Grenoble, France
    • Related Report
      2008 Final Research Report
  • [Presentation] Occupational Health Survey on workers handling titanium dioxide2008

    • Author(s)
      Ichihara G, Li W, Kobayashi T, Ding X, Fujitani Y, Liu Y, Wang Q, Cui U, Hata N, Ichihara S
    • Organizer
      The 45th Congress of the European Societies of Toxicology
    • Place of Presentation
      Rhodes, Greece
    • Related Report
      2008 Final Research Report
  • [Presentation] Recent studies of bromopropane toxicity-animal studies and newly found human cases in United States2008

    • Author(s)
      Ichihara G
    • Organizer
      China-Japan Collaboration Workshop "Environmental Health and Safety Research on new manufactured materials"
    • Place of Presentation
      Shanghai, China
    • Related Report
      2008 Final Research Report
  • [Presentation] Microarray study on bromopropane toxicity2008

    • Author(s)
      Ichihara G
    • Organizer
      China-Japan Collaboration Workshop "Environmental Health and Safety Research on new manufactured materials"
    • Place of Presentation
      Shanghai, China
    • Related Report
      2008 Final Research Report
  • [Presentation] International collaboration and coordination of nanotoxicology research2008

    • Author(s)
      Ichihara G
    • Organizer
      China-Japan Collaboration Workshop "Environmental Health and Safety Research on new manufactured materials"
    • Place of Presentation
      Shanghai, China
    • Related Report
      2008 Final Research Report
  • [Presentation] Methylation of dimethyltin in mice and rats2008

    • Author(s)
      Furuhashi K, Ogawa M, Suzuki Y, Endo Y, Ichihara G
    • Organizer
      The 47^<th> Annual Meeting of Society of Toxicology
    • Place of Presentation
      Seattle, Washington, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Effect of 1-bromopropane exposure on gene expression of neurotransmitter receptors in rat2008

    • Author(s)
      Sheik Mohideen S, Ichihara S, Liu F, Furuhashi K, Li W, Ichihara G
    • Organizer
      The 47^<th> Annual Meeting of Society of Toxicology
    • Place of Presentation
      Seattle, Washington, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Neurotoxicity and reproductive toxicity of 1-bromopropapane, an alternative to ozone-depleting solvents. International Conference on "Toxic Exposure Related Biomarker : Genomes and Health Effects"2008

    • Author(s)
      Ichihara G
    • Organizer
      National Environmental Engineering Research Institute
    • Place of Presentation
      Nagpur, India
    • Related Report
      2008 Final Research Report
  • [Presentation] Assessment of exposure and health status in workers handling titanium dioxide.2008

    • Author(s)
      Ichihara G, et al.
    • Organizer
      NANOSAFE 2008
    • Place of Presentation
      Minatec, Grenoble, France
    • Related Report
      2008 Annual Research Report
  • [Presentation] Occupational Health Survey on workers handling titanium dioxide.2008

    • Author(s)
      Ichihara G, et al.
    • Organizer
      The 45th Congress of the European Societies of Toxicology
    • Place of Presentation
      Rhodes, Greece
    • Related Report
      2008 Annual Research Report
  • [Presentation] Recent studies of bromopropane toxicity-Animal studies and newly found human cases in United states-2008

    • Author(s)
      Ichihara G
    • Organizer
      China-Japan Collaboration Workshop "Environmental Health and Safety Research on new manufactured materials"
    • Place of Presentation
      Shanghai, China
    • Related Report
      2008 Annual Research Report
  • [Presentation] Microarray study on bromopropane toxlcity.2008

    • Author(s)
      Ichihara G
    • Organizer
      China-Japan Collaboration Workshop "Environmental Health and Safety Researchon new manufactured materials"
    • Place of Presentation
      Shanghai, China
    • Related Report
      2008 Annual Research Report
  • [Presentation] International collaboration and coordination of nanotoxicology research.2008

    • Author(s)
      Ichihara G
    • Organizer
      China-Japan Collaboration Workshop "Environmental Health and Safety Researchon new manufactured materials"
    • Place of Presentation
      Shanghai, China
    • Related Report
      2008 Annual Research Report
  • [Presentation] Ablation of Nrf2 resulted in enhancement of ischemia-induced angiogenesis.2008

    • Author(s)
      Ichihara S, et al.
    • Organizer
      The 81th Scientific Sessions of American Heart Association
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] 1-ブロモプ, ロパン曝露労働者の量依存的な神経系、血液系影響2008

    • Author(s)
      李衛華, 他
    • Organizer
      第81回日本産業衛生学会
    • Place of Presentation
      札幌
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウスはラットよりも1-ブロモプロパン曝露に対して感受性が高い-マウス系統間比較研究-2008

    • Author(s)
      劉芳, 他
    • Organizer
      第81回日本産業衛生学会
    • Place of Presentation
      札幌
    • Related Report
      2008 Annual Research Report
  • [Presentation] 1-ブロモプロパンの曝露による神経伝達物質受容体遺伝子発現への影響解析と中枢神経毒性バイオマーカーの開発2008

    • Author(s)
      シェイクモヒディーンサハブディーン, 他
    • Organizer
      第81回日本産業衛生学会
    • Place of Presentation
      札幌
    • Related Report
      2008 Annual Research Report
  • [Presentation] ナノ酸化チタン取扱職場における曝露評価2008

    • Author(s)
      畑菜摘, 他
    • Organizer
      第81回日本産業衛生学会
    • Place of Presentation
      札幌
    • Related Report
      2008 Annual Research Report
  • [Presentation] ナノ酸化チタン取扱工場労働者の健康調査2008

    • Author(s)
      崔雨佳, 他
    • Organizer
      第81回日本産業衛生学会
    • Place of Presentation
      札幌
    • Related Report
      2008 Annual Research Report
  • [Presentation] ブロモプロパンによる神経障害2008

    • Author(s)
      市原学
    • Organizer
      第19回末梢神経学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report
  • [Presentation] 持続的なアンクルクローヌスを呈した新しい1-ブロモプロパン中毒症例2008

    • Author(s)
      市原学
    • Organizer
      第36回有機溶剤中毒研究会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] Reduced Expression of Dopamine and Serotonin Receptors in Rat Brainafter Exposure to 1-Bromopropane.2008

    • Author(s)
      Sheik Mohideen S, et al.
    • Organizer
      第36回有機溶剤中毒研究会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] Neurotoxicity and reproductive toxicity of 1-bromopropane, an alternative to ozone-depleting solvents.2008

    • Author(s)
      Ichihara G.
    • Organizer
      International Conference on "Toxic Exposure Related Biomarker: Genomes and Health Effects"
    • Place of Presentation
      Nagpur, India
    • Related Report
      2007 Annual Research Report
  • [Presentation] ナノマテリアルのヒト健康への影響をどのように評価するか?2007

    • Author(s)
      市原 学, ほか
    • Organizer
      第5回ナノキシコロジーアセスと微笠子・ナノチューブのバイオ応用研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-12-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] ナノテクノロジーと環境労働衛生学-ナノマテリアル安全性評価への国際労働衛生学的アプローチ2007

    • Author(s)
      市原 学
    • Organizer
      平成19年度日本産業衛生学会東海地方会学会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-11-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] 1-ブロモプロパン曝露による神経伝達物質受容体遺伝子発現への影響2007

    • Author(s)
      シェイク モヒディーン サハブディーン, ほか
    • Organizer
      平成19年度日本産業衛生学会東海地方会学会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-11-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] マウス、ラットにおけるジメチルスズのメチル化2007

    • Author(s)
      古橋功一, ほか
    • Organizer
      平成19年度日本産業衛生学会東海地方会学会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-11-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] 中国1-ブロモプロパン曝露労働者における神経障害2007

    • Author(s)
      李 衛華, ほか
    • Organizer
      平成19年度日本産業衛生学会東海地方会学会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-11-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effect of 1-bromopropane exposure on gene expression of neurotransmitter receptors and exploration of biomarkers for the central nervous system toxicity2007

    • Author(s)
      Sahabudeen S, Ichihara G
    • Organizer
      The 24th International Neurotoxicology Conference
    • Place of Presentation
      San Antonio, TX, US
    • Year and Date
      2007-11-14
    • Related Report
      2008 Final Research Report
  • [Presentation] 1-ブロモプロパン曝露による神経伝達物質受容体遺伝子発現への影響2007

    • Author(s)
      シェイク モヒディーン サハブディーン
    • Organizer
      第19回日本産業衛生学会産業神経行動研究会
    • Place of Presentation
      秋田
    • Year and Date
      2007-11-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] Study on 1-bromopropane neurotoxicity through animal experiments and human studies2007

    • Author(s)
      Ichihara G, Li W, Ding X, Valentine W, Kitoh J, Takeuchi Y
    • Organizer
      International Symposium on 1-Bromopropane Toxicity in the 77th annual meeting of the Japanese Society for Hygiene
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2007-03-26
    • Related Report
      2008 Final Research Report
  • [Presentation] Exposure to 1-bromopropane causes neurologic deficits in humans2007

    • Author(s)
      Li W, Ding X, Valentine W, Shibata E, Takeuchi Y, Ichihara G
    • Organizer
      International Symposium on 1-Bromopropane Toxicity in the 77^<th> annual meeting of the Japanese Society for Hygiene
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2007-03-26
    • Related Report
      2008 Final Research Report
  • [Presentation] Study on 1-bromopropane neurotoxicity through animal experiments and human studies2007

    • Author(s)
      Ichihara G, Li W, Ding X, Valentine W, Kitoh J, Takeuchi Y
    • Organizer
      International Symposium on 1-Bromopropane Toxicity in the 77^<th> annual meeting of the Japanese Society for Hygiene
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2007-03-26
    • Related Report
      2008 Final Research Report
  • [Presentation] EHS research strategies on manufactured nanomaterials in Japan2007

    • Author(s)
      Ichihara G
    • Organizer
      The Dialogue between Academia and the Participants of OECD's Working Party on Manufactured Nanomaterials
    • Place of Presentation
      Dortmund, Germany
    • Year and Date
      2007-03-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Occupational Health Survey on workers handling nano-titanium dioxide2007

    • Author(s)
      Ichihara G
    • Organizer
      Roundtable on Nanotechnology and engineered nanoparticles: Research perspectives in Occupational Health and Safety
    • Place of Presentation
      Canadian Embassy, Tokyo, Japan
    • Year and Date
      2007-02-12
    • Related Report
      2008 Final Research Report
  • [Presentation] Environment, Health and Safety Research on Manufactured Nanomaterials2007

    • Author(s)
      Ichihara G.
    • Organizer
      The 13^<th> International Symposium on Toxicity Assessment
    • Place of Presentation
      Toyama, Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] DNA microarray study with two dimensional analysis on susceptibility to 1-bromopropane exposure2007

    • Author(s)
      Huang F, Ichihara S, Kitagawa E, Mizugami S, Iwahashi H, Kito J, Furuhashi K, Banu S, Iida M, Ichihara G.
    • Organizer
      The 11^<th> International Congress of Toxicology
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2008 Final Research Report
  • [Presentation] Dose-dependent effects of 1-bromopropane exposure on workers2007

    • Author(s)
      Li W, Wang Q, Ding X, Shibata E, Takeuchi Y, Valentine W, Ichihara G
    • Organizer
      The 18th Korea Japan China Joint Conference on Occupational Health
    • Place of Presentation
      Nagoya, Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] Globin S-propylcysteine and urinary N-acetyl-S-propylcysteine as biomarkers of 1-bromopropane exposure2007

    • Author(s)
      Valentine W, Valentine H, Amarnath K, Ding X, Ichihara G
    • Organizer
      The 46^<th> Annual Meeting of Society of Toxicology
    • Place of Presentation
      Charlotte, North Carolina, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Susceptibility to 1-bromopropane exposure and alteration of mRNA expression in rats2007

    • Author(s)
      Huang F, Ichihara S, Kitagawa E, Mizugami S, Iwahashi H, Fukunaga S, Furuhashi K, Banu S, Iida M, Kitoh J, Ichihara G
    • Organizer
      The 46^<th> Annual Meeting of Society of Toxicology
    • Place of Presentation
      Charlotte, North Carolina, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Reversibility of the adverse effects of 1-bromopropane exposure in rats2007

    • Author(s)
      Banu S, Ichihara S, Huang F, Ito H, Inaguma Y, Furuhashi K, Fukunaga S, Wang Q, Ichihara G
    • Organizer
      The 46^<th> Annual Meeting of Society of Toxicology
    • Place of Presentation
      Charlotte, North Carolina, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Dose-dependent effects of 1-bromopropane exposure on workers2007

    • Author(s)
      Li W, et. al.
    • Organizer
      The 18th Korea Japan China Joint Conference on Occupational Health
    • Place of Presentation
      名古屋
    • Related Report
      2007 Annual Research Report
  • [Presentation] DNA microarray study with two dimensional analysis on susceptibility to 1-bromopropane exposure.2007

    • Author(s)
      Huang F, et. al.
    • Organizer
      The 11th International Congress of Toxicology
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2007 Annual Research Report
  • [Presentation] Environment Health and Safety Research on Manufactured Nanomaterials2007

    • Author(s)
      Ichihara G
    • Organizer
      Tne 13th International Symposium on Toxicity Assessment
    • Place of Presentation
      Toyama, Japan
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effect of 1-bromopropane exposure on gene expression of neurotransmitter receptors and exploration of biomarkers for the central nervous system toxicity.2007

    • Author(s)
      Sahabudeen S, et. al.
    • Organizer
      The 24th International Neurotoxicology Conference
    • Place of Presentation
      San Antonio, TX, US
    • Related Report
      2007 Annual Research Report
  • [Presentation] Association between glutathione S-transferase gene polymorphism and neural effects in workers exposed to 1-bromoproane2007

    • Author(s)
      王強毅, ほか
    • Organizer
      第80回日本産業衛生学会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effect of 1-bromopropane exposure on gene expression of neurotransmitter receptors and exploration of biomarkers for central nervous system toxicity.2007

    • Author(s)
      市原 学, ほか
    • Organizer
      弟7回分子予防医学研究会
    • Place of Presentation
      小倉
    • Related Report
      2007 Annual Research Report
  • [Presentation] Methylation of dimethyltin in mice and rats.2007

    • Author(s)
      Furuhashi K, ほか
    • Organizer
      日本産業衛生学会第39回生物学的モニタリング・バイオマーカー研究会
    • Place of Presentation
      小倉
    • Related Report
      2007 Annual Research Report
  • [Presentation] Round table discussion in the 2^<nd> Joint Science Council of Japan-Royal Society workshop on the potential health2006

    • Author(s)
      Ichihara G
    • Organizer
      environmental and societal impacts of nanotechnologies
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-02-23
    • Related Report
      2008 Final Research Report
  • [Presentation] Exposure to 1-bromopropane adversely affects vibration sense and nerve conduction velocity of lower limbs and central nervous system in workers2006

    • Author(s)
      Ichihara G, Li W, Shibata E, Ding X, Li J, Wang H, Huang F, Peng S, Gu B, Ichihara S, Miyata M, Takeuchi Y.
    • Organizer
      North American Congress of Clinical Toxicology
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Microarray studies on neuro-reproductive toxicities of bromopropanes, alternatives to ozone-depleting solvents2006

    • Author(s)
      Ichihara G.
    • Organizer
      The 3^<rd> International Workshop on Biochips and Environmental Monitoring
    • Place of Presentation
      Ikeda, Osaka, Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] Adverse effects of exposure to 1-bromopropane on central nervous system and peripheral nerve in human2006

    • Author(s)
      Ichihara G, Li W, Shibata E, Ding X, Li J, Wang H, Huang F, Peng S, Gu B, Ichihara S, Tang Y, Shao B, Sun Y, Miyata M, Takeuchi Y
    • Organizer
      28^<th> International Congress on Occupational Health
    • Place of Presentation
      Milan, Italy
    • Related Report
      2008 Final Research Report
  • [Presentation] Exposure to 1-bromopropane reduces nerve conduction velocity in human2006

    • Author(s)
      Ichihara G. Li W, Shibata E, Ding X, Li J, Peng S, Ichihara S, Wang H, Huang F, Gu B, Tang Y, Shao B, Sun Y, Miyata M, Takeuchi Y
    • Organizer
      The 45^<th> Annual Meeting of Society of Toxicology
    • Place of Presentation
      San Diego, California, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Neurotoxicity of 1-bromopropane in human.-investigation through human cases/data and animal data2005

    • Author(s)
      Ichihara G
    • Organizer
      Symposium in the meeting for young epidemiologists in China
    • Place of Presentation
      Hefei, Anhui, China
    • Year and Date
      2005-10-13
    • Related Report
      2008 Final Research Report
  • [Presentation] Exposure to 1-bromopropane reduces nerve conduction velocity in lower limb of human2005

    • Author(s)
      Ichihara G. Li W, Shibata E, Ding X, Wang H, Li Jiefei, Huang F, Peng S, Gu B, Ichihara S, Shao B, Tang Y, Sun Y, Miyata M, Takeuchi Y
    • Organizer
      9^<th> International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health
    • Place of Presentation
      Gyongiu Neurobehavior meeting in Gyeongju, Korea
    • Related Report
      2008 Final Research Report
  • [Presentation] Occupational Health in a National University Corporation in Japan2005

    • Author(s)
      Ichihara G
    • Organizer
      16^<th> Japan-China-Korea Joint Conference on Occupational Health
    • Place of Presentation
      Dalian, China
    • Related Report
      2008 Final Research Report
  • [Presentation] Exposure to 1-bromopropane reduces nerve conduction velocity in lower limb of human2005

    • Author(s)
      Li W, Shibata E, Ding X, Li Jiefei, Wang H, Huang F, Peng S, Gu B, Ichihara S, Tang Y, Shao B, Sun Y, Miyata M, Takeuchi Y, Ichihara G
    • Organizer
      16^<th> Japan-China-Korea Joint Conference on Occupational Health
    • Place of Presentation
      Dalian, China
    • Related Report
      2008 Final Research Report
  • [Book] 有機溶剤IV.中毒各論2.有毒ガス中毒症のすべて-いざという時に役立つ、的確な治療のために-(編集黒川顕)2006

    • Author(s)
      市原学
    • Publisher
      永井書店
    • Related Report
      2008 Final Research Report
  • [Book] 黒川 顕編 中毒症のすべて-いざという時に役立つ、的確な治療のために-2006

    • Author(s)
      市原 学
    • Total Pages
      410
    • Publisher
      永井書店
    • Related Report
      2006 Annual Research Report
  • [Book] 中毒症のすべて-いざという時に役立つ、的確な治療のために-(黒川 顕編)2006

    • Author(s)
      市原 学
    • Total Pages
      410
    • Publisher
      永井書店
    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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