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US-Japan comparative study of the sudden cardiac death of young males-pokkuri death syndrome (PDS).

Research Project

Project/Area Number 17406023
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Legal medicine
Research InstitutionKeio University

Principal Investigator

FUJITA Masaki q  Keio University, School of Medicine, Professor, 医学部, 教授 (00211524)

Co-Investigator(Kenkyū-buntansha) TAKEICHI Sanae  Tokai University.School of Medicine, Professor, 医学部, 教授 (20035497)
OSAWA Motoki  Tokai University School of Medicine, Professor, 医学部, 教授 (90213686)
TAKAO Masaki  Keio University, School of Medicine, Assistant Professor, 医学部, 講師 (50245487)
佐藤 文子  東海大学, 医学部, 講師 (70328128)
呂 彩子  慶應義塾大学, 医学部, 助手 (50296555)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥12,900,000 (Direct Cost: ¥12,900,000)
Fiscal Year 2006: ¥6,200,000 (Direct Cost: ¥6,200,000)
Fiscal Year 2005: ¥6,700,000 (Direct Cost: ¥6,700,000)
KeywordsPokkuri Death Syndrome (PDS) / Remnant Lipoprotein / Sudden Death / Coronary Spasm / Atherosclerosis / Arrhythmia / Brugada Syndrome / Lipid Metabolism
Research Abstract

The new concept of Pokkuri Death Syndrome (PDS) for sudden cardiac death was proposed by Takeichi and Fujita (2006), which may be caused by the strong coronary spasm associated with remnant hyperlipoproteinemia observed prevalently in 2/3 of PDS cases.
The international collaboration research on the relationship between sudden cardiac death and remnant lipoproteins (RLP) were performed with the two US research institutions. One was with Dr. Virmani of CVPath (International Registry of Pathology), a forensic medicine researcher, on plasma analysis of 76 sudden cardiac death cases with severe coronary atherosclerosis. But the postmortem alteration of plasma in sudden cardiac death cases in USA was too severe to analyze lipid and lipoproteins because of the long postmortem interval at the time of autopsy in these cases for this kind of study. The other was the lipid and lipoprotein analysis in VA-HDL Intervention Trial (VA-HIT) (2531 male patients with and without gemfibrozil) with Dr. Schaefer of Tufts Univ. on the relationship to the occurrence of cardiovascular (CV) endpoints such as fatal or non-fatal MI, stroke etc. By comparing the Japanese and US casese, VA-Hit study showed that RLP-TG was a strong predictor of CV endpoints as PDS in Japan, but not apoB and LDL-C as well. As 1/3 of PDS cases were not associated with hyperlipidemia, the genetic analysis in PDS cases on SCN5A related with Brugada Syndrome was performed as the third international collaboration with Dr. Brugada at Montreal Univ., Canada. The cases with SCN5A gene mutations similar to Brugada Syndrome were found in PDS cases. Further genetic analysis is on going in these cases.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (13 results)

All 2007 2006 2005 Other

All Journal Article (13 results)

  • [Journal Article] ApoB-100 carrying lipoprotein, but not apoB-48, is the major subset of proatherogenic remnant-like lipoprotein particles detected in plasma of sudden cardiac death cases.2007

    • Author(s)
      Nakajima K, Nakajima Y, Takeichi S, Fujita MQ
    • Journal Title

      Atherosclerosis (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] ApoB-100 carrying lipoprotein, but not apoB-48, is the major subset of proatherogenic remnant-like lipoprotein particles detected in plasma of sudden cardiac death cases.2007

    • Author(s)
      Nakajima K, Nakajima Y, Takeichi S, Fujita MQ.
    • Journal Title

      Atherosclerosis In press

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The lipid and lipoprotein profiles of apo B-carrying particles in remnant-like lipoproteins isolated from plasma in sudden cardiac death cases.2006

    • Author(s)
      Nakajima Y, Takeichi S, Osawa M, Nakajima K, Nakano T, Fujita MQ
    • Journal Title

      Tokai J Exp Clin Med 31・4

      Pages: 160-166

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] みえてきたポックリ病の正体"ポックリ病"症候群の提唱2006

    • Author(s)
      武市早苗, 藤田眞幸
    • Journal Title

      医学のあゆみ 217・4

      Pages: 347-348

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The lipid and lipoprotein profiles of apoB-carrying particles in remnant-like lipoproteins isolated from plasma in sudden cardiac death cases.2006

    • Author(s)
      Y.Nakajima, S.Takeichi, M.Osawa, K.Nakajima, T.Nakano, M.Q.Fujita.
    • Journal Title

      Tokai J Exp Clin Med 31(4)

      Pages: 160-166

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Unveiling the cause of Pokkuri Disease-Proposal of the concept for "Pokkuri Death" Syndrome.2006

    • Author(s)
      S.Takeichi, M.Q.Fujita.
    • Journal Title

      Igaku-no-Ayumi 217(4) (in Japanese)

      Pages: 347-748

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The lipid and lipoprotein profiles of apo B-carrying particles in remnant-like lipoproteins isolated from plasma in sudden cardiac death cases.2006

    • Author(s)
      Nakajima Y, Takeichi S, Osawa M, Nakajima K, Nakano T, Fujita MQ.
    • Journal Title

      Tokai J Exp Clin Med 31・4

      Pages: 160-166

    • Related Report
      2006 Annual Research Report
  • [Journal Article] みえてきたぽっくり病の正体"ぽっくり病"症候群の提唱2006

    • Author(s)
      高市早苗, 藤田眞幸
    • Journal Title

      医学のあゆみ 217・4

      Pages: 347-348

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 見えてきたポックリ病の正体-ぽっくり病症候群の提唱2006

    • Author(s)
      武市早苗, 藤田眞幸
    • Journal Title

      医学のあゆみ (印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] ポックリ病-その原因を求めて-2005

    • Author(s)
      武市早苗
    • Journal Title

      法医学の実際と研究 48

      Pages: 1-13

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Pokkuri Disease and Its Causes.2005

    • Author(s)
      S.Takeichi.
    • Journal Title

      Res. Pract. Forens Med 48 (in Japanese)

      Pages: 1-13

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] ApoB-100 carrying lipoprotein, but not apoB-48, is the major subset of proatherogenic remnant-like lipoprotein particles detected in plasma of sudden cardiac death cases.

    • Author(s)
      K.Nakajima, Y.Nakajima, S.Takeichi, M.Q.Fujita.
    • Journal Title

      Atherosclerosis 2007 (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The comparison of plasma levels of remnant-like lipoprotein particles and LDL-C associated with clinical events and coronary atherosclerosis in sudden cardiac death cases.

    • Author(s)
      K.Nakaiima, Y.Nakajima, S.Takeichi, M.Q.Fujita.
    • Journal Title

      (in submission to Atherosclerosis)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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