• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The genetic research for the ethnical differences of the susceptibility genes of rheumatic diseases in East Asia

Research Project

Project/Area Number 17406026
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionThe University of Tokyo

Principal Investigator

TAKEUCHI Fujio  The University of Tokyo, 医学部・附属病院, 講師 (70154979)

Co-Investigator(Kenkyū-buntansha) KABURAGI Toshikatsu  東京大学, 医学部・附属病院, 講師 (70343126)
HARIHARA Shinnji  東京大学, 大学院・理学系研究科, 助教 (40198932)
KUWATA Shouji  帝京大学, ちば総合医療センター, 准教授 (00241993)
SAKUTA Hiroshi  青山学院大学, 理工学部, 教授 (10170630)
Research Collaborator PARK Myoung Hee  韓国ソウル大学, 医学部, 教授
SONG Yeong Wook  韓国ソウル大学, 医学部, 教授
YU Chia-li  台湾台湾大学, 医学部, 教授
LOUTHRENOO Worawit  タイチェンマイ大学, 医学部, 教授
PATTANAKITSUL Sa-nga  タイマヒドン大学, 医学部, 准教授
Project Period (FY) 2005 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥14,960,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2007: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2006: ¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 2005: ¥5,600,000 (Direct Cost: ¥5,600,000)
Keywordsリウマチ疾患 / 疾患感受性遺伝子 / HLA / ETS1 / ハプロタイプ推定 / 東アジア / 民族差 / 国際研究者交流 / べーチェット病 / 遺伝因子 / CTGF / CARF / 自己抗体 / リウマチ因子 / タイ:韓国:台湾 / RA / Bechet Disease / Werner syndrome / ハプロタイプ / SSc / Behcet Disease
Research Abstract

リウマチ疾患の遺伝要因を東アジアで検討した。各遺伝子多型には民族差があった。RA はタイで印度の影響かDRB1*1001 が増加した。SLE ではDRB5*0101 が遺伝因子と推定した。ETS1 との相関はみられない。SScではDRB1*1502 が相関しCTGF は相関しない。ベーチェット病ではHLA-A*2601, B*39 が相関した。データーシステム ASCA と処理時間で優れたハプロタイプ推定ソフトR-SAT を作成した。

Report

(5 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (25 results)

All 2008 2007 2006 2005

All Journal Article (18 results) (of which Peer Reviewed: 9 results) Presentation (6 results) Book (1 results)

  • [Journal Article] Genetic contribution of the CD14-159C/ T dimorphism in the promoter region in Japanese RA2008

    • Author(s)
      Takeuchi F, Kuwata S, 他6名,1, 4番目
    • Journal Title

      Clin Exp Rheumatol 26

      Pages: 337-339

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular basis of complement factor I (CFI)polymorphism : one of two polymorphic suballeles responsible for CFI A is Japanese-specific2008

    • Author(s)
      Yuasa I, Harihara S, 他12名, 4番目
    • Journal Title

      J Hum Genet 53

      Pages: 1016-1021

    • NAID

      10025584984

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic contribution of the CD14-159C/T dimorphism in the promoter region in Japanese RA.2008

    • Author(s)
      Takeuchi F., et al.
    • Journal Title

      Clinical and Experimental Rheumatology 26

      Pages: 337-339

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The CTLA-4-1661A/ G and-1772T/ C dimorphisms in Japanese with systemic sclerosis2007

    • Author(s)
      Takeuchi F, Kuwata S, 他5名, 1, 4番目
    • Journal Title

      Rheumatol Int 27

      Pages: 785-787

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of Collaboration Environments for Web-Based Learning2007

    • Author(s)
      Yabuki T, Sakuta H
    • Journal Title

      J Computers 2

      Pages: 1-6

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The CTLA-4-1661A/G and -1772T/C dimorphisms in Japanese with systemic sclerosis.Rheumatol Int 272007

    • Author(s)
      Takeuchi F., et. al.
    • Journal Title

      Rheumatology International 27

      Pages: 785-787

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural alterations in outer arms of IgG oligosaccharides in patients with Werner syndron2007

    • Author(s)
      Kuroda Y., et. al.
    • Journal Title

      Experimental Gerontology 42

      Pages: 545-553

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The genetic contribution of the CTLA-4 dimorphisms in promoter and exon 1 regions in Japanese RA2006

    • Author(s)
      Takeuchi F, Kuwata S, 他6名, 1,6番目
    • Journal Title

      Scan J Rheumatol 35

      Pages: 154-155

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The genetic contribution of CTLA-4 dimorphisms in promoter and exon 1 regions in Japanese patients with rheumatoid arthritis2006

    • Author(s)
      Takeuchi f., et al.
    • Journal Title

      Scan J Rheumatol 35

      Pages: 154-155

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Enhanced expression of CD69 and CD25 antigen on human peripheral blood mononuclear cells by prolactin2006

    • Author(s)
      Takizawa K., et al.
    • Journal Title

      Endocrine J 52

      Pages: 635-641

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Telomere shortening with aging in the human pancreas2006

    • Author(s)
      Ishii A., et al.
    • Journal Title

      Exp Gerontol 41

      Pages: 882-886

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 通風と偽通風2006

    • Author(s)
      川杉要, 他
    • Journal Title

      診断と治療 94

      Pages: 1189-1194

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The CTLA-4-1661A/G&-1772T/C dimorphism in Japanese patients with systemic lupus erythematosus2005

    • Author(s)
      Takeuchi F, Kuwata S, Mori M
    • Journal Title

      J Rheumatol 32

      Pages: 2062-2063

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic contribution of the tumor necrosis factor (TNF)B+252^*2/2 genotype, but not the TNFa,b microsatellite alleles, to systemic lupus erythematosus in Japanese patients2005

    • Author(s)
      Takeuchi F., et al.
    • Journal Title

      Int J Imunogenetics 32

      Pages: 173-178

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The genetic contribution of the TNFa11 microsatellite allele and the TNFB+252^*2 allele in Japanese RA2005

    • Author(s)
      Takeuchi F., et al.
    • Journal Title

      Clin Exp Rheumatol 23

      Pages: 494-498

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The CTLA-4-1661A/G & -1772T/C dimorphism in Japanese patients with systemic lupus erythematosus.2005

    • Author(s)
      Takeuchi F., et al.
    • Journal Title

      J Rheumatol 32

      Pages: 2062-2063

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Epstein-Barr virus infection in childhood may precipitate atopic diseases.2005

    • Author(s)
      Okudaira R., et al.
    • Journal Title

      Allergology International 54

      Pages: 483-490

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Association of TAP1 and TAP2 gene polymorphisms with systemic sclerosis in Korean patients.2005

    • Author(s)
      Song YW, et al.
    • Journal Title

      Hum Immunol 66

      Pages: 810-817

    • Related Report
      2005 Annual Research Report
  • [Presentation] Diagnostic usefulness of anti-agalactosyl IgG antibodies in comparison to rheumatoid factor and anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis, systemic lupus erythematosus, and sustemic sclerosis.2008

    • Author(s)
      Louthrenoo W., et al.
    • Organizer
      The l3th Asia Pacific League of Associations for Rheumatology Congress
    • Place of Presentation
      横浜
    • Year and Date
      2008-09-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Association of HLA-DRB1* 1502 allele with the susceptibility to systemic sclerosis in Thai patients2008

    • Author(s)
      Louthrenoo W, Kuwata S, Takeuchi F, 他5名, 7, 8番目
    • Organizer
      2008 Annual European Congress of Rheumatology
    • Place of Presentation
      Paris(France)
    • Year and Date
      2008-06-14
    • Related Report
      2008 Final Research Report
  • [Presentation] Association of HLA-DRB1*1502 allele with the susceptibility to systemic sclerosis in Thai patients2008

    • Author(s)
      Louthrenoo W., et al.
    • Organizer
      2008 Annual European Congress of Rheumatology,
    • Place of Presentation
      パリ(フランス)
    • Year and Date
      2008-06-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Empirical Examination of the best method in haplotype inference of HLA gene2007

    • Author(s)
      Yabuki T, Sakuta H, Takeuchi F, KuwataS, 他2名, 3, 4, 5番目
    • Organizer
      71th Annual Scientific Meeting of American College of Rheumatology
    • Place of Presentation
      Boston(USA)
    • Year and Date
      2007-11-06
    • Related Report
      2008 Final Research Report
  • [Presentation] Empirical Examination of the best method in haplotype inference of HLA gene2007

    • Author(s)
      Yabuki T., et. al.
    • Organizer
      71th Annual Scientific Meeting of American Colege of Rheumatology
    • Place of Presentation
      ボストン(USA)
    • Year and Date
      2007-11-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] The possible genetic contribution of the TNFB+252* 2 allele and the TNFa11 micrisatellite allele to pathogenesis and therapeutical effect with infliximab in Japanese RA2006

    • Author(s)
      Takeuchi F, Kuwata S, 他7名, 1, 7番目
    • Organizer
      The 12^<th> Asia Pacific League of Associations for Rheumatology Congress
    • Place of Presentation
      Kuala Lumpur(Malaysia)
    • Year and Date
      2006-08-03
    • Related Report
      2008 Final Research Report
  • [Book] 初級プログラマのためのWeb アプリケーション構築入門2007

    • Author(s)
      矢吹太朗, 佐久田博司
    • Publisher
      森北出版
    • Related Report
      2008 Final Research Report

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi