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Discrimination of Species with Disorder of DNA Sequences and its Application to Evolution in Introns

Research Project

Project/Area Number 17500146
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Sensitivity informatics/Soft computing
Research InstitutionUniversity of Miyazaki

Principal Investigator

YOSHIHARA Ikuo  University of Miyazaki, Faculty of Engineering, Dept.of CS and Sys.Engineering, Professor (20322315)

Co-Investigator(Kenkyū-buntansha) YASUNAGA Moritoshi  University of Thukuba, Graduate School of CS, Professor (80272178)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,800,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2005: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywordsimprint of evolution / DNA sequences / evolutionary tree / information entropy / 1 / f fluctuation / fossil / 生体生命情報学 / 認知科学 / 統計力学 / ソフトコンピューティング / ニューラルネットワーク / 自己組織化マップ / カオス理論 / 量子統計力学 / 秩序度 / 生物種 / 細胞性粘菌
Research Abstract

It is believed that evolutionary imprints have been accumulated in DNA sequence of chromosome and most of the DNA analyzing methods are based on pattern matching technology. However, it is doubtful to find almost all the significant schemes are known well in advance and also it is difficult to analyze precisely in case of getting only few fossil or sample.
In such cases, a method to compare species in brief is probably welcome, even if accuracy is not enough high. Then we think out a novel method that employs disorder or irregularity of the DNA sequences to compare species. Species are compared each other from the viewpoint of irregularity of DNA sequences instead of conventional methods. The merit of the method is no need of the preliminary knowledge of the species or genes, because this method doesn't require characteristics or analyzed information of the sequence, beforehand.
On the other hand, even if irregular indices are the same, it does not directly mean the species are the same. It is desirable to check the sequences from the view point some indices of irregularity. I tried to apply various methods, e.g. statistics, physical, statistical amounts like the long distance order degree etc. of several statistics, the 1/f fluctuation, the information entropy, and the quantum statistics mechanics like the occurrence rate etc. Many experiments lead us to the conclusion that the proposed method distinguishes if the living creature is comparatively near or far, but it is hard to obtain the taxonomical trees only with the indices of irregularity.

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (34 results)

All 2010 2007 2006 2005

All Journal Article (26 results) (of which Peer Reviewed: 6 results) Presentation (8 results)

  • [Journal Article] Quest for Genetic Information Hidden behind Disorder in DNA Sequences2010

    • Author(s)
      Y.Koyama, K.Nishimuta, K Yamamori, M.Yasunaga, I Yoshihara
    • Journal Title

      Proc.Artificial Life and Robotics(AROB15th) 15th'10

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Identification of exon-intron boundaries by integration of base-oriented geneticprozramming and statistical heuristics2007

    • Author(s)
      Yamamori K, Fujita Y, Yoshihara I, Aikawa M
    • Journal Title

      Proc.Artificial Life and Robotics(AROB12th) 12th'07

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Identification of exon-intron boundaries by integration of base-oriented genetic programming and statistical heuristics2007

    • Author(s)
      Yamamori K, Fujita Y, Yoshihara I, Aikawa M
    • Journal Title

      Proc. Artificial Life and Robotics (AROB12th) 1(CD-ROM)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An Automatic Model Building for Time Series using Genetic Programming2007

    • Author(s)
      Yoshihara I, Yasunaga M, Yamamori K.
    • Journal Title

      Proc. Kantaoui Forum 1(CD-ROM)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of exon-intron boundaries by integration of base-oriented genetic programming and statistical heuristics2007

    • Author(s)
      Yamamori K, Fujita Y, Yoshihara I, Aikawa M
    • Journal Title

      Proc.Artificial Life and Robotics(AROB12th) (CD-ROM(4ページ))

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 画像圧縮技術を用いた生物種の類似性比較2006

    • Author(s)
      吉原郁夫、高島弘明、山森一人、菅原研
    • Journal Title

      宮崎大学工学部紀要 35

      Pages: 251-256

    • NAID

      110005001913

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] ゲノム解析に用いるDPマッチングの分割統治法による高速化2006

    • Author(s)
      中川匠、吉原郁夫、由森一人、安永守利
    • Journal Title

      宮崎大学工学部紀要 35

      Pages: 257-262

    • NAID

      110005001914

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 1/fゆらぎによる生物進化の解析2006

    • Author(s)
      佐藤真和、吉原郁夫、山森一人、安永守利
    • Journal Title

      宮崎大学工学部紀要 35

      Pages: 263-268

    • NAID

      110005001915

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] DNA塩基配列の統計力学的尺度を用いた生物進化の解析2006

    • Author(s)
      坂口慶幸、吉原郁夫、山森一人、剣持直哉
    • Journal Title

      宮崎大学工学部紀要 35

      Pages: 269-274

    • NAID

      110005001916

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 自己組織化マップを用いた生物進化系統の解析2006

    • Author(s)
      東祐輔、吉浜麻生、吉原郁夫、山森一人、剣持直哉
    • Journal Title

      宮崎大学工学部紀要 35

      Pages: 275-280

    • NAID

      110005001917

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Self-Organizing Map of Species using Ribosomal Protein DNA Sequences2006

    • Author(s)
      Y.Higashi, M.Yoshihama, I.Yoshihara, K.Yamamori, N.Kenmochi
    • Journal Title

      Proc.Artificial Life and Robotics(AROB11th) 11th'06(CD-ROM)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Non-transcriptional Region Analysis of Dictyostelium Discoideum using 1/fNoise2006

    • Author(s)
      M.Sato, I.Yoshihara, K.Yamamori, M.Yasunaga
    • Journal Title

      Proc.Artificial Life and Robotics(AROB11th) 11th'06(CD-ROM)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Similarity Comparisons of Seeds Using Image Comparison Technologies2006

    • Author(s)
      I.Yoshihara, H.Takashima, K.Yamamori, K.Suawara
    • Journal Title

      Memoirs of Faculty of Engineering, Univ.of Miyazaki No.35

      Pages: 251-256

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A Divide-and Conquer Method of Dynamic Programming for Genome Informatics2006

    • Author(s)
      T.Nakagawa, I.Yoshihara, K.Yamamori, M.Yasunaga
    • Journal Title

      Memoirs of Faculty of Engineering, Univ.of Miyazaki No.35

      Pages: 257-262

    • NAID

      110005001914

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Analysis of Biological Evolution using l/f Noise2006

    • Author(s)
      M.Sato, I.Yoshihara, K.Yamamori, M.Yasunaga
    • Journal Title

      Memoirs of Faculty of Engineering, Univ.of Miyazaki No.35

      Pages: 263-268

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Criterion of Evolution Analyszing DNA Sequences Based on Statistical Mechanics2006

    • Author(s)
      Y.Sakaguchi, I.Yoshihara, K.Yamamori, N.Kenmochi
    • Journal Title

      Memoirs of Faculty of Engineering, Univ.of Miyazaki No.35

      Pages: 269-274

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] SOM-based Classification of Species using Sequences of Ribosomal Protein Genes2006

    • Author(s)
      Y.Higashi, M.Yoshiharma, I.Yoshihara, K.Yamamori, N.Kenmochi
    • Journal Title

      Memoirs of Faculty of Engineering, Univ.of Miyazaki No.35

      Pages: 275-280

    • NAID

      110005001917

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 画像圧縮技術を用いた生物種の類似性比較2006

    • Author(s)
      吉原郁夫, 高島弘明, 山森一人, 菅原研
    • Journal Title

      宮崎大学工学部紀要 35

      Pages: 251-256

    • NAID

      110005001913

    • Related Report
      2006 Annual Research Report
  • [Journal Article] ゲノム解析に用いるDPマッチングの分析統治法による高速化2006

    • Author(s)
      中川匠, 吉原郁夫, 山森一人, 安永守利
    • Journal Title

      宮崎大学工学部紀要 35

      Pages: 257-262

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 1/fゆらぎによる生物進化の解析2006

    • Author(s)
      佐藤真和, 吉原郁夫, 山森一人, 安永守利
    • Journal Title

      宮崎大学工学部紀要 35

      Pages: 263-268

    • NAID

      110005001915

    • Related Report
      2006 Annual Research Report
  • [Journal Article] DNA塩基配列の統計力学的尺度を用いた生物進化の解析2006

    • Author(s)
      坂口慶幸, 吉原郁夫, 山森一人, 剣持直哉
    • Journal Title

      宮崎大学工学部紀要 35

      Pages: 269-274

    • NAID

      110005001916

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 自己組織化マップを用いた生物進化系統の解析2006

    • Author(s)
      東祐輔, 吉浜麻生, 吉原郁夫, 山森一人, 剣持直哉
    • Journal Title

      宮崎大学工学部紀要 35

      Pages: 275-280

    • NAID

      110005001917

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Self-Organizing Map of Species using Ribosomal Protein DNA Sequences2006

    • Author(s)
      Y.HIGASHI, M.YOSHIHAMA, I.OSHIHARA, K.YAMAMORI, N.KENMOCHI
    • Journal Title

      AROB 11th' 06

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Non-transcriptional Region Analysis of Dictyostelium Discoideum using 1/f Noise2006

    • Author(s)
      M.Sato, I.Yoshihara, K.Yamamori, M.Yasunaga
    • Journal Title

      AROB 11th' 06

    • Related Report
      2005 Annual Research Report
  • [Journal Article] DNA塩基配列の統計力学的尺度を用いた生物進化の解析2006

    • Author(s)
      坂口, 吉原, 山森, 剣持
    • Journal Title

      火の国情報シンポジウム 2006

    • NAID

      110005001916

    • Related Report
      2005 Annual Research Report
  • [Journal Article] リボソームタンパク質の塩基配列の自己組織化マップを用いた生物種分類2005

    • Author(s)
      東, 吉浜, 吉原, 山森, 剣持
    • Journal Title

      平成17年度電気関係学会九州支部連合大会 13-1P-01

      Pages: 526-526

    • NAID

      130004607993

    • Related Report
      2005 Annual Research Report
  • [Presentation] Quest for Genetic Information Hidden behind Disorder in DNA Sequences2010

    • Author(s)
      Y.Koyama, K.Nishimuta, K.Yamamori, M.Yasunaga, I Yoshihara
    • Organizer
      Artificial Life and Robotics(AROB 15th)
    • Place of Presentation
      Ohita, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] An Automatic Model Building for Time Series using Genetic Programming2007

    • Author(s)
      Yoshihara I, Yasunaga M, Yamamori K.
    • Organizer
      Proc.Kantaoui Forum
    • Place of Presentation
      Kantaoui, Tunisia
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Identification of exon-intron boundaries by integration of base-oriented genetic programming and statistical heuristics2007

    • Author(s)
      K.Yamamori, Y.Fujita, I.Yoshihara, M.Aikawa
    • Organizer
      Artificial Life and Robotics(AROB 12th)
    • Place of Presentation
      Ohita, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] An Automatic Model Building for Time Series using Genetic Programming2007

    • Author(s)
      I.Yoshihara, M.Yasunaga, K.Yamamori
    • Organizer
      Kantaoui Forum, Tunisia
    • Place of Presentation
      Tunis, Tunisia
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DNA塩基配列の統計力学的尺度を用いた生物進化の解析2006

    • Author(s)
      坂口、吉原、山森、剣持
    • Organizer
      火の国情報シンポジウム
    • Place of Presentation
      熊本大学
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Self-Organizing Map of Species using Ribosomal Protein DNA Sequences2006

    • Author(s)
      Y.Higashi, M.Yoshihama, I.Yoshihara, K.Yamamori, N.Kenmochi
    • Organizer
      Artificial Life and Robotics(AROB11th)
    • Place of Presentation
      Ohita, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Non-transcriptional Region Analysis of Dictyostelium Discoideum using l/f Noise2006

    • Author(s)
      M.Sato, I.Yoshihara, K.Yamamori, M.Yasunaga
    • Organizer
      Artificial Life and Robotics(AROB11th)
    • Place of Presentation
      Ohita, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Finding Evolution of Species by Analyzing DNA Sequences from the viewpoint of Statistical Mechanics2006

    • Author(s)
      Y.Sakaguchi, I.Yoshihara, K.Yamamori, N.Kenmochi
    • Organizer
      Hinokuni Symposium
    • Place of Presentation
      Kumamoto, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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