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Higy- resolution MRI-aided analysis of cortical circuit in monkey brains

Research Project

Project/Area Number 17500202
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionNational Center of Neurology and Psychiatry (2006-2007)
The University of Tokyo (2005)

Principal Investigator

NAKAHARA Kiyoshi  National Center of Neurology and Psychiatry, NCNP, Institute of Neuroscience, Section Chief (50372363)

Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2005: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsCerebral Cortex / Neuronal Circuit / Magentic Resonance Imaging / Microelectrode Recording / 単一神経細胞記録 / 局所神経回路 / 微小電極 / 核磁気共鳴画像法
Research Abstract

The localization of microelectrode recording sites in the layers of primate cerebral cortex permits the analysis of relationships between recorded neuronal activities and underlying anatomical connections. We have developed a magnetic resonance imaging method for precise in vivo localization of cortical recording sites. In this method, the susceptibility-induced effect thickens the appearance of the microelectrode and enhances the detectability of the microelectrode tip, which usually occupies less than a few percent of the volume of an image voxel. In a phantom study, the optimized susceptibility-induced effect allowed tip detection with single-voxel accuracy. We applied this method to recording microelectrodes inserted into the brains of macaque monkeys, and localized the microelectrode tip at an in-plane resolution of 150 um within the cortex of 2-3 mm in thickness. Subsequent histological analysis validated the single-voxel accuracy of the in vivo tip localization. This method opens up a way to investigate information flow during cognitive processes in the brain.

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (13 results)

All 2007 2006 2005

All Journal Article (7 results) (of which Peer Reviewed: 2 results) Presentation (6 results)

  • [Journal Article] MRI-based localization of electrophysiological recording sites within the cerebral cortex at single-voxel accuracy2007

    • Author(s)
      Teppei Matsui
    • Journal Title

      Nature Methods 4

      Pages: 161-168

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] MRI in monkeys:multi-modal links between human fMRI and macaque neurophysiology2007

    • Author(s)
      Kiyoshi Nakahara
    • Journal Title

      Trends in Cognitive Sciences 11

      Pages: 84-92

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] MRI-based localization of electrophysiological recording sites within the cerebral cortex at single-voxel accuracy2007

    • Author(s)
      Matsui T., et. al.
    • Journal Title

      Nature Methods 4

      Pages: 161-168

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] MRI in monkeys: multi-modal links between human fMRI and macaque neurophysiology2007

    • Author(s)
      Nakahara K., et. al.
    • Journal Title

      Trends in Cognitive Sciences 11

      Pages: 84-92

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] MRI-based localization of electrophysiological recording sites within the cerebral cortex at single-voxel accuracy2007

    • Author(s)
      Matsui T.
    • Journal Title

      nature methods 4

      Pages: 161-168

    • Related Report
      2006 Annual Research Report
  • [Journal Article] MRI in monkeys : multi-modal links between human fMRI and macaque neurophysiology2007

    • Author(s)
      Nakahara K.
    • Journal Title

      Trends in Cognitive sciences 11

      Pages: 84-92

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Program No.456.10. 4.7 T MRI-based detection of the tip of an electrode in monkey cortex.2005

    • Author(s)
      Matsui T.
    • Journal Title

      2005 Abstract Viewer and Itinerary Planner. Washington, DC : Society for Neuroscience Abstract, 2005. (CD-ROM)

    • Related Report
      2005 Annual Research Report
  • [Presentation] A non-magnetic mini-manipulaor for an MRI-based method for localization of a microelectrode tip within monkey cerebral cortex2007

    • Author(s)
      Kenji W.Koyano
    • Organizer
      日本生理学会大会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A non-magnetic mini-manipulaor for an MRI-based method for localization of a microelectrode tip within monkey cerebral cortex2007

    • Author(s)
      Koyano W.K., et. al.
    • Organizer
      Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Osaka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Localization of a microelectrode tip within the monkey temporal cortex using high-resolution MRI2006

    • Author(s)
      Kenji W.Koyano
    • Organizer
      日本神経科学大会
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Localization of a microelectrode tip within the monkey temporal cortex using high-resolution MRI2006

    • Author(s)
      Koyano W.K., et. al.
    • Organizer
      Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 4.7 T MRI-based detection of the tip of an electrode in monkey cortex2005

    • Author(s)
      Teppei Matsui
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington,DC
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 4.7 T MRI-based detection of the tip of an electrode in monkey cortex2005

    • Author(s)
      Matsui T., et. al.
    • Organizer
      Annual Meeting of the Society of Neuroscience
    • Place of Presentation
      Washington, DC
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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