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Magnetic resonance imaging mapping of brain functions based on brain surface normalization analysis using functional information

Research Project

Project/Area Number 17500203
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionThe University of Tokyo

Principal Investigator

KONISHI Seiki  The University of Tokyo, Graduate School of Medicine, Associate Professor (90323609)

Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2006: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2005: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordsfunctional MRI / frontal lobe / prefrontal cortex / inhibitory control / cognitive memory / temporal cortex / 抑制機能
Research Abstract

We developed the method by which different individual brain can be normalized into a standard template brain and better sensitivity to brain activation can be achieved. The method is based on two-dimensional cortical surface map and functional information obtained by functional magnetic resonance imaging (fMRI). We first explored, using fMRI, how the cerebral cortex, particularly the prefrontal cortex, is functionally organized. Three threads of results were revealed, each along one of the three axes in a stereotaxic atlas. The first concerns the left-right hemispheric axis, and it was found that the brain mechanism in the inferior frontal gyrus that supports inhibitory control is distributed in a traditional manner, such that the left hemisphere implements verbal functions and the right hemisphere implements nonverbal functions (Morimoto, et al., 2008). The second concerns the superior-inferior axis, and it was found that inhibitory control in naive subjects was supported by dorsal prefrontal mechanism whereas inhibitory control in naive subjects was supported by ventral prefrontal mechanism (Konishi, et al., 2008). The third one concerns the anterior-posterior axis, and it was found that the inhibitory control is implemented in the posterior part of the inferior frontal gyrus (pIFG) whereas processing of infrequent stimuli is implemented in the inferior frontal junction, located approximately 2 cm posterior to the pIFG (Chikazoe, et al., 2008). The information regarding functional organization of cerebral cortical functions obtained in these results provide the important fundamental principle necessary for precise mapping of the human brain functions.

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (38 results)

All 2008 2007 2006 2005

All Journal Article (24 results) (of which Peer Reviewed: 11 results) Presentation (14 results)

  • [Journal Article] Right temporopolar activation associated with unique perception2008

    • Author(s)
      Asari T.
    • Journal Title

      Neuroimage 41

      Pages: 145-152

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] On verba/nonverbal modality dependence of left and right inferior prefrontal activation during performance of flanker interference task2008

    • Author(s)
      Morimoto H.
    • Journal Title

      Journal of Cognitive Neuroscience 20(印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Differential superior prefrontal activity on initial versus subsequent shifts in naive subjects2008

    • Author(s)
      Konishi S.
    • Journal Title

      Neuroimage 41(印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Functional dissociation in right inferior frontal cortex during performance of go/no-go task2008

    • Author(s)
      Chikazoe J.
    • Journal Title

      Cerebral Cortex 18(印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Right temporopolar activation associated with unique perception2008

    • Author(s)
      Asari T., Konishi S., Jimura K., Chikazoe J., Nakamura N., Miyashita Y.
    • Journal Title

      Neuroimage 41

      Pages: 145-152

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] On verbal/nonverbal modality dependence of left and right inferior prefrontal activation during performance of flanker interference task2008

    • Author(s)
      Morimoto H., Hirose S., Chikazoe J., Jimura K., Asari T., Yamashita K., Miyashita Y., Konishi S.
    • Journal Title

      Journal of Cognitive Neuroscience 20

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Hirose S., Miyashita Y. Differential superior prefrontal activity on initial versus subsequent shifts in naive subjects2008

    • Author(s)
      Konishi S., Morimoto H., Jimura K., Asari T., Chikazoe J., Yamashita K.
    • Journal Title

      Neuroimage (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Functional dissociation in right inferior frontal cortex during performance of go/no-go task2008

    • Author(s)
      Chikazoe J., Jimura K., Asari T., Yamashita K., Morimoto H., Hirose S., Miyashita Y., Konishi S.
    • Journal Title

      Cerebral Cortex (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] On verbal/nonverbal modality dependence of left and right inferior prefrontal activation during performance of flanker interference task2008

    • Author(s)
      Morimoto H., Hirose S., Chikazoe J., Jimura K., Asari T., Yamashita K., Miyashita Y., Konishi S.
    • Journal Title

      Journal of Cognitive Neuroscience 20((印刷中)掲載確定)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential superior prefrontal activity on initial versus subsequent shifts in naive subjects2008

    • Author(s)
      Konishi S., Morimoto H., Jimura K., Asari T., Chikazoe J., Yamashita K., Hirose S., Miyashita Y
    • Journal Title

      Neuroimage 41((印刷中)掲載確定)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional dissociation in right inferior frontal cortex during performance of go/no-go task2008

    • Author(s)
      Chikazce J., Jimura K., Asari T., Yamashita K., Morimoto H., Hirose S., Miyashita Y., Konishi S.
    • Journal Title

      Cerebral Cortex 18((印刷中)掲載確定)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of right inferior frontal gyrus during response inhibition across response modalities2007

    • Author(s)
      Chikazoe J.
    • Journal Title

      Journal of Cognitive Neuroscience 19

      Pages: 69-80

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Activation of right inferior frontal gyrus during response inhibition across response modalities2007

    • Author(s)
      Chikazoe J., Konishi S., Asari T., Jimura K., Miyashita Y.
    • Journal Title

      Journal of Cognitive Neuroscience 19

      Pages: 69-80

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Activation of Right Inferior Frontal Gyrus during Response Inhibition across Response Modalities2007

    • Author(s)
      Chikazoe, et al.
    • Journal Title

      Journal of Cognitive Neuroscience 19

      Pages: 69-80

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Activation shift from medial to lateral temporal cortex associated with recency judgments following impoverished encoding2006

    • Author(s)
      Konishi S.
    • Journal Title

      Cerebral Cortex 16

      Pages: 469-474

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Activation shift from medial to lateral temporal cortex associated with recency judgments following impoverished encoding2006

    • Author(s)
      Konishi S., Asari, T., Jimura K., Chikaozoe J., Miyashita Y.
    • Journal Title

      Cerebral Cortex 16

      Pages: 469-474

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Activation shift from medial to lateral temporal cortex following impoverished encoding2006

    • Author(s)
      Konishi, et al.
    • Journal Title

      Cerebral Cortex 16

      Pages: 469-474

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Activation shift from medial to lateral temporal cortex following impoverished encoding.2006

    • Author(s)
      Konishi et al.
    • Journal Title

      Cerebral Cortex 16

      Pages: 469-474

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Neural mechanism in anterior prefrontal cortex for inhibition of prolonged set interference2005

    • Author(s)
      Konishi S.
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America 102

      Pages: 12584-12588

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Multiple components of lateral posterior parietal activation associated with cognitive set shifting2005

    • Author(s)
      Asari T.
    • Journal Title

      Neuroimage 26

      Pages: 694-702

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Neural mechanism in anterior prefrontal cortex for inhibition of prolonged set interference2005

    • Author(s)
      Konishi S., Chikazoe C., Jimura K., Asari T., Miyashita Y.
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America 102

      Pages: 12584-12588

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Multiple components of lateral posterior parietal activation associated with cognitive set shifting2005

    • Author(s)
      Asari T., Konishi S., Jimura K., Miyashita Y.
    • Journal Title

      Neuroimage 26

      Pages: 694-702

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Multiple components of lateral parietal activation associated with cognitive set shifting2005

    • Author(s)
      Asari et al.
    • Journal Title

      Neuroimage 26

      Pages: 694-702

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Neural mechanism in anterior prefrontal cortex for inhibition of prolonged set interference2005

    • Author(s)
      Konishi et al.
    • Journal Title

      Proceedings of national academy of sciences of the United States of America 102-35

      Pages: 12584-12588

    • Related Report
      2005 Annual Research Report
  • [Presentation] Superior prefrontal cortical recruitment during cognitive set shifting in naive subject2007

    • Author(s)
      Hirose S.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2007-11-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Miyashita Y., Konishi S. Superior prefrontal cortical recruitment during cognitive set shifting in naive subjects2007

    • Author(s)
      Hirose S., Morimoto H., Jimura K., Asari T., Chikazoe J., Yamashita K.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2007-11-07
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Superior prefrontal cortical recruitment during cognitive set shifting in naive subject2007

    • Author(s)
      Hirose S., Morimoto H., Jimura K., Asari T., Chikazoe J., Yamashita K., Miyashita Y., Konishi S.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2007-11-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] Functional dissociation in inferior frontal cortex during the go/no-go Task2007

    • Author(s)
      Chikazoe J.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2007-11-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Functional dissociation in inferior frontal cortex during the go/no-go task2007

    • Author(s)
      Chikazoe J., Jimura K., Asari T., Yamashita K., Morimoto H., Hirose S., Miyashita Y., Konishi S.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2007-11-06
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Temporal pole recruitment for 'theory of mind' associated with Neuroticism2007

    • Author(s)
      Jimura K.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The right anterior temporal activation associated with unique perception: an event-related fMRI study2007

    • Author(s)
      Asari T.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Temporal pole recruitment for 'theory of mind' associated with neuroticism Soc Neurosci abstr, 20072007

    • Author(s)
      Jimura K., Konishi S., Hirose S., Asari T., Chikazoe J., Miyashita Y.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Miyashita Y. The right anterior temporal activation associated with unique perception : an event-related fMRI study2007

    • Author(s)
      Asari T., Konishi S., Jimura K., Chikazoe J., Hirose S., Nakamura N.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Right and left inferior prefrontal activation associated with inhibition of flanker interference is independent of material modality of presented stimulus2007

    • Author(s)
      Morimoto H.
    • Organizer
      Organization for Human Brain Mapping
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2007-06-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Konishi S. Right and left inferior prefrontal activation associated with inhibition of flanker interference is independent of material modality of presented stimulus2007

    • Author(s)
      Morimoto H., Jimura K., Asari T., Chikazoe J., Yamashita K., Miyashita Y.
    • Organizer
      Organization for Haman Brain Mapping
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2007-06-12
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Asymmetric inferior frontal activation associated with inhibitory control of prepotent saccadic eye movements2006

    • Author(s)
      Chikazoe J.
    • Organizer
      Cognitive Neuroscience Society
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2006-04-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Transient activation of left anterior prefrontal cortex during inhibition of prolonged proactive interference from a previously acquired cognitive set2005

    • Author(s)
      Konishi S.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2005-11-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Transient activation of left anterior prefrontal cortex during inhibition of prolonged proactive interference from a previously acquired cognitive set Soc Neurosci abstr, 20052005

    • Author(s)
      Konishi S., Chikazoe J., Jimura K., Asari T., Miyashita Y.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2005-11-22
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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