| Project/Area Number |
17500240
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Nagoya University (2007)
Nippon Medical School (2005-2006) |
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Principal Investigator |
YAMAMOTO Naoyuki Nagoya University, Graduate Schcol of Bioagricultural Sciences, Associate Professor (80256974)
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| Co-Investigator(Kenkyū-buntansha) |
HAO-GANG Xue Nippon Medical School, Graduate School of Medicine, Assistant Professor (10328809)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,740,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2006: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2005: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | Neural circuitry / Brain / Evolution / GnRH / terminal nerve / fish / midbrain / 硬骨魚類 |
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| Research Abstract |
Neurons that contain gonadotropin-releasing hormone (GnRH) have been reported in most vertebrates. Although these cells contain GnRH, they do rot appear to control directly the gonadotropin release from the pituitary but may be involved in neuromodulatory action on behavior, e.g. sexual behavior. The functions of this peptidergic system still remain rather obscure, and this is due, in part, to pair knowledge on the input and output pathways of this system
1) Afferent sources to the GnRH-immunoreactive terminal nerve cells (TN cells) were studied in medaka and goldfish. The medaka was found to receive inputs from the nucleus tegmento-terminalis of the midbrain as in percomorph teleosts that am closely related to medaka Midbrain inputs presumably convey visual and somatosensory inputs to TN cells of medaka as in percomorphs. However, the goldfish was found to lack a nucleus tegmento-terminalis Instead, TN rats were suggested to receive fibers from the diencephalic, preglomerular nuclear complex, and preglomerular nuclei were hind to receive multiple modalities including visual, somatosensory, and lateral line inputs. Although neural circuitries may be different, multimodal inputs to the TN cells may be a character shared in teleosts.
2) Distribution of GnRH receptor subtypes (GnRHRs) were studied by means of immunohistocehmistry in a percomorph teleost, the dwarf gourami GnRBRimmunoreactive neurons were detected in a number of brain structures and mainly in the preoptic area and the secondary general visceral nucleus. The preoptic area is known to central reproductive behavior.
These findings suggest that multimodal sensory inputs presumably affect the activities TN cells, resulting in the modulation of behavior (e.g. sexual motivation) and processing of visceral senses.
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