| Project/Area Number |
17500269
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Hirosaki University |
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Principal Investigator |
KURATA Kiyoshi Hirosaki University, School of Medicine, Professor, 医学部, 教授 (30170070)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2005: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | reaching / adaptation / neuronal activity / cerebral cortex / premotor cortex / reference frame / 視覚座標系 / 運動座標系 / 座標変換 / 最適運動 / 利得制御 / 視覚運動変換 / 運動学習 |
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| Research Abstract |
In reaching, a spatial visuomotor transformation should occur in our brain. We can make the transformation not only when the relationship between visual and motor coordinates is default, but also when a gain for the relationship is changed, for example, in a microsurgery. We trained monkeys to make reaching movements when visuospatially identical targets were presented on a computer display by aligning a cursor that indicated their hand position, while the gain was systematically changed. We recorded and analyzed movement-related neuronal activity in the ventral premotor cortex (PMv) and the primary motor cortex (MI) during reaction time. It was revealed that a majority of the MI neurons and a part of the PMv neurons showed activity changes depending on executed movement direction, amplitude, and velocity, whereas a number of the PMv neurons exhibited activity consistent to the visual location of the targets, but not to motor parameters such as amplitude and velocity. Furthermore, introcortical microstimulation in the PMv evoked changes in direction and amplitude (gain) of reaching movements. The results indicate that the PMv contributes to gain control of reaching during visuomotor transformation.
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