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Functional analysis of premotor neurons in the brain stem during orienting movement ; neural responses to gaze perturbation.

Research Project

Project/Area Number 17500274
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurophysiology and muscle physiology
Research InstitutionTottori University

Principal Investigator

MATSUO Satoshi  Tottori University, Faculty of Medicine, Assistant Professor, 医学部, 講師 (40219390)

Co-Investigator(Kenkyū-buntansha) SHIRAISHI Yoshimitsu  Tottori University, Faculty of Medicine, Research Associate, 医学部, 助手 (80108810)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2005: ¥2,400,000 (Direct Cost: ¥2,400,000)
KeywordsSuperior Colliculus / Cat / Saccade / Eye-head coordination / Brain stem / Gaze / Saccade / 眼球運動
Research Abstract

This study was undertaken to investigate roles of the superior colliculus (SC) and saccade-related premotor areas during gaze saccades in alert cats. The animals were trained to obtain memory guided gaze shifts in darkness. The head is attached to a shaft connected to a friction clutch, which allowed us to immobilize the head for controlled time periods (10 ms-400 ms). A brake immobilized the head shortly after its onset. The eye saccade stopped soon after head velocity declined to zero and, during the ensuing period of head-immobilization, the eye remained immobile in the orbit. The mean time between the onset of the brake-induced head deceleration and when eye velocity became zero (i.e. the onset of the gaze plateau) was 48.5ms ± 19.2ms. Upon brake release the head resumed its movement and an ocular counter-rotation compensated for initial head motion so as to stabilize gaze, resulting in a gaze plateau. After the plateau, a corrective eye saccade was triggered together with head mot … More ion. No corrective saccades, that preceded head-release, were ever seen. Thus, these results showed that cats actually compensated for the brake-induced gaze perturbation.
We first explored the SC's motor map using electrical stimulation. Then, we recorded gaze saccade-related neurons (GSRNs) on the map in the intermediate and deep layers during gaze perturbation. We also recorded the activity of collicular fixation neurons (SCFNs) in the fixation zone of the rostral SC. Activity of both the SC neurons reflected gaze perturbation trajectories, and not related to eye and head velocities. Both the cells encoded gaze-position error which is distance between a target and current gaze position. Axons of GSRNs projected to the ventral part of the abducens nucleus. SCFNs projected to the pontine raphe nucleus where the omnipause neurons (OPNs) were located. A part of the SCFNs have axon collaterals projecting to further caudal areas. Next, we recorded OPNs in the pontine raphe nuclei. Activity of OPNs was higher than SCFNs during gaze fixations. The discharges were related to eye movement during brake-induced gaze plateau. However SCFNs were not related to eye movement. Therefore, these results suggest that activity of OPNs requires additive inputs besides SCFNs. Less

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (6 results)

All 2007 2006 2005

All Journal Article (6 results)

  • [Journal Article] Axonal projections of collicular fixation neurons and the responses to gaze shift perturbations in head-unrestrained cat2007

    • Author(s)
      Satoshi Matsuo
    • Journal Title

      The Journal of Physiological Sciences 57 suppl.

    • NAID

      130005449085

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Axonal projections of collicular fixation neurons and the responses to gaze shift perturbations in head-unrestrained cat2007

    • Author(s)
      Satoshi Matsuo
    • Journal Title

      The Journal of Physiological Sciences 57 suppl

    • NAID

      130005449085

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Firing pattern of the cat superior colliculus neurons during head unrestrained gaze shifts and their axonal projections2006

    • Author(s)
      Satoshi Matsuo
    • Journal Title

      The Journal of Physiological Sciences 56 suppl.

    • NAID

      130007038900

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Firing pattern of the cat superior colliculus neurons during head unrestrained gaze shifts and their axonal projections2006

    • Author(s)
      Satoshi Matsuo
    • Journal Title

      The Journal of Physiological Sciences 56 suppl

    • NAID

      130007038900

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Firing pattern of the cat superior colliculus neurons during head unrestrained gaze and their axonal projections2006

    • Author(s)
      Satoshi Matsuo
    • Journal Title

      The Journal of Physiological Sciences 56 suppl.

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 頭部無拘束ネコにおけるGaze Saccade時の上丘ニューロンの活動2005

    • Author(s)
      松尾 聡, 他
    • Journal Title

      Equilibrium Research 64・3

      Pages: 180-185

    • NAID

      10017269365

    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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