| Project/Area Number |
17500309
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kumamoto University |
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Principal Investigator |
NISHIDA Kenro Kumamoto University, University, Hospital, Research Associate, 医学部附属病院, 助手 (50336244)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAMURA Nobuhiro Kumamoto University, University, Hospital, Assistant Professcr, 医学部附属病院, 講師 (40274716)
TOYONAGA Tetsushi Kumamoto University, Faculty of Medical and Phamaceutical Scienc es, Assistant Professor, 大学院医学薬学研究部, 講師 (60295128)
ARAKI Eiichi Kumamoto University, Faculty of Medical and Phamaceutical Sciences, Professor, 大学院医学薬学研究部, 教授 (10253733)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2005: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | non-invasive measuring system / blood glucose measurement / haemoglobin A1C / multivariate analysis |
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| Research Abstract |
To development of near-infrared measuring system for blood glucose and hemoglobin A1e, we fabricated the Fourier-transform near-infrared spectroscopy with diffuse reflection prism.
1. Development of blood glucose measurement system use of near-infrared rays diffuse reflection light.
The spectrum of the glucose solution concentration 0mg/dl and 1000mg/dl was measured by using the near-infrared rays diffuse reflection light, and the difference spectrum was calculated, glucose specific spectrum was admitted around 6000cm-1. In addition, correlation coefficient r=0.84 and a high correlation were admitted in the range of glucose concentration from 0 to 1000mg/dl since the relation between a spectrum strength and glucose concentration to glucose was analyzed in the multivariate. In addition, non-invasive blood glucose measurement system was basic examined for the able-bodied person. The relation between a spectrum strength and glucose concentration to glucose was analyzed by the multivariate a
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nalysis, therefore correlation coefficient r=0.68 and a significant correlation were admitted in the range of glucose concentration from 70 to 300mg/dl between the spectrum and the blood sugar level having obtained it in the forearm flexor aspect. Moreover, the spectrum of diabetic's forearm flexor aspect; was measured, and the same analysis as the able-bodied person was done. As a result, correlation coefficient r=0.60 and a significant correlation were admitted in the range of glucose concentration from 80 to 260mg/dl between the spectrum and the blood glucose level having obtained it in the forearm flexor aspect.
2. Development of haemoglobin A1c measurement system use of near-infrared rays diffuse reflection light.
The change of the spectrum by the haemoglobin A1C was derived by subtracting the spectrum of all bloods of an already-known density of the haemoglobin from the Shica spectrum of the sample for haemoglobin A1c measurement to identify a spectrum in the near-infrared rays region of haemoglobin A1c, and a spectrum to haemoglobin A1c in the near-infrared rays region was identified. In addition, correlation coefficient r=0.64 and a significant correlation were admitted in the range of haemoglobin A1c from 5.2 to 8.6% by the multivariate analysis. Next, the spectrum of forearm flexor aspect of healthy subjects was admitted and neither correlation coefficient 0.41 nor a significant correlation were admitted in the range of haemoglobin A1c from 4.5 to 5.3% by the multivariate analysis. A similar examination was done in the diabetic, therefore correlation coefficient 0.54 and a significant correlation were admitted in the range of haemoglobin A1c from 5.2 to 8.1%. Less
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