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Development of blood flow analysis system for total blood through micro-channel in biochip

Research Project

Project/Area Number 17500321
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionKansai University

Principal Investigator

BANDO Kiyoshi  Kansai University, Faculty of Engineering, Professor, 工学部, 教授 (70156545)

Co-Investigator(Kenkyū-buntansha) OHBA Kenkichi  Kansai University, Faculty of Engineering, Professor, 工学部, 教授 (30029186)
SAKURAI Atsushi  Kansai University, Faculty of Engineering, Lecturer, 工学部, 専任講師 (50162334)
TAJIKAWA Tsutomu  Kansai University, Faculty of Engineering, Lecturer, 工学部, 専任講師 (80351500)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2005: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsBiochip / Micro-channel / Coupled analysis / Red blood cell / Immersed boundary method / Capillary blood vessel / Deformability / In vitro experiment / 生体外実験 / 数値シミュレーション
Research Abstract

Practical two-dimensional, axi-symmetric and three-dimensional calculation methods by means of the immersed boundary method were shown in order to solve the coupled problem between flow of blood plasma and deformation of red blood cell in the flow channel as a model of micro-channel in biochips. In the immersed boundary method, the membrane of red blood cell is treated as body force in the flow equation. Therefore, by incorporating the structural analysis program into user-subroutine of flow analysis software whose code is highly tuned, it is possible to increase efficiencies of making program and calculation speed remarkably. Such a method was proposed and the effectiveness of the method was shown by performing numerical simulations of the tank-treading motion and the parachute-shaped deformation of red blood cell. Approximation method assuming axi-symmetric deformation of red blood cell will be useful in some situations. Then, basic equations for axi-symmetric deformation of membrane … More of red blood cell were shown and numerical simulation of the deformation of red blood cell flowing in the micro-channel was performed. The results thus obtained were compared with two-dimensional results and applicability of the axi-symmetric deformation theory was checked. In order to validate the calculation results, in-vitro experiment was carried out on the behavior and the deformability of red blood cell passing through micro-channel array as a model of blood capillary. Deformation and recovery process of the red blood cell was observed and theoretical analysis was performed. Through modeling of basement membrane of the airway to obtain reasonable membrane characteristics, it was clarified that viscous effect of the membrane is necessary to take into account in small time-scale phenomena, and the estimation method of the damping coefficient of the membrane was proposed based on validation experiment. Young's modulus of modeled red blood cell was calculated which was deformed in the micro-manipulator in order to obtain contact characteristics of red blood cell with channel wall. Furthermore, blood flow in blood collecting system fabricated by MEMS was observed and the applicability was checked. Less

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (27 results)

All 2007 2006 2005

All Journal Article (24 results) Book (3 results)

  • [Journal Article] 毛細血管中の赤血球の変形挙動に関する数値シミュレーション2007

    • Author(s)
      明珍英仁, 板東潔, 大場謙吉
    • Journal Title

      第11回関西大学先端科学技術シンポジウム講演論文集

      Pages: 233-236

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] マイクロチャンネルを用いた毛細血管中の赤血球の変形挙動に関する実験(保存期間と変形能の関係)2007

    • Author(s)
      大野貴也, 田地川勉, 大場謙吉
    • Journal Title

      第19回バイオエンジニアリング講演会講演論文集 No. 06-65

      Pages: 290-291

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Development and application of an ultra-miniaturized blood collecting/testing system by MEMS2007

    • Author(s)
      S.Nakahara, S.Aoyagi, N.Tagawa, Y.Arai, K.Bando, S.Tamura, T.Tajikawa
    • Journal Title

      Technology Reports of Kansai University No. 49(印刷中)

    • NAID

      110006556841

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Numerical Simulation of Deformation Behavior of Red Blood Cell in Blood Capillary2007

    • Author(s)
      H.Myochin, K.Bando, K.Ohba
    • Journal Title

      Proceedings of 11th Innovative Science and Technology Symposium of Kansai University

      Pages: 233-236

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Experiment on Deformation Behavior of Red Blood Cell in Blood Capillary Modeled by Micro-channel (Relation between Preservation Time and Deformability)2007

    • Author(s)
      T.Ohno, T.Tajikawa, K.Ohba
    • Journal Title

      Proceedings of 19th Bioengineering Conference No.06-65

      Pages: 290-291

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Development and application of an ultra-miniaturized blood collecting/testing system by MEMS2007

    • Author(s)
      S.Nakahara, S.Aoyagi, N.Tagawa, Y.Arai, K.Bando, S.Tamura, T.Tajikawa
    • Journal Title

      Technology Reports of Kansai University No.49(in press)

    • NAID

      110006556841

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 毛細血管中の赤血球の変形挙動に関する数値シミュレーション2007

    • Author(s)
      明珍英仁, 板東潔, 大場鎌吉
    • Journal Title

      第11回関西大学先端科学技術シンポジウム講演論文集

      Pages: 233-236

    • Related Report
      2006 Annual Research Report
  • [Journal Article] マイクロチャンネルを用いた毛細血管中の赤血球の変形挙動に関する実験(保存期間と変形能の関係)2007

    • Author(s)
      大野貴也, 田地川勉, 大場鎌吉
    • Journal Title

      第19回バイオエンジニアリング講演会講演論文集 No.06-65

      Pages: 290-291

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Development and application of an ultra-miniaturized blood collecting/testing system by MEMS2007

    • Author(s)
      S.Nakahara, S.Aoyagi, N.Tagawa, Y.Arai, K.Bando, S.Tamura, T.Tajikawa
    • Journal Title

      Technology Reports of Kansai University No.49(印刷中)

    • NAID

      110006556841

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 気道狭窄の動的座屈モデルによる解析2006

    • Author(s)
      板東潔, 大場謙古, 岩崎正隆
    • Journal Title

      日本機械学会論文集C編 72・717

      Pages: 1462-1469

    • NAID

      110004738280

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 数値シミュレーションによる鼻腔,咽頭の実形状モデル内の気流動態の解明2006

    • Author(s)
      竹内尚哉, 板東潔, 田地川勉, 大場謙吉, 上杉康夫
    • Journal Title

      第84期流体工学部門講演会CD-ROM版講演論文集

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Analysis of Airway Narrowing Based on Dynamic Buckling Model2006

    • Author(s)
      K.Bando, K.Ohba, M.Iwasaki
    • Journal Title

      Transactions of JSME, Ser.C 72-717

      Pages: 1462-1469

    • NAID

      110004738280

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Clarification of Respiratory Airflow in Realistic Model of Hman Nasal Cavity and Nasopharynx by Means of Numerical Simulation2006

    • Author(s)
      N.Takeuchi, K.Bando, T.Tajikawa, K.Ohba, Y.Uesugi
    • Journal Title

      Proceedings CD-ROM of 84th Fluids Engineering Conference

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 気道狭窄の動的座屈モデルによる解析2006

    • Author(s)
      板東潔, 大場鎌吉, 岩崎正隆
    • Journal Title

      日本機械学会論文集C編 72・717

      Pages: 1462-1469

    • NAID

      110004738280

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 数値シミュレーションによる鼻腔、咽頭の実形状モデル内の気流動態の解明2006

    • Author(s)
      竹内尚哉, 板東潔, 田地川勉, 大場鎌吉, 上杉康夫
    • Journal Title

      第84期流体工学部門講演会CD-ROM版講演論文集

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Development of fine alginate gel particles as model /artificial blood cells and measurement of its elastic characteristics2006

    • Author(s)
      K.Ohba, A.Sakurai, T.Tajikawa, K.Bando, K.Maeda, N.Yamakawa
    • Journal Title

      CD-ROM of 5th World Congress of Biomechanic

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 気道狭窄の動的座屈モデルによる解析2006

    • Author(s)
      板東潔, 大場謙吉, 岩崎正隆
    • Journal Title

      日本機械学会論文集(C編) (印刷中)

    • NAID

      110004738280

    • Related Report
      2005 Annual Research Report
  • [Journal Article] マイクロチャンネルアレイを用いた毛細血管中の赤血球の挙動と変形能に関する生体外実験-変形及び回復過程の観測と解析II-2006

    • Author(s)
      榊原千礼, 田地川勉, 大場謙吉
    • Journal Title

      第18回バイオエンジニアリング講演会講演論文集 No.05-66

      Pages: 117-118

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 鼻腔,咽頭の実形状モデルにおける呼吸に伴う往復気流に関する数値シミュレーション2006

    • Author(s)
      竹内尚哉, 板東潔, 田地川勉, 大場謙吉, 上杉康夫
    • Journal Title

      第10回関西大学先端科学技術シンポジウム講演集

      Pages: 176-179

    • Related Report
      2005 Annual Research Report
  • [Journal Article] マイクロチャンネルアレイを用いた毛細血管中の赤血球の挙動と変形能に関する生体外実験2005

    • Author(s)
      田地川勉, 大場謙吉, 樋口勝啓, 榊原千礼
    • Journal Title

      可視化情報学会論文集 25・12

      Pages: 84-91

    • NAID

      10013272688

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Visualization and Observation of Deformation of Human Red Blood Cell Passing through a Micro-channel Array as a Model of Human Blood Capillary2005

    • Author(s)
      T.Tajikawa, K.Ohba, K.Higuchi, C.Sakakibara
    • Journal Title

      Transactions of the Visualization Society of Japan 25-12

      Pages: 84-91

    • NAID

      110006636835

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 喘息時に発症する気道狭窄の動的座屈モデルによる解析2005

    • Author(s)
      板東潔, 大場謙吉
    • Journal Title

      第18回計算力学講演会講演論文集 No.05-2

      Pages: 49-50

    • Related Report
      2005 Annual Research Report
  • [Journal Article] マイクロチャンネルアレイを用いた毛細血管中の赤血球の挙動と変形能に関する生体外実験-変形及び回復過程の観測と解析-2005

    • Author(s)
      榊原千礼, 田地川勉, 大場謙吉
    • Journal Title

      第16回バイオフロンティア講演会講演論文集 No.05-53

      Pages: 151-152

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 鼻腔,咽頭の実形状モデルにおける呼吸に伴う往復気流に関する数値シミュレーション2005

    • Author(s)
      竹内尚哉, 田地川勉, 桜井篤, 板東潔, 大場謙吉
    • Journal Title

      第16回バイオフロンティア講演会講演論文集 No.05-53

      Pages: 157-158

    • Related Report
      2005 Annual Research Report
  • [Book] 流体の力学-現象とモデル化-2006

    • Author(s)
      大場謙吉, 板東潔
    • Total Pages
      203
    • Publisher
      コロナ社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] Fluid Mechanics -Phenomenon and Its Modeling-2006

    • Author(s)
      K.Ohba, K.Bando
    • Total Pages
      203
    • Publisher
      CORONA Publishing Co. Ltd
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 流体の力学-現象とモデル化-2006

    • Author(s)
      大場兼吉, 板東潔
    • Total Pages
      203
    • Publisher
      コロナ社
    • Related Report
      2006 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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