Vaslcular Dilatation and Improvement of Tissue Perfusion Induced by Low-Frequency Ultrasound: Influence of Nitric Oxide in Tissue
| Project/Area Number |
17500327
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Osaka University |
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Principal Investigator |
ASANUMA Toshihiko Osaka University, Graduate School of Medicine, Assistant Prof, 大学院・医学系研究科, 特任助手 (80379271)
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| Co-Investigator(Kenkyū-buntansha) |
BEPPU Shintaro Osaka University, Graduate School of Medicine, Prof, 大学院・医学系研究科, 教授 (40113500)
ISHIKURA Fuminobu Osaka University, Graduate School of Medicine, Associate Prof, 大学院・医学系研究科, 助教授 (50303970)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2005: ¥3,000,000 (Direct Cost: ¥3,000,000)
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| Keywords | Untrasound / Nitric Oxide / Biomolecule |
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| Research Abstract |
Background : Noninvasive application of low-frequency ultrasound causes arterial vasodilation and improves tissue perfusion. Although the mechanism is unclear, a nitric oxide (NO)-dependent mechanism is considered. We evaluated whether low-frequency ultrasound can produce expression of endothelial nitric oxide synthase (eNOS) in the rat heart.
Methods : Using 22 anesthetized Sprague-Dawley rats, 45 kHz ultrasound (750 mW) was insonated to the hearts (group A: 30 minutes of insonation × 1 day; group B: 30 minutes of insonation × 6 days). The expression of eNOS was analyzed by Western blotting.
Results : Compared to the expression of eNOS in sham group (100%), that in group A did not change (107±24%); however, that in group B increased (141±38%).
Conclusion : The finding of the current study indicates that the energy of low-frequency ultrasound can produce expression of eNOS.
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Report
(3 results)
Research Products
(18 results)
