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Vaslcular Dilatation and Improvement of Tissue Perfusion Induced by Low-Frequency Ultrasound: Influence of Nitric Oxide in Tissue

Research Project

Project/Area Number 17500327
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionOsaka University

Principal Investigator

ASANUMA Toshihiko  Osaka University, Graduate School of Medicine, Assistant Prof, 大学院・医学系研究科, 特任助手 (80379271)

Co-Investigator(Kenkyū-buntansha) BEPPU Shintaro  Osaka University, Graduate School of Medicine, Prof, 大学院・医学系研究科, 教授 (40113500)
ISHIKURA Fuminobu  Osaka University, Graduate School of Medicine, Associate Prof, 大学院・医学系研究科, 助教授 (50303970)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2005: ¥3,000,000 (Direct Cost: ¥3,000,000)
KeywordsUntrasound / Nitric Oxide / Biomolecule
Research Abstract

Background : Noninvasive application of low-frequency ultrasound causes arterial vasodilation and improves tissue perfusion. Although the mechanism is unclear, a nitric oxide (NO)-dependent mechanism is considered. We evaluated whether low-frequency ultrasound can produce expression of endothelial nitric oxide synthase (eNOS) in the rat heart.
Methods : Using 22 anesthetized Sprague-Dawley rats, 45 kHz ultrasound (750 mW) was insonated to the hearts (group A: 30 minutes of insonation × 1 day; group B: 30 minutes of insonation × 6 days). The expression of eNOS was analyzed by Western blotting.
Results : Compared to the expression of eNOS in sham group (100%), that in group A did not change (107±24%); however, that in group B increased (141±38%).
Conclusion : The finding of the current study indicates that the energy of low-frequency ultrasound can produce expression of eNOS.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (18 results)

All 2006 2005

All Journal Article (17 results) Book (1 results)

  • [Journal Article] Impact of the coronary flow reduction at rest on myocardial perfusion and functional indices derived from myocardial contrast and strain echocardiography2006

    • Author(s)
      Okuda K, et al.
    • Journal Title

      J Am Soc Echocardiogr 19

      Pages: 781-787

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A fundamental study for quantitative measurement of ultrasound contrast concentration by low mechanical index contrast ultrasonography2006

    • Author(s)
      Yamada S, et al.
    • Journal Title

      J Med Ultrasonics 33

      Pages: 77-83

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Corrected quantification method to determine myocardial blood flow using real-time myocardial contrast echocardiography2006

    • Author(s)
      Otani K, et al.
    • Journal Title

      J Am Soc Echocardiogr 19

      Pages: 973-981

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Destruction of microbubbles in ventricular cavities affects the quantitative assessment of myocardial perfusion during real-time myocardial contrast echocardiography2006

    • Author(s)
      Otani K, et al.
    • Journal Title

      J Echocardiogr 4

      Pages: 78-83

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Spatial extent of postsystolic thickening during myocardial ischemia : evaluation by velocity vector imaging2006

    • Author(s)
      Asanuma T, et al.
    • Journal Title

      J Echocardiogr 4

      Pages: 84-85

    • NAID

      130004471049

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 心筋虚血進展のカスケードと心エコー法 : 灌流と壁運動評価の意義2006

    • Author(s)
      浅沼 俊彦, 別府 慎太郎
    • Journal Title

      心エコー 7

      Pages: 416-424

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Ischemic Cascade and Echocardiography (Japanese)2006

    • Author(s)
      Asanuma T, Beppu S.
    • Journal Title

      Journal of Clinical Echocardiography 7

      Pages: 416-424

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Complete bubble destruction is essential for quantitative assessment from the replenishment curve in real-time myocardial contract echocardiography2005

    • Author(s)
      Otani K, et al.
    • Journal Title

      J Echocardiogr 3

      Pages: 21-26

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Noninvasive quantification of regional ventricular function in rats : assessment of serial change and spatial distribution using ultrasound strain analysis2005

    • Author(s)
      Hirano T, et al.
    • Journal Title

      J Am Soc Echocardiogr 18

      Pages: 907-912

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Efficacy of 1.5 harmonic imaging for intravenous myocardial contrast echocardiography2005

    • Author(s)
      Toshida T, et al.
    • Journal Title

      J Echocardiogr 3

      Pages: 104-108

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 心筋虚血の考え方2005

    • Author(s)
      別府 慎太郎
    • Journal Title

      心エコー 6

      Pages: 1028-1035

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 血栓形成の考え方2005

    • Author(s)
      別府 慎太郎
    • Journal Title

      心エコー 6

      Pages: 1116-1123

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 循環器領域における造影超音波の現状と展望2005

    • Author(s)
      浅沼 俊彦, 別府 慎太郎
    • Journal Title

      Ultrasonic Technology 17

      Pages: 21-24

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Myocardial Ischemia (Japanese)2005

    • Author(s)
      Beppu S.
    • Journal Title

      Journal of Clinical Echocardiography 6

      Pages: 1028-1035

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Cardiac Thrombus (Japanese)2005

    • Author(s)
      Beppu S.
    • Journal Title

      Journal of Clinical Echocardiography 6

      Pages: 1116-1123

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Contrast Echocardiography (Japanese)2005

    • Author(s)
      Asanuma T, Beppu S.
    • Journal Title

      Ultrasonic Technology 17

      Pages: 21-24

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Myocardial contrast echocardiography (Japanese)2005

    • Author(s)
      Beppu S.
    • Journal Title

      Practical Cardiology : Coronary Artery Disease I (Bunkodo)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 心筋コントラストエコー法新・心臓病診療プラクティス・冠動脈疾患を診るI2005

    • Author(s)
      別府 慎太郎(共著)
    • Publisher
      文光堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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