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Analysis of biological malignancy in early stage HCC using low MI contrast ultrasound and angiogenesis factors.

Research Project

Project/Area Number 17500336
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionHyogo College of Medicine

Principal Investigator

IIJIMA Hiroko  Hyogo College of Medicine, Faculty of Medicine, Associate Professor, 医学部, 助教授 (80289066)

Co-Investigator(Kenkyū-buntansha) MORIYASU Fuminori  Tokyo Medical University, Faculty of Medicine, Professor, 医学部, 教授 (80191055)
MIYAHARA Takeo  Tokyo Medical University, Faculty of Medicine, Assistant Professor, 医学部, 講師 (10333056)
IKEDA Naoto  Hyogo College of Medicine, Faculty of Medicine, Hospital Assistant, 医学部, 病院助手 (00425125)
鈴木 史朗  東京医科大学, 医学部, 助手 (10372955)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2005: ¥2,700,000 (Direct Cost: ¥2,700,000)
Keywordscontrast ultrasound / microbubble / Neovascularize / hepatocellular carcinoma
Research Abstract

PUROPOSE: We have performed visualization of hepatic microcirculation using a new modality of contrast ultrasound, Micro Flow Imaging (MFI) composed of a flash replenishment and maximum intensity holding sequences.
MTHODS and MATERIALS: Flash replenishment imaging is an imaging mode which visualizes a re-perfusion of microbubbles with a harmonic ultrasound of a low mechanical index (MI) after destruction of microbubbles with a short time high MI ultrasound exposure. We combined the replenishment imaging with a maximum intensity holding sequence and it is called as MFI, in which the maximum signal reaching at an imaging pixel is hold and images are overlayed. We applied this technique to visualization of neovascularized microcirculation of hepatocellular carcinoma (HCC). The contrast agents used were SonoVue. The subjects were 54 patients with HCCs. The tumor size was ranged from 1 to 5cm and the average was 2.5cm.
RESULTS: Hepatic vasculature was opacified with contrast media continuousl … More y until the terminal branches of the neovascularized tumor vessels. The minimum size was 200 μm or less. Tumor vessels of HCC were 1) irregularity in the caliber, 2) tortuosity of traveling and 3) heterogeneity of vascular distribution. These findings were categorized into three patterns. One is "cotton pattern", second "vascular pattern" and the third is "dead branch patter". Pathological findings were compared to these MFI patterns. The "cotton pattern" was often seen in well differentiated HCC, the "vascular pattern" in moderately differentiated HCC and the "dead branch patter" in poorly differentiated HCC. Manifestation of MFI was explained by biological features of neovascularization and vascular invasion according to the histological differentiation.
CONCLUSIONS: It has been successfully performed to visualize tumor microcirculation using the MFI sequence, which has not been observed using conventional imaging modalities. Neovascularized tumor vessels were characteristically recognized and it is suggested that this technique will contribute greatly to clinical diagnosis of biological malignant features of HCCs. Less

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (28 results)

All 2007 2006 2005

All Journal Article (28 results)

  • [Journal Article] Parametric imaging of contrast ultrasound for the evaluation of neovascularization in liver tumors.2007

    • Author(s)
      Sugimoto, K. et al.
    • Journal Title

      Hepatol. Res. 37・6

      Pages: 464-472

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Phagocytosis of ultrasound contrast agent microbubbles by Kupffer cells.2007

    • Author(s)
      Yanagisawa, K. et al.
    • Journal Title

      Ultrasound Med. Biol. 33・2

      Pages: 318-325

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Dynamic US contrast study of the liver : Vascular and delayed parenchymal phase.2007

    • Author(s)
      Iijima, H. et al.
    • Journal Title

      Hepatol. Res. 37・1

      Pages: 27-34

    • NAID

      10018567661

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Parametric imaging of contrast ultrasound for the evaluation of neovascularization in liver tumors.2007

    • Author(s)
      Sugimoto, K. et al.
    • Journal Title

      Hepatol. Res. 37(6)

      Pages: 464-472

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Phagocytosis of ultrasound contrast agent microbubbles by Kupffer cells.2007

    • Author(s)
      Yanagisawa, K. et al.
    • Journal Title

      Ultrasound Med. Biol. 33(2)

      Pages: 318-325

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Dynamic US contrast study of the liver : Vascular and delayed parenchymal phase.2007

    • Author(s)
      Iijima, H. et al.
    • Journal Title

      Hepatol. Res. 37(1)

      Pages: 27-34

    • NAID

      10018567661

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Dynamic US contrast study of the liver : Vascular and delayed parenchymal phase.2007

    • Author(s)
      Iijima, H. et al.
    • Journal Title

      Hepatol.Res. 37・1

      Pages: 27-34

    • NAID

      10018567661

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Phagocytosis of ultrasound contrast agent microbubbles by Kupffer cells.2007

    • Author(s)
      Yanagisawa, K. et al.
    • Journal Title

      Ultrasound Med.Biol. 33・2

      Pages: 318-325

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Quantification of hepatic parenchymal blood flow by contrast ultrasonography with flash-replenishment imaging.2006

    • Author(s)
      Metoki, R. et al.
    • Journal Title

      Ultrasound Med. Biol. 32・10

      Pages: 1459-1466

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Ultrasound contrast agent, Levovist microbubbles are phagocytosed by Kupffer cells - In vitro and in vivo studies.2006

    • Author(s)
      Iijima, H. et al.
    • Journal Title

      Hepatol. Res. 35・4

      Pages: 235-237

    • NAID

      10018774508

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Visualization of the drainage veins with contrast enhanced sonography was useful in diagnosis of small focal nodular hyperplasia.2006

    • Author(s)
      Iijima, H. et al.
    • Journal Title

      J Ultrasound Med. 25・6

      Pages: 799-803

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Quantification of hepatic parenchymal blood flow by contrast ultrasonography with flash-replenishment imaging.2006

    • Author(s)
      Metoki, R. et al.
    • Journal Title

      Ultrasound Med. Biol. 32(10)

      Pages: 1459-1466

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Ultrasound contrast agent, Levovist microbubbles are phagocytosed by Kupffer cells-In vitro and in vivo studies.2006

    • Author(s)
      Iijima, H. et al.
    • Journal Title

      Hepatol. Res. 35(4)

      Pages: 235-237

    • NAID

      10018774508

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Visualization of the drainage veins with contrast-enhanced sonography was useful in diagnosis of small focal nodular hyperplasia.2006

    • Author(s)
      Iijima, H. et al.
    • Journal Title

      J. Ultrasound Med. 25(6)

      Pages: 799-803

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Ultrasound contrast agent, Levovist microbubbles are phagocytosed by Kupffer cells-In vitro and in vivo studies.2006

    • Author(s)
      Iijima, H. et al.
    • Journal Title

      Hepatol.Res. 35・4

      Pages: 235-237

    • NAID

      10018774508

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Quantification of hepatic parenchymal blood flow by contrast ultrasonography with flash-replenishment imaging.2006

    • Author(s)
      Metoki, R. et al.
    • Journal Title

      Ultrasound Med.Biol. 32・10

      Pages: 1459-1466

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Visualization of the drainage veins with contrast-enhanced sonography was useful in diagnosis of small focal nodular hyperplasia.2006

    • Author(s)
      Iijima, H. et al.
    • Journal Title

      J Ultrasound Med. 25・6

      Pages: 799-803

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 微小気泡造影剤を使った造影超音波診断の現状と展望2006

    • Author(s)
      森安史典, 飯島尋子
    • Journal Title

      肝臓 38・5

      Pages: 570-578

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 腹部領域における超音波技術の新しい潮流 コントラストエコー -次世代造影剤とその臨床応用-2005

    • Author(s)
      飯島尋子, 森安史典, Wilson, S.R
    • Journal Title

      総合臨牀 54・増刊

      Pages: 968-972

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 造影超音波によるNon-alcoholic Steatohepatitis(NASH)の診断.2005

    • Author(s)
      飯島尋子 他
    • Journal Title

      消化器科 40・1

      Pages: 90-94

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 肺血管腫の造影超音波診断2005

    • Author(s)
      飯島尋子 他
    • Journal Title

      超音波医学 32・3

      Pages: 305-311

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 肝の循環動態 基礎から臨床への展開 血流動態からみた肝の病態 その新たな展開 肝硬変の血行動態2005

    • Author(s)
      飯島尋子, 森安史典
    • Journal Title

      肝・胆・膵 51・3

      Pages: 355-361

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 膵癌の早期診断へのアプローチ 造影超音波検査による膵腫瘤性病変の血流動態と鑑別診断の有用性2005

    • Author(s)
      祖父尼淳 他
    • Journal Title

      膵臓 19・6

      Pages: 608-616

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 肝臓癌の臨床検査 超音波による肝臓癌診断2005

    • Author(s)
      山田昌彦, 飯島尋子, 森安史典
    • Journal Title

      臨床検査 49・11

      Pages: 1235-1239

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Diagnosis of NASH using delayed parenchymal imasing of contrast ultrasound2005

    • Author(s)
      oriyasu, F., Iijima, H.et al.
    • Journal Title

      Hepato.Res 33

      Pages: 97-99

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Differrential diagnosis of pancreatic tumors using ultrasound contrast imaging.2005

    • Author(s)
      Sofuni, A., Iijima, H.et al.
    • Journal Title

      J.Gastroenterol. 40・5

      Pages: 518-525

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Angiomyolipoma of the liver presenting a homogeneously hypoechoic mass.2005

    • Author(s)
      Iijima, H. et al.
    • Journal Title

      J.Gastroenterol. 40・9

      Pages: 916-917

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 局所療法後、増殖、転移が誘発された症例 膵頭十二指腸切除後肝転移を来し局所療法などで5年間の治療経過を有する膵腺房細胞癌の1例2005

    • Author(s)
      工藤幸正 他
    • Journal Title

      Liver Cancer 11・1

      Pages: 63-72

    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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