| Project/Area Number |
17500368
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Rehabilitation science/Welfare engineering
|
|---|
| Research Institution | Wakayama medical university |
|---|
Principal Investigator |
TAJIMA F. Wakayama medical university, medical department, professor, 医学部, 教授 (00227076)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Takeshi Wakayama medical university, medical department, lecturer, 医学部, 講師 (80299635)
TOGE Yasushi Wakayama medical university, medical department, lecturer, 医学部, 講師 (10372864)
|
|---|
| Project Period (FY) |
2005 – 2006
|
| Project Status |
Completed (Fiscal Year 2006)
|
| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2006: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2005: ¥1,600,000 (Direct Cost: ¥1,600,000)
|
|---|
| Keywords | Adrenaline / Cortisol / Prostaglandin / Immune system / Exercise / Spinal cord injuries |
|---|
| Research Abstract |
The purpose of the present study was to determine natural killer cell activity (NKCA) to 2-hour arm ergometer exercise in persons with spinal cord injuries (SCI) and the underlying mechanism of such responses. We examined NKCA response to 2-hour arm crank ergometer exercise at 60% of maximum oxygen consumption (VO2max) in SCI and able-bodied persons. NKCA and plasma concentrations of prostaglandin E2 (PGE2), adrenaline and cortisol were measured before, during, immediately after, and recovery of the exercise. The study included seven subjects with SCI between Thl 1 and L4 and 6 able-bodied persons. NKCA in able-bodied subjects increased (P <0.05) at 60 min of exercise and immediately after the exercise, and remained elevated up to 2 h after exercise. However, NKCA in SCI decreased (P <0.05) immediately after exercise but recovered at 2 h after exercise. Plasma adrenaline in both groups increased significantly (P <0.05) immediately after exercise and returned to baseline level 2 h after the exercise. Plasma cortisol in both groups remained constant throughout the study. In SCI, PGE2 significantly increased immediately after 2 h exercise and returned to the baseline level 2 h after exercise, however it remained unchanged during the test in able-bodied subjects. Our results suggested that increase of PGE2 in SCI partially contributes to NKCA.
|
