| Project/Area Number |
17500369
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Rehabilitation science/Welfare engineering
|
|---|
| Research Institution | Saitama Medical University |
|---|
Principal Investigator |
MAKITA Shigeru Saitama Medical University, Faculty of Medicine, Associate Professor (40316708)
|
|---|
| Project Period (FY) |
2005 – 2007
|
| Project Status |
Completed (Fiscal Year 2007)
|
| Budget Amount *help |
¥2,950,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2006: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2005: ¥1,500,000 (Direct Cost: ¥1,500,000)
|
|---|
| Keywords | cardiac rehabilitation / open heart suraery / cellular immunit / サイトカイン / 運動耐容能 / LVAS |
|---|
| Research Abstract |
It is widely recognized that cardiac rehabilitation improves exercise capacity, various coronary risk factors, anxiety and prognosis of cardiac patients. But little is known about effect of cardiac rehabilitation on cellular immunity. The purpose of this study was to reveal the influence of cardiac rehabilitation on cellular immunity.
[Subjects and Methods] 9 male patients(average 63.4 years old)after coronary artery bypass grafting or acute myocardial infarction participated in out-patient cardiac rehabilitation once a week in institutional formal program and 5 times a week home-based working program for 3 months. We measured exercise capacity and activities of NK(natural killer)cell and soluble TNF receptor1 by taking venous blood before and after rehabilitation.
[Results] Peak. VO2 increased significantly form 16.8±2.7 to 19.4±2.2mL/kg/min(p=0.008) and HDL cholesterol levels showed also increased from 42.0±10.9 to 49.0±10.4mg/dL(p=0.028). But NK cell activities showed no significant changes between 49.4±14. 7 and 50.2±11.2% and there was a tendency of decrease in soluble TNF receptor1 between 1283±634 and 915±102pg/mL(p=0.051).
[Conclusion] Out-patient cardiac rehabilitation system in recovery phase should be brought into Japan. This system is safe and effective and shows no worse effects on cellular immunity.
|
