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Basic researches on the high altitude training : mechanism of vascular and pulmonary systems

Research Project

Project/Area Number 17500441
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Sports science
Research InstitutionKokushikan University

Principal Investigator

KUSAKABE Tatsumi  Kokushikan University, Faculty of Physical Education, Ph.D. Professor (80117663)

Co-Investigator(Kenkyū-buntansha) MATSUDA Hideki  Yokohama City University, School of Medicine, Ph.D. Associate Professor (80305458)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2005: ¥2,500,000 (Direct Cost: ¥2,500,000)
KeywordsCarotid body / Denervation / Chronic hypoxia / Hypertansion / Neuropeptides / Morphometry / Immunohistochemistry / 免疫組織化学
Research Abstract

Morphological changes in the carotid bodies of three types of denervated rats were examined after hypocapnic hypoxic exposure (10% 02 in N2 for 8 weeks). The carotid bodies of rats denervated of both sinus and sympathetic nerves (SD+S) were significantly enlarged with vascular expansion. But there were no significant changes in the carotid bodies of rats denervated of the sinus nerve alone (SD) or rats denervated of the sinus, sympathetic, and vagal nerves (SD+S+V). These findings indicate that there would be no morphological changes in the carotid bodies of rats denervated of the sympathetic and vagal nerves rats or rats with these two nerves intact (SD rats). This suggests that the enlargement of the carotid body in hypoxic conditions may depend on well-balanced sympathetic and para-sympathetic control.
Morphological characteristics in the carotid bodies of spontaneously hypertensive rats (SHR) and those of age-matched normotensive Wistar rats (NWR) as well as age-matched genetically comparable Wistar rats (WKY) were examined. The carotid bodies of SHR were greater than those of NWR and WKY. The density of VIP varicose fibers in the carotid bodies of SHR were smaller than that in the carotid bodies of WKY, although that of SP, CGRP, and NPY fibers was similar to that in the carotid bodies of NWR and WKY. These findings suggest that the mechanisms of carotid body enlargement in hypertensive rats are different from those in hypoxic rats.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (18 results)

All 2006 2005

All Journal Article (18 results)

  • [Journal Article] Morphological changes in the rat carotid bodyin acclimatization and deacclimatization to hypoxia2006

    • Author(s)
      H. Matsuda, et. al.
    • Journal Title

      Adv.Exp.Med.Biol. 580

      Pages: 49-54

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect of carbon dioxide on the structure of the rat carotid body2006

    • Author(s)
      T. Kusakabe, et. al.
    • Journal Title

      Adv.Exp.Med.Biol. 580

      Pages: 55-61

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Chronic hypoxia alters calbindin D-28k immunoreactivity in lingual and laryngeal taste buds in the rats2006

    • Author(s)
      T. Yoshida, et. al.
    • Journal Title

      Histol.Histopathol. 21

      Pages: 1271-1276

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Morphological changes in the rat carotid body in acclimatization and deacclimatization to hypoxia.2006

    • Author(s)
      H. Matsuda, et. al.
    • Journal Title

      Adv. Exp. Med. Biol. 580

      Pages: 49-54

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect of carbon dioxide on the structure of the rat carotid body.2006

    • Author(s)
      T. Kusalabe, et. al.
    • Journal Title

      Adv. Exp. Med. Biol. 580

      Pages: 55-61

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Chronic hypoxia alters calbindin D-28k immunoreactivity in lingual and laryngeal taste buds in the rats.2006

    • Author(s)
      T. Yoshida, et. al.
    • Journal Title

      Histol. Histopathol. 21

      Pages: 1271-1276

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Morphological changes in the rat carotid body in acclimatization and deacclimatization to hypoxia2006

    • Author(s)
      H.Matsuda, et al.
    • Journal Title

      Adv.Exp.Med.Biol. 580

      Pages: 49-54

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effect of carbon dioxide on the structure of the rat carotid body2006

    • Author(s)
      T.Kusakabe, et al.
    • Journal Title

      Adv.Exp.Med.Biol. 580

      Pages: 55-61

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Chronic hypoxia alters calbindin D-28k immunoreactivity in lingual and laryngeal taste buds in the rats2006

    • Author(s)
      T.Yoshida, et al.
    • Journal Title

      Histol.Histopathol. (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Hypoxic adaptation of the rat carotid body2005

    • Author(s)
      T. Kusakabe, et. al.
    • Journal Title

      Histol.Histopathol. 20

      Pages: 987-997

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Autonomic cardiovascular responses to hypercapnia in conscious rats:the roles of chemo-and baroreceptors2005

    • Author(s)
      S. Oilcawa, et. al.
    • Journal Title

      Auton.Neurosci. 117

      Pages: 105-114

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Vascular changes in the rat brain during chronic hypoxia in the presence atad absence of hypercapnia2005

    • Author(s)
      O. Miyamoto, et. al.
    • Journal Title

      Acta Med.Okayama 59

      Pages: 135-143

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Hypoxic adaptation of the rat carotid body.2005

    • Author(s)
      T. Kusakabe, et. al.
    • Journal Title

      Histol. Histopathol. 20

      Pages: 987-997

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Autonomic cardiovascular responses to hyper-capnia in conscious rats : the roles of the chemo-and baroreceptors.2005

    • Author(s)
      S. Oikawa, et. al.
    • Journal Title

      Auton Neurosci. 117

      Pages: 105-114

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Vascular changes in the rat brain during chronic hypoxia in the presence and absence of hyper-capnia.2005

    • Author(s)
      0. Miyamoto, et. al.
    • Journal Title

      Acta Med. Okayama 59

      Pages: 135-143

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Hypoxic adaptation of the rat carotid body2005

    • Author(s)
      T.Kusakabe, et al.
    • Journal Title

      Histol.Histopathol. 20

      Pages: 387-397

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Autonomic cardiovascular responses to hypercapnia in conscious rats : the roles of the chemo- and baroreceptors.2005

    • Author(s)
      S.Oikawa, et al.
    • Journal Title

      Auton Neurosci. 117

      Pages: 105-114

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Vascular changes in the rat brain during chronic hypoxia in the presence and absence of hypercapnia2005

    • Author(s)
      O.Miyamoto, et al.
    • Journal Title

      Acta Med.Okayama 59

      Pages: 135-143

    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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