| Project/Area Number |
17500467
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied health science
|
|---|
| Research Institution | University of Toyama |
|---|
Principal Investigator |
SASAKI Kazuo University of Toyama, Grad. Sch. of Sci and Eng., Prof. (60042826)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ISOBE Masaharu University of Toyama, Grad. Sch. of Sci and Eng., Prof. (70211050)
NAKAJIMA Kazuki University of Toyama, Grad. Sch. Of Sci and Eng., Assoc. Prof. (50207776)
|
|---|
| Project Period (FY) |
2005 – 2006
|
| Project Status |
Completed (Fiscal Year 2006)
|
| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2005: ¥2,200,000 (Direct Cost: ¥2,200,000)
|
|---|
| Keywords | stress / forest-bathing / green odor / cedrol / lateral hypothalamic area / serntonin / dopamine / 神経科学 |
|---|
| Research Abstract |
1. The paraventricular nucleus of the thalamus (PVNT) is a relay nucleus from the midbrain and hypothalamus to the cerebral cortex, and a important brain site for formation of behavior. Fos expression in the PVNT increased after forced swimming in rats, but it significantly decreased in rats exposed to green odor, an odorant emanating from green leaves.
2. There was no significant difference in extracellular 5-HT levels in the lateral hypothalamic area (LHA) after immobilization stress between green odor-exposed and-non-exposed rats. However, 5-HIAA levels in the LHA augmented after immobilization stress in green odor-non-exposed rats was significantly decreased in green odor-exposed rats.
3. Cedrol is an odorant emanating from the trunk of trees. Levels of dopamine and its metabolites increased after immobilization stress in rats, but their levels were significantly decreased in cedrol-exposed rats.
4. These results suggest that odorants emanating from trees have anti-stress effects through a mechanism which decreases 5-HT and/or dopamine release in the LHA.
|
