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Establishment and application of stress assessment system for health expectancy

Research Project

Project/Area Number 17500487
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionMie University (2006-2007)
Hamamatsu University (2005)

Principal Investigator

TSUBOI Hirohito  Mie University, Graduate School of Medicine, Associate Professor (20319338)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Fumio  Aichi Medical University, 医学部, Professor (80135342)
TAKAGI Kuniaki  University of Shizuoka, 薬学部, Associate Professor (00187931)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,650,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2006: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2005: ¥200,000 (Direct Cost: ¥200,000)
Keywordsdepressive symptoms / psychological stress / cortisol / IgA / chemiluminescence / oxidation / 抑うつ状態 / ストレス / フォトン / 分泌型IgA / 抑うつ度 / 心理的ストレス
Research Abstract

<Aim>Depression is an object of public concern and a significant risk factor for life-style diseases, which affects health expectancy. The aim of this study was(1) to investigate associations between psychological stress and oxidative stress, and to establish assessment systems for psychosomatic stress, (2) to apply ultra-weak chemiluminescence(uwCL), an indicator of oxidative activity, to the measurement of psychological stress.
<Methods>It was examined whether or not salivary uwCL, ultra-weak photons emitted from saliva, can be a sensitive biomarker for acute psychological changes. We also investigated the way to assess depressive symptoms, one of the typical responses for chronic stress, utilizing uwCL, cortisol and sIgA in saliva.
<Results>Acute psychological changes induced by angry and depressive moods increased oxidative activity and transiently weaken immunity detected by salivary sIgA concentrations. In relation to chronic psychological status, morning responses of uwCL, cortisol and sIgA were measured ; consequently, the concentration and the flow rate of sIgA significantly decreased, those of cortisol increased and uwCL decreased in 30 min after awakening even after controlling for covariates.
<Conclusion>We indicated temporal changes of uwCL induced by acute psychological challenges, which may be modified by trait anger. Although the association between psychological and oxidative stress was found, assessment systems for chronic psychosomatic stress remain to be elucidated.

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (43 results)

All 2008 2007 2006 2005 Other

All Journal Article (15 results) (of which Peer Reviewed: 3 results) Presentation (25 results) Book (3 results)

  • [Journal Article] Responses of ultra-weak chemiluminescence and secretory IgA in saliva to the induction of angry and depressive moods.2008

    • Author(s)
      Hirohito Tsuboi, et. al.
    • Journal Title

      Brain, Behavior and Immunity Vol22

      Pages: 209-214

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Responses of ultra-weak chemiluminescence and secretory IgA in saliva to the induction of angry and depressive moods2008

    • Author(s)
      Hirohito, Tsuboi, et. al.
    • Journal Title

      Brain, Behavior and Immunity Vol.22

      Pages: 209-214

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Gender differences in stress response to mental workload2008

    • Author(s)
      Kuniaki, Takagi, et. al.
    • Journal Title

      The Journal of Japan Mibyou System Association Vol.12

      Pages: 94-97

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Responses of ultra-weak chemiluminescence and secretory IgA in saliva to the induction of angry and depressive moods2008

    • Author(s)
      Hirohito Tsuboi, Mark Hamer, Gohichi Tanaka, Kuniaki Takagi, Naohide Kinae, Andrew Steptoe.
    • Journal Title

      Brain, Behavior and Immunity 22

      Pages: 209-214

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 精神作業負荷に対する急性ストレス応答の性差2006

    • Author(s)
      高木邦明, 他10名
    • Journal Title

      日本未病システム学会雑誌別刷 第12巻1号

      Pages: 94-97

    • NAID

      130004068880

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 精神作業負荷に対する急性ストレス応答の性差.2006

    • Author(s)
      高木邦明, 五井伸博, 平井優子, 原田均, 五十里彰, 寺島結芽子, 木苗直秀, 中村公嗣, 平松光夫, 坪井宏仁, 小野孝彦
    • Journal Title

      日本未病システム学会雑誌別刷 12・1

      Pages: 94-97

    • NAID

      130004068880

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Differences of lipids, oxidants/antioxidants and ultra-weak chemiluminescence between nurses with high and low job stress.2006

    • Author(s)
      Hirohito Tsuboi, Asami Tatsumi, Keiko Yamamoto, Kuniaki Takagi, Naohide Kinae, Fumio Kobayashi
    • Journal Title

      International Journal of Behavioral Medicine. 13・Suppl

      Pages: 82-82

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Oxidation detected by ultra-weak chemiluminescence may be related to neural-immune interactions under acute, psychological stress.2006

    • Author(s)
      Hirohito Tsuboi, Nobuhiro Goi, Naohide Kinae, Hitoshi Harada, Mitsuo Hiramatsu, Kimitsugu Nakamura, Kuniaki Takagi
    • Journal Title

      Journal of Neuroimmunology 178・Suppl

      Pages: 177-178

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Therapeutic effects of color on acute psychological stress.2006

    • Author(s)
      Kuniaki Takagi, Nobuhiro Goi, Yuko Hirai, Hitoshi Harada, Akira Ikari, Kimitsugu Nakamura, Mitsuo Hiramatsu, Hiroh ito Tsuboi, Reiko Horiki, Takahiko Ono, Naohide Kinae
    • Journal Title

      Journal of Neuroimmunology 178・Suppl

      Pages: 178-178

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 心身ストレスによる唾液微弱発光量変化への重炭酸イオンの関与2006

    • Author(s)
      高木邦明, 五井伸博, 蓮沼毅, 平井優子, 原田均, 五十里彰, 寺島結芽子, 木苗直秀, 中村公嗣, 平松光夫, 坪井宏仁, 小野孝彦
    • Journal Title

      第126回 日本薬学会抄録集

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Lipid peroxidation and antioxidant status concerning job stress2005

    • Author(s)
      Tsuboi H, Tatsumi A, Yamamoto K, Kinae N, Takagi K, Shimoi K, Kobayashi F
    • Journal Title

      Journal of Psychosomatic Research 58(suppl)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 精神作業負荷に対する急性ストレス応答の性差2005

    • Author(s)
      高木邦明, 五井伸博, 平井優子, 原田均, 五十里彰, 寺島結芽子, 木苗直秀, 中村公嗣, 平松光夫, 坪井宏仁, 小野孝彦
    • Journal Title

      第12回 日本未病システム学会学術総会抄録集

    • NAID

      130004068880

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Stress and aging

    • Author(s)
      Hirohito, Tsuboi (Hidehiko, Yokogoshi, Ed.)
    • Journal Title

      CMC Publishing Co.,Ltd. 2006 Development and Perspectives of Anti-stress Food

      Pages: 21-24

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Stress and pain

    • Author(s)
      Hirohito, Tsuboi (Hidehiko, Yokogoshi, Ed.)
    • Journal Title

      CMC Publishing Co.,Ltd. 2006 Development and Perspectives of Anti-stress Food

      Pages: 45-47

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Oxidation detected by ultra-weak chemiluminescence may be related to neural-immune interactions under acute psychological stress.

    • Author(s)
      Hirohito Tsuboi, Nobuhiro Goi, Naohide Kinae, Hitoshi Harada, Mitsuo Hiramatsu, Kimitsugu Nakamura, Kuniaki Takagi
    • Journal Title

      Proceedings of Internatioanl Conference of Neuroimmunology (MEDIMOND社) (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Presentation] 精神的ストレスと生物フォトン量の変化2008

    • Author(s)
      坪井 宏仁, 高木 邦明, 田中 豪一, 小林 章雄, 成田 正明
    • Organizer
      日本行動医学会
    • Place of Presentation
      津
    • Year and Date
      2008-03-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] だ液中フォトン量の精神的ストレスによる変化2008

    • Author(s)
      坪井 宏仁, 高木 邦明, 成田 正明
    • Organizer
      日本疲労学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2008-02-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] 精神的ストレスと生物フォトン量の変化2008

    • Author(s)
      坪井宏仁, 他4名
    • Organizer
      第14回 日本行動医学会学術総会
    • Place of Presentation
      津
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] だ液中フォトン量の精神的ストレスによる変化2008

    • Author(s)
      坪井宏仁, 他2名
    • Organizer
      第4回 日本疲労学会総会・学術集会
    • Place of Presentation
      熊本
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The relationship between psychological stress and biophoton2008

    • Author(s)
      Hirohito, Tsuboi, et. al.
    • Organizer
      The 14th Japanese Congress of Behavioral Medicine
    • Place of Presentation
      Tsu
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Psychologocal stress affects salivary photon volume2008

    • Author(s)
      Hirohito, Tsuboi, et. al.
    • Organizer
      The 4th Japanese Congress of Fatigue Science
    • Place of Presentation
      Kumamoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 微弱発光-新しいストレスマーカーとしての可能性2007

    • Author(s)
      坪井宏仁, 他4名
    • Organizer
      第60回 日本心身医学会中部地方会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-11-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Ultra-weak chemiluminescence can be a new stress maker2007

    • Author(s)
      Hirohito, Tsuboi, et. al.
    • Organizer
      The 60th Chube-Japan Congress of Psychosomatic Medicine
    • Place of Presentation
      Nagoya
    • Year and Date
      2007-11-24
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 微弱発光-新しいストレスマーカ-としての可能性2007

    • Author(s)
      坪井 宏仁, 高木 邦明, 田中 豪一, 成田 正明, 木苗 直秀
    • Organizer
      日本心身医学会中部地方会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-11-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] Depressive symptoms and responses to awakening of cortisol, sIgA and ultra-weak chemiluminesence.2007

    • Author(s)
      Hirohito Tsuboi, et. al.
    • Organizer
      65 the Annual Scientific Meeting of American Psychosomatic Society
    • Place of Presentation
      ブダペスト
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Depressive symptoms and responses to awakening of cortisol, sIgA and ultra-weak chemiluminesence2007

    • Author(s)
      Hirohito, Tsuboi, et. al.
    • Organizer
      65 the Annual Scientific Meeting of American Psychosomatic Society
    • Place of Presentation
      Budapest
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Differences of lipids, oxidants/antioxidants and ultra-weak chemiluminescence between nurses with high and low job stress.2006

    • Author(s)
      Hirohito Tsuboi, et. al.
    • Organizer
      The Ninth International Congress of Behavioral Medicine
    • Place of Presentation
      バンコク
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Oxidation detected by ultra-weak chemiluminescence may be related to neural-immune interactions under acute psychological stress.2006

    • Author(s)
      Hirohito Tsuboi, et. al.
    • Organizer
      The 8th International Congress of Neuroimmunology
    • Place of Presentation
      名古屋
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Therapeutic effects of color on acute psychological stress.2006

    • Author(s)
      Kuniaki Takagi, et. al.
    • Organizer
      The 8th International Congress of Neuroimmunology
    • Place of Presentation
      名古屋
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The relationship between secretory IgA and ultra-weak chemiluminescence in saliva exposed to performance anxiety.2006

    • Author(s)
      Hirohito Tsuboi, et. al.
    • Organizer
      The 13th Annual Meeting of the Psychoneuroimm unology Research Society
    • Place of Presentation
      マイアミ
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Psychological stress secrets peroxdase and thiocyanate in oral cavity quickly.2006

    • Author(s)
      Nobuhiro Goi, et. al.
    • Organizer
      The 13th Annual Meeting of the Psychoneuroimm unology Research Society
    • Place of Presentation
      マイアミ
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 心身ストレスによる唾液微弱発光量変化への重炭酸イオンの関与2006

    • Author(s)
      高木邦明, 他11名
    • Organizer
      第126回 日本薬学会
    • Place of Presentation
      仙台
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 精神作業負荷に対する急性ストレス応答の性差2006

    • Author(s)
      高木邦明, 他10名
    • Organizer
      第12回 日本未病システム学会学術総会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Differences of lipids, oxidants/antioxidants and ultra-weak chemiluminescence between nurses with high and low job stress2006

    • Author(s)
      Hirohito, Tsuboi, et. al.
    • Organizer
      The Ninth International Congress of Behavioral Medicine
    • Place of Presentation
      Bangkok
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Oxidation detected by ultra-weak chemiluminescence may be related to neural-immune interactions under acute psychological stress2006

    • Author(s)
      Hirohito, Tsuboi, et. al.
    • Organizer
      The 8th International Congress of Neuroimmunology
    • Place of Presentation
      Nagoya
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Therapeutic effects of color on acute psychological stress2006

    • Author(s)
      Kuniaki, Takagi, et. al.
    • Organizer
      The 8th International Congress of Neuroimmunology
    • Place of Presentation
      Nagoya
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The relationship between secretory IgA and ultra-weak chemiluminescence in saliva exposed to performance anxiety2006

    • Author(s)
      Hirohito, Tsuboi, et. al.
    • Organizer
      The 13th Annual Meeting of the Psychoneuroimmunology Research Society
    • Place of Presentation
      Miami
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Psychological stress secrets peroxdase and thiocyanate in oral cavity quickly2006

    • Author(s)
      Nobuhiro, Goi, et. al.
    • Organizer
      The 13th Annual Meeting of the Psychoneuroimmunology Research Society
    • Place of Presentation
      Miami
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Bicarbonate ion affects changes of salivary chemiluminescence induced by psychologcal stress2006

    • Author(s)
      Kuniaki, Takagi, et. al.
    • Organizer
      The 126th Pharmaceutical Congress of Japan
    • Place of Presentation
      Sendai
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Gender differences in stress response to mental workload2006

    • Author(s)
      Kuniaki, Takagi, et. al.
    • Organizer
      The 12th Japan Mibyo System Congress
    • Place of Presentation
      Osaka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 「抗ストレス食品の開発と展望」第1編 基礎編 第2章 ストレスの生体応答 6 ストレスと老化2006

    • Author(s)
      坪井宏仁(横越英彦編)
    • Publisher
      シーエムシー出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 第1編 基礎編 第3章 ストレスと疾患 5 ストレスと疼痛2006

    • Author(s)
      坪井宏仁(横越英彦編)
    • Publisher
      シーエムシー出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 抗ストレス食品の開発と展望(横越英彦編)2006

    • Author(s)
      坪井宏仁
    • Total Pages
      338
    • Publisher
      シーエムシー出版
    • Related Report
      2006 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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