Establishment and application of stress assessment system for health expectancy
| Project/Area Number |
17500487
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Mie University (2006-2007)
Hamamatsu University (2005) |
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Principal Investigator |
TSUBOI Hirohito Mie University, Graduate School of Medicine, Associate Professor (20319338)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Fumio Aichi Medical University, 医学部, Professor (80135342)
TAKAGI Kuniaki University of Shizuoka, 薬学部, Associate Professor (00187931)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,650,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2006: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2005: ¥200,000 (Direct Cost: ¥200,000)
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| Keywords | depressive symptoms / psychological stress / cortisol / IgA / chemiluminescence / oxidation / 抑うつ状態 / ストレス / フォトン / 分泌型IgA / 抑うつ度 / 心理的ストレス |
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| Research Abstract |
<Aim>Depression is an object of public concern and a significant risk factor for life-style diseases, which affects health expectancy. The aim of this study was(1) to investigate associations between psychological stress and oxidative stress, and to establish assessment systems for psychosomatic stress, (2) to apply ultra-weak chemiluminescence(uwCL), an indicator of oxidative activity, to the measurement of psychological stress.
<Methods>It was examined whether or not salivary uwCL, ultra-weak photons emitted from saliva, can be a sensitive biomarker for acute psychological changes. We also investigated the way to assess depressive symptoms, one of the typical responses for chronic stress, utilizing uwCL, cortisol and sIgA in saliva.
<Results>Acute psychological changes induced by angry and depressive moods increased oxidative activity and transiently weaken immunity detected by salivary sIgA concentrations. In relation to chronic psychological status, morning responses of uwCL, cortisol and sIgA were measured ; consequently, the concentration and the flow rate of sIgA significantly decreased, those of cortisol increased and uwCL decreased in 30 min after awakening even after controlling for covariates.
<Conclusion>We indicated temporal changes of uwCL induced by acute psychological challenges, which may be modified by trait anger. Although the association between psychological and oxidative stress was found, assessment systems for chronic psychosomatic stress remain to be elucidated.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] 精神作業負荷に対する急性ストレス応答の性差.2006
Author(s)
高木邦明, 五井伸博, 平井優子, 原田均, 五十里彰, 寺島結芽子, 木苗直秀, 中村公嗣, 平松光夫, 坪井宏仁, 小野孝彦
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Journal Title
日本未病システム学会雑誌別刷 12・1
Pages: 94-97
NAID
Related Report
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[Journal Article] Therapeutic effects of color on acute psychological stress.2006
Author(s)
Kuniaki Takagi, Nobuhiro Goi, Yuko Hirai, Hitoshi Harada, Akira Ikari, Kimitsugu Nakamura, Mitsuo Hiramatsu, Hiroh ito Tsuboi, Reiko Horiki, Takahiko Ono, Naohide Kinae
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Journal Title
Journal of Neuroimmunology 178・Suppl
Pages: 178-178
Related Report
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[Journal Article] 心身ストレスによる唾液微弱発光量変化への重炭酸イオンの関与2006
Author(s)
高木邦明, 五井伸博, 蓮沼毅, 平井優子, 原田均, 五十里彰, 寺島結芽子, 木苗直秀, 中村公嗣, 平松光夫, 坪井宏仁, 小野孝彦
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Journal Title
Related Report
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[Journal Article] 精神作業負荷に対する急性ストレス応答の性差2005
Author(s)
高木邦明, 五井伸博, 平井優子, 原田均, 五十里彰, 寺島結芽子, 木苗直秀, 中村公嗣, 平松光夫, 坪井宏仁, 小野孝彦
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Journal Title
NAID
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