| Co-Investigator(Kenkyū-buntansha) |
HANAOKA Tomoyuki Showa university, Faculty of Medicine, Adjunct, Professor, 医学部, 非常勤講師 (00228503)
ISHIHARA Jyunko National Cancer Center, Research Center for Cancer Prevention and Screening, Epidemiology and Prevention Division, Research Resident, がん予防・検診研究センター・予防研究部, リサーチレジデント (30415509)
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| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2006: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2005: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Research Abstract |
Food frequency questionnaire (FFQ) is easy to administer, is less expensive than other dietary assessment methods, and provides a rapid estimate of dietary habit. Therefore FFQ has been the dietary assessment method used most frequently in epidemiological studies. Often the validity of FFQ is evaluated by comparing its performance with more intensive recording reference methods, such as weight-dietary records (DR). The correlation coefficients derived from such relative validity studies may be biased because of the random error of dietary assessment methods. Biomarkers are used to independently determine the validity of the reference methods, however, there are few validation study using biomarkers.
We examined the availability of HCAs in hair as a biochemical indicator of dietary intake of HCAs using the grilled/stir-fried meat or fish intake from 28 days DR and indicated that the PhIP level in hair can be used as a biological indicator of dietary intake of HCAs (Mutat Res., 588, 136-4
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2, 2005). We also examined the validity of HCA intake estimated from FFQ using PhIP level in hair as a reference method and indicated that HCA intake estimated from FFQ provides a reasonable ranking of individuals to allow the analysis of associations between HCA intake and risk of cancer in large-scale epidemiological studies (Mutat Res., 2007 (in press)).
Furthermore, we examined the relationship between serum carotenoid and plasma vitamin C, B6, B12, folate concentration and corresponding vitamin intake using food database including cooked food or those composed of only raw food. The relationship between vitamin intake and biomarker did not improve when the vitamin intake was calculated using food database including cooked food. Therefore, when the vitamin intake is estimated on the epidemiological study, the effect of cooking loss may not take in consideration. (Sixth International Conference on Dietary Assessment Method; 2006)
In addition, we investigated the effect of revision of the nutrient database on the validity of FFQ. Despite changes in intake levels for many nutrients, the validity of FFQ using rank correlation between estimated nutrient intake according to FFQ and biomarkers were not influenced by revision of the nutrient database in Japan (J Epidemiol., 16, 107-116, 2006). Less
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