| Project/Area Number |
17510052
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Risk sciences of radiation/Chemicals
|
|---|
| Research Institution | National Institute for Environmental Studies |
|---|
Principal Investigator |
SUZUKI Akira National Institute for Environmental Studies, RESEARCH CENTER OF ENVIRONMENTAL RISK, SENIOR RESEARCHER (20124349)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TANEDA Shinji NIES, 環境リスク研究センター, POST DOCTORIAL FELLOWS (90391127)
|
|---|
| Project Period (FY) |
2005 – 2007
|
| Project Status |
Completed (Fiscal Year 2007)
|
| Budget Amount *help |
¥3,450,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2005: ¥1,600,000 (Direct Cost: ¥1,600,000)
|
|---|
| Keywords | Nitroohenol / PNP / diesel exhaust Particles / DEP / PNMC / PNMPP / reproductive effects / toxicology |
|---|
| Research Abstract |
We examined the effects of nitrophenols, firstly isolated from diesel exhaust particles by us, on reproductive endocrine system using rats and Japanese quails. We dearly showed that these nitrophenols had estrogenic and anti-androgenic activities in rats by in vivo or in vitro experiments. The activities of these compounds, however, were different by differences of the architecture of the compounds. Two species of the compounds were clarified to a primary reductive substance of insecticide showing very important suggestions on ecological effects. The results were summarized as follows; 1). 4-ntorophenol (PNP) dearly showed high estrogenic and anti-androgenic activities. PNP is a primary reductive substance of insecticide parathion that is widely used in the developing country in the world. PNP caused severe atrophy of testes of Japanese quails suggesting a high anti-androgenic activity 2). 3-methyl-4-nitrophenol showed lower activities than that of PNP. PNMC is a primary reductive substance of insecticide fenitrothion that is used in the world include in Japan. 3). 4-nitro-3-phenyl phenol (PNMPP) showed the highest activities in these compounds. 4). 2-nitrophenol did not show any activities in rats. These results dearly showed structure-activity relationships, too.
|
