Signaring molecule : Antibodies and inhibitors
Project/Area Number |
17580089
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Applied biochemistry
|
Research Institution | National Institute of Advanced Industrial Science and Technology |
Principal Investigator |
SAIDA Kaname National Institute of Advanced Industrial Science and Technology, Research Institute of Advanced Bionics, Senior Researcher (00357055)
|
Co-Investigator(Kenkyū-buntansha) |
UCHIDE Tsuyoshi Kitasato University, School of Veterinary Medicine and Animal Science, Assistant Professor (20327456)
|
Project Period (FY) |
2005 – 2006
|
Project Status |
Completed (Fiscal Year 2006)
|
Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2005: ¥3,000,000 (Direct Cost: ¥3,000,000)
|
Keywords | biotechnology / gene expression / peptide / Antibody / inhibitor / 遺伝子 / 細胞組織 / 生体分子 / 生理学 / 生物活性 / シグナル分子 / 細胞・組織 |
Research Abstract |
Elucidation of VIC/ET-2 biosignaling system We discovered a novel signaling peptide (VIC/ET2) from mammalian genome. ET2/VIC induces hypertension, intestinal contraction, vasoconstriction, secretion, cell growth, differentiation, and apoptosis. At higher doses ET2/VIC, which is structurally similar to snake venom SRTX, induces sudden death. Gene expression profiles have revealed organ-specific expression in brain, uterus, ovary, fetus, and intestine. ET2/VIC holds great promise in displaying intriguing physiological functions during neuronal differentiation, embryonic development, and reproduction in addition to its effects on the gastrointestinal system. In this grant, we have focused on antibody raising against ET2/VIC and are revealing the specific functions of ET2/VIC.
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Report
(3 results)
Research Products
(17 results)