| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2005: ¥3,000,000 (Direct Cost: ¥3,000,000)
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| Research Abstract |
Elucidation of VIC/ET-2 biosignaling system
We discovered a novel signaling peptide (VIC/ET2) from mammalian genome. ET2/VIC induces hypertension, intestinal contraction, vasoconstriction, secretion, cell growth, differentiation, and apoptosis. At higher doses ET2/VIC, which is structurally similar to snake venom SRTX, induces sudden death. Gene expression profiles have revealed organ-specific expression in brain, uterus, ovary, fetus, and intestine. ET2/VIC holds great promise in displaying intriguing physiological functions during neuronal differentiation, embryonic development, and reproduction in addition to its effects on the gastrointestinal system. In this grant, we have focused on antibody raising against ET2/VIC and are revealing the specific functions of ET2/VIC.
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