| Project/Area Number |
17580260
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
KATO Keiko Osaka Prefecture University, Graduate School of Life and Environmental Sciences, Associate professor, 生命環境科学研究科, 助教授 (90252684)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2005: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | neural plasticity / epilepsy / neural circuit / microinjection / model mice |
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| Research Abstract |
I have focused on kindling mice, which is an epileptic model and induces abnormal neural plasticity with changes in neural circuits. The purpose in this grant is to investigate a flow of information at the molecular level occurring in a series of neural nuclei during stimulation of kindling and to evaluate molecular processes in acquirement of neural plasticity.
In 2005, I have developed to prepare kindling mice containing microinjection cannula, in which an anode electrode and the cannula were implanted into the basolateral amygdaloid complex and the hippocampus, respectively. The model mice are a system causing both of the kindling stimulation and administration of a drug. At the same time, I have identified a molecular candidate A up-regulated tremendously during kindling epileptogenesis.
In 2006, I have injected the molecular candidate A into the present kindling mice, resulting in accelerating stages of kindling-epileptogenesis being dependent on the injection of the molecular candidate A. The result suggests that molecular candidate A involves in inducing epilepsy. Now, I prepare a journal article based on a series of data, which has been supported by this grant.
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