| Co-Investigator(Kenkyū-buntansha) |
OKADA Keiji Iwate University, Faculty of Agriculture, Associate profess, 農学部, 助教授 (60233326)
YAMAGISHI Norio Iwate University, Faculty of Agriculture, Associate professor, 農学部, 助教授 (30281877)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2005: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Research Abstract |
In this studies, we did vaginal or transdermal absorption of 1,25(OH)_2D_3 for prevention of hypocalcaemia in dairy cows.
1.Vaginal absorption of 1,25(OH)_2D_3 in cattle
In the first study, the 1,25(OH)_2D_3 was administered into the bovine vaginal lumen, subsequently to observe the blood biochemical changes in the 1,25(OH)_2D_3 and some minerals. The plasma 1,25(OH)_2D_3 levels reached to a peak at 6 hr. The plasma Ca increased from 6 hr, and reached at 24 hr in the peak. The plasma iP increased at 6 hr, and reached to the plateu during 24 to 96hr.
2.Transdermal absorption of 1,25(OH)_2D_3 in cattle.
In the second study, the 1,25(OH)_2D_3 was dropped into the ventral root of tail of Jersey cattle, subsequently to observe the blood biochemical changes in the 1,25(OH)_2D_3 and some minerals. The plasma 1,25(OH)_2D_3 of increased at 2 hr after dropping. The plasma Ca at skin dropping test was higher from 6 hr. The plasma iP at skin dropping test was higher from 24 to 120 hr.
In conclusion, these results indicates the possibility of the intravaginal or transdermal dropping 1,25(OH)_2D_3 for prophylaxis of parturient hypocalcaemia in cows.
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