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Pathophysiology of prolonged luteal phase after first postpartum ovulation in dairy cows and its treatment

Research Project

Project/Area Number 17580279
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Clinical veterinary science
Research InstitutionYamaguchi University

Principal Investigator

NAKAO Toshihiko  Yamaguchi University, Faculty of agriculture, Professor (30094824)

Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2005: ¥2,400,000 (Direct Cost: ¥2,400,000)
Keywordsdairy cow / postpartum ovarian cycles / prolonged luteal phase / delayed first ovulation postpartum / progesterone / fertility / first ovulation postpartum / 分娩後卵巣機能 / 黄体機能 / 卵巣静止 / 不受胎 / 受胎
Research Abstract

A total of 344 dairy cows from 11 dairy farms across Japan were investigated for 12 months for their resumption of ovarian cycles postpartum to show the incidence of prolonged luteal phase after first ovulation and for the factors causing the prolongation. Prolonged luteal phase was diagnosed based on milk progesterone profiles indicating the presence of CL for 21 days or longer after the formation. Incidence of prolonged luteal phase after first ovulation in 344 cows was 10.2 %, while 41.6 % had normal resumption of ovarian cycles and 36.9 % showed delayed first postpartum ovulation. Cows with prolonged luteal phase showed lower first AI conception rate, and pregnancy rate within 100 days postpartum than cows with the normal ovarian cycles (P<0.05). Among 11 herds, five herds had 11 to 22 % incidence of prolonged luteal phase, whereas six other herd had almost no incidence. All the five herds with incidence of prolonged luteal phase were using free-stalls and their average milk yield was relatively higher. On the other hand, all of the six herds with no incidence had relatively lower milk yield and four of the six were using tie-stalls. Within a herd, heavier and higher producing cows with normal BCS and body weight changes after calving were more prone to the prolongation of luteal phase, while cows with decreasing body weight and BCS showed the delay of first ovulation postpartum. Nutritional state of cow during dry period and at parturition and high milk production are likely major factors causing the prolonged luteal phase after postpartum ovulation. Both PGF2α and estradiol benzoate administered intramuscularly were effective to induce estrus with normal fertility in cows with prolonged luteal phase. Thus pathophysiology of prolonged luteal phase after first postpartum ovulation was partly described and practical methods of treatment was suggested.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (30 results)

All 2007 2006 2005

All Journal Article (29 results) Book (1 results)

  • [Journal Article] Pathophysiology of postpartum ovarian dysfunction and repeat breeding in high-producing dairy cows2007

    • Author(s)
      Nakao T.
    • Journal Title

      Proc.14th Int.Conference on Biotechnology in Animal Reproduction

      Pages: 82-88

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Abnormal resumption of postpartum ovarian cycles in high-producing dairy cows:incidence,consequent sub-fertility,and risk factors2007

    • Author(s)
      Nakao T.
    • Journal Title

      Reproduction in Domestic Animals 42(suppl.2)

      Pages: 111-111

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Incidence of error in estrus detection based on secondary estrus signs in a 24h tie-stall dairy herd with low fertility2007

    • Author(s)
      Ranasinghe R.M.S.B.K.
    • Journal Title

      Reproduction in Domestic Animals (Accepted for Aublication)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Pathophysiology of postpartum ovarian dysfunction and repeat breeding in high-producing dairy cows2007

    • Author(s)
      Nakao, T.
    • Journal Title

      Proc. 14th Int. Conference on Biotechnology in Animal Reproduction

      Pages: 82-88

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Abnormal resumption of postpartum ovarian cycles in high-producing dairy cows : incidence, consequen sub-fertility, and risk factors2007

    • Author(s)
      Nakao, T.
    • Journal Title

      Reproduction in Domestic Animals,(suppl.2) 42

      Pages: 111-111

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Incidence o error in estrus detection based on secondary estrus signs in a 24 h tie-stall dairy herd with low fertility2007

    • Author(s)
      Ranasinghe R.M.S.B.K., Nakao T., Kobayashi A.
    • Journal Title

      Reproduction in Domestic Animals (Accepted for publication)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Incidence of delayed first postpartum ovulation and prolonged luteal phase after the first or second ovulation postpartum in2006

    • Author(s)
      Nakao T.
    • Journal Title

      Theriogenology 66

      Pages: 679-680

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Milk progesterone profile at and after artlficial insemination in repeat breeding cows:effects on conception rate and embryonic death2006

    • Author(s)
      Ghanem M.
    • Journal Title

      Reproduction in Domestic Animals 41

      Pages: 180-183

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Some characteristics of reproductive disorders in high-producing dairy cows and strategies to improve reproductive performance2006

    • Author(s)
      Nakao T.
    • Journal Title

      Korean Journal for Buiatrics 11

      Pages: 1-22

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] 乳牛における受胎率低下の原因と対策2006

    • Author(s)
      中尾 敏彦
    • Journal Title

      山口獣医学雑誌 32

      Pages: 13-20

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Incidence of delayed first postpartum ovulation am prolonged luteal phase after the first or second ovulation postpartum in Holstein cows and its effect on subsequen reproductive performance2006

    • Author(s)
      Nakao T.
    • Journal Title

      Theriogenology 66

      Pages: 679-680

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Milk progesterone profile at and after artificial insemination in repeat breeding cows : effects on conception rate and embryonic death2006

    • Author(s)
      Ghanem M.
    • Journal Title

      Reproduction in Domestic Animals 41

      Pages: 180-183

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Some characteristics of reproductive disorders it high-producing dairy cows and strategies to improve reproductive performance2006

    • Author(s)
      Nakao T.
    • Journal Title

      Korean Journal for Buiatrics 11

      Pages: 1-22

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Incidence of delayed first postpartum ovulation and prolonged luteal phase after the first or second ovulation postpartum in Holstein cows and its effect on subsequent reproductive performance2006

    • Author(s)
      Nakao T., et al.
    • Journal Title

      Theriogenology 66

      Pages: 679-680

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Milk progesterone profile at and after artificial insemination in repeat breeding cows : effects on conception rate and embryonic death2006

    • Author(s)
      Ghanem M., et al.
    • Journal Title

      Reproduction in Domestic Animals 41

      Pages: 180-183

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 乳牛の乾乳期および泌乳初期における代謝プロファイルテストの成績と排卵同期化・定時人工授精の受胎率との関係2006

    • Author(s)
      山田恭嗣, 他
    • Journal Title

      日本獣医師会雑誌 59

      Pages: 40-44

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 乳牛の泌乳初期から最盛期までの乳量および乳成分が排卵同期化・定時人工授精の受胎率に及ぼす影響2006

    • Author(s)
      山田恭嗣, 他
    • Journal Title

      日本獣医師会雑誌 59

      Pages: 389-392

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 乳牛における受胎率低下の原因と対策2006

    • Author(s)
      中尾敏彦
    • Journal Title

      山口獣医学雑誌 32

      Pages: 13-20

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 近年における乳牛の受胎率低下の原因と対策2006

    • Author(s)
      中尾敏彦
    • Journal Title

      山口獣医学雑誌 32(印刷中)

    • NAID

      40015221968

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Onset and duration of luteal activity postpartum and their effect on first insemination conception rate in lactating dairy cows2005

    • Author(s)
      Hommeida A.
    • Journal Title

      Journal of Veterinary Medical Science 67.10

      Pages: 1031-1035

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Abnormal resumption of ovarian cyclicity postpartum as an important cause of poor reproductive performance in high-producing dairy cows2005

    • Author(s)
      Nakao T.
    • Journal Title

      Proc.12th Int.Conference on Biotechnology in Animal Reproduction

      Pages: 2-10

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Relationship between body condition score,body weight,and some nurrirional paramerers in plasma and resumprion of ovarlan cyclicity2005

    • Author(s)
      Shrestha H.
    • Journal Title

      Theriogenology 64

      Pages: 855-866

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Onset and duration of luteal activit postpartum and their effect on first insemination conception rate in lactating dairy cows2005

    • Author(s)
      Hommeida A.
    • Journal Title

      Journal of Veterinary Medical Science 67

      Pages: 1031-1035

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Abnormal resumption of ovarian cyclicit'postpartum as an important cause of poor reproductive performance in high-producing dairy cows2005

    • Author(s)
      NakaoT.
    • Journal Title

      Proc. 12th Int. Conference on Biotechnolo' in Animal Reproduction

      Pages: 2-10

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Relationship between body condition score, bod weight, and some nutritional parameters in plasma am resumption of ovarian cyclicity postpartum during pre-service period in a subtropical region in Japan2005

    • Author(s)
      Shrestha H.
    • Journal Title

      Theriogenology 64

      Pages: 855-866

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Declining fertility in today's dairy cows : causes and possible solutions2005

    • Author(s)
      Nakao, T.
    • Journal Title

      Yamaguchi Journal of Veterinary Medicine 32

      Pages: 13-20

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Onset and duration of luteal activity postpartum and their effect on first insemination conception rate in lactating dairy cows2005

    • Author(s)
      Hommeida A., Nakao T., Kubota H.
    • Journal Title

      Journal of Veterinary Medical Sciences 67・10

      Pages: 1031-1035

    • NAID

      110003983123

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Abnormal resumption of ovarian cyclicity postpartum as an important cause of poor reproductive performance in high-producing dairy cows2005

    • Author(s)
      Nakao T., Shrestha H.K., Hommeida A.
    • Journal Title

      Proc.12^<th> Int.Cong.Biotech.Animal Reprod.

      Pages: 2-10

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Relationships between body condition score, body weight, and some nutritional parameters in plasma and resumption of ovarian cyclicity postpartum during pre-service period in a subtropical region in Japan2005

    • Author(s)
      Shrestha H.K., Nakao T., Suzuki T., Akita M., Higaki T.
    • Journal Title

      Theriogenology 64

      Pages: 855-866

    • Related Report
      2005 Annual Research Report
  • [Book] 牛の繁殖技術マニュアル2007

    • Author(s)
      金 田
    • Total Pages
      48
    • Publisher
      (社)日本家畜人工授精師協会
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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