| Project/Area Number |
17590099
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Tokyo University of Pharmacy and Life Science (2007)
Kyoto Pharmaceutical University (2005-2006) |
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Principal Investigator |
HAYAHI Yoshio Tokyo University of Pharmacy and Life Science, School of Pharmacy, Professor (10322562)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,830,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2005: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | Chemical Pharmaceutics / Pharmaceutical Science / Prodrug / Organic Chemistry / Cancer / Taxiods / Oligo arginine / Lactic polymer / 水溶性 / 化学的メカニズム |
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| Research Abstract |
Much like conventional pharmaceutics, chemical pharmaceutics deals with the delivery of drugs. However, contrary to conventional pharmaceutics that focused on formulation techniques, chemical pharmaceutics delivers drugs using techniques based on organic chemistry. We developed water-soluble prodrugs based on intramolecular migration reaction in sparingly-water-soluble protease inhibitors and taxoids. Additionally, a new anticancer drug was developed from a structure-activity relationship study of phenylahistin derivatives based on cytotoxic activity derived from anti-microtubule activity and vascular disrupting activity. Furthermore, a novel oligoarginine-based cargo-transporter system for effective intestinal absorption of drugs was developed by applying a new chemical-triggered self-cleavable peptide spacers, and also new lactic acid polymer for better introduction of drugs to the targeted tissues.
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