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Pharmaceuticals in hospital sewages and their toxicities to ecosystem

Research Project

Project/Area Number 17590102
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental pharmacy
Research InstitutionHIROSHIMA UNIVERSITY

Principal Investigator

SUGIHARA Kazumi  Hiroshima University, Faculty of Pharmacy, Teaching Associate, 薬学部, 教務員 (20271067)

Co-Investigator(Kenkyū-buntansha) NISHIJIMA Wataru  Hiroshima University, Environment Research and Management Center, Professor, 環境安全センター, 教授 (20243602)
OHTA Shigeru  Hiroshima University, Graduate School of Biomedical Sciences, Professor, 大学院医歯薬学総合研究科, 教授 (60160503)
KITAMURA Shigeyuki  Nihon Pharmaceutical University, Professor, 薬学部, 教授 (40136057)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2006: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2005: ¥2,800,000 (Direct Cost: ¥2,800,000)
KeywordsPharmaceuticals / Environmental pollution / Hospital sewage / Effect to ecosystem / 生態影響
Research Abstract

Aquatic environmental pollution by pharmaceuticals has been emerging as a worldwide problem. Many chemicals have been detected at ng/L - ug /L levels in the environment. In this study, we analyzed several pharmaceuticals and their metabolites in hospital sewage by using liquid chromatography ion electrospray ionization tandem mass spectrometry (LC/MS/MS). We detected some pharmaceuticals, acetaminophen (antipyretic), chlorhexidine. (antiseptic) and levofloxacin (antibiotic). The contents in the sewage varied among individual samples. The sewage samples showed toxicity in the Daphnia magna mortality test, Daphnia magna reproduction test and Microtox^<【O!R】> test with P. phosphoreum. Hospital sewage might be having a significant impact on the ecosystem.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (21 results)

All 2006 2005

All Journal Article (18 results) Book (3 results)

  • [Journal Article] Effects of stilbene and related compounds on reproductive organs in B6C3F1/Crj mouse.2006

    • Author(s)
      Sanoh, Seigo, etal.
    • Journal Title

      Journal of Health Science 52(5)

      Pages: 613-622

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect of green tea beverages on efficacy of povidone-iodine.2006

    • Author(s)
      Tayama, Yoshitaka, etal.
    • Journal Title

      Journal of Health Science 52(3)

      Pages: 324-328

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Drug-metabolizing ability of molybdenum hydroxylases.2006

    • Author(s)
      Kitamura, Shigeyuki, etal.
    • Journal Title

      Drug Metabolism and Pharmacokinetics 21(2)

      Pages: 83-98

    • NAID

      10017422927

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Estimation of aldehyde oxidase activity in vivo from conversion ratio of N1-methylnicotinamide to pyridones, and intraspecies variation of the enzyme activity in rats.2006

    • Author(s)
      Sugihara, Kazumi, etal.
    • Journal Title

      Drug Metabolism and Disposition 34(2)

      Pages: 208-212

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effects of stilbene and related compounds on reproductive organs in B6C3F1/Crj mouse.2006

    • Author(s)
      Sanoh, Seigo, et al.
    • Journal Title

      Journal of Health Science 52(5)

      Pages: 613-622

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect of green tea beverages on efficacy of povidone-iodine.2006

    • Author(s)
      Tayama, Yoshitaka, et al.
    • Journal Title

      Journal of Health Science 52(3)

      Pages: 324-328

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Drug-metabolizing ability of molybdenum hydroxylases.2006

    • Author(s)
      Kitamura, Shigeyuki, et al.
    • Journal Title

      Drug Metabolism and Pharmacokinetics 21(2)

      Pages: 83-98

    • NAID

      10017422927

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Estimation of aldehyde oxidase activity in vivo from conversion ratio of Nl-methylnicotinamide to pyridones, and intraspecies variation of the enzyme activity in rats.2006

    • Author(s)
      Sugihara, Kazumi,. et al.
    • Journal Title

      Drug Metabolism and Disposition 34(2)

      Pages: 208-212

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Academic Press2006

    • Author(s)
      Kitamura, Shigeyuki, et al.
    • Journal Title

      Toxicology of Organophosphate and Carbamate Compounds

      Pages: 481-494

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effectsof stilbene and related compounds on reproductive organs in B6C3F1/Crj mouse.2006

    • Author(s)
      Sanoh, Seingo, et al.
    • Journal Title

      Journal of Health Science 52(5)

      Pages: 613-622

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effect of green tea beverages on efficacy of providone-iodine.2006

    • Author(s)
      Tayama, Yoshida, et al.
    • Journal Title

      Journal of Health Science 52(3),

      Pages: 324-328

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Estimation of aldehyde oxidase activity in vivo from conversion ratio of N1-methylnicotinamide to pyridones, and intraspecies variation of the enzyme activity in rats.2006

    • Author(s)
      Sugihara, Kazumi, et al.
    • Journal Title

      Drug Metabolism and Disposition 34(2),

      Pages: 208-212

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Estimation of aldehyde oxidase activity in vivo from conversion ratio of N1-methylnicotinamide to pyridones, and intraspecies variation of the enzyme activity in rats.2006

    • Author(s)
      Sugiharta, K. et al.
    • Journal Title

      Drug Metabolism and Disposition 34(2)

      Pages: 208-212

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Involvement of molybdenum hydroxylases in reductive metabolism of nitro polycyclic aromatic hydrocarbons in mammalian skin.2005

    • Author(s)
      Ueda, O.et al.
    • Journal Title

      Drug Metabolism and Disposition 33(9)

      Pages: 1312-1318

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Metabolism of the α,β-unsaturated ketones, chalcone and trans-4-phenyl-3-buten-2-one, by rat liver microsomes and estrogenic activity of the metabolites.2005

    • Author(s)
      Kohno, Y.et al.
    • Journal Title

      Drug Metabolism and Disposition 33(8)

      Pages: 1115-1123

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Production of superoxide radical in reductive metabolism of a synthetic food-coloring agent, indigocarmine, and related compounds.2005

    • Author(s)
      kohno, Y.et al.
    • Journal Title

      Life Sciences 77(6)

      Pages: 601-614

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Comparative Study of the Endocrine-Disrupting Activity of Bisphenol A and 19 Related Compounds.2005

    • Author(s)
      Kitamura, S.et al.
    • Journal Title

      Toxicological Sciences 84(2)

      Pages: 249-259

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Thyroid hormone-like and estrogenic activity of hydroxylated PCBs in cell culture.2005

    • Author(s)
      Kitamura, S.et al.
    • Journal Title

      Toxicology 208(3)

      Pages: 377-387

    • Related Report
      2005 Annual Research Report
  • [Book] Toxicology of Organophosphate and Carbamate Compounds2006

    • Author(s)
      Kitamura, Shigeyuk, etal.
    • Publisher
      Academic Press
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] Toxicology of Organophosphate and Carbamate Compounds2006

    • Author(s)
      Kitamura, Shigeyuki, et al.
    • Publisher
      Academic Press
    • Related Report
      2006 Annual Research Report
  • [Book] Toxicology of Organophosphate and Carbamate Compounds (Endocrine disruption by organophosphate and carbamate pesticides)2005

    • Author(s)
      Kitamura et al.分担(R.C.Gupta編集)
    • Total Pages
      763
    • Publisher
      Elsevier
    • Related Report
      2005 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

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