| Project/Area Number |
17590102
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | HIROSHIMA UNIVERSITY |
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Principal Investigator |
SUGIHARA Kazumi Hiroshima University, Faculty of Pharmacy, Teaching Associate, 薬学部, 教務員 (20271067)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIJIMA Wataru Hiroshima University, Environment Research and Management Center, Professor, 環境安全センター, 教授 (20243602)
OHTA Shigeru Hiroshima University, Graduate School of Biomedical Sciences, Professor, 大学院医歯薬学総合研究科, 教授 (60160503)
KITAMURA Shigeyuki Nihon Pharmaceutical University, Professor, 薬学部, 教授 (40136057)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2006: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2005: ¥2,800,000 (Direct Cost: ¥2,800,000)
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| Keywords | Pharmaceuticals / Environmental pollution / Hospital sewage / Effect to ecosystem / 生態影響 |
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| Research Abstract |
Aquatic environmental pollution by pharmaceuticals has been emerging as a worldwide problem. Many chemicals have been detected at ng/L - ug /L levels in the environment. In this study, we analyzed several pharmaceuticals and their metabolites in hospital sewage by using liquid chromatography ion electrospray ionization tandem mass spectrometry (LC/MS/MS). We detected some pharmaceuticals, acetaminophen (antipyretic), chlorhexidine. (antiseptic) and levofloxacin (antibiotic). The contents in the sewage varied among individual samples. The sewage samples showed toxicity in the Daphnia magna mortality test, Daphnia magna reproduction test and Microtox^<【O!R】> test with P. phosphoreum. Hospital sewage might be having a significant impact on the ecosystem.
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