| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2005: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Research Abstract |
In this study, we have developed the results of the Grant-in-Aid for Exploratory Research (2003-2004) from the Ministry of Education, Culture, Sports, Science and Technology, and the project (2003-2006) of the research institute of Science and Technology for Society, Japan Science and Technology Agency. The database of Drug Safety Information Community in the Information-Pharmacy was applied to the education/research for pharmaceutical health care and sciences in the faculty of pharmaceutical Sciences.
In the Information Community, the drug safety information about teratogenicity can circulate between medical consumers, health care workers, and researchers on the Internet. We constructed a web-based database system, anzen-drug com, consisting of three subsystems i.e. basic drug information, chemical structures and clinical data. A variety of community members can retrieve necessary information on the database. The health care consumers can register their own medication history during pr
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egnancy and delivery outcome on the database. The site of anzen-drug com (http://anzen-drug.ph.tokushima-u.ac.jp/) has been opened for the trial use. We also developed a novel algorithm and implemented in the program, SimScore, to evaluate quantitatively the structural similarity score of a target compound with the teratogenic drugs which are defined as human teratogens by the FDA. We applied to patent those developed technology (Number of patent application 2005-34393).
The information from the established DB of basic drug information and chemical structures are effectively utilized in the educational research of undergraduate and graduate students. In particular, we have proposed "the Clinical QSAR", in which the drug excretion into breast-milk or the placental drug transport in human can be predicted by using the analysis method of quantitative structure activity relationship (QSAR) for the clinical application of cheminformatics.
The intellectual infrastructure of the information community contributes to the practice of evidence-based medicine, the efficient drug research and development, and the training of staffs in the areas of pharmaceutical information who play important roles in clinical risk communication. Less
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