| Project/Area Number |
17590130
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Nagasaki University |
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Principal Investigator |
NAKAMURA Junzo Nagasaki University, Graduate School of Biomedical Sciences, Professor, 大学院医歯薬学総合研究科, 教授 (30115901)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIDA Koyo Nagasaki University, Graduate School of Biomedical Sciences, Associate Professor, 大学院医歯薬学総合研究科, 助教授 (20237704)
FUMOTO Shintaro Nagasaki University, Graduate School of Biomedical Sciences, Assistant Professor, 大学院医歯薬学総合研究科, 助手 (70380988)
NAKASHIMA Mikiro Nagasaki University, Graduate School of Biomedical Sciences, Professor, 大学院医歯薬学総合研究科, 教授 (00260737)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2006: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2005: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | Pharmacy / Cancer / Gene / Anticancer agent / Liver / 5-Fluorouracil / Drug targeting / Drug delivery system |
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| Research Abstract |
It is important to develop the formulation for improving the regional delivery of anticancer agent. In the present study, we examined the effect of viscous additives on the absorption of 5-fluorouracil (5-FU) from the liver surface in rats. As a result, it is suggested the possibility to control the absorption of 5-FU from the liver surface utilizing the viscous additives.
Gene therapy is a novel therapeutic method for the treatment of acquired, refractory, and fatal diseases in addition to inheritable gene deficiency diseases. In clinical gene therapy, one of the critical barriers is construction of a gene delivery system. Previously, we developed a method for the application of drugs to the surface of intraperitoneal organs and found it to be useful for site-selective drug delivery. In the present study, we have demonstrated liver- and lobe-selective gene transfer following the instillation of naked plasmid DNA onto the liver surface in mice. Furthermore, liver- and lobe-specific gene tranfer following the continuous microinstillation of naked plasmid DNA using infusion pump was observed. This novel gene transfer method is expected to be a safe and effective treatment against liver cancer.
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