| Budget Amount *help |
¥3,810,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2006: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2005: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Research Abstract |
In 2005 - 2007, we first developed highly sensitive determination methods for kynurenic acid, kynurenine, N-acetylaspartic acid, amino acids, serotonin, and catecholamines and their metabolites,so on. Using these originally developed methods, novel findings listed below were obtained in our laboratory.
1. Plasma kynurenic acid was significantly increased in the ketamine-treated rats.
2. Plasma glutamate was significantly increased, while cerebrospinal fluids glutamate was significantly decreased in the ketamine-treated rats.
3. Following an intraperitoneal administration of D, L-kynurenine, AUC value of plasma D-KYN was significantly lower than that of L-KYN.
4. Plasma glutamate was significantly increased in the male schizophrenic patients, while plasma proline was significantly increased in the female patients.
5. Plasma kynurenic acid was unequivocally increased following intraperitoneal D-kynurenine administration to male rats. It was suggested that D-Amino acid oxidase was responsible for the production of kynurenic acid from D-kynurenine.
6. During constant infusion of N-acetyl-L-aspartic acid to rat prefrontal cortex, an increase of kynurenic acid accompanied by decreases of glutamate and glycine in the microdialysis sample was observed.
These findings are expected to be useful information for the further research on the schizophrenia.
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