| Project/Area Number |
17590140
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Mukogawa Women's University |
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Principal Investigator |
UCHIDA Takahiro Mukogawa Women's University, School of Pharmacy and Pharmaceutical Sciences, Professor, 薬学部, 教授 (70203536)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2006: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2005: ¥2,800,000 (Direct Cost: ¥2,800,000)
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| Keywords | Molecularly imprinted polymers / quinine / bitterness / L-Arg / 苦味アミノ酸 / 分岐鎖アミノ酸 |
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| Research Abstract |
Molecularly imprinted polymers (MIPs) for cinchonidine (CD) were prepared using methacyclic acid (MAA) as a functional monomer and ethylene glycol dimethacrylate (EDMA) as a crosslinker. CD-imprinted MAA-co-EDMA polymers can recognaize the related compounds quinidine and quinine, respectively, as well as the target molecules. We decided to use this CD-imprinted polymer system as a platform for screening suppressing agents for quinine.
The magnitudes of the association constants indicate the remarking of the inhibitory effect of the test chemicals on the CD-imprinted polymers. The association constants were calculated to be 12.6 mol^<-1>L for L-Arg. In the case of L-Lys, no association constant could be determined. This indicates that L-Arg have stronger affinities for the MIP for CD than L-Lys. The association constants obtained in an MIP study may therefore provide an indication of the bitterness-suppressing effects of test substances. The results of human gustatory sensation tests correlated well with the MIP data. The method using Taste sensor with MIPs seems to have specificity and more excellent sensitivity.
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