| Project/Area Number |
17590164
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Yamaguchi University |
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Principal Investigator |
TOKUDA Nobuko Yamaguchi Univ., Graduate Sch. Med., assistant professor, 大学院医学系研究科, 講師 (70227578)
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| Co-Investigator(Kenkyū-buntansha) |
ADACHI Yasuhiro Yamaguchi Univ. Graduate Sch. Med., research associate, 大学院医学系研究科, 助手 (10346546)
SIODA Seiji Showa Univ. Sch. Med., professor, 医学部, 教授 (80102375)
福本 哲夫 山口大学, 医学部, 教授 (00040171)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2005: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | cell ＆ tissue / brain ＆ nerve / radiation / immunology / thymus / neuropeptide / stromal cell / PACAP |
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| Research Abstract |
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a multifunctional and pleiotropic signal molecule with important activities related to immunity. We previously reported that the PACAP receptor (PAC1-R) is strongly expressed in storomal cells in the medulla of the rat thymus and that its expression in affected by irradiation. In this study we present a detailed investigation of PAC1-R-positive cells in the rat thymus and examine thymus cells of rhesus monkeys TCDD a chemical known to impair thymus and T cells.
In the rat thymus, PAC-1-R-positive cells were found in the intermediate type of thymic epithelial cells of the medulla. PAC1-R-potive cells were also seen in the thymic medulla of the rhesus monkey. The thymus showed unusual structures in some rhesus monkey dams and offspring exposed TCDD. Additionally, in these rhesus monkeys, PAC1-R expression was different from that in the control thymus.
PACAP has been reported to decrease ischemic neuronal damage and increase IL-6secretion in rats. We also investigated the role played by PACAP and IL-6 in mediating neuroprotection after ischemia. Our results suggest that PACAP prevents neuronal cell death after ischemia via a signaling mechanism involving IL-6.
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