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Characterizing the sympathetic premotor neurons participating in thermoregulatory responses

Research Project

Project/Area Number 17590199
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionUniversity of Yamanashi

Principal Investigator

SAIGUSA Takeshi  University of Yamanashi, Interdisciplinary Graduate School of Medicine and Engineering, Assistant Professor, 大学院医学工学総合研究部, 講師 (70215523)

Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥2,500,000 (Direct Cost: ¥2,500,000)
Keywordsbody-temperature regulation / sympathetic nerve / premotor neuron / medulla oblongata / multi-unit recording / unit discrimination
Research Abstract

1. In urethane-anesthetized spontaneously-breathing rabbits, activities of sympathetic premotor neurons in the raphe nuclei were recorded extracellularly to investigate the effects of thermal stimuli applied to the preoptic area and anterior hypothalamus ( PO/AH ) on the raphe neurons. Some neurons were activated by cold stimuli and inhibited by warming. The responses were well correlated with the changes in ear skin temperature, suggesting that these neurons were involved in the cutaneous vasoconstrictor pathway. Other neurons were inhibited by cooling and activated by warming. Although the role of these neurons was not clarified, it is possible that they are involved in the sympathetic pathway innervating visceral blood vessels, because visceral blood flow responds reciprocally to cutaneous one during thermal stimuli. Some of the neurons responding to thermal stimuli had phasic activities synchronized to cardiac and/or respiratory cycles, suggesting that baroreceptor and respiratory signals, as well as thermoregulatory signals, are converged to the raphe nuclei.
2. A new spike-sorting software was developed to improve separation of multi-unit activities. In this system, all the signals crossing a threshold are analyzed to get 12 kinds of peak and valley parameters. Any pair of these parameters can be displayed as a x-y scatter plot, on which any number of spike-sorting area can be defined. Based on the scatter plot, 2-dimensional histogram can also be displayed as a 3-dimensional surface plot, which makes easier to define sorting areas and to find out overlapped area of multiple units. As a result, the system improves quality of both single-unit recordings and simultaneous multi-unit recordings.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (3 results)

All 2007

All Journal Article (1 results) Book (2 results)

  • [Journal Article] The autonomic nervous system and body-temperature regulation.2007

    • Author(s)
      T.Saigusa
    • Journal Title

      In : Saishin jiritsu-shinkei-gaku(The latest neurology of the autonomic nervous system), Shinko-Igaku-Shuppan.

      Pages: 458-458

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 最新自律神経学(執筆担当箇所 : 第I章第3節 自律神経系と体温調節)2007

    • Author(s)
      三枝岳志
    • Total Pages
      458
    • Publisher
      新興医学出版社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 最新自律神経学 (執筆担当箇所 : 第1章第3節 自律神経系と体温調節)2007

    • Author(s)
      三枝岳志
    • Total Pages
      458
    • Publisher
      新興医学出版社
    • Related Report
      2006 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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