Clarification and application of vestibulo-cardiovascular reflex duringgravitational change

• Project/Area Number: 17590200
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Gifu University
• Principal Investigator: KUNIHIKO Tanaka Gifu University, 大学院・医学系研究科, 講師 (60313871)
• Co-Investigator(Kenkyū-buntansha): MORITA Hironobu 岐阜大学, 大学院・医学系研究科, 教授 (80145044)
• Project Period (FY): 2005 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,190,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000); Fiscal Year 2005: ¥800,000 (Direct Cost: ¥800,000)
• Keywords: 前庭-動脈圧反射 / 重力 / 圧受容器反射 / 起立性低血圧 / 内耳前庭器官 / 動脈血圧 / 前庭交感神経反射 / 内耳電気刺激 / 下半身陰圧負荷 / 心拍変動 / ウェーブレット変換

Research Abstract

重力変化時の動脈圧上昇に内耳前庭系が重要な役割を果たしていることを明らかにした。
内耳前庭系を電気刺激することにより前庭破壊同様の効果が得られることを発見した。
ヒトの起立時動脈圧調節に内耳前庭系が重要な役割を果たしていることを明らかにした。
ヒトに微弱な前庭電気刺激を行うことで起立性低血圧の治療が行える可能性を見出した。

Research Products

• [Journal Article] A novel type of implantable and programmable infusion pump for small laboratory animals. (2009)
  • Author(s): Abe C, Tashiro T, Tanaka K, Ogihara R, Morita H.
  • Journal Title: J Pharmacol Toxicol Methods. 59 Pages: 7-12
  • Peer Reviewed
• [Journal Article] Vestibular system plays a significant role in arterial pressure control during head-up tilt in young subjects. (2009)
  • Author(s): Tanaka K, Abe C, Awazu C Morita H.
  • Journal Title: Auton Neurosci (In press)
  • Peer Reviewed
• [Journal Article] The vestibular system is integral in regulating plastic alterations in the pressor response to free drop mediated by the nonvestibular system (2008)
  • Author(s): Abe C, Tanaka K, Awazu C, Morita H.
  • Journal Title: Neurosci. Lett. 445 Pages: 149-52
  • Peer Reviewed
• [Journal Article] Impairment of vestibular-mediated cardiovascular response and motor coordination in rats born and reared under hypergravity (2008)
  • Author(s): Abe C, Tanaka K, Awazu C, Morita H.
  • Journal Title: Am J Physiol 295
  • Peer Reviewed
• [Journal Article] Strong galvanic vestibular stimulation obscures arterial pressure response to gravitational change in conscious rats (2008)
  • Author(s): Abe C, Tanaka K, Awazu C, Morita H.
  • Journal Title: J Appl Physiol 104 Pages: 34-40
  • Peer Reviewed
• [Journal Article] 宇宙環境下での循環調節 : 重力変化に対する動脈血圧応答 (2008)
  • Author(s): 森田啓之、安部力、田中邦彦
  • Journal Title: 麻酔 57
• [Journal Article] The vestibular system is integral in regulating plasticalterations in the pressor response to free drop mediated by the nonvestibular system. (2008)
  • Author(s): Abe C, Tanaka K, Awazu C Morita H.
  • Journal Title: Neurosci Lett. 445 Pages: 149-152
  • Peer Reviewed
• [Journal Article] Impairment of vestibular-mediated cardiovascular response and motor coordination in rats born and reared underhypergravity. (2008)
  • Author(s): Abe C, Tanaka K, Awazu C Morita H.
  • Journal Title: Am J Physiol Regul Integr Comp Physiol 295
  • Peer Reviewed
• [Journal Article] Strong galvanic vestibular stimulation obscures arterial pressure response to gravitational change in conscious rats. (2008)
  • Author(s): Abe C, Tanaka K, Awazu C, Morita H.
  • Journal Title: J. Appl. Physiol. 104 Pages: 34-40
  • Peer Reviewed
• [Journal Article] Plastic alteration of vestibulo-cardiovascular reflex induced by 2 weeks of 3-G load in conscious rats (2007)
  • Author(s): Abe C, Tanaka K, Awazu C, Chen H, Morita H.
  • Journal Title: Exp Brain Res. 181 Pages: 639-646
  • Peer Reviewed
• [Journal Article] Long-term hypergravity induces plastic alterations in vestibulo-cardiovascular reflex in conscious rats. (2007)
  • Author(s): Morita H, Abe C, Awazu C, Tanaka K.
  • Journal Title: Neurosci Lett. 412 Pages: 201-205
  • Peer Reviewed
• [Journal Article] Strong galvanic vestibular stimulation obscures arterial pressure response to gravitational change in conscious rats. (2007)
  • Author(s): Abe C, Tanaka K, Awazu C, Chen H, Morita H.
  • Journal Title: Exp. Brain. Res. 181 Pages: 639-646
  • Peer Reviewed
• [Journal Article] Long-term hypergravity induces plastic alterations in vestibulo-cardiovascular reflex in conscious rats. (2007)
  • Author(s): Morita H, Abe C, Awazu C, Tanaka K
  • Journal Title: Neuroscience Letters 412(3) Pages: 201-205
• [Journal Article] Roles of vestibular system in controlling arterial pressure in conscious rats during a short period of microgravity (2006)
  • Author(s): Tanaka K, Gotoh TM, Awazu C, Morita H.
  • Journal Title: Neurosci Let. 397 Pages: 40-43
  • Peer Reviewed
• [Journal Article] 耳と血圧と宇宙医学 (2006)
  • Author(s): 田中邦彦、後藤太郎、安部力、森田啓之
  • Journal Title: 形の科学会誌 21 Pages: 361-365
  • NAID: 10020293674
• [Journal Article] Roles of vestibular system in controlling arterial pressure in conscious rats during a short period of microgravity. (2006)
  • Author(s): Tanaka K, Gotoh MT, Awazu C, Morita H
  • Journal Title: Neuroscience Letters 397(1-2) Pages: 40-43
• [Journal Article] Roles of vestibular system in controlling arterial pressure in conscious rats during a short period of microgravity. (2005)
  • Author(s): Tanaka K, Gotoh MT, Awazu C, Morita H
  • Journal Title: Neuroscience Letters (In press)
• [Journal Article] Vestibular system plays a significant role in arterial pressure control during head-up tilt in young subjects
  • Author(s): Tanaka K, Abe C, Awazu C, Morita H.
  • Journal Title: Auton Neurosci (in press)
  • Peer Reviewed
• [Presentation] 経皮的内耳電気刺激による起立性低血圧治療の試み (2009)
  • Author(s): 田中邦彦、安部力、坂井田譲、青木光広、森田啓之
  • Organizer: 第19回日本病態生理学会大会
  • Place of Presentation: 神奈川
  • Year and Date: 2009-01-24
• [Presentation] 前庭-動脈血圧応答低下に対する前庭電気刺激の効果 (2009)
  • Author(s): 安部力、田中邦彦、粟津ちひろ、森田啓之
  • Organizer: 第19回日本病態生理学会大会
  • Place of Presentation: 神奈川
  • Year and Date: 2009-01-24
• [Presentation] 前庭一動脈血圧応答低下に対する前庭電気刺激の効果 (2009)
  • Author(s): 安部力, 田中邦彦, 粟津ちひろ, 森田啓之
  • Organizer: 第19回日本病態生理学会大会
  • Place of Presentation: 神奈川
  • Year and Date: 2009-01-24
• [Presentation] 前庭-動脈血圧応答低下に対する前庭電気刺激の効果 (2009)
  • Author(s): 安部力、田中邦彦、森田啓之
  • Organizer: 第25回宇宙利用シンポジウム
  • Place of Presentation: 神奈川
  • Year and Date: 2009-01-14
• [Presentation] 起立時の血圧調節における前庭系の役割とその可塑性 (2009)
  • Author(s): 森田啓之、安部力、粟津ちひろ、田中邦彦
  • Organizer: 第25回宇宙利用シンポジウム
  • Place of Presentation: 神奈川
  • Year and Date: 2009-01-14
• [Presentation] 過重力環境下飼育ラットの代謝における前庭系の関与 (2008)
  • Author(s): 粟津ちひろ、安部力、田中邦彦、森田啓之
  • Organizer: 第54回日本宇宙航空環境医学会大会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-14
• [Presentation] 前庭-動脈血圧応答低下に対する前庭電気刺激の効果 (2008)
  • Author(s): 安部力、田中邦彦、粟津ちひろ、森田啓之
  • Organizer: 第54回日本宇宙航空環境医学会大会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-14
• [Presentation] 前庭一動脈血圧応答低下に対する前庭電気刺激の効果 (2008)
  • Author(s): 安部力, 田中邦彦, 粟津ちひろ, 森田啓之
  • Organizer: 第54回日本宇宙航空環境医学会大会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-14
• [Presentation] 経皮的内耳電気刺激による起立性低血圧予防の可能性 (2008)
  • Author(s): 田中邦彦、安部力、森田啓之
  • Organizer: 第55回中部日本生理学会大会
  • Place of Presentation: 愛知
  • Year and Date: 2008-10-18
• [Presentation] 微弱な内耳電気刺激は起立性低血圧を予防できるか (2008)
  • Author(s): 田中邦彦、安部 力、東南杏香、森田啓之
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京 京王プラザホテル
  • Year and Date: 2008-03-27
• [Presentation] 過重力環境が前庭-動脈血圧反射に与える影響 (2008)
  • Author(s): 安部 力、田中邦彦、粟津ちひろ、森田啓之
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京 京王プラザホテル
  • Year and Date: 2008-03-27
• [Presentation] 重力ストレス時の動脈血圧調節 : 自律神経の役割 (2008)
  • Author(s): 森田啓之、安部力、粟津ちひろ、田中邦彦
  • Organizer: 第85回日本生理学会大会シンポジウム「Whole bodyへのアプローチ : 自律神経・神経内分泌研究の新たな潮流」
  • Place of Presentation: 東京
  • Year and Date: 2008-03-25
• [Presentation] 微弱な内耳電気刺激は起立性低血圧を予防できるか (2008)
  • Author(s): 田中邦彦、安部力、東南杏香、森田啓之
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-25
• [Presentation] 過重力環境が前庭-動脈血圧反射に与える影響 (2008)
  • Author(s): 安部力、田中邦彦、粟津ちひろ、森田啓之
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-25
• [Presentation] 前庭系発達期における過重力負荷が前庭-動脈血圧応答に与える影響 (2008)
  • Author(s): 安部力、田中邦彦、森田啓之
  • Organizer: 第18回日本病態生理学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-01-26
• [Presentation] 動脈圧周波数成分と末梢血管抵抗の関係 (2008)
  • Author(s): 田中邦彦、安部力、森田啓之
  • Organizer: 第18回日本病態生理学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-01-26
• [Presentation] 前庭系発達期における過重力負荷が前庭-動脈血圧応答に与える影響 (2008)
  • Author(s): 安部 力、田中邦彦、森田啓之
  • Organizer: 第18回日本病態生理学会大会
  • Place of Presentation: 神戸学院大学
  • Year and Date: 2008-01-26
• [Presentation] XY平面上の直線加速に対する前庭-動脈血圧応答の可塑性 (2007)
  • Author(s): 安部 力、田中邦彦、森田啓之
  • Organizer: 第53回日本宇宙航空環境医学会総会
  • Place of Presentation: 愛知医科大学
  • Year and Date: 2007-11-09
• [Presentation] Galvanic vestibular stimulation impairs arterial pressure response during posture and gravity change in human subjects (2007)
  • Author(s): Tanaka K, Abe C, Awazu C, Morita H.
  • Organizer: The 37th annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2007-11-04
• [Presentation] Feasibility of employing galvanic vestibular stimulation to block the vestibular origin pressor response in conscious rats (2007)
  • Author(s): Morita H, Abe C, Awazu C, Tanaka K.
  • Organizer: The 37th annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2007-11-04
• [Presentation] Effect of long-term hypergravity load on linear acceleration-induced pressor response in conscious rats (2007)
  • Author(s): Abe C, Tanaka K, Awazu C, Morita H.
  • Organizer: The 37th annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2007-11-04
• [Presentation] Galvanic vestibular stimulation impairs arterial pressure response during posture and gravity change in human subjects. (2007)
  • Author(s): Tanaka K, Abe C, Awazu C, Morita H.
  • Organizer: The 37th annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, CA, U. S. A
  • Year and Date: 2007-11-03
• [Presentation] Feasibility of employing galvanic vestibular stimulation to block the vestibular orig(in press)or response in conscious rats. (2007)
  • Author(s): Morita H, Abe C, Awazu C, Tanaka K.
  • Organizer: The 37th annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, CA, U.S.A
  • Year and Date: 2007-11-03
• [Presentation] Effect of long-term hypergravity load on linear acceleration-induced pressor response in conscious rats. (2007)
  • Author(s): Abe C, Tanaka K, Awazu C, Morita H.
  • Organizer: The 37th annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, CA, U.S.A
  • Year and Date: 2007-11-03
• [Presentation] 3G環境下飼育ラットにおける前庭-動脈圧反射の可塑性 (2007)
  • Author(s): 安部力、田中邦彦、森田啓之
  • Organizer: 第84回日本生理学会大会
  • Place of Presentation: 大阪
  • Year and Date: 2007-03-21
• [Presentation] 前庭系によるフィードフォワード的血圧制御 (2007)
  • Author(s): 森田啓之、田中邦彦、安部力
  • Organizer: 第84回日本生理学会大会
  • Place of Presentation: 大阪
  • Year and Date: 2007-03-21
• [Presentation] 姿勢変化時の血圧調節における経皮的内耳電気刺激の効果 (2007)
  • Author(s): 田中邦彦, 安部力, 粟津ちひろ, 森田啓之
  • Organizer: 第17回日本病態生理学会大会
  • Place of Presentation: 沖縄
  • Year and Date: 2007-01-27
• [Presentation] Galvanic vestibular stimulation (GVS)による前庭系応答の遮断 (2007)
  • Author(s): 安部力、田中邦彦、粟津ちひろ、森田啓之
  • Organizer: 第17回日本病態生理学会大会
  • Place of Presentation: 沖縄
  • Year and Date: 2007-01-27
• [Presentation] 姿勢変化時の血圧調節における前庭系の役割 (2006)
  • Author(s): 粟津ちひろ、田中邦彦、安部力、森田啓之
  • Organizer: 第52回日本宇宙航空環境医学会総会
  • Place of Presentation: 米子
  • Year and Date: 2006-11-10
• [Presentation] 3G環境下飼育ラットにおける前庭-動脈血圧反射の可塑性 (2006)
  • Author(s): 安部力、田中邦彦、粟津ちひろ、森田啓之
  • Organizer: 第52回日本宇宙航空環境医学会総会
  • Place of Presentation: 米子
  • Year and Date: 2006-11-10
• [Presentation] 耳と血圧と宇宙医学 (2006)
  • Author(s): 田中邦彦、後藤太郎、安部力、森田啓之
  • Organizer: 形の科学会形シューレ2006
  • Place of Presentation: 岐阜
  • Year and Date: 2006-09-24
• [Presentation] Role of Vestibular System in Controlling Arterial Pressure during a Short Period of Microgravity (2006)
  • Author(s): Tanaka K, Awazu C, Abe C, Morita H.
  • Organizer: 27th Annual International Gravitational Physiology Meeting
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2006-04-24
• [Presentation] 60度頭高位意識下ラットの動脈圧調節における内耳前庭系の役割 (2006)
  • Author(s): 安部力、田中邦彦、森田啓之
  • Organizer: 第83回日本生理学会大会
  • Place of Presentation: 群馬
  • Year and Date: 2006-03-29
• [Presentation] 意識下ラットにおける微小重力曝露時の動脈圧変化 (2005)
  • Author(s): 田中邦彦、安部力、粟津ちひろ、森田啓之
  • Organizer: 第33回自律神経生理研究会
  • Place of Presentation: 東京
  • Year and Date: 2005-12-03
• [Presentation] 微小重力暴露時動脈血圧調節における内耳と体性感覚の役割 (2005)
  • Author(s): 田中邦彦、粟津ちひろ、後藤太郎、森田啓之
  • Organizer: 日本宇宙生物科学会第19回大会
  • Place of Presentation: 東京
  • Year and Date: 2005-09-29
• [Remarks]
  • URL: http://wwwl.gifu-u.ac.jp/~physiol/
• [Remarks]
  • URL: http://www1.gifu-u.ac.jp/~physiol/our_lab.html