| Project/Area Number |
17590266
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
|
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| Research Institution | Osaka University |
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Principal Investigator |
OJI Yusuke Osaka University, Dept.of Biomedical Informatics, Associate Professor, 医学系研究科, 助教授 (20294100)
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| Co-Investigator(Kenkyū-buntansha) |
OKA Yoshihiro Osaka University, Dept.of Molecular Medicine, Associate Professor, 医学系研究科, 講師 (20273691)
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| Project Period (FY) |
2005 – 2006
|
| Project Status |
Completed (Fiscal Year 2006)
|
| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2006: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2005: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | WT1 / anti-apootosis / motility / leukemia / solid cancer / 癌遺伝子 / 抗アポトーシス / 浸潤能 / 発がん遺伝子 / プロテオミクス |
|---|
| Research Abstract |
The WT1 gene has four isoforms by alternative splicing at two sites [17AA(+)KTS(+),17AA(+)KTS(-),17AA(-)KTS(+),17AA(-)KTS(-)]. In the present project, we have demonstrated that WT1 17AA(+) isoforms [17AA(+)KTS(+),17AA(+)KTS(-)] played antiapoptotic roles in leukemia and various kinds of solid cancers and that WT1 17AA(-)KTS(-) isoform promoted cell motility and played antiapoptotic roles in solid cancers. Moreover, the studies using deletion mutants revealed several sites of the WT1 gene associated with its antiapoptotic function and enhancement of cell motility.
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