Regulatory role of phosphorylation of tumor suppressor Fhit protein

• Project/Area Number: 17590275
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Jichi Medical University
• Principal Investigator: ISHII Hideshi Jichi Medical University, School of Medicine, Lecturer (10280736)
• Project Period (FY): 2005 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥3,140,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2006: ¥800,000 (Direct Cost: ¥800,000); Fiscal Year 2005: ¥1,300,000 (Direct Cost: ¥1,300,000)
• Keywords: Biochemistry / Tumor Suppressor Gene / Checkpoints / genomic / Lgenomic Instability / Cancer Stem Cells / FHIT

Research Abstract

The fragile FHIT gene is among the first targets of DNA damage in preneoplastic lesions and recent studies have shown that Fhit protein is involved in surveillance of genome integrity and checkpoint response after genotoxin exposure. We studied that Fhit modulate the checkpoint response via regulation of phosphorylation at Y114 of Fhit protein. The response was regulated Atr kinase, and define the responsiveness of normal and cancer cells. Furthermore, Fhit-deficient hematopoietic cells, exposed to the genotoxin hydroquinone, are resistant to the suppression of stem cell in vitro colony formation observed with wild type hematopoietic cells. The present results indicate that reduced oxidative stress, coupled with efficient but error-prone DNA damage repair, allows unscheduled, long-term survival of genotoxin-exposed Fhit-deficient hematopoietic stem cells carrying deleterious mutations, suggesting the significance in the multistep carcinogenesis.

Research Products

• [Journal Article] Clinical significance of the reduced expression of G protein gamma 7(GNG7) in esophageal cancer (2008)
  • Author(s): Ishii, H., (9人中7番目)
  • Journal Title: Br.J.Cancer 98 Pages: 410-417
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Fez 1/Lzts 1 deficient mice are more susceptible to N-butyl-N-(4-hydroxybutil) nitrosamine(BBN) carcinogenesis (2008)
  • Author(s): Baffa R, Fassan M, Sevignani C, Vecchione A, Isha H, Giarnieri E, Iozzo, RV, Gomella, LG, Croce, CM
  • Journal Title: Carcinogenesis (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Fhit-deficient hematopoietic stem cells survive hydroquinone exposure carrying precancerous changes (2008)
  • Author(s): Ishii, H., Mimori, K., Ishikawa, K., Okumura, H., Pichiorri, F., Druck, T., Inoue, H., Vecchione, A., Saito, T., Mori, M., Huebner, K
  • Journal Title: Cancer Res (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Clinical significance of the reduced expression of G protein gamma 7(GNG7) in esophageal cancer (2008)
  • Author(s): Ohta, M., Mimori, K., Fukuyoshi, Y., Kita, Y., Motoyama, K., Yamashita, K., Ishii, H., Inoue, H., Mori, M
  • Journal Title: Br. J. Cancer 98 Pages: 410-7
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Clinical significance of the reduced expression of G protein gamma 7 (GNG7) esophageal cancer. (2008)
  • Author(s): Ishii, H., (9人中7番目)
  • Journal Title: Br. J. Cancer 98 Pages: 410-417
  • Peer Reviewed
• [Journal Article] Fezl/Lztsl absence impairs Cdkl/Cdc25C interaction during mitosis and predisposes to cancer development (2007)
  • Author(s): Ishii, H., (13人中3番目)
  • Journal Title: Cancer Cell 11 Pages: 275-289
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Rad9 modulates the P21WAF1 pathway by direct association with p53 (2007)
  • Author(s): Ishii, H., (10人中2番目)
  • Journal Title: BMC Mol.Biol 8 Pages: 37-37
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Rad9 modulates the P21WAF1 pathway by direct association with p53 (2007)
  • Author(s): Ishikawa K, Ishii H, Murakumo Y, Mimori K, Kobayashi M, Yamamoto, KI, Mori M, Nishino H, Furukawa Y, Ichimura, K
  • Journal Title: BMC Mol. Biol 8(1) Pages: 37-37
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Fezl/Lztsl absence impairs Cdkl/Cdc25C interaction during mitosis and predisposes to cancer development (2007)
  • Author(s): Vecchione, A., Bladassarre, G., Ishii, H., Belletti, B., Nicoloso, M.S., Fong, LY.Y., Zanesi, N., Petrocca, F., Fidanza, V., Alder, H., Donovan, P.J., Baffa, R., Croce, C.M
  • Journal Title: Cancer Cell 11 Pages: 275-289
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Fezl/Lztsl absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes to cancer development. (2007)
  • Author(s): Ishii, H., (13人中3番目)
  • Journal Title: Cancer Cell 11 Pages: 275-289
  • Peer Reviewed
• [Journal Article] Rad9 modulates the P21WAF1 pathway by direct association with p53. (2007)
  • Author(s): Ishii, H., (10人中2番目)
  • Journal Title: BMC Mol. Biol. 8 Pages: 37-37
  • Peer Reviewed
• [Journal Article] The epidermal growth factor receptor gene sequence is highly conserved in primary gastric cancers (2006)
  • Author(s): Mimori, K., et. al.
  • Journal Title: J.Surg.Oncol 93 Pages: 44-6
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Histone deacetylase inhibitor depsipeptide(FK228)induces apoptosis in leukemic cells by facilitating mitochondrial translocation of Bax,which is enhanced by the proteasome inhibitor bortezomib (2006)
  • Author(s): Sutheesophon, K., et. al.
  • Journal Title: Acta Haematol 115 Pages: 78-90
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Fhit modulation of the Akt-survivin pathway in lung cancer cells:Fhit-tyrosine 114(Y114)is essential (2006)
  • Author(s): Semba, S., et. al.
  • Journal Title: Oncogene 25 Pages: 2860-72
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] FHIT is up-regulated by inflammatory stimuli and inhibits prostaglandin E2-mediated cancer progression (2006)
  • Author(s): Mimori, K., et. al.
  • Journal Title: Cancer Res 66 Pages: 2683-90
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Fhit Modulates the DNA Damage Checkpoint Response (2006)
  • Author(s): Ishii, H., et. al.
  • Journal Title: Cancer Res 66(23) Pages: 11287-92
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Radiation induced response of micro RNA expression in murine embryonic stem cells (2006)
  • Author(s): Ishii, H., et. al.
  • Journal Title: Med.Chem 2(6) Pages: 555-63
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Loss of MAL expression in precancerous lesions of the esophagus (2006)
  • Author(s): Mimori, K., Nishida, K., Nakamura, Y., Ieta, K., Yoshikawa, Y., Sasaki, A., Ishii, H., Alonso, M.A., Mori, M
  • Journal Title: Ann. Surg. Oncol
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Radiation-induced response of micro RNA expression in murine embryonic stem cells (2006)
  • Author(s): Ishii., H., Saito, T
  • Journal Title: Med. Chem 2 Pages: 555-63
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Fhit Modulates the DNA Damage Checkpoint Response (2006)
  • Author(s): Ishii., H., Mimori, K., Inoue, H., Inageta, T., Ishikawa, K., Semba, S., Druck, T., Trapasso, F., Tani, K., Vecchione, A., Croce, C.M., Mori, M., Huebner, K
  • Journal Title: Cancer Res 66 Pages: 11287-92
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] FHIT is up-regulated by inflammatory stimuli and inhibits prostaglandin E2-mediated cancer progression (2006)
  • Author(s): Mimori, K., Ishii, H., Nagahara, H., Sudo, T., Yamashita, K., Inoue, H., Barnard, G.F., Mori, M
  • Journal Title: Cancer Res 66 Pages: 2683-90
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Fhit modulation of the Akt-survivin pathway in lung cancer cells : Fhit-tyrosine 114(Y114) is essential (2006)
  • Author(s): Semba, S., Trapasso, F., Fabbri, M., McCorkell, K.A., Volinia, S., Druck, T., Iliopoulos, D., Pekarsky, Y., Ishii. H., Garrison, P.N., Barnes, LD., Croce, C.M., Huebner, K
  • Journal Title: Oncogene 25 Pages: 2860-72
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Histone deacetylase inhibitor depsipeptide(FK228) induces apoptosis in leukemic cells by facilitating mitochondrial translocation of Bax, which is enhanced by the proteasome inhibitor bortezomib (2006)
  • Author(s): Sutheesophon, K., Kobayashi, Y., Takatoku, M.A., Ozawa, K., Kano, Y., Ishii E, Furukawa, Y
  • Journal Title: Acta Haematol 115 Pages: 78-90
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The epidermal growth factor receptor gene sequence is highly conserved in primary gastric cancers (2006)
  • Author(s): Mimori, K., Nagahara, H., Sudo, T., Jshii, H., Yamashita, K., Barnard, G.F., Mori, M
  • Journal Title: J. Surg. Oncol 93
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The epidermal growth factor receptor gene sequence is highly conserved in primary gastric cancers. (2006)
  • Author(s): Mimori, K. et al.
  • Journal Title: J.Sung.Oncol. 93 Pages: 44-6
• [Journal Article] Histone deacetylase inhibitor depsipeptide (FK228) induces apoptosis in leukemic cells by facilitating mitochondrial translocation of Bax, which is enhanced by the proteasome inhibitor bortezomib. (2006)
  • Author(s): Sutheesopphon, K., et al.
  • Journal Title: Acta Haematol. 115 Pages: 78-90
• [Journal Article] Fhit modulation of the Akt-survivin pathway in lung cancer cells : Fhit-tyrosine 114(Y114) is essential. (2006)
  • Author(s): Semba, S., et al.
  • Journal Title: Oncogene 25 Pages: 2860-72
• [Journal Article] FHIT is up-regulated by inflammatory stimuli and inhibits prostaglandin E2-mediated cancer progression. (2006)
  • Author(s): Mimori, K. et al.
  • Journal Title: Cancer Res. 66 Pages: 2683-90
• [Journal Article] Fhit Modulates the DNA Damage Checkpoint Response. (2006)
  • Author(s): Ishii, H. et al.
  • Journal Title: Cancer Res. 66(23) Pages: 11287-92
• [Journal Article] Radiation-induced response of micro RNA expression in murine embryonic stem cells. (2006)
  • Author(s): Ishii, H. et al.
  • Journal Title: Med.Chem. 2(6) Pages: 555-63
• [Journal Article] Fragl,a homelog of alternative replication factor C subunits,links replication stress surveillance with apoptosis (2005)
  • Author(s): Ishii, H., et. al.
  • Journal Title: Proc.Natl.Acad.Sci.USA 102.27 Pages: 9655-9660
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Differential roles of E-type cyclins during transformation of murine E2F-1-deficient cells (2005)
  • Author(s): Ishii, H., et. al.
  • Journal Title: DNA Cell.Biol 24 Pages: 173-179
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Involvement of the tumor necrosis factor(TNF)/TMF receptor system in leukemic cell apoptosis by an histone deacetylase inhibitor depsideptide(FK228) (2005)
  • Author(s): Sutheesophon, K., et. al.
  • Journal Title: J.Cell.Physiol 203 Pages: 387-97
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Differentially expressed genes in endothelial differentiation (2005)
  • Author(s): Ishii, H., et. al.
  • Journal Title: DNA Cell.Biol 24 Pages: 432-7
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Components of DNA damage checkpoint pathway regulate ultraviolet exposure dependent alterations of gene expression of FHIT and WWOX in chromosome fragile sites (2005)
  • Author(s): Ishii, H., et. al.
  • Journal Title: Mol.Cancer Res 3 Pages: 130-8
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Methylation Silencing of the Apaf-1 Gene in Acute Leukemia (2005)
  • Author(s): Furukawa Y., et. al.
  • Journal Title: Mol. Cancer Res 3・6 Pages: 325-34
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] ゲノム不安定性と造血器腫瘍 (2005)
  • Author(s): 石井 秀始
  • Journal Title: 医学のあゆみ「血液疾患State of Arts, Ver3」 別冊 Pages: 218-220
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis (2005)
  • Author(s): Ishii., H., Inageta, T., Mimori, K., Saito, T., Sasaki, H., Isobe, M., Mori, M., Croce, C.M., Huebner, K., Ozawa, K. Furukawa, F., Fragl
  • Journal Title: Proc. Natl. Acad. Sci. USA 102 Pages: 9655-60
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Components of DNA damage checkpoint pathway regulate ultraviolet exposure-dependent alterations of gene expression of FHIT and WWOX in chromosome fragile sites (2005)
  • Author(s): Jshii, H., Mimori, K., Inageta, T., Murakumo, Y., Vecchione, A., Mori, M., Furukawa, Y
  • Journal Title: Cancer Res 3 Pages: 130-8
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Involvement of the tumor necrosis factor(TNF)/TNF-receptor system in leukemic cell apoptosis by an histone deacetylase inhibitor depsidepti de(FK228) (2005)
  • Author(s): Sutheesophon, K., Nishimura, N., Furukawa, Y., Kawano, M., Ito, K., Kano, Y., Ishii. H., Furukawa, Y
  • Journal Title: J. Cell. Physiol 203 Pages: 387-97
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Methylation silencing of the Apaf-1 gene in acute leukemia (2005)
  • Author(s): Furukawa Y., Sutheesophon K., Wada T., Nishimura M., Saito Y., Ishii H., Furukawa, Y
  • Journal Title: Mol. Cancer Res 3 Pages: 325-34
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Differentially expressed genes in endothelial differentiation (2005)
  • Author(s): Jshii, H., Mimori, K., Mori, M., Vecchione, A
  • Journal Title: DNA Cell. Biol 24 Pages: 432-7
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Differential roles of E-type cyclins during transformation of murine E2F- 1-deficient cells (2005)
  • Author(s): Ishii, H., Mimori, K., Yoshikawa, Y., Mori, M., Furukawa, Y., Vecchione, A
  • Journal Title: DNA Cell. Biol 24 Pages: 173-9
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis. (2005)
  • Author(s): Ishii, H., et al.
  • Journal Title: Proc.Natl.Acad.Sci.USA 102・27 Pages: 9655-9660
• [Journal Article] Differential roles of E-type cyclins during transformation of murine E2F-1-deficient cells. (2005)
  • Author(s): Ishii, H., et al.
  • Journal Title: DNA Cell.Biol. 24 Pages: 173-179
• [Journal Article] Involvement of the tumor necrosis factor (TNF)/TNF-receptor system in leukemic cell apoptosis by an histone deacetylase inhibitor depsideptide (FK228). (2005)
  • Author(s): Sutheesophon, K., et al.
  • Journal Title: J.Cell.Physiol. 203 Pages: 387-397
• [Journal Article] Differentially expressed genes in endothelial differentiation. (2005)
  • Author(s): Ishii, H., et al.
  • Journal Title: DNA Cell.Biol. 24 Pages: 432-437
• [Journal Article] Components of DNA damage checkpoint pathway regulate ultraviolet exposure-dependent alterations of gene expression of FHIT and WWOX in chromosome fragile sites. (2005)
  • Author(s): Ishii, H., et al.
  • Journal Title: Mol.Cancer Res. 3 Pages: 130-138
• [Journal Article] Methylation Silencing of the Apaf-1 Gene in Acute Leukemia. (2005)
  • Author(s): Furukawa Y., et al.
  • Journal Title: Mol.Cancer Res. 3・6 Pages: 325-334
• [Presentation] Implication of Rad9-p53 pathway in head and neck cancer (2007)
  • Author(s): Ishii, H., (5人中2番目)
  • Organizer: 第30回日本分子生物学会年会、第80回日本生化学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-11
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 第18回消化器癌発生学会総会 (2007)
  • Author(s): Ishii, H., (5人中2番目)
  • Organizer: 炎症応答が関わる食道粘膜上皮幹細胞の発癌機構と癌挿制遣伝子FHITの役割
  • Place of Presentation: 札幌
  • Year and Date: 2007-11-08
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Functional study of a tumor suppressor gene, FEZ1/LZTS1, from aregion at human chromosome 8p22 (2007)
  • Author(s): Ishii, H., (4人中1番目)
  • Organizer: 第69回日本血会液学会総会、第49回日本臨床血液学会合同総会
  • Place of Presentation: 構浜
  • Year and Date: 2007-10-11
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] FHIT is associated with the inflammation related cancers of esophagus and colon (2007)
  • Author(s): Ishii, H., (4人中2番目)
  • Organizer: The 12th Taishotoyama International Symposium on Gastroenterology
  • Place of Presentation: Shimoda,Japan
  • Year and Date: 2007-04-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] FHIT is associated with the inflammation related cancers of esoohaaus and colon (2007)
  • Author(s): Ishii, H., (4人中2番目)
  • Organizer: The 12th Taishotoyama International Symposium on Gastroenterology
  • Place of Presentation: Shimoda,Japan
  • Year and Date: 2007-04-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] FHIT is associated with the inflammation related cancers of esophagus and colon (2007)
  • Author(s): Mimori K, Ishii H, Inoue H, Mori, M
  • Organizer: The 12th Taishotoyama International Symposium on Gastroenterology Session
  • Place of Presentation: Shimoda, Japan
  • Year and Date: 2007-04-28
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] FHIT is associated with the inflammation related cancers of esophagus and colon. (2007)
  • Author(s): Ishii, H., (4人中2番目)
  • Organizer: The 12^<th> Taishotoyama International Symposium on Gastroenterology
  • Place of Presentation: Shimoda, Japan
  • Year and Date: 2007-04-28
• [Presentation] 第66回日本がん学会総会 (2007)
  • Author(s): Ishii, H., (4人中2番目)
  • Organizer: Rad9 associates with p53 directly and modulates the P21^<WFA1> pathway
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 共通染色体脆弱部位遺伝子のゲノム安定性制御への関与 (2006)
  • Author(s): Ishii, H., (3人中1番目)
  • Organizer: 第68回日本血液学会緯会、第48回目本臨床血液学会合同総会
  • Place of Presentation: 福岡
  • Year and Date: 2006-10-06
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] p53を介するP21発現制御におけるRad9の役割と腫瘍増殖への関与 (2006)
  • Author(s): Ishii.H., (8人中2番目)
  • Organizer: 第30回日本頭頸部癌学会
  • Place of Presentation: 大阪
  • Year and Date: 2006-06-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Fhit Modulates the DNA Damage Checkpoint Response (2006)
  • Author(s): Ishii, H., (11人中1番目)
  • Organizer: 第20回国際生化学、分子生物学会議(20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress)
  • Place of Presentation: Kyoto,Japan
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] A role of Rad9 in regulation of p53-dependent p21^<waf1> activation after exposure to UV light (2006)
  • Author(s): Ishii, H., (8人中2番目)
  • Organizer: 第20回国際生化学、分子生物学会議(20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress)
  • Place of Presentation: Kyoto,Japan
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Fhit Modulates the DNA Damage Checkpoint Response (2006)
  • Author(s): Ishii, H-Mimori, K., Inoue, H., Inageta, T., Ishikawa, K., Semba, S., Druck, T., Trapasso, F., Mori, M., Croce, C.M., Huebner, K
  • Organizer: 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
  • Place of Presentation: Kyoto, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Arole of Rad9 in regulation of p53-dependent p21^waf1 activation after exposure to UV light (2006)
  • Author(s): Ishikawa, K., Ishii. H., Kobayashi, M., Yamamoto, K.-i., Yokota, J., Karnitz, LM., Furukawa, Y., Ichimura, K
  • Organizer: 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
  • Place of Presentation: Kyoto, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Identification of Bone-fide Characterstics of Esophageal Cancer by Adenobiral-FHIT Treatment (2005)
  • Author(s): Mimori K, IshiLE, Okamoto M, Barnard, GF, Huebner K, Croce, CM, Mori, M
  • Organizer: The 58th Annual Cancer Symposium of SSO
  • Place of Presentation: Atlanta, USA
  • Year and Date: 2005-03-06
  • Description: 「研究成果報告書概要(欧文)」より
• [Patent(Industrial Property Rights)] 癌治療薬及びそのスクリーニング法 (2006)
  • Inventor(s): イシカワ、カズヒロ イシイ、ヒデシ イチムラ、ケイイチ
  • Industrial Property Rights Holder: 自治医科大学
  • Industrial Property Number: 2006-164890
  • Filing Date: 2006-06-14
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 癌治療薬及びそのスクリーング法 (2006)
  • Inventor(s): イシカワカズヒロ, イシイヒデシ, イチムラケイイチ
  • Industrial Property Rights Holder: 自治医科大学
  • Industrial Property Number: 2006-164890
  • Filing Date: 2006-06-14