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Overexpression of c-Maf in angioimmunoblastic T cell lymphoma

Research Project

Project/Area Number 17590299
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionNagoya University

Principal Investigator

MORI Naoyoshi  Nagoya University, Graduate School of Medicine, Professor, 大学院医学系研究科, 教授 (90045732)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Satoru  Tsukuba University, Graduate School of Comprehensive Human Sciences, Professor, 大学院人間総合科学研究科, 教授 (50271896)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2006: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2005: ¥2,900,000 (Direct Cost: ¥2,900,000)
KeywordsAILD-T / AILT / c-Maf / cyclinD / ATL / PTCL(U) / ALCL / nasal lymphoma / T細胞性リンパ腫 / 多発性骨髄腫 / 免疫組織化学 / cyclinD1 / cyclinD2 / AILD-Tリンパ腫 / Tリンパ腫
Research Abstract

The oncogene c-Maf was recently found to be overexpressed in approximately 50% of multiple myeloma cases, and a role for c-Maf in promoting cyclin D2 expression has been postulated. We previously examined c-Maf expression in various T-cell lymphomas by RT-PCR and found extremely elevated c-Maf levels in angioimmunoblastic T-cell lymphoma (AILT). In this study, we examined T-cell lymphomas for c-Maf and cyclin expression immunohistochemically as well as by real time RT-PCR method. We examined 72 cases of T-cell lymphomas. As a result, c-Maf expression was seen in 23/31cases of AILT, 3/11 of adult T-cell leukemia/lymphoma (ATL), 4/19 of peripheral T-cell lymphoma, unspecified and 0/11 cases of mycosis fungoides. Double immunostaining in AILT revealed that the majority of c-Maf positive cells were also positive for CD43 (MT1), CD45RO (UCHL-1) and CD4 but were negative for CD20 (L26). Additionally, cyclins D1 and D2, which stimulate cell cycle progression, were overexpressed in a large number of the c-Maf positive AILT samples. Quantitative RT-PCR analysis also showed that c-Maf was overexpressed in 8/31 cases of AILT, 0/19 of PTCL(U), 2/8 of multiple myeloma, presenting significant difference between AILT and PTCL(U). These findings strongly suggest that CD4 positive neoplastic T-cells in AILT show c-Maf expression. These findings provide new insight into the pathogenesis of AILT and suggest that c-Maf may be a useful diagnostic marker for AILT

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (5 results)

All 2007 2006

All Journal Article (5 results)

  • [Journal Article] c-Maf expression in angioimmunoblastic T cell lymphoma2007

    • Author(s)
      Murakami IY
    • Journal Title

      American Journal of Surgical Pathology (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] c-Maf expression in angioimmunoblastic T cell lymphoma.2007

    • Author(s)
      Murakami IY, et al.
    • Journal Title

      American Jounal of Surgical Pathology (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Overexpression of c-Maf contribute to T cell lymphoma in both the mouse and human2006

    • Author(s)
      Morito N
    • Journal Title

      Cancer Research 66

      Pages: 812-819

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Overexpression of c-Maf contribute to T cell lymphoma in both the mouse and human2006

    • Author(s)
      Morito N et al.
    • Journal Title

      Cancer Research 66

      Pages: 812-819

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Overexpression of c-Maf contributes to T-cell lymphoma in both the mouse and human2006

    • Author(s)
      Morito N
    • Journal Title

      Cancer Res 66

      Pages: 812-819

    • Related Report
      2005 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

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