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Role of laminin alpha5 and its receptors in fibrotic liver and hepatocellular carcinoma

Research Project

Project/Area Number 17590307
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionTokyo University of Pharmacy and Life Science

Principal Investigator

KIKKAWA Yamato  Tokyo University of Pharmacy and Life Science, School of Pharmacy, Lecturer (20274227)

Co-Investigator(Kenkyū-buntansha) MITAKA Toshihiro  Sapporo Medical University School of Medicine, Department of Pathophysiology, Professor (50231618)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥4,060,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2005: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywordsextarcellular matrix / laminin / integrin / lutheran / hepatocellular carcinoma / fibrotic liver / liver
Research Abstract

Laminins are a diverse group of alpha/beta/gamma heterotrimers formed from five alpha, three beta and three gamma chains ; they are major components of all basal laminae (BLs). One laminin chain that has garnered particular interest due to its widespread expression pattern and importance during development is laminin alpha5. Little is known, however, about the expression and function of laminins containing the alpha5 chain in human hepatocellular carcinoma (HCC). Here, using a specific antibody, we examined the expression of laminin alpha5 in normal liver and in HCCs. In normal liver, although laminin alpha5 was observed in hepatic BLs underlying blood vessels and bile ducts, it was absent from the parenchyma, which may be the origin of HCC. On the other hand, laminin alpha5 deposition was observed throughout all HCCs tested, regardless of tumor grade. In well differentiated HCCs, it localized along the trabecules of the tumor. In poorly-differentiated HCCs, it was present in surrounding tumor nodules. In HCC cell lines, laminin alpha5 heterotrimerized with beta and gamma chains and was secreted into the culture media. To attempt to understand the function of laminins containing alpha5, the expression of its receptors in HCCs was also determined. In this regard, alpha3betal/alpha6betal integrins and Lutheran/basal cell adhesion molecule (Lu/B-CAM) were expressed in HCC cells. In vitro studies showed that HCC cells readily attached to laminin containing the alpha5 chain, more so than did primary hepatocytes. In addition to alpha3betal/alpha6betal integrins and Lu/B-CAM, laminin alpha5 was recognized by integrin alphalbetal, which also was expressed in HCC cells. These results suggest that laminins containing alpha5 serve as functional substrates regulating progression of HCC.

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (59 results)

All 2008 2007 2006 2005 Other

All Journal Article (41 results) (of which Peer Reviewed: 17 results) Presentation (16 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Blood vessels of human islets of Langerhans are surrounded by a double basement membrane2008

    • Author(s)
      Virtanen, I., Banerjee, M., Palgi, J., Korsgren, O., Lukinius, A., Thornell, L. E., Kikkawa, Y., Sekiguchi, K., Hukkanen, M., Konttinen, Y. T., Otonkoski, T
    • Journal Title

      Diabetologia (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Laminin alpha5 mediates ectopic adhesion of hepatocellular carcinoma through integrins and/or Lutheran/basal cell adhesion molecule2008

    • Author(s)
      Kikkawa, Y., Sudo, R., Kon, J., Mizuguchi, T., Nomizu, M., Hirata, K., Mitaka, T
    • Journal Title

      Esp. Cell Res (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The LG1-3 tandem of laminin alphas harbors the binding sites of Luther an/basal cell adhesion molecule and alpha3betal/alpha6betal integrins2007

    • Author(s)
      Yamato Kikkawa
    • Journal Title

      Journal of Biological Chemistry 282

      Pages: 14853-14860

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Integrin-dependent cell behavior on ECM peptide-conjugated chitosan membranes2007

    • Author(s)
      Mayumi Mochizuki
    • Journal Title

      Biopolymers 88

      Pages: 122-130

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cyclic Peptide Analysis of the Biologically Active Loop Region in the Laminin alpha3 Chain LG4 Module Demonstrates the Importance of Peptide Conformation on Biological Activity2007

    • Author(s)
      Kozue Kato-Takagaki
    • Journal Title

      Biochemistry 46

      Pages: 1952-1960

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Lutheran blood group antigen as a receptor for alphas laminins in gingival epithelia2007

    • Author(s)
      Jaana Willberg
    • Journal Title

      Journal of Periodontology 78

      Pages: 1810-1818

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Lutheran blood group antigen as a receptor for alpha5 laminins in gingival epithelia2007

    • Author(s)
      Willberg, J., Hormia, M., Takkunen, M., Kikkawa. Y., Sekiguchi, K., Virtanen, I
    • Journal Title

      J. Periodontol 78

      Pages: 1810-1818

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Integrin-dependent cell behavior on ECM peptide-conjugated chitosan membranes2007

    • Author(s)
      Mochizuki, M., Yamagata, N., Philp, D., Hozumi, K., Watanabe, T., Kikkawa. Y., Kadoya, Y., Kleinman, H. K., Nomizu, M
    • Journal Title

      Biopolymers 88

      Pages: 122-130

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The LG1-3 tandem of laminin alpha5 harbors the binding sites of Lutheran/basal cell adhesion molecule and alpha3beta1/alpha6beta1 integrins J. Biol. Chem2007

    • Author(s)
      Kikkawa. Y., Sasaki, T., Nguyen, M. T., Nomizu, M., Mitaka, T., and Miner, J. H
    • Journal Title

      J. Biol. Chem 282

      Pages: 14853-14860

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cyclic peptide analysis of the biologically active loop region in the laminin alpha3 chain LG4 module demonstrates the importance of peptide conformation on biological activity2007

    • Author(s)
      Kato-Takagaki, K., Suzuki, N., Yokoyama, F., Takaki, S., Umezawa, K., Higo, J., Mochizuki, M., Kikkawa. Y., Oishi, S., Utani, A., Nomizu, M
    • Journal Title

      Biochemistry 46

      Pages: 1952-1960

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The LG1-3 tandem of laminin alpha5 harbors the binding sites of Lutheran/basal cell adhesion molecule and alpha3betal/alpha6betal integrins2007

    • Author(s)
      Kikkawa, Y
    • Journal Title

      Journal of Biological Chemistry 282

      Pages: 14853-14860

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lutheran blood group antigen as a receptor for alpha5 laminins in gingival epithelia.2007

    • Author(s)
      Willberg, J
    • Journal Title

      Journal of Periodontology 78

      Pages: 1810-1818

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular dissection of laminin alpha 5 in vivo reveals separable domain-specific roles in embryonic development and kidney ftunction2006

    • Author(s)
      Yamato Kikkawa
    • Journal Title

      Developmental Biology 296

      Pages: 265-277

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Expression of CD44 in rat hepatic progenitor cells2006

    • Author(s)
      Junko Kon
    • Journal Title

      Journal of Hepatology 45

      Pages: 90-98

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Lutheran blood group glycoproteins in adhesion of human endothelial cells2006

    • Author(s)
      Noora Vainidnpaa
    • Journal Title

      American Journal of Physiology-Cell Physiology 290

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Liver repopulation and long-term function of rat small hepatocyte traps plantation as an alternative cell source for hepatocyte transplantation2006

    • Author(s)
      Chihiro Shibata
    • Journal Title

      Liver Transplantation 12

      Pages: 78-87

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 肝再生とラミニンα1鎖2006

    • Author(s)
      吉川 大和
    • Journal Title

      Surgery Frontier 13

      Pages: 93-95

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Laminin-10 and Lutheran blood group glycoproteins in adhesion of human endothelial cells2006

    • Author(s)
      Vainionpaa, N., Kikkawa, Y., Lounatmaa, K., Miner, J. H., Rousselle, P., and Virtanen, I
    • Journal Title

      Am. J. Physiol. Cell Physiol 290

      Pages: 764-775

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Liver repopulation and long-term function of rat small hepatocyte transplantation as an alternative cell source for hepatocyte transplantation2006

    • Author(s)
      Shibata, C., Mizuguchi, T., Kikkawa. Y., Nobuoka, T., Oshima, H., Kawasaki, H., Kawamoto, M., Katsuramaki, T., Mitaka, T., Hirata, K
    • Journal Title

      Liver Transpl 12

      Pages: 78-87

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Expression of CD44 in rat hepatic progenitor cells2006

    • Author(s)
      Kon, J., Ooe, H., Oshima, H., Kikkawa, Y., Mitaka, T
    • Journal Title

      J. Hepatol 45

      Pages: 90-98

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Molecular dissection of laminin alpha 5 in vivo reveals separable domain-specific roles in embryonic development and kidney function2006

    • Author(s)
      Kikkawa, Y., and Miner, J. H
    • Journal Title

      Dev. Biol 296

      Pages: 265-277

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Molecular dissection of laminin alpha 5 in vivo reveals separable domain-specific roles in embryonic development and kidney function2006

    • Author(s)
      KiKKawa, Y
    • Journal Title

      Developmental Biology 296

      Pages: 265-277

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Expression of CD44 in rat hepatic progenitor cells2006

    • Author(s)
      Kon, J
    • Journal Title

      Journal of Hepatology 45

      Pages: 90-98

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Lutheran blood group glycoproteins in adhesion of human endothelial cells2006

    • Author(s)
      Vainionpaa, N
    • Journal Title

      American Journal of Physiology-Cell Physiology 290

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Liver repopulation and long-term function of rat small hepatocyte transplantation as an alternative cell source for hepatocyte transplantation2006

    • Author(s)
      Shibata, C
    • Journal Title

      Liver Transplantation 12

      Pages: 78-87

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Thermoreversible gelation polymer induces the emergence of hepatic stem cells in the partially injured rat liver2006

    • Author(s)
      Nagaya, M
    • Journal Title

      Hepatology 43

      Pages: 1053-1062

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 肝再生とラミニンα1鎖2006

    • Author(s)
      吉川 大和
    • Journal Title

      Surgery Frontier 13, 93-95 13

      Pages: 93-95

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Transient expression of laminin alphal chain in regenerating marine liver:restricted localization of laminin chains and nidogen-12005

    • Author(s)
      Yamato Kikkawa
    • Journal Title

      Experimental Cell Research 305

      Pages: 99-109

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Lutheran/B-CAM:A Laminin Receptor on Red Blood Cells and in Various Tissues2005

    • Author(s)
      Yamata Kikkawa
    • Journal Title

      Connective Tissue Research 46

      Pages: 193-199

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The immortalized human corneal epithelial cells adhere to laminin-10 by using Lutheran glycoproteins and integrin.alpha3betal2005

    • Author(s)
      Sissi Hasenson
    • Journal Title

      Experimental Eye Research 81

      Pages: 412-421

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Hyperbaric oxygen stimulates cell proliferation and normalizes multidrug resistance protein-2 protein localization in primary rat hepatocytes2005

    • Author(s)
      Toru Mizuguchi
    • Journal Title

      Wound Repair Regeneration 13

      Pages: 551-557

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary 2005 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transient expression of laminin alphal chain in regenerating murine liver : restricted localization of laminin chains and nidogen-12005

    • Author(s)
      Kikkawa, Y., Mochizuki, Y., Miner, J. H., and Mitaka, T
    • Journal Title

      Esp. Cell Res 305

      Pages: 99-109

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Lutheran/B-CAM : a laminin receptor on red blood cells and in various tissues2005

    • Author(s)
      Kikkawa, Y., Miner, J. H. Review
    • Journal Title

      Connect. Tissue Res 46

      Pages: 193-199

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The immortalized human corneal epithelial cells adhere to laminin-10 by using Lutheran glycoproteins and integrin alpha3beta12005

    • Author(s)
      Hasenson, S., Maatta, M., Rousselle, P., Kikkawa. Y., Miner, J. H., Tervo, T., Virtanen, I
    • Journal Title

      Exp. Eye Res 81

      Pages: 415-421

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Hyperbaric oxygen stimulates cell proliferation and normalizes multidrug resistance protein-2 protein localization in primary rat hepatocytes2005

    • Author(s)
      Mizuguchi, T., Oshima, H., Imaizumi, H., Kohara, H., Kawamoto, M., Nobuoka, T., Kawasaki, H., Harada, K, Masuda, Y., Kikkawa, Y. Mitaka, T., Asai, Y., Hirata, K
    • Journal Title

      Wound Repair Regen 13

      Pages: 551-557

    • NAID

      10016938609

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Transient expression of laminin alphal chain in regenerating murine liver : restricted localization of laminin chains and nidogen-12005

    • Author(s)
      Yamato Kikkawa
    • Journal Title

      Experimental Cell Research 305

      Pages: 99-109

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Lutheran/B-CAM : A Laminin Receptor on Red Blood Cells and in Various Tissues2005

    • Author(s)
      Yamato Kikkawa
    • Journal Title

      Connective Tissue Research 46

      Pages: 193-199

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The immortalized human corneal epithelial cells adhere to laminin-10 by using Lutheran glycoproteins and integrin alpha3betal2005

    • Author(s)
      Sissi Hasenson
    • Journal Title

      Experimental Eye Research 81

      Pages: 412-421

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Blood vessels of human islets of langerhans are surrounded by d ouble basement membrane

    • Author(s)
      Ismo Virtanen
    • Journal Title

      Diabetologia (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Laminin alphas mediates ectopic adhesion of hepatocellular carcinoma through integrins and/or Lutheran/basal cell adhesion molecule

    • Author(s)
      Yamato Kikkawa
    • Journal Title

      Experimental Cell Research (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Blood vessels of human islets of langerhans are surrounded by double basement membrane

    • Author(s)
      Virtanen, I
    • Journal Title

      Diabetologia (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] The LG1-3 tandem of laminin alpha5 harbors the binding sites of Lutheran/basal cell adhesion molecule and alpha3betal/alpha6betal integrins2007

    • Author(s)
      Yamato Kikkawa
    • Organizer
      13rd International Symposium on Basement membranes
    • Place of Presentation
      Cologne,Germany
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Identification of B-CAM/Lutheran binding site on laminin alphas chain2007

    • Author(s)
      吉川 大和
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ラミニンα5鎖のLG1-3におけるルテランとインテグリン(α3β1、α6β1)の結合2007

    • Author(s)
      吉川 大和
    • Organizer
      日本生化学会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] The LG1-3 tandem of laminin alpha5 harbors the binding sites of Lutheran/basal cell adhesion molecule and alpha3beta1/alpha6beta1 integrins2007

    • Author(s)
      Kikkawa, Y., Sasaki, T., Nguyen, M.T., Nomizu, M., Mitaka, Miner, J.H
    • Organizer
      13rd International Symposium on Basement Membranes
    • Place of Presentation
      Cologne, Germany
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Identification of B-CAM/Lutheran binding site on laminin alpha5 chain2007

    • Author(s)
      Kikkawa, Y., Mitaka, T., Nomizu, M
    • Organizer
      66th Annual meeting of the Japanese Cancer Associatio
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Identification of B-CAM/Lutheran binding site on laminin alpha5 chain2007

    • Author(s)
      吉川 大和
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Molecular dissection of laminin alphas in vivo reveals separable domain-specific roles in embryonic development and kidney function2006

    • Author(s)
      Yamato Kikkawa
    • Organizer
      Gordon Research Conference, Basement membranes
    • Place of Presentation
      Barga,Italy
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ヒト肝細胞癌におけるラミニンα鎖の発現2006

    • Author(s)
      吉川 大和
    • Organizer
      肝細胞研究会
    • Place of Presentation
      旭川
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ヒト肝細胞癌におけるラミニンα鎖の発現とその役割2006

    • Author(s)
      吉川 大和
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular dissection of laminin alpha 5 in vivo reveals separable domain-specific roles in embryonic development and kidney function2006

    • Author(s)
      Kikkawa, Y., Miner, J.H
    • Organizer
      Gordon Research Conference, Basement membranes
    • Place of Presentation
      Barga, Italy
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Transient expression of laminin alphal chain in regenerating murine liver:restricted localization of laminin chains and nidogen-12005

    • Author(s)
      Yamato Kikkawa
    • Organizer
      12th International Symposium on Basement membranes
    • Place of Presentation
      Philadelphia,USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 肝再生過程におけるラミニンの発現とその役割2005

    • Author(s)
      吉川 大和
    • Organizer
      肝細胞研究会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ヒト肝臓におけるラミニン鎖の分布と肝細胞癌における発現2005

    • Author(s)
      吉川 大和
    • Organizer
      日本癌学会
    • Place of Presentation
      札幌
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Transient expression of laminin alphal chain in regenerating liver2005

    • Author(s)
      吉川 大和
    • Organizer
      日本生化学会
    • Place of Presentation
      神戸
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Transient expression of laminin alphal chain in regenerating murine liver : restricted localization of laminin chains and nidogen-12005

    • Author(s)
      Kikkawa, Y., Mochizuki, Y., Miner, J.H., Mitaka, T
    • Organizer
      12th International Symposium on Basement membranes
    • Place of Presentation
      Philadelphia,USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Transient expression of laminin alphal chain in regenerating liver2005

    • Author(s)
      Kikkawa, Y., Mochizuki, Y., Miner, J.H., Mitaka T
    • Organizer
      78th Annual meeting of The Japanese Biomedical Society
    • Place of Presentation
      Kobe
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.ps.toyaku.ac.jp/~nomizu/

    • Related Report
      2007 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 肝細胞培養用ペプチド2006

    • Inventor(s)
      吉川 大和
    • Industrial Property Rights Holder
      野水 基義
    • Filing Date
      2006-12-05
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

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