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Molecular epidemiology of radiation induced thyroid cancer

Research Project

Project/Area Number 17590330
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionNational Hospital Organization Nagasaki Medical Center

Principal Investigator

ITO Masahiro  Nagasaki Medical Center, Clinical Research Center, Morphological Department, Chief of Pathology Division, 形態研究部, 病理室長 (30184691)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Minoru  Nagasaki Medical Center, Clinical Research Center, Morphological Department, Chief of Pathology Division, 臨床研究センター・先端技術研究部, 部長 (40217906)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2005: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordsthyroid cancer / childhood / radiation / Chernobyl / epidemiology / BRAF / 放射線発癌 / 分子疫学
Research Abstract

A large increase in thyroid carcinoma incidence among those exposed as children to the high levels of fallout from the nuclear accident at Chernobyl in 1986 has been reported. The Chernobyl Tissue Bank (CTB) is an internationally supported project and ensures that materials (frozen tissue, fixed tissue sections, extracted DNA/RNA and blood samples) are available for appropriate research studies. Up to date more over 2,500 cases have been registered, and the CTB holds DNA and RNA from more than 280 thyroid tumors from the patients younger than 19 at the time of the explosion.
Although over 95% of the cancers are classified as papillary carcinomas in the population around Chernobyl following exposure to fallout, they vary in their morphology, ranging from a solid immature phenotype, to well differentiated tumors dominated by either papillary or follicular architecture. Some of the early reports on the thyroid carcinomas around Chernobyl suggested that the solid morphology, aggressiveness, … More and the apparently high frequency of RET/PTC3 rearrangements were indicative of radiogenic tumors. However, recent studies have shown that the morphological pattern of papillary carcinomas is changing with increasing latency. We showed that short latency is associated with solid morphology and significantly more invasive spread when compared to tumors with a longer latent period. In contrast, the type of differentiation is associated with age at exposure. Many reports have suggested that RET/PTC3 rearrangements are associated with the solid morphology seen in short latency tumors, while well diffrentiated papillary carcinomas more often show RET/PTC1 rearrangements. The frequency of BRAF mutation is low in post Chernobyl thyroid cancer and is similar to that observed in other studies of childhood thyroid papillary carcinoma, and this may be related to the age of the patient at diagnosis. More recent study revealed that the unexposed group of tumors from Ukraine and Russia were essentially identical morphologically to the exposed tumors from the same area. The tumors from Japanese children were significantly different from the tumors from around Chernobyl, whether exposed or unexposed, showing significantly more differentiation, more papillary differentiation. One possibility deserving serious consideration is the iodine content of the diet. Less

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (27 results)

All 2007 2006 2005

All Journal Article (27 results)

  • [Journal Article] Anti-gp210 and anti-centromere antibodies are different risk factors for the progression of primary biliary cirrhosis.2007

    • Author(s)
      Nakamura M, Takii Y, Ito M, et al.
    • Journal Title

      Hepatology 45

      Pages: 118-127

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Anti-gp210 and anti-centromere antibodies are different risk factors for the progression of primary biliary cirrhosis.2007

    • Author(s)
      Nakamura M, Kondo H, Mori T, Komori A, Matsuyama M, Ito M, Takii Y, Koyabu M, Yokoyama T, Migita K, Daikoku M, Abiru S, Yatsuhashi H, Takezaki E, Masaki N, Sugi K, Honda K, Adachi H, Nishi H, Watanabe Y, Nakamura Y, Shimada M, Komatsu T, Saito A, Soashiro T, Harada H, Sodeyama T, Hayashi S, Masumoto A, Sando T, Yamamoto T, SakaiH, Kobayashi M, Muro T, Koga M, Shums Z, Norman GL, Ishibashi H.
    • Journal Title

      Hepatology 45(1)

      Pages: 118-27

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Anti-gp210 and anti-centromere antibodies are different risk factors for the progression of primary biliary cirrhosis.2007

    • Author(s)
      Nakamura M, Kondo H, Ito M, et al.
    • Journal Title

      Hepatology 45

      Pages: 118-27

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Chernobyl Tissue Bank project : Pathology review2006

    • Author(s)
      Ito M
    • Journal Title

      Acta Med Nagasaki 51

      Pages: 143-143

    • NAID

      110006000786

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Childhood thyroid carcinoma with BRAFT1799A mutation shows unique pathological features of poor differentiation.2006

    • Author(s)
      Kumagai A, Namba H, Ito M et al.
    • Journal Title

      Oncol Rep 16

      Pages: 123-126

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Chernobyl Tissue Bank project : Pathology review.2006

    • Author(s)
      Ito M.
    • Journal Title

      Acta Med Nagasaki 51

      Pages: 143-143

    • NAID

      110006000786

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Childhood thyroid carcinoma with BRAFT1799A mutation shows unique pathological features of poor differentiation.2006

    • Author(s)
      Kumagai A, Namba H, Mitsutake N, Saenko VA, Ohtsuru A, Ito M, Noh JY, Sugino K, Ito K, Yamashita S.
    • Journal Title

      Oncol Rep. 16(1)

      Pages: 123-6

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Chernobyl Tissue Bank project : Pathology review2006

    • Author(s)
      Ito M
    • Journal Title

      Acta Med. Nagasaki 51

      Pages: 143-143

    • NAID

      110006000786

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Childhood thyroid carcinoma with BRAFT1799A mutation shows unique pathological features of poor differentiation.2006

    • Author(s)
      Kumagai A, Namba H, Ito M, et al.
    • Journal Title

      Oncol Rep. 16

      Pages: 123-6

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Serum cytokine and soluble cytokine receptor levels in patients with non-alcoholic steatohepatitis.2006

    • Author(s)
      Abiru S, Migita K, Ito M, et al.
    • Journal Title

      Liver Int. 26

      Pages: 39-45

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Incleased expression of nuclear envelope gp210 antigen in small bile ducts in primary biliary cirrhosis.2006

    • Author(s)
      Nakamura M, Takii Y, Ito M, et al.
    • Journal Title

      J Autoimmun. 26

      Pages: 138-45

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Correlation of donor-derived keratinocytes and severity of graft-versus-host disease (GVHD) in epidermis.2005

    • Author(s)
      Niino D, Ito M, et al.
    • Journal Title

      Pathology Res Pract 200

      Pages: 775-781

    • NAID

      10020560319

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Cyclin D1 overexpression in thyroid papillary microcarcinoma : its association with tumour size and aberrant beta-catenin expression.2005

    • Author(s)
      Lantsov D, Meirmanov S, Ito M, et al.
    • Journal Title

      Histopathology 47

      Pages: 248-256

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Enhanced expression of type I interferon and toll-like receptor-3 in primary biliary cirrhosis.2005

    • Author(s)
      Takii Y, Nakamura M, Ito M, et al.
    • Journal Title

      Lab Invest 85

      Pages: 908-920

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Risk of thyroid cancer after exposure to ^<131> I in childhood.2005

    • Author(s)
      Cardis E, A Kesminiene A, Ito M, et al.
    • Journal Title

      J Natl Cancer Inst 97

      Pages: 724-732

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Overexpression of Ets-1 proto-oncogene in latent and clinical prostatic carcinomas.2005

    • Author(s)
      Alipov G, Nakayama T, Ito M et al.
    • Journal Title

      Histopathology 46

      Pages: 202-208

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Correlation of donor-derived keratinocytes and severity of graft-versus-host disease (GVHD) in epidermis.2005

    • Author(s)
      Niino D, Nakashima M, Kondo H, Ito M, Matsuu M, Nakayama T, Tomonaga M, Sekine I.
    • Journal Title

      Pathology Res Pract 200

      Pages: 775-781

    • NAID

      10020560319

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Cyclin D1 overexpression in thyroid papillary microcarcinoma : its association with tumour size and aberrant β-catenin expression.2005

    • Author(s)
      Lantsov D, Meirmanov S, Nakashima M, Kondo H, Saenko V, Naruke Y, Namba H, Ito M, Abrosimov A, Lushnikov E, Sekine I, Yamashita Sh
    • Journal Title

      Histopathology 47

      Pages: 248-256

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Enhanced expression of type I interferon and toll-like receptor-3 in primary biliary cirrhosis.2005

    • Author(s)
      Takii Y, Nakamura M, Ito M, Yokoyama T, Komori A, Shimizu-Yoshida Y, Nakao R, Kusumoto K, Nagaoka S, Yano K, Abiru S, Ueki T, Matsumoto T, Daikoku M, Taniguchi K, Fujioka H, Migita K, Yatsuhashi H, Nakashima M, Harada M, Ishibashi H.
    • Journal Title

      Lab Invest 85

      Pages: 908-920

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Risk of thyroid cancer after exposure to 1311 in childhood.2005

    • Author(s)
      E Cardis, A Kesminiene, V Ivanov, I Malakhova, Y Shibata, V Khrouch, V Drozdovitch, E Maceika, I Zvonova, O Vlasov, A Bouville, G Goulko, M Hoshi, A Abrosimov, Ya Anoshko, L Astakhova, S Chekin, E Demidchik, R Galanti, M Ito, E Koroboba, E Lushnikov
    • Journal Title

      J Natl Cancer Inst. 97(10)

      Pages: 724-32

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Overexpression of Ets-1 proto-oncogene in latent and clinical prostatic carcinomas.2005

    • Author(s)
      Alipov G, Nakayama T, Ito M, Kawai K, Naito S, Nakashima M, Niino D, Sekine I.
    • Journal Title

      Histopathology. 46(2)

      Pages: 202-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Sympathetic hyperfunction causes increased sensitivity of the autonomic nervous system to whole-body X irradiation.2005

    • Author(s)
      Matsuu M, Shichijo K, Ikeda Y, Ito M, Naito S, Okaichi K, Nakashima M, Nakayama T, Sekine I.
    • Journal Title

      Radiat Res. 163(2)

      Pages: 137-43

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Expression of the ets-1 proto-oncogene in human breast carcinoma : differential expression with histological grading and growth pattern.2005

    • Author(s)
      Katayama S, Nakayama T, Ito M, Naito S, Sekine I.
    • Journal Title

      Histol Histopathol. 20(1)

      Pages: 119-26

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Cyclin D1 overexpression in thyroid papillary microcarcinoma : its association with tumour size and aberrant β-catenin expression.2005

    • Author(s)
      Lantsov D, Meirmanov S, Nakashima M, Ito M, et al.
    • Journal Title

      Histopathology 47

      Pages: 248-256

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Enhanced expression of type I interferon and toll-like receptor-3 in primary biliary cirrhosis.2005

    • Author(s)
      Takii Y, Nakamura M. Ito M. et al.
    • Journal Title

      Lab Invest 85

      Pages: 908-920

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Risk of thyroid cancer after exposure to 131I in childhood.2005

    • Author(s)
      Carbis E, Kesminiene A, Ivanov V, I M Ito, et al.
    • Journal Title

      J Natl Cancer Inst 97

      Pages: 724-732

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Sympathetic hyperfunction causes increased sensitivity of the autonomic nervous system to whole-body X irradiation.2005

    • Author(s)
      Matsuu M, Shichijo K, Ikeda Y, Ito M, et al.
    • Journal Title

      Radiat Res 163

      Pages: 137-143

    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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