Function of BCL11A in B-cell development
| Project/Area Number |
17590364
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Japanese Foundation For Cancer Research |
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Principal Investigator |
KUWATA Takeshi Japanese Foundation For Cancer Research, The Cancer Institute, Staff Scientist (00327321)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Takuro Japanese Foundation for Cancer Research, The Cancer Institute, Chief (00180373)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,680,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2005: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | BCLIIA / SUM0-1 / UBC9 / Senp / BCL6 / PML / Nuclear body / B cell / SUMOylation / de-SUMOylation / Senp2 / リンパ球 / 核内小体 / SUMO化 / lkaros / T細胞 / 遺伝子再構成 / IL7 / Pax5 / SUMO |
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| Research Abstract |
BCLI IA is a zinc-finger protein predominantly expressed in brain and hematopoietic cells. Previous studies show that BCLI1A is involved in acute myelo/monocytic leukemia and chronic lymphoid leukemia in mouse and human, respectively. Moreover, BCL1 IA is localized in the characteristic nuclear body in which BCL6 is co-localized. However, the significance of BCL11A in leukemogenesis and nuclear function remains unknown. In this study we show that BCLI1A interacts with Ubc9, a SUMO E2 ligase, and recruits SUMO-1 into the nuclear body. A lysine residue at amino acid 634 of BCLI1A is SUMOylated but not required for the SUMO-1 recruitment. The N-terminal region of BCLI IA is responsible for SUMO-1 recruitment as well as its nuclear body formation. We also show that Senp2, a SUMO specific peptidase, is co-localized in the nuclear body. Our results suggest that BCL1 IA could be involved in the SUMO conjugation system.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model2005
Author(s)
Iwasaki M, Kuwata T, Yamazaki Y, Jenkins N A, Copeland N G, Osato M, Ito Y, Kroon E, Sauyageau G, Nakamura T
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Journal Title
Blood 15, 105(2)
Pages: 784-93
Description
「研究成果報告書概要(欧文)」より
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