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Pharmacogenomics-based tailored strategy for eradication of H. pylori

Research Project

Project/Area Number 17590470
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied pharmacology
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

FURUTA Takahisa  Hamamatsu University School of Medicine, Center for Clinical Research, 医学部附属病院, 准教授 (10303546)

Co-Investigator(Kenkyū-buntansha) SHIRAI Naohito  Hamamatsu University School of Medicine, Department of Laboratory Meicine, 医学部, 助手 (90362194)
SUGIMOTO Mistustuge  Hamamatsu University School of Medicine, First Department of Medicine, 医学部, 助教授 (80397398)
NAKAMURA Akiko  Hamamatsu University School of Medicine, First Department of Medicine, 医学附属病院, 医員 (80397413)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥2,500,000 (Direct Cost: ¥2,500,000)
KeywordsCYP2C19 / Helicobacter pylori / 23S rRNA / tailored Medicine / lansoprazole / clarithromycin / amoxicillin / eradication / CYP2C19 / H.pylori / 23S rRNA / テーラーメイド / 遺伝子多型
Research Abstract

Background : H. pylori eradication rates by triple therapy with a proton pump inhibitor, amoxicillin and clarithromycin at standard doses depend on bacterial susceptibility to clarithromycin and patient CYP2C19 genotypes. We examined the usefulness of a personalized therapy for H. pylori infection based on these factors as determined by genetic testing.
Methods : First, optimal lansoprazole dosing schedules that would achieve sufficient acid inhibition to allow H. pylori eradication therapy in each of different CYP2C19 genotype groups were determined by a 24-hour intragastric pH monitoring. Next, 300 H. pylori-positive patients were randomly assigned to the standard regimen group (lansoprazole 30 mg bid, clarithromycin 400 mg bid, and amoxicillin 750 mg bid for one week) or the tailored regimen group based on CYP2C19 status and bacterial susceptibility to clarithromycin assessed by genetic testing. Patients with failure of eradication underwent the second-line regimen. The per-patient cost required for successful eradication was calculated for each of the groups.
Results : In the first-line therapy, the intention-to-treat eradication rate in the tailored regimen group was 96.0% (95%CI=91.5%-98.2%, 144/150), significantly higher than that in the standard regimen group (70.0% : 95%CI = 62.2%-77.2%, 105/150) (P < 0.001). Final costs per successful eradication in the tailored and standard regimen groups were $ 377.1 and $ 376.9, respectively.
Conclusions : The pharmacogenomics-based tailored treatment for H. pylori infection allowed a higher eradication rate by the initial treatment without an increase of the final per-patient cost for successful eradication. However, the precise cost-effectiveness of this strategy remains to be determined.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (59 results)

All 2007 2006 2005 Other

All Journal Article (57 results) Book (2 results)

  • [Journal Article] Pharmacogenomics-based tailored versus standard therapeutic regimen for eradication of H. pylori2007

    • Author(s)
      Furuta T, Shirai N, Kodaira M, Sugimoto M, Nogaki A, Kuriyama S, Iwaizumi M, Yamade M, Terakawa I, Ohashi K, Ishizaki T, Hishida A
    • Journal Title

      Clin Pharmacol Ther 22

      Pages: 521-528

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Different effects of polymorphisms of tumor necrosis factor-alpha and interleukin-1 beta on development of peptic ulcer and gastric cancer2007

    • Author(s)
      Sugimoto M, Furuta T, Shirai N, Nakamura A, Xiao F, Kajimura M, Sugimura H, Hishida A
    • Journal Title

      J Gastroenterol Hepatol 22

      Pages: 51-59

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] THE ACID-RELATED SYMPTOM (ARS) RESEARCH GROUP. Efficacy of rabeprazole on heartburn symptom resolution in patients with non-erosive and erosive gastro-oesophageal reflux disease : a multicenter study from Japan.2007

    • Author(s)
      Miwa H, Sasaki M, Furuta T, Koike T, Habu Y, Ito M, Fujiwara Y, Wada T, Nagahara A, Hongo M, Chiba T, Kinoshita Y
    • Journal Title

      Aliment Pharmacol Ther 26

      Pages: 69-77

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Pharmacogenomics-based tailored versus standard therapeuti regimen for eradication of H. pylori.2007

    • Author(s)
      Furuta T, Shirai N, Kodaira M, Sugimoto M, Nogaki Kuriyama S, Iwaizumi M, Yamade M, Terakawa I, Ohashi K, Ishizaki T, Hishida A.
    • Journal Title

      Clin Pharmacol Ther 81

      Pages: 521-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Different effects of polymorphisms of tumor necrosis factor-alpha an interleukin-1 beta on development of peptic ulcer and gastric cancer2007

    • Author(s)
      Sugimoto M, Furuta T, Shirai N, Nakamura A, Xiao I, Kajimura M, Sugimura H, Hishida A.
    • Journal Title

      J Gastroenterol Hepatol 22

      Pages: 51-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] THE ACID-RELATED SYMPTOM (ARS) RESEARCH GROUP. Efficacy of rabeprazole on heartburn symptom resolution in patients with non-erosive and erosive gastro-oesophageal reflux disease : a multicenter study from Japan.2007

    • Author(s)
      Miwa H, Sasaki M, Furuta T, Koike T, Habu Y, Ito M, Fujiwara Y, Wada T, Nagahara A, Hongo M, Chiba T, Kinoshita Y.
    • Journal Title

      Aliment Pharmacol Ther 26

      Pages: 69-77

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Pharmacogenomics-based tailored versus standard therapeutic regimen for eradication of H. pylori2007

    • Author(s)
      Furuta T, Shirai N, Kodaira M, Sugimoto M, Nogaki A, Kuriyama S, Iwaizumi M, Yamade M, Terakawa I, Ohashi K, Ishizaki T, Hishida A
    • Journal Title

      Clin Pharmacol Ther 81

      Pages: 521-528

    • Related Report
      2006 Annual Research Report
  • [Journal Article] p21(CDKNIA) allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine2006

    • Author(s)
      Furuta T, Hayward RL, Meng LH, Takemura H, Aune G J, Bonner WM, Aladjem MI, Kohn KW, Pommier Y
    • Journal Title

      Oncogene 25

      Pages: 2839-2849

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Influences of Chymase and Angiotensin-I Converting Enzyme Gene Polymorphisms on Gastric Cancer Risks in Japan2006

    • Author(s)
      Sugimoto M, Furuta T, Shirai N, Ikuma M, Sugimura H, Akira Hishida A
    • Journal Title

      Cancer Epidemiol Biomarkers Prev 15

      Pages: 1929-1934

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Initial 48-hour acid inhibition by intravenous infusion of omeprazole, famotidine, or both in relation to cytochrome P450 2C19 genotype status.2006

    • Author(s)
      Sugimoto M, Furuta T, Shirai N, Ikuma M, Hishida A, Ishizaki T
    • Journal Title

      Clin Pharmacol Ther 80

      Pages: 539-548

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] A deficiency of gastric interstitial cells of Cajal accompanied by decreased expression of neuronal nitric oxide synthase and substance P in patients with type 2 diabetes mellitus.2006

    • Author(s)
      Iwasaki H, Kajimura M, Osawa S, Kanaoka S, Furuta T, Ikuma M, Hishida A
    • Journal Title

      J Gastroenterol 41

      Pages: 1076-1087

    • NAID

      10018814873

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Helicobacter pylori eradication and metachronous gastric cancer after endoscopic mucosal resection of early gastric cancer.2006

    • Author(s)
      Nakagawa S, Asaka M, Kato M, Nakamura T, Kato C, Fujioka T, Tatsuta M, Keida K, Terao S, Takahashi S, Uemura N, Kato T, Aoyama N, Saito D, Suzuki M, Imamura A, Sato K, Miwa H, Nomura H, Kaise M, Oohara S, Kawai T, Urabe K, Sakaki N, Ito S, Noda Y, Yanaka A, Kusugami K, Goto H, Furuta T, Fujino M, Kinjyou F, Ookusa T
    • Journal Title

      Aliment Pharmacol Ther. 2006 Suppl 4

      Pages: 214-218

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Defective MRE11-dependent activation of CHK2 by ATM in colorectal carcinoma cells in response toreplication-dependent DNA double-strand breaks.2006

    • Author(s)
      Takemura H, Rao VA, Sordet O, Furuta T, Miao ZH, Meng L, Zhang H, Pommier Y
    • Journal Title

      Biol Chem 28

      Pages: 30814-30823

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Influences of pro- and anti-inflammatory cytokine polymorphisms on eradication rates of clarithromycin-sensitive strains of Helicobacter pylori by triple therapy.2006

    • Author(s)
      Sugimoto M, Furuta T, Shirai N, Kajimura M, Hishida A, Ishizaki T
    • Journal Title

      Clin Pharmacol Ther 80

      Pages: 41-50

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Hydroxylation of lansopraozle in poor metabolizers of CYP2C19.2006

    • Author(s)
      Furuta T, Shirai N, Sugimoto M, Nakamura A, Hishida A
    • Journal Title

      British Journal of Clin Pharmacol 61

      Pages: 361-361

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] 消化器疾患治療における適応外使用のエビデンス-胃・食道両性疾患、H.pylori除菌、炎症成長疾患を例に-2006

    • Author(s)
      古田隆久, 白井直人, 杉本光繁
    • Journal Title

      EBMジャーナル 7

      Pages: 472-477

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] p21(CDKN1A) allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine.2006

    • Author(s)
      Furuta T, Hayward RL, Meng LH, Takemura H, Aune G J, Bonner WM, Aladjem MI, Kohn KW, Pommier Y.
    • Journal Title

      Cncogene 25

      Pages: 2839-49

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Influences of Chymase and Angiotensin-I Converting Enzyme Gene Polymorphisms on Gastric Cancer Risks in Japan2006

    • Author(s)
      Sugimoto M, Furuta T, Shirai N, Ikuma M, Sugimura H, Akira Hishida A.
    • Journal Title

      Cancer Epidemiol Biomarkers Prev 15

      Pages: 1929-34

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Initial 48-hour acid inhibition by intravenous infusion of omeprazole, famotidine, or both in relation to cytochrome P450 2C19 genotype p e status.2006

    • Author(s)
      Sugimoto M, Furuta T, Shirai N, Ikuma M, Hishida A, Ishizaki T.
    • Journal Title

      Clin Pharmacol Ther 80

      Pages: 539-48

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A deficiency of gastric interstitial cells of Cajal accompanied by decreased expression of neuronal nitric oxide synthase and substance P in patients with type 2 diabetes mellitus.2006

    • Author(s)
      Iwasaki H, Kajimura M, Osawa S, Kanaoka S, Furuta T, Ikuma M, Hishida A.
    • Journal Title

      Gastroenterol 41

      Pages: 1076-87

    • NAID

      10018814873

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Helicobacter pylori eradication and metachronous gastric cancer after endoscopic mucosal resection of earl gastric cancer.2006

    • Author(s)
      Nakagawa S, Asaka M, Kato M, Nakamura T, Kato C, Fujioka T, Tatsuta M, Keida K, Terao S, Takahashi S, Uemura N, Kato T, Aoyama N, Saito D, Suzuki M, Imamura A, Sato K, Miwa H, Nomura H, Kaise M, Oohara S, Kawai T, Urabe K, Sakaki N, Ito S, Noda Y, Yanaka A, Kusugami K, Goto H, Furuta T, Fujino M, Kinjyou F, Ookusa T.
    • Journal Title

      Aliment Pharmacol Ther Suppl 4

      Pages: 214-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Defective MRE11-dependent activation of CHK2 by ATM in colorectal carcinoma cells in response toreplication-dependent DNA double-strand breaks.2006

    • Author(s)
      Takemura H, Rao VA, Sordet O, Furuta T, Miao ZH, Meng L, Zhang H, Pommier Y.
    • Journal Title

      J Biol Chem 28

      Pages: 30814-23

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Influences of pro-and anti-inflammatory cytokine polymorphisms on eradication rates of clarithromycin-sensitive strains of Helicobacter pylori by triple therapy.2006

    • Author(s)
      Sugimoto M, Furuta T, Shirai N, Kajimura M, Hishida A, Ishizaki T.
    • Journal Title

      Clin Pharmacol Ther 80

      Pages: 41-50

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Hydroxylation of lansopraozle in poor metabolizers of CYP2C19.2006

    • Author(s)
      Furuta T, Shirai N, Sugimoto M, Nakamura A, Hishida A.
    • Journal Title

      British Journal of Clin Pharmacol 61

      Pages: 361-361

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] p21(CDKN1A) allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine2006

    • Author(s)
      Furuta T, Hayward RL, Meng LH, Takemura H, Aune G J, Bonner WM, Aladjem MI, Kohn KW, Pommier Y
    • Journal Title

      Oncogene 25

      Pages: 2839-2849

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Influence of CYP 2C19 polymorphism and H. pylori genotype determined from gastric tissue samples on response to triple therapy for H. pylori infection2005

    • Author(s)
      Furuta T, Sagehashi Y, Shirai N, Sugimoto M, Nakamura A, Kodaira M, et al.
    • Journal Title

      Clin Gastroenterol Hepatol 3

      Pages: 564-573

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect of concomitant dosing of famotidine with lansoprazole on gastric acid secretion in relation to CYP2C19 genotype status2005

    • Author(s)
      Furuta T, Shirai N, Sugimoto M, Nakamura A, Okudaira K, Kajimura M, Hishida A
    • Journal Title

      Aliment Pharmacol Ther 22

      Pages: 67-74

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Influence of CYP2C19 Pharmacogenetic Polymorphism on Proton Pump Inhibitor-based Therapies.2005

    • Author(s)
      Furuta T, Shirai N, Sugimoto M, Nakamura A, Hishida A, Ishizaki T
    • Journal Title

      Drug Metab Pharmacokinet 20

      Pages: 153-167

    • NAID

      130004462957

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Poor metabolizer genotype status of CYP2C19 is a risk factor for developing gastric cancer in Japanese patients with Helicobacter pylori infection2005

    • Author(s)
      Sugimoto M, Furuta T, Shirai N, Nakamura A, Kajimura M, Sugimura H, Hishida A, Ishizaki
    • Journal Title

      Aliment Pharmacol Ther 22

      Pages: 1033-1040

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] PPIの効果と遺伝子多型.2005

    • Author(s)
      古田隆久, 白井直人, 杉本光繁, 中村明子
    • Journal Title

      治療学 2005,39(5):532-4. 39

      Pages: 532-534

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 肝薬物代謝酵素の関与におけるPPI・H2RAの比較.2005

    • Author(s)
      古田隆久, 白井直人, 杉本光繁, 中村明子
    • Journal Title

      臨床消化器内科 20

      Pages: 1137-1147

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] CYP2C19遺伝子多型とプロトンポンプ阻害薬動態の個体差に基づく薬物投与設計.2005

    • Author(s)
      古田隆久, 白井直人, 杉本光繁, 中村明子, 菱田明, 石崎高志
    • Journal Title

      DMPKレクチャーノート 20

      Pages: 8-15

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 消化器疾患用薬のファーマコジェノミクスと薬力学薬-効・副作用・相互作用-.2005

    • Author(s)
      古田隆久, 白井直人, 杉本光繁, 中村明子, 菱田 明
    • Journal Title

      最新医学 60

      Pages: 1879-1890

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] プロトンポンプ阻害剤 ラベプラゾール2005

    • Author(s)
      杉本光繁, 古田隆久, 白井直人, 中村明子
    • Journal Title

      日本臨床 63 Supple 11

      Pages: 350-353

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 抗菌力を「有しない抗潰瘍薬 H2受容体拮抗薬」除菌療法に対するH2プロッカーの上乗せ効果2005

    • Author(s)
      奥平圭輔, 古田隆久, 白井直人, 杉本光繁, 三浦総一郎
    • Journal Title

      日本臨床 63 Supple 11

      Pages: 391-396

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 二次除菌療法の検討 一次除菌無効例における薬物感受性、薬物代謝・動態とそれに基づく投与法の検討-CAM感受性検査、CYP2Cl9のSNP検査-2005

    • Author(s)
      古田隆久, 白井直人, 杉本光繁, 中村明子
    • Journal Title

      日本臨床 63 Supple 11

      Pages: 426-433

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 二次除菌治療の検討 二次除菌レジメの検討 高用量2剤併用療法(PPI+AMPC分轄投与)2005

    • Author(s)
      白井直人, 古田隆久, 杉本光繁, 中村明子
    • Journal Title

      日本臨床 63 Supple 11

      Pages: 438-441

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Influence of CYP 2C19 polymorphism and H. pylori genotype determined from gastric tissue samples on response to triple therapy for H. pylori infection.2005

    • Author(s)
      Furuta T, Sagehashi Y, Shirai N, Sugimoto M, Nakamura A, Kodaira M, Kenmotsu K, Nagano M, Egashira T, Ueda K, Yoneyama M, Ohashi K, Ishizaki T, Hishida A.
    • Journal Title

      Clin Gastroenterol Hepatol 3

      Pages: 564-73

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect of concomitant dosing of famotidine with lansoprazole on gastric acid secretion in relation to CYP2C19 genotype status.2005

    • Author(s)
      Furuta T, Shirai N, Sugimoto M, Nakamura A, Okudaira K, Kajimura M, Hishida A.
    • Journal Title

      Aliment Pharmacol Ther 22

      Pages: 67-74

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Influence of CYP2C19 Pharmacogenetic Polymorphism on Proton Pump Inhibitor-based Therapies.2005

    • Author(s)
      Furuta T, Shirai N, Sugimoto M, Nakamura A, Hishida A, Ishizaki T.
    • Journal Title

      Drug Metab Pharmacokinet. 20

      Pages: 153-67

    • NAID

      130004462957

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Poor metabolize genotype status of CYP2C19 is a risk factor for developing gastric cancer in Japanese patients with Helicobacter pylori infection2005

    • Author(s)
      Sugimoto M, Furuta T, Shirai N, Nakamura A, Kajimura M, Sugimura H, Hishida A,, Ishizaki.
    • Journal Title

      Aliment Pharmacol Ther 22

      Pages: 1033-40

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Influence of CYP 2C19 polymorphism and H.pylori genotype determined from gastric tissue samples on response to triple therapy for H.pylori infection2005

    • Author(s)
      Furuta T, Sagehashi Y, Shirai N, Sugimoto M, Nakamura A, Kodaira M, et al.
    • Journal Title

      Clin Gastroenterol Hepatol 3

      Pages: 564-573

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effect of concomitant dosing of famotidine with lansoprazole on gastric acid secretion in relation to CYP2C19 genotype status2005

    • Author(s)
      Furuta T, Shirai N, Sugimoto M, Nakamura A, Okudaira K, Kajimura M. Hishida A
    • Journal Title

      Aliment Pharmacol Ther 22

      Pages: 67-74

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 二次除菌療法の検討 一次除菌無効例における薬物感受性、薬物代謝・動態とそれに基づく投与法の検討-CAM感受性検査、CYP2C19のSNP検査-2005

    • Author(s)
      古田隆久, 白井直人, 杉本光繁, 中村明子
    • Journal Title

      日本臨床 63・Supple 11

      Pages: 426-433

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Modified allele specific primer-PCR method for analyses of susceptibility of H. pylori strains to clarithromycin

    • Author(s)
      Furuta T, Soya Y, Sugimoto M, Shirai N, Nakamura A, Kodaira, Nishino M, Okuda M, Okimoto T, Murakami K, Fujioka T, Akira Hishida A
    • Journal Title

      J Gastroenterol Hepatol (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effects of Interleukin-10 gene polymorphism on the development of gastric cancer and peptic ulcer in Japanese.

    • Author(s)
      Sugimoto M, Furuta T, Shirai N, Nakamura A, Kajimura M, Haruhiko Sugimura H, Hishida A
    • Journal Title

      J Gastroenterol Hepatol (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Determination of Mutations of 23S rRNA Gene of H. pylori by Allele Specific Primer-PCR method.

    • Author(s)
      Nakamura A, Furuta T, Shirai N, Sugimoto M, Kajimuram M, Soya Y, Hishida A
    • Journal Title

      J Gastroenterol Hepatol (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Serum pepsinogens as an early diagnostic marker of H. pylori eradication.

    • Author(s)
      Shirai N, Furuta T, Sugimoto M, Watanabe F, Takashima M, Yamada M, Futami H, Sato Y, Kubota H, Kodaira M, Kajimura M, Masato M, Hishida A
    • Journal Title

      Hepatogastroenterology (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Role of angiotensinogen gene polymorphism on Helicobacter pylori infection-related gastric cancer risk in Japanese.

    • Author(s)
      Sugimoto M, Furuta T, Shirai N, Kodaira C, Nishino M, Ikuma M, Sugimura H, Hishida A
    • Journal Title

      Carcinogenesis (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Dual therapy with high doses of rabeprazole and amoxicillin versus triple therapy with rabeprazole, amoxicillin and metronidazole as the rescue regimen for Helicobacter pylori infection after triple therapy.

    • Author(s)
      Shirai N, Sugimoto M, Kodaira C, Nishino M, Ikuma M, Kajimura M, Ohashi K, Ishizaki T, Hishida A, Furuta T
    • Journal Title

      Eur J Clin Pharmacol (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Modified allele specific primer-PCR method for analyses of susceptibility of H. pylori strains to clarithromycin.

    • Author(s)
      Furuta T, Soya Y, Sugimoto M, Shirai N, Nakamura A, Kodaira, Nishino M, Okuda M, Okimoto T, Murakami K, Fujioka T, Akira Hishida A.
    • Journal Title

      J Gastroenterol Hepatol (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effects of Interleukin-10 gene polymorphism on the development of gastric cancer and peptic ulcer in Japanese.

    • Author(s)
      Sugimoto M, Furuta T, Shirai N, Nakamura A, Kajimura M, Haruhiko Sugimura H, Hishida A.
    • Journal Title

      J Gastroenterol Hepatol (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Determination of Mutations of 23S rRNA Gene of H. pylori by Allele Specific Primer-PCR method

    • Author(s)
      Nakamura A, Furuta T, Shirai N, Sugimoto M, Kajimuram M, Soya Y, Hishida A.
    • Journal Title

      J Gastroenterol Hepatol (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Serum pepsinogens as an early diagnostic marker of H. pylori eradication.

    • Author(s)
      Shirai N, Furuta T, Sugimoto M, Watanabe F, Takashima M, Yamada M, Futami H, Sato Y, Kubota H, Kodaira M, Kajimura M, Masato M, Hishida A.
    • Journal Title

      Hepatogastroenterology (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Role of angiotensinogen gene polymorphism on Helicobacter pylori infection-related gastric cancer risk in Japanese.

    • Author(s)
      Sugimoto M, Furuta T, Shirai N, Kodaira C, Nishino M, Ikuma M, Sugimura H, Hishida A.
    • Journal Title

      Carcinogenesis (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Dual therapy with high doses of rabeprazole and amoxicillin versus triple therapy with rabeprazole, amoxicillin and metronidazole as the rescue regimen for Helicobacter pylori infection after triple therapy

    • Author(s)
      Shirai N, Sugimoto M, Kodaira C, Nishino M, Ikuma M, Kajimura M, Ohashi K, Ishizaki T, Hishida A, Furuta T.
    • Journal Title

      Eur J Clin Pharmacol (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Modified allele specific primer-PCR method for analyses of susceptibility of H. pylori strains to clarithromycin

    • Author(s)
      Furuta T, Soya Y, Sugimoto M, Shirai N, Nakamura A, Kodaira, Nishino M, Okuda M, Okimoto T, Murakami K, Fujioka T, Akira Hishida A.
    • Journal Title

      J Gastroenterol Hepatol (In press)

    • Related Report
      2006 Annual Research Report
  • [Book] Recent Advance in Gastrointestinal Carcinogenesis, polymorphisms associated with gastric cancer risks2006

    • Author(s)
      Furuta T, Shirai N, Sugimoto M, Nakamura A, Sugimura H, Hishida A
    • Publisher
      TRANSWORLD RESEARCH NETWORK
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] Recent Advance in Gastrointestinal Carcinogenesis

    • Author(s)
      Furuta T, Shirai N, Sugimoto M, Nakamura A, Sugimura H, Hishida A.
    • Related Report
      2006 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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