• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Comprehensive proteome analyses toward biomaker discovery for gastrointestinal and hepatobiliary cancers

Research Project

Project/Area Number 17590485
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionChiba University

Principal Investigator

NOMURA Fumio  Graduate School of Medicine, Chiba University, Department of Molecular Diagnosis, Professor, 大学院医学研究院, 教授 (80164739)

Co-Investigator(Kenkyū-buntansha) TOMONAGA Takeshi  Graduate School of Medicine, Chiba University, Department of Molecular Diagnosis, Associate Professor, 大学院医学研究院, 助教授 (80227644)
MIYAZAKI Masaru  Graduate School of Medicine, Chiba University, First Department of Surgery, Professor, 大学院医学研究院, 教授 (70166156)
YAMAGUCHI Taketo  Graduate School of Medicine, Chiba University, Department of Medicine and Clinical Oncology, Assistant Professor, 大学院医学研究院, 講師 (00241969)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥2,600,000 (Direct Cost: ¥2,600,000)
Keywordsprotome / poroteomics / SELDI-TOF MS / 2D-DIGE / esophageal cancer / pancreatic cancer / alcohol / biomarker / SELDE-TOF MS / アルコール依存 / IPMN / プロテインチップシステム
Research Abstract

In search for novel biomarkers for gastrointestinal cancers, comprehensive proteome analyses were performed combining the ProteinChip system (SELDI-TOF MS) and fluorescent 2-D differential gel electrophoresis (2D-DIGE).
Proteins with altered expression in primary esophageal cancer and adjacent non-cancer tissues were analyzed by agarose 2D-DIGE and identified by mass spectrometry. Among them, a 195-kDa protein, periplakin, was significantly downregulated in esophageal cancer, which was confirmed by immunoblotting. Imunohistochemistry showed that periplakin was mainly localized at cell-cell boundaries in normal epithelium and dysplastic lesions, while it disappeared from cell boundaries, shifted to cytoplasm, in early cancers and scarcely expressed in advanced cancers.
Pancreatic cancer still remains one of the cancers with extremely poor prognosis. To find a novel serum biomarkers for this cancer, the ProteinChip system (SELDI-TOF MS) was utilized. We compared pre- and postoperative serum profiles obtained from patients with invasive pancreatic ductal carcinoma who underwent curative pancreatomy. We identified 6630Da protein as more abundantly expressed in preoperative serum than in postoperative serum. It was found that the high preoperative serum levels of this protein suggests poorer prognosis. Immunostaining revealed abundant expression of the 6630Da protein in pancreatic cancer cells, but not in normal pancreatic ductal cells.
Habitual alcohol drinking is a risk factor for a variety of cancers. Combining the SELDI-TOF Ms and 2D-DIGE, we could detect and identify several biomarkers for excessive alcohol drinking.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (65 results)

All 2007 2006 2005

All Journal Article (56 results) Patent(Industrial Property Rights) (9 results)

  • [Journal Article] Role of the Genetic Polymorphisms in the 5'-Flanking Region for Transcriptional Regulation of the Human CYP2E1 Gene.2007

    • Author(s)
      Uchimoto T. et al.
    • Journal Title

      Alcohol Clin Exp Res 31(1 Suppl)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Diagnostic values of surface-enhanced laser desorption/ionization technology for screening of habitual drinkers.2007

    • Author(s)
      Sogawa K, et al.
    • Journal Title

      Alcohol Clin Exp Res 31(1 Suppl)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Clinical study of 7 cases of familial Mediterranean fever with MEFV gene mutation.2007

    • Author(s)
      Kim S, et al.
    • Journal Title

      Intern Med 46(5)

      Pages: 221-225

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Serum anti-myomegalin antibodies in patients with esophageal squamous cell carcinoma.2007

    • Author(s)
      Shimada H, et al.
    • Journal Title

      Int J Oncol 30(1)

      Pages: 97-103

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Rapid detection of metastasis of gastric cancer using reverse transcription loop-mediated isothermal amplification.2007

    • Author(s)
      Horibe D, et al.
    • Journal Title

      Int J Cancer 120(5)

      Pages: 1063-1069

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Two distinct cytotoxic activities of subtilase cytotoxin produced by shiga-toxigenic Escherichia coli.2007

    • Author(s)
      Morinaga N, et al.
    • Journal Title

      Infect Immun 75(1)

      Pages: 488-496

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Development of a novel fragments absorbed immunocapture enzyme assay system for tartrate-resistant acid phosphatase 5b.2007

    • Author(s)
      Ohashi T, et al.
    • Journal Title

      Clin Chim Acta. 376(1-2)

      Pages: 205-212

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Detection of biomarkers for alcoholism by two-dimensional differential gel electrophoresis.2007

    • Author(s)
      Wu D, et al.
    • Journal Title

      Alcohol Clin Exp Res 31(1 Suppl)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Role of the Genetic Polymorphism in the 5'-Flanking Region for Transcriptional Regulation of the Human CYP2E1 Gene.2007

    • Author(s)
      Uchimoto T, et al.
    • Journal Title

      Alcohol Clin Exp Res 31(1 Suppl)

      Pages: 36-42

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Development of a novel fragments absorbed immunocapture enzyme assay system for tartrate-resistant acid phosphatase 5b.2007

    • Author(s)
      Ohashi T, et al.
    • Journal Title

      Clin Chim Acta 376(1-2)

      Pages: 205-212

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Role of the Genetic Polymorphisms in the 5'-Flanking Region for Transcriptional Regulation of the Human CYP2E1 Gene.2007

    • Author(s)
      Uchimoto T, et al.
    • Journal Title

      Alcohol Clin Exp Res 31(1 Suppl)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Development and characterization of novel monoclonal antibodies against tartrate-resistant acid phosphatase 5.2006

    • Author(s)
      Ohashi T, et al.
    • Journal Title

      Hybridoma (Larchmt) 25(6)

      Pages: 358-366

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Identification and characterization of receptors for vacuolating activity of subtilase cytotoxin.2006

    • Author(s)
      Yahiro K, et al.
    • Journal Title

      Mol Microbiol 62(2)

      Pages: 480-490

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Presence of serum tripartite motif-containing 21 antibodies in patients with esophageal squamous cell carcinoma.2006

    • Author(s)
      Kuboshima M, et al.
    • Journal Title

      Cancer Sci 97(5)

      Pages: 380-386

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Critical roles of muscle-secreted angiogenic factors in therapeutic neovascularization.2006

    • Author(s)
      Tateno K, et al.
    • Journal Title

      Circ Res 98(9)

      Pages: 1194-1202

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] An essential role of alternative splicing of c-myc suppressor FUSE-binding protein-interacting repressor in carcinogenesis.2006

    • Author(s)
      Matsushita K, et al.
    • Journal Title

      Cancer Res. 66(3)

      Pages: 1409-1417

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Proteomic analysis of primary esophageal squamous cell carcinoma reveals downregulation of a cell adhesion protein, periplakin.2006

    • Author(s)
      Nishimori T, et al.
    • Journal Title

      Proteomics 6(3)

      Pages: 1011-1018

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Identification of a novel SEREX antigen, SLC2A1/GLUT1, in esophageal squamous cell carcinoma.2006

    • Author(s)
      Kuboshima M, et al.
    • Journal Title

      Int J Oncol 28(2)

      Pages: 463-468

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 【新しい臨床検査・未来の臨床検査】疾患プロテオミクスの現状と将来展望2006

    • Author(s)
      野村文夫
    • Journal Title

      検査と技術 34(11)

      Pages: 1007-1012

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 【蛍光ディファレンスゲル二次元電気泳動】消化器扁平上皮癌の分子腫瘍マーカーの検索と蛍光ディファレンスゲル二次元電気泳動2006

    • Author(s)
      西森孝典, 他
    • Journal Title

      生物物理化学 50(3)別冊

      Pages: 187-191

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] ProteinChip SystemによるWeighted voting algorithm解析を用いた飲酒マーカーの探索2006

    • Author(s)
      曽川一幸, 他
    • Journal Title

      アルコールと医学生物学 26

      Pages: 5-7

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] 臨床検査と疾患プロテオミクス2006

    • Author(s)
      野村文夫
    • Journal Title

      臨床病理 54(4)

      Pages: 413-420

    • NAID

      10018015113

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] 【膵癌診断の将来展望】膵液中のバイオマーカー蛋白検索の将来性2006

    • Author(s)
      白井嘉彦, 他
    • Journal Title

      胆と膵 27(3)

      Pages: 171-174

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] ポストゲノム時代の生命科学と臨床検査への応用 臨床検査への実用化を目指した癌プロテオーム研究2006

    • Author(s)
      朝長毅, 他
    • Journal Title

      日本臨床検査自動化学会会誌 31(2)

      Pages: 191-195

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Critical roles of muscle-secreted angiogenic factors in therapeutic neovascularization2006

    • Author(s)
      Tateno K, et al.
    • Journal Title

      Circ Res 98(9)

      Pages: 1194-1202

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] An essential role of alternative splicing of c-myc suppressor FUSE-binding protein-interacting repressor in carcinogenesis.2006

    • Author(s)
      Matsushita K, et al.
    • Journal Title

      Cancer Res 66(3)

      Pages: 1409-1417

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Proteomic analysis of primary esophageal squamous cell carcinoma reveals downregulation of a cell adhesion protein, periplankin.2006

    • Author(s)
      Nishimori T, et al.
    • Journal Title

      Proteomics 6(3)

      Pages: 1011-1018

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Clinical proteomics : Current status and future perspectives2006

    • Author(s)
      Nomura F
    • Journal Title

      Mdern medical laboratory 34(11)

      Pages: 1007-1012

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Proteomic analysis of primary esophageal squamous cell carcinoma reveals downregulation of a cell adhesion protein, periplakin.2006

    • Author(s)
      Nishimori T, et al.
    • Journal Title

      Journal of Electrophoresis 50(3)

      Pages: 187-191

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Proteomic analysis for biomarkers of alcoholism by proteinchip system and WVA2006

    • Author(s)
      Sogawa K, et al.
    • Journal Title

      Alcohol and biomedical research 26

      Pages: 5-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Clinical proteomics from viewpoint of laboratory medicine2006

    • Author(s)
      Nomura F
    • Journal Title

      Rinsho Byori 54(4)

      Pages: 413-420

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Possibilities of the Biomarker Protein Search in Pancreatic Juice.2006

    • Author(s)
      Shirai Y, et al.
    • Journal Title

      The Biliary tract & pancreas 27(3)

      Pages: 171-174

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Proteomic Application for Molecular Diagnosis of Cancer.2006

    • Author(s)
      Tomonaga T.
    • Journal Title

      JJCLA 31(2)

      Pages: 191-195

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Development and characterization of novel monoclonal antibodies against tartrate-resistant acid phosphatase 5.2006

    • Author(s)
      Ohashi T, et al.
    • Journal Title

      Hybridoma(Larchmt) 25(6)

      Pages: 358-366

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Presence of serum tripartite motif-containing 21 antibodies in patients with esophageal squamous cell carcinoma.2006

    • Author(s)
      Kuboshima M. et al.
    • Journal Title

      Cancer Sci 97(5)

      Pages: 380-386

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Critical roles of muscle-secreted angiogenic factors in therapeutic neovascularization.2006

    • Author(s)
      Tateno K. et al.
    • Journal Title

      Circ Res 98(9)

      Pages: 1194-1202

    • Related Report
      2006 Annual Research Report
  • [Journal Article] An essential role of alternative splicing of c-myc suppressor FUSE-binding protein-interacting repressor in carcinogenesis.2006

    • Author(s)
      Matsushita K. et al.
    • Journal Title

      Cancer Res. 66(3)

      Pages: 1409-1417

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Identification of a novel SEREX antigen, SLCIIAI/GLUT1, in esophageal squamous cell carcinoma.2006

    • Author(s)
      Kuboshima M, et al.
    • Journal Title

      Int J Oncol 28(2)

      Pages: 463-468

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 【新しい臨床検査・未来の臨床検査】 疾患プロテオミクスの現状と将来展望2006

    • Author(s)
      野村文夫
    • Journal Title

      検査と技術 34(11)

      Pages: 1007-1012

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Proteomic analysis of primary esophageal squamous cell carcinoma reveals downregulation of a cell adhesion protein, periplakin.2006

    • Author(s)
      Nishimori, T, et al.
    • Journal Title

      Proteomics 6(3)

      Pages: 1011-1018

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Significance of a novel sucrose permeability test using serum in the diagnosis of early gastric cancer.2005

    • Author(s)
      Shishido T, et al.
    • Journal Title

      World J Gastroenterol 11(44)

      Pages: 6905-6909

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Pancreatic juice cytology in the diagnosis of intraductal papillary mucinous neoplasm of the pancreas : significance of sampling by peroral pancreatoscopy.2005

    • Author(s)
      Yamaguchi T, et al.
    • Journal Title

      Cancer. 104(12)

      Pages: 2830-2836

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A polymorphism in the 5'-flanking region of the CYP2E1 gene and elevated lung adenocarcinoma risk in a Japanese population.2005

    • Author(s)
      Iizasa T, et al.
    • Journal Title

      Oncol Rep 14(4)

      Pages: 919-923

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Expression of the fetal-oncogenic fibroblast growth factor-8/17/18 subfamily in human hematopoietic tumors.2005

    • Author(s)
      Nezu M, et al.
    • Journal Title

      Biochem Biophys Res Commun 335(3)

      Pages: 843-849

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Centromere protein H is up-regulated in primary human colorectal cancer and its overexpression induces aneuploidy.2005

    • Author(s)
      Tomonaga T, et al.
    • Journal Title

      Cancer Res 65(11)

      Pages: 4683-4689

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] プロテインチップシステムにより見出された5.9kdペプチドの飲酒マーカーとしての有用性2005

    • Author(s)
      曽川一幸, 他
    • Journal Title

      アルコールと医学生物学 25

      Pages: 129-131

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] CYP2E1遺伝子5'上流2.5kb領域の転写調節への遺伝子多型の関与と転写調節領域の解明2005

    • Author(s)
      内本高之, 他
    • Journal Title

      アルコールと医学生物学 25

      Pages: 27-33

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 蛍光標識二次元ディファレンス電気泳動法によるアルコール依存症患者血清のプロテオーム解析2005

    • Author(s)
      呉迪, 他
    • Journal Title

      アルコールと医学生物学 25

      Pages: 132-134

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Significance of a novel sucrose permeability test using serum in the diagnosis of early gastric cancer.2005

    • Author(s)
      Shishido T, et al.
    • Journal Title

      World J Gastroenterol. 11(44)

      Pages: 6905-6909

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Pancreatic juice cytology in the diagnosis of intraductal papillary mucinous neoplasm of the pancreas : significance of sampling by peroral pancreatoscopy.2005

    • Author(s)
      Yamaguchi T, et al.
    • Journal Title

      Cancer 104(12)

      Pages: 2830-2836

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Centromere protein H is up-regulated in primary human colorectal cancer and its overexpression induces aneuploidy.2005

    • Author(s)
      Tomonaga T, et al.
    • Journal Title

      Cancer Res. 65(11)

      Pages: 4683-4689

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Diagnostic values of surface-enhanced laser desorption/ionization technology for screening of habitual drinkers.2005

    • Author(s)
      Sogawa K, et al.
    • Journal Title

      Alcohol and biomedical research 25

      Pages: 129-131

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Role of the Genetic Polymorphisms in the 5'-Flanking Region for Transcriptional Regulation of the Human CYP2E1 Gene.2005

    • Author(s)
      Uchimoto T, et al.
    • Journal Title

      Alcohol and biomedical research 25

      Pages: 27-33

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Detection of biomarkers for alcoholism by two-dimensional differential gel electrophoresis.2005

    • Author(s)
      Wu D, et al.
    • Journal Title

      Alcohol and biomedical research 25

      Pages: 132-134

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Pancreatic juice cytology in the diagnosis of intraductal papillary mucinous neoplasm of the pancreas.2005

    • Author(s)
      Yamaguchi T, et al.
    • Journal Title

      Cancer 15(104)

      Pages: 2830-2836

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Serological identification of tumor antigens of esophageal squamous cell carcinoma.2005

    • Author(s)
      Shimada H, et al.
    • Journal Title

      Int J Oncol 26(1)

      Pages: 77-86

    • Related Report
      2005 Annual Research Report
  • [Patent(Industrial Property Rights)] 特許権2007

    • Industrial Property Rights Holder
      千葉大, 日東紡績株式会社
    • Industrial Property Number
      2007-048523
    • Filing Date
      2007-02-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 特許権2007

    • Industrial Property Rights Holder
      千葉大学, 日東紡績株式会社
    • Industrial Property Number
      2007-048523
    • Filing Date
      2007-02-28
    • Related Report
      2006 Annual Research Report
  • [Patent(Industrial Property Rights)] 特許権2007

    • Industrial Property Rights Holder
      千葉大学, 日東紡績株式会社
    • Industrial Property Number
      2007-048523
    • Filing Date
      2007-02-28
    • Related Report
      2006 Annual Research Report
  • [Patent(Industrial Property Rights)] 特許権2006

    • Inventor(s)
      外川明, 高野重紹 他4名
    • Industrial Property Rights Holder
      外川明, 高野重紹 他4名
    • Industrial Property Number
      2005-001033
    • Filing Date
      2006-05-31
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 特許権2006

    • Inventor(s)
      外川明, 高野重紹 他2名
    • Industrial Property Rights Holder
      外川明, 高野重紹 他2名
    • Industrial Property Number
      2005-160715
    • Filing Date
      2006-05-31
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 特許権2006

    • Inventor(s)
      外川明, 松下一之 他3名
    • Industrial Property Rights Holder
      外川明, 松下一之 他3名
    • Industrial Property Number
      2006-018341
    • Filing Date
      2006-01-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 特許権2006

    • Inventor(s)
      本村真理, 朝長毅 他6名
    • Industrial Property Rights Holder
      本村真理, 朝長毅 他6名
    • Industrial Property Number
      2006-072631
    • Filing Date
      2006-03-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 特許権2006

    • Inventor(s)
      島田英昭, 松下一之 他3名
    • Industrial Property Rights Holder
      島田英昭, 松下一之 他3名
    • Industrial Property Number
      2006-109310
    • Filing Date
      2006-04-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 特許権2006

    • Inventor(s)
      島田英昭, 松下一之・他3名
    • Industrial Property Rights Holder
      島田英昭, 松下一之・他3名
    • Industrial Property Number
      2006-109310
    • Filing Date
      2006-04-12
    • Related Report
      2006 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi